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[PMID]:28448827
[Au] Autor:Broyd A; Balzan RP; Woodward TS; Allen P
[Ad] Endereço:Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, UK.
[Ti] Título:Dopamine, cognitive biases and assessment of certainty: A neurocognitive model of delusions.
[So] Source:Clin Psychol Rev;54:96-106, 2017 Jun.
[Is] ISSN:1873-7811
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper examines the evidence that delusions can be explained within the framework of a neurocognitive model of how the brain assesses certainty. Here, 'certainty' refers to both low-level interpretations of one's environment and high-level (conscious) appraisals of one's beliefs and experiences. A model is proposed explaining how the brain systems responsible for assigning certainty might dysfunction, contributing to the cause and maintenance of delusional beliefs. It is suggested that delusions arise through a combination of perturbed striatal dopamine and aberrant salience as well as cognitive biases such as the tendency to jump to conclusions (JTC) and hypersalience of evidence-hypothesis matches. The role of emotion, stress, trauma and sociocultural factors in forming and modifying delusions is also considered. Understanding the mechanisms involved in forming and maintaining delusions has important clinical implications, as interventions that improve cognitive flexibility (e.g. cognitive remediation therapy and mindfulness training) could potentially attenuate neurocognitive processes.
[Mh] Termos MeSH primário: Cognição/fisiologia
Delusões/psicologia
Dopamina/metabolismo
Modelos Psicológicos
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Delusões/metabolismo
Seres Humanos
Testes Neuropsicológicos
Incerteza
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:28449271
[Au] Autor:Jacobs D; Willekens D; de Die-Smulders C; Frijns JP; Steyaert J
[Ad] Endereço:Centre for Human Genetics, University of Leuven, Leuven, Belgium.
[Ti] Título:Delusional and psychotic disorders in juvenile myotonic dystrophy type-1.
[So] Source:Am J Med Genet B Neuropsychiatr Genet;174(4):359-366, 2017 Jun.
[Is] ISSN:1552-485X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the clinically derived hypothesis of a relatively high incidence of delusional and psychotic disorders in adolescents with juvenile Myotonic Dystrophy type-1 (DM1). Twenty-seven subjects of age 16-25 with juvenile DM1 and their parents were invited to have a clinical psychiatric interview, and to complete an ASEBA behavior checklist (YSR, ASR, CBCL, and ABCL). We diagnosed a Delusional Disorder in 19% of our patients and a Psychotic Disorder not otherwise specified in another 19%. These two groups of patients had a significantly worse level of clinically defined general functioning. It is clinically relevant to investigate in patients with juvenile DM the symptom of delusions and the presence of a delusional and psychotic disorder, and to consider the presence of juvenile DM in youngsters presenting with such a thought disorder. These disorders compromise the general functioning of the subjects and are often to some extent treatable. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Delusões/etiologia
Distrofia Miotônica/complicações
Transtornos Psicóticos/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Delusões/diagnóstico
Delusões/psicologia
Feminino
Seguimentos
Seres Humanos
Masculino
Distrofia Miotônica/psicologia
Prognóstico
Escalas de Graduação Psiquiátrica
Transtornos Psicóticos/diagnóstico
Transtornos Psicóticos/psicologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.b.32524


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[PMID]:28463717
[Au] Autor:Wang YY; Shi HS; Liu WH; Yan C; Wang Y; Chiu CD; So SH; Lui SSY; Cheung EFC; Chan RCK
[Ad] Endereço:Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, Weifang Medical University, Shandong Province, China; Department of Psychology, University of Chinese Ac
[Ti] Título:Invariance of factor structure of the 21-item Peters et al. Delusions Inventory (PDI-21) over time and across samples.
