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  1 / 29213 MEDLINE  
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[PMID]:29431926
[Au] Autor:Kalaev VN; Nechaeva MS
[Ti] Título:[The study of the frequency of buccal epithelium cells with nuclear in athletes in dependence on the place got in the competition].
[So] Source:Gig Sanit;95(10):992-7, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Cytogenetic homeostasis ofathletes involved in hand-to-hand armyfighting, depending on the outcome of the fight and the level of aggressiveness has been studied. Status of the genetic apparatus in athletes was evaluated in buccal epithelium with the use of micronucleus test, which is widely usedfor the determination of the influence of various factors on the genetic stability of the organism. Psychological testing of athletes was executed with the use of Spielberger's State-Trait Anger Expression Inventory scale, Bass-Darky questionnaire for the diagnostics of aggression and hostile reactions, Eysenck Personality Questionnaire test for the evaluation ofpsychic conditions and method of U.P. Ilyin and P.A. Kovalev for the identification of the propensity to conflictness and aggressiveness (positive and negative) as the personal characteristics. The place taken by the athlete on the competition was shown to have an impact on the frequency of buccal epithelium cells with nuclear abnormalities (micronuclei, perinuclear vacuoles, notches, protrusions "tongue" and "broken egg"). Losers have nuclear aberrations more than winners. At that in athletes with higher aggressiveness and its attendant psychological characteristics the influence of the outcome of the competition on the number of cells with aberrations core is more pronounced.
[Mh] Termos MeSH primário: Agressão
Desempenho Atlético
Artes Marciais
Testes para Micronúcleos/métodos
Mucosa Bucal/patologia
[Mh] Termos MeSH secundário: Adolescente
Agressão/fisiologia
Agressão/psicologia
Atletas/psicologia
Desempenho Atlético/fisiologia
Desempenho Atlético/psicologia
Análise Citogenética/métodos
Seres Humanos
Masculino
Artes Marciais/fisiologia
Artes Marciais/psicologia
Testes Psicológicos
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 29213 MEDLINE  
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[PMID]:29408910
[Au] Autor:Whitaker L; Brown SL; Young B; Fereday R; Coyne SM; Qualter P
[Ad] Endereço:Department of Psychological Sciences, University of Liverpool, Liverpool, United Kingdom.
[Ti] Título:Pervasive, hard-wired and male: Qualitative study of how UK adolescents view alcohol-related aggression.
[So] Source:PLoS One;13(2):e0191269, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Laboratory studies of alcohol-inexperienced adolescents show that aggression can be primed by alcohol-related stimuli, suggesting that alcohol-related aggression is partly socially learned. Script theory proposes that alcohol-related aggression 'scripts' for social behaviors are culturally-available and learned by individuals. The purpose of the study was to understand the content and origins of alcohol-related aggression scripts learned by adolescents. This qualitative focus group study of 40 adolescents (ages 14-16 years) examined alcohol-related aggression scripts. Participants believed aggression and severe injury to be pervasive when young people drink. Viewed through a biological lens, participants described aggression as an 'instinctive' and 'hard-wired' male trait facilitated by intoxication. As such, alcohol-related aggression was not seen as intended or personally controllable and participants did not see it in moral terms. Females were largely viewed as either bystanders of inter-male aggression or potential victims of male sexual aggression. Participants attributed their views on the frequency and nature of alcohol-related aggression to current affairs and reality television, which they felt portrayed a reality of which they had little experience. The origins of the explicitly biological frameworks that participants used seemed to lie in pre-existing beliefs about the nature of gender differences. Perceptions of the pervasiveness of male alcohol-related aggression, and the consequent failure to view alcohol-related aggression in moral terms, could dispose some young people to alcohol-related aggression. Interventions could target (1) the beliefs that alcohol-related aggression is pervasive and uncontrollable in males, and (2) participants' dysfunctional views of masculinity that underpin those beliefs.
[Mh] Termos MeSH primário: Comportamento do Adolescente
Agressão
Consumo de Bebidas Alcoólicas
[Mh] Termos MeSH secundário: Adolescente
Seres Humanos
Masculino
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191269


  3 / 29213 MEDLINE  
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[PMID]:29246985
[Au] Autor:Limb M
[Ti] Título:Cage fighting: vets divided over poultry management.
