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[PMID]:28202482
[Au] Autor:Lally L; McCarthy G; Meehan K
[Ad] Endereço:Department of Old Age Psychiatry, Galway Roscommon Mental Health Service, Galway, Ireland.
[Ti] Título:Hyperactive delirium following administration of intra-articular corticosteroid.
[So] Source:BMJ Case Rep;2017, 2017 Feb 15.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Intra-articular administration of corticosteroids is a commonly used treatment for osteoarthritis as well as other inflammatory disorders of the joints. It is well known that delirium and psychosis can arise following the administration of oral corticosteroids but there are few documented cases of the development of acute hyperactive delirium with psychosis following intra-articular administration. We describe a case of an 82-year-old female patient with moderate dementia who developed a delirium with psychosis which responded well to a first-generation antipsychotic.
[Mh] Termos MeSH primário: Anti-Inflamatórios/efeitos adversos
Delírio/induzido quimicamente
Metilprednisolona/análogos & derivados
Psicoses Induzidas por Substâncias/etiologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Anti-Inflamatórios/administração & dosagem
Antipsicóticos/uso terapêutico
Delírio/tratamento farmacológico
Feminino
Seres Humanos
Injeções Intra-Articulares
Metilprednisolona/administração & dosagem
Metilprednisolona/efeitos adversos
Comportamento Paranoide/induzido quimicamente
Comportamento Paranoide/tratamento farmacológico
Psicoses Induzidas por Substâncias/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antipsychotic Agents); 43502P7F0P (methylprednisolone acetate); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE


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[PMID]:27344587
[Au] Autor:Paolini E; Moretti P; Compton MT
[Ad] Endereço:School of Psychiatry, University of Perugia, Perugia, PG, Italy; Lenox Hill Hospital, Department of Psychiatry, New York, NY, USA. Electronic address: enricopaolini85@gmail.com.
[Ti] Título:Delusions in first-episode psychosis: Principal component analysis of twelve types of delusions and demographic and clinical correlates of resulting domains.
[So] Source:Psychiatry Res;243:5-13, 2016 Sep 30.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Although delusions represent one of the core symptoms of psychotic disorders, it is remarkable that few studies have investigated distinct delusional themes. We analyzed data from a large sample of first-episode psychosis patients (n=245) to understand relations between delusion types and demographic and clinical correlates. First, we conducted a principal component analysis (PCA) of the 12 delusion items within the Scale for the Assessment of Positive Symptoms (SAPS). Then, using the domains derived via PCA, we tested a priori hypotheses and answered exploratory research questions related to delusional content. PCA revealed five distinct components: Delusions of Influence, Grandiose/Religious Delusions, Paranoid Delusions, Negative Affect Delusions (jealousy, and sin or guilt), and Somatic Delusions. The most prevalent type of delusion was Paranoid Delusions, and such delusions were more common at older ages at onset of psychosis. The level of Delusions of Influence was correlated with the severity of hallucinations and negative symptoms. We ascertained a general relationship between different childhood adversities and delusional themes, and a specific relationship between Somatic Delusions and childhood neglect. Moreover, we found higher scores on Delusions of Influence and Negative Affect Delusions among cannabis and stimulant users. Our results support considering delusions as varied experiences with varying prevalences and correlates.
[Mh] Termos MeSH primário: Delusões/diagnóstico
Delusões/psicologia
Demografia/métodos
Análise de Componente Principal
Transtornos Psicóticos/diagnóstico
Transtornos Psicóticos/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Delusões/epidemiologia
Feminino
Alucinações/diagnóstico
Alucinações/epidemiologia
Alucinações/psicologia
Seres Humanos
Masculino
Comportamento Paranoide/diagnóstico
Comportamento Paranoide/psicologia
Transtornos Psicóticos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160627
[St] Status:MEDLINE


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[PMID]:27337786
[Au] Autor:McGowan S
[Ti] Título:"Dementia awareness must not turn into dementia paranoia".
[So] Source:Nurs Times;112(17):11, 2016 Apr 27-May 3.
[Is] ISSN:0954-7762
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Demência/enfermagem
Enfermeiras e Enfermeiros/provisão & distribuição
Recursos Humanos de Enfermagem/educação
Melhoria de Qualidade
[Mh] Termos MeSH secundário: Conscientização
Economia
Política de Saúde
Habitação/economia
Seres Humanos
Londres
Comportamento Paranoide
Salários e Benefícios
Medicina Estatal
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE


