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[PMID]:28470157
[Au] Autor:Jeong IJ; Kim SJ
[Ad] Endereço:Department of Nursing, Dongkang University, Gwangju, Korea.
[Ti] Título:[Effects of Group Counseling Program Based on Goal Attainment Theory for Middle School Students with Emotional and Behavioral Problems].
[So] Source:J Korean Acad Nurs;47(2):199-210, 2017 Apr.
[Is] ISSN:2093-758X
[Cp] País de publicação:Korea (South)
[La] Idioma:kor
[Ab] Resumo:PURPOSE: The purpose of this study was to examine the effects of a group counseling program based on goal attainment theory on self-esteem, interpersonal relationships, and school adjustment of middle school students with emotional and behavioral problems. METHODS: Forty-four middle school students with emotional and behavioral problems (22 in the experimental group and 22 in the control group) from G city participated in this study. Data were collected from July 30 to September 24, 2015. The experimental group received the 8-session program, scheduled once a week, with each session lasting 45 minutes. Outcome variables included self-esteem, interpersonal relationship, and school adjustment. RESULTS: There were significant increases for self-esteem (t=3.69, p=.001), interpersonal relationship (t=8.88, p<.001), and school adjustment (t=4.92, p<.001) in the experimental group compared to the control group. CONCLUSION: These results indicate that the group counseling program based on goal attainment theory is very effective in increasing self-esteem, interpersonal relationship, and school adjustment for middle school students with emotional and behavioral problems. Therefore, it is recommended that the group counseling program based on goal attainment theory be used as an effective psychiatric nursing intervention for mental health promotion and the prevention of mental illness in adolescents.
[Mh] Termos MeSH primário: Aconselhamento
Avaliação de Programas e Projetos de Saúde
Estudantes/psicologia
[Mh] Termos MeSH secundário: Adolescente
Emoções
Feminino
Seres Humanos
Relações Interpessoais
Masculino
Comportamento Problema
Autoimagem
Ajustamento Social
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4040/jkan.2017.47.2.199


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[PMID]:29179827
[Au] Autor:Oruche UM; Robb SL; Aalsma M; Pescosolido B; Brown-Podgorski B; Draucker CB
[Ad] Endereço:School of Nursing, Indiana University-Purdue University Indianapolis, United States. Electronic address: uoruche@iu.edu.
[Ti] Título:Developing a Multiple Caregiver Group for Caregivers of Adolescents With Disruptive Behaviors.
[So] Source:Arch Psychiatr Nurs;31(6):596-601, 2017 12.
[Is] ISSN:1532-8228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article describes the development of a 6-week multiple caregiver group intervention for primary caregivers of adolescents diagnosed with Oppositional Defiant Disorder or Conduct Disorder in low-income African American families. The intervention is aimed at increasing the primary caregivers' self-efficacy in managing interactions within the family and especially with child serving educational, mental health, juvenile justice, and child welfare systems. Development of the intervention involved seven iterative activities performed in a collaborative effort between an interdisciplinary academic team, community engagement specialists, members of the targeted population, and clinical partners from a large public mental health system. The intervention development process described in this article can provide guidance for teams that aim to develop new mental health interventions that target specific outcomes in populations with unique needs.
[Mh] Termos MeSH primário: Cuidadores/educação
Cuidadores/psicologia
Comportamento Problema/psicologia
Autoeficácia
[Mh] Termos MeSH secundário: Adolescente
Grupo com Ancestrais do Continente Africano
Transtorno da Conduta/terapia
Feminino
Seres Humanos
Transtornos Mentais/psicologia
Pais/psicologia
Pobreza
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29220673
[Au] Autor:Martin S; Chamberlin A; Shinde DN; Hempel M; Strom TM; Schreiber A; Johannsen J; Ousager LB; Larsen MJ; Hansen LK; Fatemi A; Cohen JS; Lemke J; Sørensen KP; Helbig KL; Lessel D; Abou Jamra R
[Ad] Endereço:Institute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany.
[Ti] Título:De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.