[So] Source:Vet Rec;181(24):640-641, 2017 12 16.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dissidências e Disputas
Abrigo para Animais
Aves Domésticas
Médicos Veterinários/psicologia
[Mh] Termos MeSH secundário: Agressão
Bem-Estar do Animal/normas
Animais
Seres Humanos
Influenza Aviária/prevenção & controle
Reino Unido
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  4 / 29213 MEDLINE  
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[PMID]:29231006
[Au] Autor:Sun ZW; Shi TT; Fu PX
[Ad] Endereço:Beijing Ankang Hospital, Beijing 101300, China.
[Ti] Título:[Characteristics of Schizophrenia Patients' Homicide Behaviors and Their Correlations with Criminal Capacity].
[So] Source:Fa Yi Xue Za Zhi;33(1):32-35, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the characteristics of schizophrenia patients' homicide behaviors and the influences of the assessments of criminal capacity. METHODS: Indicators such as demographic and clinical data, characteristics of criminal behaviors and criminal capacity from the suspects whom were diagnosed by forensic psychiatry as schizophrenia ( =110) and normal mental ( =70) with homicide behavior, were collected by self-made investigation form and compared. The influences of the assessments of criminal capacity on the suspects diagnosed as schizophrenia were also analyzed using logistic regression analysis. RESULTS: There were no significant statistical differences between the schizophrenic group and the normal mental group concerning age, gender, education and marital status ( >0.05). There were significant statistical differences between the two groups concerning thought disorder, emotion state and social function before crime ( <0.05) and there were significant statistical differences in some characteristics of the case such as aggressive history ( <0.05), cue, trigger, plan, criminal incentives, object of crime, circumstance cognition and self-protection ( <0.05). Multivariate logistic regression analysis suggested that thought disorder, emotion state, social function, criminal incentives, plan and self-protection before crime of the schizophrenic group were positively correlated with the criminal capacity ( <0.05). CONCLUSIONS: The relevant influences of psychopathology and crime characteristics should be considered comprehensively for improving the accuracy of the criminal capacity evaluation on the suspects diagnosed as schizophrenia with homicide behavior.
[Mh] Termos MeSH primário: Agressão/psicologia
Crime
Homicídio/psicologia
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Criminosos
Psiquiatria Legal
Seres Humanos
Motivação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.008


  5 / 29213 MEDLINE  
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[PMID]:29231005
[Au] Autor:He JF; Hong W; Shao Y; Han HQ; Xie B
[Ad] Endereço:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
[Ti] Título:[Application of MOAS for Evaluating of Violence Risk in the Inpatients with Mental Disorders].
[So] Source:Fa Yi Xue Za Zhi;33(1):28-31, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the value of Modified Overt Aggression Scale (MOAS) on predicting serious aggressive behavior in the inpatients with mental disorders and to provide theoretical basis for violence risk assessments in the inpatients with mental disorders. METHODS: Total 918 inpatients in a psychiatric hospital were evaluated by trained medical workers using MOAS in September 2009, and their serious violent behavior were followed up for 2 years. The value of MOAS on predicting violence in the inpatients with mental disorders was analyzed by SPSS 21.0. RESULTS: (1) Compared to the patients without serious aggressive behaviors, the patients with serious aggressive behavior within 2 years showed significantly higher scores (P<0.05) on verbal aggression, aggression against property, physical aggression and total weighted score of MOAS; (2) Significant correlation was found between the score of verbal aggression and the serious acts of violence within 2 years (P<0.05); (3) Scores of verbal aggression, physical aggression and total weighted score of MOAS had predictive value on serious aggressive behaviors within 2 years. CONCLUSIONS: MOAS has certain value on predicting the serious aggressive behaviors of patients with mental disorders within 2 years.
[Mh] Termos MeSH primário: Agressão/psicologia
Hospitais Psiquiátricos
Pacientes Internados
Transtornos Mentais/psicologia
Violência/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Indicadores Básicos de Saúde
Seres Humanos
Masculino
Transtornos Mentais/diagnóstico
Escalas de Graduação Psiquiátrica
Medição de Risco
Fatores de Risco
Assunção de Riscos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.007


  6 / 29213 MEDLINE  
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[PMID]:28448987
[Au] Autor:Weitekamp CA; Solomon-Lane TK; Del Valle P; Triki Z; Nugent BM; Hofmann HA
[Ad] Endereço:Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.
[Ti] Título:A Role for Oxytocin-Like Receptor in Social Habituation in a Teleost.
[So] Source:Brain Behav Evol;89(3):153-161, 2017.