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[PMID]:26492591
[Au] Autor:Bullock G; Newman-Taylor K; Stopa L
[Ad] Endereço:Psychology Academic Unit, University of Southampton, Building 44, Highfield, Southampton, SO17 1BJ, UK.
[Ti] Título:The role of mental imagery in non-clinical paranoia.
[So] Source:J Behav Ther Exp Psychiatry;50:264-8, 2016 Mar.
[Is] ISSN:1873-7943
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & OBJECTIVES: Cognitive models of paranoia incorporate many of the processes implicated in the maintenance of anxiety disorders. Despite this, the role of mental imagery in paranoia remains under-researched. The current study examined the impact of a self-imagery manipulation in people with high non-clinical paranoia. METHODS: We used a mixed design with one between-subjects variable (type of self-imagery) and one within-subjects variable (time--pre and post imagery manipulation). Thirty participants with high trait paranoia were allocated alternately to a positive or negative self-imagery condition. Scripts were used to elicit positive and negative self-imagery. All participants completed self-report state measures of paranoia, mood, self-esteem and self-compassion. RESULTS: Group by time interaction effects were found for each of the dependent variables. Positive imagery led to less state paranoia, anxiety and negative affect, and more positive affect, self-esteem and self-compassion, compared with the negative imagery group. LIMITATIONS: This was a non-blind study, limited by allocation method and a brief time-frame which did not allow us to assess longevity of effects. We recruited a relatively small and predominantly female sample of people with high non-clinical paranoia. The study did not include a neutral control condition, a low paranoia comparison group, or a manipulation check following the imagery task. CONCLUSIONS: Self-imagery manipulations may affect paranoia, mood and self-beliefs. If the findings are replicated with clinical groups, and maintained over a longer period, this would suggest that imagery-based interventions targeting persecutory delusions might be usefully examined.
[Mh] Termos MeSH primário: Imaginação
Comportamento Paranoide/psicologia
[Mh] Termos MeSH secundário: Afeto
Ansiedade/psicologia
Empatia
Feminino
Seres Humanos
Masculino
Escalas de Graduação Psiquiátrica
Autoimagem
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151023
[St] Status:MEDLINE


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[PMID]:26554588
[Au] Autor:Liu YC; Liu YY; Yip PK; Akanuma K; Meguro K
[Ad] Endereço:Division of Geriatric Behavioral Neurology, CYRIC, Tohoku University, Sendai, Japan.
[Ti] Título:More Delusions May Be Observed in Low-Proficient Multilingual Alzheimer's Disease Patients.
[So] Source:PLoS One;10(11):e0140714, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Language impairment and behavioral symptoms are both common phenomena in dementia patients. In this study, we investigated the behavioral symptoms in dementia patients with different language backgrounds. Through this, we aimed to propose a possible connection between language and delusion. METHODS: We recruited 21 patients with Alzheimer's disease (AD), according to the DSM-IV and NINCDS-ADRDA criteria, from the memory clinic of the Cardinal Tien Hospital in Taipei, Taiwan. They were classified into two groups: 11 multilinguals who could speak Japanese, Taiwanese and Mandarin Chinese, and 10 bilinguals who only spoke Taiwanese and Mandarin Chinese. There were no differences between age, education, disease duration, disease severity, environment and medical care between these two groups. Comprehensive neuropsychological examinations, including Clinical Dementia Rating (CDR), Mini-Mental Status Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), Verbal fluency, Chinese version of the Boston naming test (BNT) and the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), were administered. RESULTS: The multilingual group showed worse results on the Boston naming test. Other neuropsychological tests, including the MMSE, CASI and Verbal fluency, were not significantly different. More delusions were noted in the multilingual group. Three pairs of subjects were identified for further examination of their differences. These three cases presented the typical scenario of how language misunderstanding may cause delusions in multilingual dementia patients. Consequently, more emotion and distorted ideas may be induced in the multilinguals compared with the MMSE-matched controls. CONCLUSION: Inappropriate mixing of language or conflict between cognition and emotion may cause more delusions in these multilingual patients. This reminds us that delusion is not a pure biological outcome of brain degeneration. Although the cognitive performance was not significantly different between our groups, language may still affect their delusion.
[Mh] Termos MeSH primário: Doença de Alzheimer/psicologia
Delusões/etiologia
Transtornos da Linguagem/etiologia
Multilinguismo
[Mh] Termos MeSH secundário: Atividades Cotidianas
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Cognição
Delusões/epidemiologia
Delusões/psicologia
Emoções
Feminino
Seres Humanos
Incidência
Transtornos da Linguagem/epidemiologia
Transtornos da Linguagem/psicologia
Imagem por Ressonância Magnética
Masculino
Testes Neuropsicológicos
Comportamento Paranoide/etiologia
Comportamento Paranoide/psicologia
Trauma Psicológico/psicologia
Índice de Gravidade de Doença
Taiwan
Lobo Temporal/patologia
Lobo Temporal/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151116
[Lr] Data última revisão:
151116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0140714