[So] Source:Psychiatry Res;254:190-197, 2017 Aug.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The present study aimed to explore the latent structure of the 21-item Peters et al. Delusions Inventory (PDI-21) and to test the invariance of its factor structure over time and across samples. The PDI-21 was administered in two samples; one consisting of 1655 undergraduate students investigated in three waves, each separated by six months; and another consisting of 196 outpatients with schizophrenia. Exploratory factor analysis was performed to explore the internal structure of the PDI-21 based on number of beliefs and the grand total scores separately. The number of factors was determined by optimal implementation of parallel analysis. Confirmatory factor analysis, cross-time and cross-sample invariance analyses were carried out with Mplus. Both exploratory factor analysis and the optimal implementation of parallel analysis (based on the number of beliefs and the total score of the PDI-21) suggested a one-factor solution. However, the confirmatory factor analysis revealed a single-dimension structure based on number of beliefs only, which exhibited goodness of fit and stability across time and samples. Our study demonstrated a single-dimension structure of the PDI-21, which can be widely used in screening the number of delusional ideations both in clinical and non-clinical populations.
[Mh] Termos MeSH primário: Delusões/diagnóstico
Delusões/psicologia
Escalas de Graduação Psiquiátrica/normas
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
Estudantes/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
China/epidemiologia
Delusões/epidemiologia
Análise Fatorial
Feminino
Seres Humanos
Masculino
Meia-Idade
Psicometria/métodos
Esquizofrenia/epidemiologia
Fatores de Tempo
Universidades
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28460283
[Au] Autor:Vorontsova N; Ellett L
[Ad] Endereço:Royal Holloway, University of London, London, UK.
[Ti] Título:Depression, goals and motivations in people with persecutory delusions.
[So] Source:Psychiatry Res;254:133-134, 2017 Aug.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Goals motivated by avoidance, rather than approach, and by external, rather than internal, motivations, have been implicated in the persistence of depression. This paper reports the first empirical investigation of the goals and motivations of individuals experiencing persecutory delusions. Participants completed assessments of goals and motivations, depression and paranoia. Higher levels of depression were associated with more avoidant motivations and lower goal self-concordance, but not with numbers of approach motivations. More avoidant motivations were also associated with greater paranoia. The findings are consistent with proposals that avoidant and externally-motivated goal pursuit could contribute to symptom persistence.
[Mh] Termos MeSH primário: Delusões/psicologia
Depressão/psicologia
Metas
Motivação
Transtornos Paranoides/psicologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Delusões/diagnóstico
Delusões/epidemiologia
Depressão/diagnóstico
Depressão/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos Paranoides/diagnóstico
Transtornos Paranoides/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28745673
[Au] Autor:Pyatnitskyi NY
[Ad] Endereço:Mental Health Research Center, Moscow, Russia.
[Ti] Título:[Doctrine of psychopathy typology: E. Kretschmer's concept of 'key experience' and inherited defect].
[Ti] Título:Uchenie o tipologii psikhopatii: kontseptsiia É. Krechmera 'kliuchevogo perezhivaniia' i vrozhdennogo defekta..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(6):59-65, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The author analyzes the first concept of E. Kretschmer which preceded his famous concept of cycloid and schizoid temperaments: specific 'root' or 'key' experience characteristic of the personality type. This concept was built on the clinical data of patients with delusions but E. Kretschmer assumed that the difference in the degree of disease was not essential ('neurosis of reference' and 'sensitive delusion of reference' were more close than 'sensitive delusion of reference' and 'expansive delusion'). For a sensitive psychopath, the key and specific experience is 'shameful defeat', for expansive psychopath - 'the violence over will by the common will'. Explanations of the phenomenon of psychopathic personalities made by E. Kraepelin and E. Kretschmer are compared as well as the relationship of psychopathic types determined by E. Kretschmer to 'the general psychopathic constitution'.