[Is] ISSN:1421-9743
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Oxytocin (OT) mediates social habituation in rodent model systems, but its role in mediating this effect in other vertebrates is unknown. We used males of the African cichlid fish, Astatotilapia burtoni, to investigate two aspects of isotocin (IT; an OT homolog) signaling in social habituation. First, we examined the expression of IT receptor 2 (ITR2) as well as two immediate early genes in brain regions implicated in social recognition. Next, we examined IT neuron activity using immunohistochemistry. Patterns of gene expression in homologs of the amygdala and hippocampus implicate IT signaling in these regions in social habituation to a territorial neighbor. In the preoptic area, the expression of the ITR2 subtype and IT neuron activity respond to the presence of a male, independent of familiarity. Our results implicate IT in mediating social habituation in a teleost.
[Mh] Termos MeSH primário: Ciclídeos/genética
Ocitocina/análogos & derivados
[Mh] Termos MeSH secundário: Agressão/fisiologia
Tonsila do Cerebelo
Animais
Comportamento Animal/fisiologia
Encéfalo/metabolismo
Ciclídeos/fisiologia
Feminino
Hibridização In Situ
Masculino
Ocitocina/metabolismo
Ocitocina/fisiologia
Área Pré-Óptica/metabolismo
Receptores de Ocitocina/fisiologia
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Oxytocin); 50-56-6 (Oxytocin); 550-21-0 (isotocin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1159/000464098


  7 / 29213 MEDLINE  
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[PMID]:29308601
[Au] Autor:Ostinelli EG; Jajawi S; Spyridi S; Sayal K; Jayaram MB
[Ad] Endereço:Department of Health Sciences, Università degli Studi di Milano, Via Antonio di Rudinì 8, Milan, Italy, 20142.
[Ti] Título:Aripiprazole (intramuscular) for psychosis-induced aggression or agitation (rapid tranquillisation).
[So] Source:Cochrane Database Syst Rev;1:CD008074, 2018 01 08.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: People experiencing psychosis may become aggressive. Antipsychotics, such as aripiprazole in intramuscular form, can be used in such situations. OBJECTIVES: To evaluate the effects of intramuscular aripiprazole in the treatment of psychosis-induced aggression or agitation (rapid tranquillisation). SEARCH METHODS: On 11 December 2014 and 11 April 2017, we searched the Cochrane Schizophrenia Group's Study-based Register of Trials which is based on regular searches of CINAHL, BIOSIS, AMED, Embase, PubMed, MEDLINE, PsycINFO, and registries of clinical trials. SELECTION CRITERIA: All randomised controlled trials (RCTs) that randomised people with psychosis-induced aggression or agitation to receive either intramuscular aripiprazole or another intramuscular intervention. DATA COLLECTION AND ANALYSIS: We independently inspected citations and, where possible, abstracts, ordered papers and re-inspected and quality assessed these. We included studies that met our selection criteria. At least two review authors independently extracted data from the included studies. We chose a fixed-effect model. We analysed dichotomous data using risk ratio (RR) and the 95% confidence intervals (CI). We analysed continuous data using mean differences (MD) and their CIs. We assessed risk of bias for included studies and used GRADE to create 'Summary of findings' tables. MAIN RESULTS: Searching found 63 records referring to 21 possible trials. We could only include three studies, all completed over the last decade, with 885 participants, of which 707 were included for quantitative analyses in this systematic review. Due to limited comparisons, small size of trials and a paucity of investigated and reported 'pragmatic' outcomes, evidence was mostly graded as low or very low quality. No trials reported useful data for one of our primary outcomes of tranquil or asleep by 30 minutes. Economic outcomes were also not reported in the trials.When compared with placebo, fewer people in the aripiprazole group needed additional injections compared to the placebo group (2 RCTs, n = 382, RR 0.69, 95% CI 0.56 to 0.85, very low-quality evidence). Clinically important improvement in agitation at two hours favoured the aripiprazole group (2 RCTs, n = 382, RR 1.50, 95% CI 1.17 to 1.92, very low-quality evidence). The numbers of non-responders after the first injection also favoured aripiprazole (1 RCT, n = 263, RR 0.49, 95% CI 0.34 to 0.71, low-quality evidence). Although no effect was found, more people in the aripiprazole compared to the placebo group experienced adverse effects (1 RCT, n = 117, RR 