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[PMID]:26514791
[Au] Autor:Röhlinger J; Wulf F; Fieker M; Moritz S
[Ad] Endereço:University Medical Center Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistraße 52, 20246 Hamburg, Germany.
[Ti] Título:Sensory properties of obsessive thoughts in OCD and the relationship to psychopathology.
[So] Source:Psychiatry Res;230(2):592-6, 2015 Dec 15.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:For decades hallucinations and perception-laden thoughts were considered specific indicators of schizophrenia. This assumption has been revised over the years. Novel studies indicate that a subgroup of patients with obsessive-compulsive disorder (OCD), borderline disorder or depression display hallucinations and "loud"/perceptual thoughts. The present study examined the frequency of sensory-laden obsessive thoughts and their relationship with the severity of obsessive-compulsive, paranoid and depressive symptoms in a sample of 137 OCD patients who were recruited via the Internet. Participants were asked to fill out the Sensory Properties of Obsessions Questionnaire (SPOQ), the Obsessive-Compulsive Inventory-Revised (OCI-R), the Paranoia Checklist and the Patient Health Questionnaire (PHQ9). In line with a prior study, a total of 72% displayed perceptual intrusions (i.e. vivid obsessions). Correlations emerged between perceptual thoughts and obsessive-compulsive, paranoid and depressive symptoms. Results further strengthen the assumption of a continuum ranging from "silent" thoughts to vivid intrusions and hallucinations.
[Mh] Termos MeSH primário: Alucinações/fisiopatologia
Transtorno Obsessivo-Compulsivo/fisiopatologia
Comportamento Paranoide/fisiopatologia
Pensamento/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Alucinações/etiologia
Seres Humanos
Masculino
Meia-Idade
Transtorno Obsessivo-Compulsivo/complicações
Comportamento Paranoide/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151121
[Lr] Data última revisão:
151121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151031
[St] Status:MEDLINE


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[PMID]:26462402
[Au] Autor:Dervin D
[Ti] Título:Political Leaders and Psychohistorical Approaches in a Time of Borderline Polarization.
[So] Source:J Psychohist;43(2):89-109, 2015.
[Is] ISSN:0145-3378
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since the breakup of the Soviet Empire in 1989, followed by Yugoslavia, many otherwise secure countries have been collapsing and splitting apart. The maps in the Middle East are continually being redrawn, more often than not, in blood. Scotland is poised to break away from the UK, Catalonia from Spain, and here at home several states toy around with secession. Much of this turmoil on the macro level seems to dovetail with my present focus on the micro. Whether the two are related in some fashion is tantalizingly beyond the present scope. In this paper my micro-purpose is to delve into the deeper recesses of our public life and explore the intra-psychic fissures. The key concept for this quest is a relative newcomer to psychoanalytic nomenclature: the borderline. Coming to the fore in the 1970s, the term addresses the widespread splitting both within the self and in relationships, manifest in either-or, all-or-nothing ideation, along with an impulsivity that further distances actions from consequences. These and related features-are conducive to an anything-goes politics of us-against-them. Richard Hofstadter's 1965 "paranoid style," of political leaders is recalled and modified to a borderline-mode factored into a psychohistorical dynamic which construes politicians as delegates for group-fantasy. Recent presidential elections offer a rich field for testing the aptness of this approach. Then, after brief detours into how Freud and Darwin disrupted polarizing forces in their own cultures, we revisit political turmoil during the Woodrow Wilson years for historical similarities and differences in which repeated recourse to purity serves as a bridge word. The inquiry closes with reflections on how psychohistory may avoid pitfalls in further probing this vexing state of affairs and primes the reader to ponder whether the disaffected young males drawn to ISIS are functioning on borderline levels. If so, we have a plausible bridge between macro and micro realms.
[Mh] Termos MeSH primário: Internacionalidade/história
Política
[Mh] Termos MeSH secundário: História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
Liderança
Comportamento Paranoide
Psicanálise
Fatores Socioeconômicos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1511
[Cu] Atualização por classe:151014
[Lr] Data última revisão:
151014
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:151015
[St] Status:MEDLINE