[Mh] Termos MeSH primário: Transtorno da Personalidade Antissocial/história
[Mh] Termos MeSH secundário: Transtorno da Personalidade Antissocial/classificação
Transtorno da Personalidade Antissocial/diagnóstico
Delusões/diagnóstico
Delusões/história
História do Século XX
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171176159-65


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[PMID]:28858444
[Au] Autor:Reeves S; Bertrand J; McLachlan E; D'Antonio F; Brownings S; Nair A; Greaves S; Smith A; Dunn JT; Marsden P; Kessler R; Uchida H; Taylor D; Howard R
[Ad] Endereço:Division of Psychiatry, University College London, 6th Floor, Maple House, 149 Tottenham Court Rd, London W1T 7NF. suzanne.reeves@ucl.ac.uk.
[Ti] Título:A Population Approach to Guide Amisulpride Dose Adjustments in Older Patients With Alzheimer's Disease.
[So] Source:J Clin Psychiatry;78(7):e844-e851, 2017 Jul.
[Is] ISSN:1555-2101
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We have previously reported high dopamine D2/3 receptor occupancies at low amisulpride concentrations in older people with Alzheimer's disease (AD), during off-label treatment of AD-related psychosis. This post hoc analysis explored pharmacokinetic (concentration) and pharmacodynamic (prolactin, D2/3 occupancy) contributions to symptom reduction and extrapyramidal side effects (EPS) to inform AD-specific dose adjustments. METHODS: Population pharmacokinetic-pharmacodynamic models were developed by combining pharmacokinetic data from a phase 1 study in 20 healthy older people with pharmacokinetic prolactin, [¹8F]fallypride D2/3 receptor imaging, and clinical outcome data from 28 older patients prescribed open amisulpride (25-75 mg/d) to treat AD-related psychosis. Model predictions were used to simulate dose-response and dose-EPS. RESULTS: Symptom reduction (delusions) was associated with amisulpride concentration (P = 1.3e-05) and D2/3 occupancy (P < .01, caudate, putamen, thalamus). Model predictions suggested that across concentrations of 40-100 ng/mL, and occupancies of 40% to 70% in the caudate and thalamus and 30% to 60% in the putamen, there was a 50% to 90% probability of response and < 30% probability of EPS. Simulations, based on concentration-delusions and concentration-EPS model outputs, showed that 50 mg/d of amisulpride was the appropriate dose to achieve this target range in those aged > 75 years; increasing the dose to 75 mg/d increased the risk of EPS, particularly in those aged > 85 years of low body weight. CONCLUSIONS: These findings argue strongly for the consideration of age- and weight-based dose adjustments in older patients with AD-related psychosis and indicate that 50 mg/d of amisulpride may be both the minimal clinically effective dose and, in those aged > 75 years, the maximally tolerated dose.
[Mh] Termos MeSH primário: Doença de Alzheimer/sangue
Doença de Alzheimer/tratamento farmacológico
Transtornos Psicóticos/sangue
Transtornos Psicóticos/tratamento farmacológico
Sulpirida/análogos & derivados
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/psicologia
Doenças dos Gânglios da Base/sangue
Doenças dos Gânglios da Base/induzido quimicamente
Doenças dos Gânglios da Base/prevenção & controle
Encéfalo/efeitos dos fármacos
Delusões/sangue
Delusões/tratamento farmacológico
Delusões/psicologia
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Masculino
Prolactina/sangue
Transtornos Psicóticos/psicologia
Receptores de Dopamina D2/efeitos dos fármacos
Receptores de Dopamina D3/efeitos dos fármacos
Valores de Referência
Fatores de Risco
Sulpirida/administração & dosagem
Sulpirida/efeitos adversos
Sulpirida/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Dopamine D2); 0 (Receptors, Dopamine D3); 7MNE9M8287 (Sulpiride); 9002-62-4 (Prolactin); AA0G3TW31W (sultopride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE


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[PMID]:28817967
[Au] Autor:Kianirad Y; Simuni T
[Ad] Endereço:a Department of Neurology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA.
[Ti] Título:Pimavanserin, a novel antipsychotic for management of Parkinson's disease psychosis.