1.51, 95% CI 0.93 to 2.46, very low-quality evidence).Aripiprazole required more injections compared to haloperidol (2 RCTs, n = 477, RR 1.28, 95% CI 1.00 to 1.63, very low-quality evidence), with no significant difference in agitation (2 RCTs, n = 477, RR 0.94, 95% CI 0.80 to 1.11, very low-quality evidence), and similar non-responders after first injection (1 RCT, n = 360, RR 1.18, 95% CI 0.78 to 1.79, low-quality evidence). Aripiprazole and haloperidol did not differ when taking into account the overall number of people that experienced at least one adverse effect (1 RCT, n = 113, RR 0.91, 95% CI 0.61 to 1.35, very low-quality evidence).Compared to aripiprazole, olanzapine was better at reducing agitation (1 RCT, n = 80, RR 0.77, 95% CI 0.60 to 0.99, low-quality evidence) and had a more favourable effect on global state change scores (1 RCT, n = 80, MD 0.58, 95% CI 0.01 to 1.15, low-quality evidence), both at two hours. No differences were found in terms of experiencing at least one adverse effect during the 24 hours after treatment (1 RCT, n = 80, RR 0.75, 95% CI 0.45 to 1.24, very low-quality evidence). However, participants allocated to aripiprazole experienced less somnolence (1 RCT, n = 80, RR 0.25, 95% CI 0.08 to 0.82, low-quality evidence). AUTHORS' CONCLUSIONS: The available evidence is of poor quality but there is some evidence aripiprazole is effective compared to placebo and haloperidol, but not when compared to olanzapine. However, considering that evidence comes from only three studies, caution is required in generalising these results to real-world practice. This review firmly highlights the need for more high-quality trials on intramuscular aripiprazole in the management of people with acute aggression or agitation.
[Mh] Termos MeSH primário: Agressão/efeitos dos fármacos
Antipsicóticos/administração & dosagem
Aripiprazol/administração & dosagem
Agitação Psicomotora/tratamento farmacológico
[Mh] Termos MeSH secundário: Agressão/psicologia
Antipsicóticos/efeitos adversos
Aripiprazol/efeitos adversos
Benzodiazepinas/administração & dosagem
Haloperidol/administração & dosagem
Seres Humanos
Injeções Intramusculares
Agitação Psicomotora/psicologia
Ensaios Clínicos Controlados Aleatórios como Assunto
Tranquilizantes/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Tranquilizing Agents); 12794-10-4 (Benzodiazepines); 82VFR53I78 (Aripiprazole); J6292F8L3D (Haloperidol); N7U69T4SZR (olanzapine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD008074.pub2


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[PMID]:29364936
[Au] Autor:Guo M; Wu Z; Zhu H
[Ad] Endereço:Department of Aeronautics and Astronautics, Fudan University, Shanghai, China.
[Ti] Título:Empirical study of lane-changing behavior on three Chinese freeways.
[So] Source:PLoS One;13(1):e0191466, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lane-changing (LC) behavior is investigated on Chinese freeways, where the driving circumstances are relatively aggressive. Three data sets were collected from urban expressways and an intercity highway in the form of traffic videos. Different aspects of LC behaviors are analyzed, i.e., the LC rate, motivation, target lane choice and impact on traffic. The results suggest that LC is a transient behavior that randomly occurs with high frequency, which is the main feature of aggressive driving. Several LC patterns and the combination effect of ramps, fast lanes and various vehicle types are presented. The influence of LC on local traffic endures for approximately 15 to 30 s, which rapidly increases and slowly declines. LC behavior will increase the risk of high-speed car-following. All results are obtained from the empirical data; they will be useful for traffic management and traffic modeling.
[Mh] Termos MeSH primário: Condução de Veículo/psicologia
[Mh] Termos MeSH secundário: Acidentes de Trânsito/prevenção & controle
Acidentes de Trânsito/psicologia
Agressão
Condução de Veículo/estatística & dados numéricos
Comportamento
China
Seres Humanos
Modelos Psicológicos
Motivação
Gestão da Segurança
População Urbana
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191466


  9 / 29213 MEDLINE  
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[PMID]:28455183
[Au] Autor:Vongas JG; Al Hajj R
[Ad] Endereço:Ithaca College, School of Business, Department of Management, 953 Danby Road, Ithaca, NY 14850, USA. Electronic address: jvongas@ithaca.edu.
[Ti] Título:The effects of competition and implicit power motive on men's testosterone, emotion recognition, and aggression.
[So] Source:Horm Behav;92:57-71, 2017 Jun.