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[PMID]:26277535
[Au] Autor:Holper L; Aleksandrowicz A; Müller M; Ajdacic-Gross V; Haker H; Fallgatter AJ; Hagenmuller F; Rössler W; Kawohl W
[Ad] Endereço:Department of Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Psychiatry Zurich, Switzerland. Electronic address: lisa.holper@puk.zh.ch.
[Ti] Título:Brain correlates of verbal fluency in subthreshold psychosis assessed by functional near-infrared spectroscopy.
[So] Source:Schizophr Res;168(1-2):23-9, 2015 Oct.
[Is] ISSN:1573-2509
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The prevalence of subthreshold psychotic symptoms in the general population has gained increasing interest as a possible precursor of psychotic disorders. The goal of the present study was to evaluate whether neurobiological features of subthreshold psychotic symptoms can be detected using verbal fluency tasks and functional near-infrared spectroscopy (fNIRS). A large data set was obtained from the Zurich Program for Sustainable Development of Mental Health Services (ZInEP). Based on the SCL-90-R subscales 'Paranoid Ideation' and 'Psychoticism' a total sample of 188 subjects was assigned to four groups with different levels of subthreshold psychotic symptoms. All subjects completed a phonemic and semantic verbal fluency task while fNIRS was recorded over the prefrontal and temporal cortices. Results revealed larger hemodynamic (oxy-hemoglobin) responses to the phonemic and semantic conditions compared to the control condition over prefrontal and temporal cortices. Subjects with high subthreshold psychotic symptoms exhibited significantly reduced hemodynamic responses in both conditions compared to the control group. Further, connectivity between prefrontal and temporal cortices revealed significantly weaker patterns in subjects with high subthreshold psychotic symptoms compared to the control group, possibly indicating less incisive network connections associated with subthreshold psychotic symptoms. The present findings provide evidence that subthreshold forms of psychotic symptoms are associated with reduced hemodynamic responses and connectivity in prefrontal and temporal cortices during verbal fluency that can be identified using fNIRS.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Oxiemoglobinas/metabolismo
Sintomas Prodrômicos
Transtornos Psicóticos/complicações
Distúrbios da Fala
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Feminino
Hemodinâmica
Seres Humanos
Masculino
Comportamento Paranoide/etiologia
Transtornos Psicóticos/epidemiologia
Espectroscopia de Luz Próxima ao Infravermelho
Distúrbios da Fala/epidemiologia
Distúrbios da Fala/etiologia
Distúrbios da Fala/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oxyhemoglobins)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151001
[Lr] Data última revisão:
151001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150817
[St] Status:MEDLINE


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[PMID]:26076787
[Au] Autor:Babinkostova Z; Stefanovski B; Janicevic-Ivanovska D; Samardziska V; Stojanovska L
[Ad] Endereço:University Clinic of Psychiatry, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, R. Macedonia.
[Ti] Título:Serum cortisol and DHEA-S levels in schizophrenic patients with different response to antipsychotic therapy: association with psychopathology.
[So] Source:Pril (Makedon Akad Nauk Umet Odd Med Nauki);36(1):175-83, 2015.
[Is] ISSN:1857-9345
[Cp] País de publicação:Macedonia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous studies suggested that alterations in serum cortisol and DHEA-S levels may play a role in the pathophysiology of schizophrenia. Imbalance in serum cortisol and DHEA-S levels may be related to responsivity to antipsychotic treatment. AIM: To compare serum cortisol and DHEA-S levels between patients with schizophrenia and healthy controls and to evaluate their association with psychopathology in schizophrenic patients with different response to antipsychotic treatment. MATERIAL AND METHODS: This clinical prospective study included 60 patients with schizophrenia and 40 healthy age and sex matched controls. All patients experienced an acute exacerbation of the illness (PANSS: P1 and P3 ≥ 4). Clinical evaluation of patients was performed using the Positive and Negative Symptom Scale. A questionnaire for socio-demographic and clinical data collection was used. For the purposes of the study, the examined group was divided in two subgroups: responders and nonresponders. Serum cortisol and DHEA-S levels were measuredat baseline in all participants and after 3 and 6 weeks of the antipsychotic treatment in patients with schizophrenia. RESULTS: Patients with schizophrenia had significantly higher serum cortisol and DHEA-S levels comparedwith control group. Responders had significantly higher serum cortisol and DHEA-S levels compared with nonresponders. Responders group had significant correlation between serum cortisol and PANSS positive scale score as well as between hostility and serum DHEA-S. CONCLUSION: Elevated serum cortisol and DHEA-S levels may play a role in the pathophysiology of schizophrenia. Serum cortisol and DHEA-S are associated with psychopathology in schizophrenic patients with different response to antipsychotic therapy.
[Mh] Termos MeSH primário: Antipsicóticos/uso terapêutico
Sulfato de Desidroepiandrosterona/sangue
Hidrocortisona/sangue
Esquizofrenia/sangue
Esquizofrenia/tratamento farmacológico
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Delusões/tratamento farmacológico
Delusões/psicologia
Alucinações/tratamento farmacológico
Alucinações/psicologia
Hostilidade
Seres Humanos
Comportamento Paranoide/tratamento farmacológico
Comportamento Paranoide/psicologia
Prognóstico
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); 57B09Q7FJR (Dehydroepiandrosterone Sulfate); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150616
[Lr] Data última revisão:
150616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150617
[St] Status:MEDLINE