[So] Source:Expert Rev Clin Pharmacol;10(11):1161-1168, 2017 Nov.
[Is] ISSN:1751-2441
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Parkinson's disease psychosis (PDP) may develop in up to 60% of Parkinson's patients and is associated with increased morbidity and mortality. It also correlates with depression and dementia, and can contribute to caregiver stress and burnout. Pimavanserin is the first FDA approved drug for the treatment of hallucinations and delusions associated with PDP. Areas covered: For this review, a MEDLINE literature search (via PubMed) and information provided by ACADIA Pharmaceuticals were used. This review will discuss the pathophysiology and current management of PDP. In addition, this review will focus on the rationales behind the development of pimavanserin, mechanism of action, pharmacokinetics, pharmacodynamics, and the clinical trials evaluating the efficacy and safety of pimavanserin. Last, the review will address the drug's package insert warning. Expert commentary: Pimavanserin, a 5HT2A receptor inverse agonist, is the first FDA approved drug for the treatment of PDP which has been shown to reduce psychosis in PD through its unique mechanism of action. Pimavanserin, does not worsen PD motor symptoms and has an acceptable safety profile. The development of pimavanserin as an antipsychotic opened a new therapeutic avenue in the treatment of PDP as well as targeting psychosis in other disorders such as Alzheimer's disease.
[Mh] Termos MeSH primário: Doença de Parkinson/tratamento farmacológico
Piperidinas/uso terapêutico
Transtornos Psicóticos/tratamento farmacológico
Ureia/análogos & derivados
[Mh] Termos MeSH secundário: Antipsicóticos/efeitos adversos
Antipsicóticos/farmacologia
Antipsicóticos/uso terapêutico
Delusões/tratamento farmacológico
Delusões/etiologia
Agonismo Inverso de Drogas
Alucinações/tratamento farmacológico
Alucinações/etiologia
Seres Humanos
Doença de Parkinson/fisiopatologia
Doença de Parkinson/psicologia
Piperidinas/efeitos adversos
Piperidinas/farmacologia
Transtornos Psicóticos/etiologia
Transtornos Psicóticos/fisiopatologia
Agonistas de Receptores 5-HT2 de Serotonina/efeitos adversos
Agonistas de Receptores 5-HT2 de Serotonina/farmacologia
Agonistas de Receptores 5-HT2 de Serotonina/uso terapêutico
Ureia/efeitos adversos
Ureia/farmacologia
Ureia/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Piperidines); 0 (Serotonin 5-HT2 Receptor Agonists); 8W8T17847W (Urea); JZ963P0DIK (pimavanserin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1080/17512433.2017.1369405


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[PMID]:28767584
[Au] Autor:Ugwoke SC; Eseadi C; Igbokwe CC; Chiaha GTU; Nwaubani OO; Orji CT; Ugwuanyi LT; Chukwuma IS; Edikpa EC; Ogakwu VN; Onu EA; Agu P; Nwobi UA; Omeke F; Okeke FC; Ezema RN; Abugu LI
[Ad] Endereço:aDepartment of Educational Foundations bDepartment of Human Kinetics & Health Education cDepartment of Social Science Education, Faculty of Education dDepartment of Industrial Technical Education, Faculty of Vocational and Technical Education eInstitute for Development Studies fDepartment of Adult Education & Extra-Mural Studies, Faculty of Education, University of Nigeria, Nsukka, Enugu, Nigeria.
[Ti] Título:Effects of a rational-emotive health education intervention on stress management and irrational beliefs among technical college teachers in Southeast Nigeria.