[Is] ISSN:1095-6867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A contribution to a special issue on Hormones and Human Competition. We investigated the effects of competition on men's testosterone levels and assessed whether androgen reactivity was associated with subsequent emotion recognition and reactive and proactive aggression. We also explored whether personalized power (p Power) moderated these relationships. In Study 1, 84 males competed on a number tracing task and interpreted emotions from facial expressions. In Study 2, 72 males competed on the same task and were assessed on proactive and reactive aggression. In both studies, contrary to the biosocial model of status (Mazur, 1985), winners' testosterone levels decreased significantly while losers' levels increased, albeit not significantly. Personalized power moderated the effect of competition outcome on testosterone change in both studies. Using the aggregate sample, we found that the effect of decreased testosterone levels among winners (compared to losers) was significant for individuals low in p Power but not for those with medium or high p Power. Testosterone change was positively related to emotion recognition, but unrelated to either aggression subtype. The testosterone-mediated relationship between winning and losing and emotion recognition was moderated by p Power. In addition, p Power moderated the direct (i.e., non-testosterone mediated) path between competition outcome and emotion recognition and both types of aggression: high p-Power winners were more accurate at deciphering others' emotions than high p-Power losers. Finally, among high p-Power men, winners aggressed more proactively than losers, whereas losers aggressed more reactively than winners. Collectively, these studies highlight the importance of implicit power motivation in modulating hormonal, cognitive, and behavioral outcomes arising from human competition.
[Mh] Termos MeSH primário: Agressão/fisiologia
Comportamento Competitivo/fisiologia
Emoções/fisiologia
Poder (Psicologia)
Recognição (Psicologia)/fisiologia
Testosterona/análise
[Mh] Termos MeSH secundário: Adolescente
Adulto
Seres Humanos
Masculino
Motivação/fisiologia
Saliva/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  10 / 29213 MEDLINE  
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[PMID]:28463343
[Au] Autor:Correll CU; Yu X; Xiang Y; Kane JM; Masand P
[Ti] Título:Biological treatment of acute agitation or aggression with schizophrenia or bipolar disorder in the inpatient setting.
[So] Source:Ann Clin Psychiatry;29(2):92-107, 2017 05.
[Is] ISSN:1547-3325
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Schizophrenia and bipolar disorders are chronic illnesses that commonly present with symptoms of acute agitation and aggression. These symptoms must be managed rapidly to prevent potential harm to the patient and others, including their caregivers, peers, and health care workers. A number of treatment options are available to clinicians to manage acute agitation and aggression, including non-pharmacologic behavioral and environmental de-escalation strategies, as well as biological treatment options such as pharmacologic agents and electroconvulsive therapy. We summarize the available biological treatment options for patients with schizophrenia or bipolar disorder presenting with acute agitation or aggression in the inpatient setting, focusing on antipsychotics. METHODS: The following searches were used in PubMed to obtain the most relevant advances in treating schizophrenia or bipolar disorder with acute agitation and aggression: (agitation, agitated, aggression, aggressive, hostile, hostility, violent, or violence) and (schizophr*, psychosis, psychot*, psychos*, mania, manic, or bipolar) and (*pharmacologic, antipsychotic*, neuroleptic*, antiepileptic*, anti-seizure*, mood stabilizer*, lithium, benzodiazepine*, beta blocker, beta-blocker, alpha2, alpha-2, *histamine*, electroconvulsive, ECT, shock, or transcranial). Individual searches were performed for each drug class. The studies were limited to peer-reviewed, English-language, and human studies. Most were placebo-controlled randomized controlled trials (RCTs) or meta-analyses. RESULTS: Among pharmacologic agents, antipsychotics, benzodiazepines, anticonvulsants, and lithium have been studied in randomized trials. Some typical and, more recently, atypical antipsychotics are available as both oral and short-acting intramuscular (IM) formulations, with 1 typical antipsychotic also available as an inhalable formulation. CONCLUSIONS: Among the pharmacologic agents studied in RCTs, atypical antipsychotics have the best evidence to support efficacy both in oral and short-acting IM formulations, as well as in one instance in an inhalable formulation.
[Mh] Termos MeSH primário: Transtorno Bipolar
Agitação Psicomotora/terapia
Psicotrópicos/farmacologia
Esquizofrenia/terapia
[Mh] Termos MeSH secundário: Agressão/efeitos dos fármacos
Agressão/psicologia
Transtorno Bipolar/psicologia
Transtorno Bipolar/terapia
Eletroconvulsoterapia/métodos
Serviços de Emergência Psiquiátrica/métodos
Seres Humanos
Agitação Psicomotora/psicologia
Ensaios Clínicos Controlados Aleatórios como Assunto
Psicologia do Esquizofrênico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Psychotropic Drugs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE



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