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[PMID]:26016697
[Au] Autor:Freeman D; Sheaves B; Goodwin GM; Yu LM; Harrison PJ; Emsley R; Bostock S; Foster RG; Wadekar V; Hinds C; Espie CA
[Ad] Endereço:Sleep & Circadian Neuroscience Institute, Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, UK. daniel.freeman@psych.ox.ac.uk.
[Ti] Título:Effects of cognitive behavioural therapy for insomnia on the mental health of university students: study protocol for a randomized controlled trial.
[So] Source:Trials;16:236, 2015 May 28.
[Is] ISSN:1745-6215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Insomnia, defined as repeated difficulties getting or staying asleep, is common in the general population. Such sleep difficulties are a problem in their own right, but increasingly it is being recognised that they may also be a contributory factor in the development of a wide range of mental health problems. Our focus is upon the relationship between insomnia and psychotic experiences, such as paranoia and hallucinations. Psychotic experiences commonly occur in mild forms in the general population and have been linked to disrupted sleep. These psychotic-like experiences raise the risk of development of a clinical disorder. Our aim is to reduce insomnia in a large general population group, and examine the effect on paranoia and hallucinations at the age when mental health problems typically emerge. The primary hypotheses are that cognitive behaviour therapy (CBT) for insomnia will reduce insomnia and also levels of paranoia and hallucinations. The theoretical links will be substantiated by a planned mediation analysis. Improvements in a number of other mental health outcomes are also predicted. METHODS/DESIGN: We will carry out a parallel group, randomised controlled trial of 2,614 students with insomnia in universities across the UK. In the Oxford Access for Students Improving Sleep (OASIS) trial, participants will be randomised to digital CBT for insomnia (in addition to treatment as usual) or treatment as usual. Online assessments will take place at zero, three, 10 (post-treatment), and 22 (follow-up) weeks. Primary outcomes are insomnia and psychotic-like experiences (paranoia or hallucinatory experiences) at 10 weeks. Secondary outcomes are levels of mania, depression, anxiety, nightmares, psychological wellbeing, and the development of mental health disorders. All main analyses will be carried out at the end of the last follow-up assessment and will be based on the intention-to-treat principle. The trial is funded by the Wellcome Trust. DISCUSSION: This study will be the first large-scale causal test of the relationship between sleep disturbance and psychotic experiences. It will provide evidence concerning the clinical effects of treating insomnia in young adults. TRIAL REGISTRATION: This trial was registered with Current Controlled Trials (identifier: ISRCTN61272251 ) on 29 January 2015.
[Mh] Termos MeSH primário: Terapia Cognitiva
Saúde Mental
Distúrbios do Início e da Manutenção do Sono/terapia
Sono
Estudantes/psicologia
Universidades
[Mh] Termos MeSH secundário: Adolescente
Adulto
Protocolos Clínicos
Feminino
Alucinações/prevenção & controle
Alucinações/psicologia
Seres Humanos
Análise de Intenção de Tratamento
Masculino
Comportamento Paranoide
Transtornos Paranoides/prevenção & controle
Transtornos Paranoides/psicologia
Escalas de Graduação Psiquiátrica
Projetos de Pesquisa
Método Simples-Cego
Distúrbios do Início e da Manutenção do Sono/diagnóstico
Distúrbios do Início e da Manutenção do Sono/psicologia
Fatores de Tempo
Resultado do Tratamento
Reino Unido
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150529
[St] Status:MEDLINE
[do] DOI:10.1186/s13063-015-0756-4



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