[So] Source:Medicine (Baltimore);96(31):e7658, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stress is the product of how an individual reacts and adapts to the specific demands and threats they encounter while carrying out given tasks. The main purpose of this study was to investigate the effects of a rational-emotive health education intervention (REHEI) on stress management, and irrational beliefs in a sample of technical college teachers in Southeast Nigeria. METHOD: The study design was a pretest-posttest control group. Repeated measures analysis of variance, paired t test and Mann-Whitney U tests were used to analyze the data collected. RESULTS: The REHEI significantly reduced teacher stress in those teaching staff exposed to the treatment intervention, relative to a waitlist control group. Furthermore, the REHEI program significantly decreased irrational beliefs about teaching in those teaching staff exposed to the treatment intervention compared to a waitlist control group. CONCLUSION: The REHEI program can be used to coach teachers on how to manage and cope with stress and overcome irrational beliefs in teaching.
[Mh] Termos MeSH primário: Delusões/terapia
Docentes/psicologia
Educação em Saúde
Estresse Psicológico/terapia
[Mh] Termos MeSH secundário: Adaptação Psicológica
Adulto
Análise de Variância
Feminino
Seres Humanos
Masculino
Nigéria
Inquéritos e Questionários
Resultado do Tratamento
Universidades
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007658


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[PMID]:28596465
[Au] Autor:Akita S; Akiyama T; Mimura M
[Ad] Endereço:Department of Neuropsychiatry, Keio University School of Medicine.
[Ti] Título:[Somatoparaphrenia].
[So] Source:Brain Nerve;69(6):629-638, 2017 Jun.
[Is] ISSN:1881-6096
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Somatoparaphrenia (SP) typically occurs after a right-hemisphere stroke, where the patient refers to his/her hemiplegic left hand as belonging to someone else. In this report, we review the literature for the brain structures affected in SP. We also report three cases with varying degrees of SP: a typical case, one case where SP affected the visceral sensations, and one case where a concurring psychiatric condition lead to a very complex, bizarre delusion.
[Mh] Termos MeSH primário: Distúrbios Somatossensoriais
[Mh] Termos MeSH secundário: Encefalopatias/complicações
Encefalopatias/diagnóstico por imagem
Delusões
Seres Humanos
Distúrbios Somatossensoriais/etiologia
Distúrbios Somatossensoriais/fisiopatologia
Distúrbios Somatossensoriais/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.11477/mf.1416200794


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[PMID]:28581537
[Au] Autor:Remberk B
[Ad] Endereço:Klinika Psychiatrii Dzieci i Mlodziezy, Instytut Psychiatrii i Neurologii w Warszawie.
[Ti] Título:Clinical significance of psychotic-like experiences in children and adolescents.
[Ti] Título:Znaczenie kliniczne doznan podobnych do psychotycznych u dzieci i mlodziezy..
[So] Source:Psychiatr Pol;51(2):271-282, 2017 Apr 30.
[Is] ISSN:2391-5854
[Cp] País de publicação:Poland
[La] Idioma:eng; pol
[Ab] Resumo:Psychotic-like experiences (PLEs) are subtle, subclinical hallucinations and delusions which are quite common in general population. In children and youth prevalence rate is probably age-dependent with higher rate in younger population. PLEs are suggested to be a form of extended psychosis phenotype. Similar demographic, genetic and environmental risk factors observed for PLEs and schizophrenia support this hypothesis. Other mental health problems associated with PLEs include depression, suicidality, low functioning and psychiatric comorbidity. PLEs may be a risk factor for psychosis, but probably only for a minor subgroup of population. It is possible however, that PLEs are a risk factor for different psychiatric disorders. In the majority of children and adolescents PLEs disappear over time. PLEs are supposed to be a heterogenic phenomenon with different subtypes: associated with psychosis risk, associated with other psychiatric disorders and being within the normal range of experiences. Due to lack of widely acknowledged PLEs definition and because of substantial diversity of research methodology interpretation of the previous research should be made with caution.
[Mh] Termos MeSH primário: Desenvolvimento do Adolescente
Desenvolvimento Infantil
Transtornos Psicóticos/psicologia
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Criança
Delusões/psicologia
Feminino
Alucinações/psicologia
Seres Humanos
Masculino
Fatores de Risco
Autoimagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE



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