[So] Source:Am J Hum Genet;101(6):1013-1020, 2017 Dec 07.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using trio whole-exome sequencing, we have identified de novo heterozygous pathogenic variants in GRIA4 in five unrelated individuals with intellectual disability and other symptoms. GRIA4 encodes an AMPA receptor subunit known as GluR4, which is found on excitatory glutamatergic synapses and is important for learning and memory. Four of the variants are located in the highly conserved SYTANLAAF motif in the transmembrane protein M3, and the fifth is in an extra-cellular domain. Molecular modeling of the altered protein showed that three of the variants in the SYTANLAAF motif orient toward the center of the pore region and most likely lead to disturbance of the gating mechanism. The fourth variant in the SYTANLAAF motif most likely results in reduced permeability. The variant in the extracellular domain potentially interferes with the binding between the monomers. On the basis of clinical information and genetic results, and the fact that other subunits of the AMPA receptor have already been associated with neurodevelopmental disorders, we suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features.
[Mh] Termos MeSH primário: Transtornos Neurológicos da Marcha/genética
Deficiência Intelectual/genética
Transtornos dos Movimentos/genética
Receptores de AMPA/genética
Convulsões/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Pré-Escolar
Feminino
Seres Humanos
Masculino
Modelos Moleculares
Comportamento Problema
Comportamento Social
Sequenciamento Completo do Exoma
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, AMPA); 0 (glutamate receptor ionotropic, AMPA 4)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:28459280
[Au] Autor:Kaminski JW; Claussen AH
[Ad] Endereço:a National Center on Birth Defects and Developmental Disabilities , Centers for Disease Control and Prevention.
[Ti] Título:Evidence Base Update for Psychosocial Treatments for Disruptive Behaviors in Children.
[So] Source:J Clin Child Adolesc Psychol;46(4):477-499, 2017 Jul-Aug.
[Is] ISSN:1537-4424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This article reviews the state of the science on psychosocial treatments for disruptive behaviors in children, as an update to Eyberg, Nelson, and Boggs (2008). We followed procedures for literature searching, study inclusion, and treatment classification as laid out in Southam-Gerow and Prinstein (2014), focusing on treatments for children 12 years of age and younger. Two treatments (group parent behavior therapy, and individual parent behavior therapy with child participation) had sufficient empirical support to be classified as well-established treatments. Thirteen other treatments were classified as probably efficacious. Substantial variability in effectiveness of different programs within the same treatment family has been previously documented; thus, a particular level of evidence might not hold true for every individual program in a treatment family. Systematic investigations of implementation, dissemination, and uptake are needed to ensure that children and families have access to effective treatments. Investigations into how to blend the strengths of the effective approaches into even more effective treatment might also lead to greater impact.
[Mh] Termos MeSH primário: Medicina Baseada em Evidências/métodos
Comportamento Problema/psicologia
Psicoterapia/métodos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Seres Humanos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1080/15374416.2017.1310044


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[PMID]:27771536
[Au] Autor:Khoddam R; Jackson NJ; Leventhal AM
[Ad] Endereço:Department of Psychology, University of Southern California, United States.
[Ti] Título:Internalizing symptoms and conduct problems: Redundant, incremental, or interactive risk factors for adolescent substance use during the first year of high school?
[So] Source:Drug Alcohol Depend;169:48-55, 2016 12 01.
[Is] ISSN:1879-0046
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:AIM: The complex interplay of externalizing and internalizing problems in substance use risk is not well understood. This study tested whether the relationship of conduct problems and several internalizing disorders with future substance use is redundant, incremental, or interactive in adolescents. METHODS: Two semiannual waves of data from the Happiness and Health Study were used, which included 3383 adolescents (M age=14.1years old; 53% females) in Los Angeles who were beginning high school at baseline. Logistic regression models tested the likelihood of past six-month alcohol, tobacco, marijuana, and any substance use at follow-up conditional on baseline conduct problems, symptoms of one of several internalizing disorders (i.e., Social Phobia and Major Depressive, Generalized Anxiety, Panic, and Obsessive-Compulsive Disorder), and their interaction adjusting for baseline use and other covariates. FINDINGS: Conduct problems were a robust and consistent risk factor of each substance use outcome at follow-up. When adjusting for the internalizing-conduct comorbidity, depressive symptoms were the only internalizing problem whose risk for alcohol, tobacco, and any substance use was incremental to conduct problems. With the exception of social phobia, antagonistic interactive relationships between each internalizing disorder and conduct problems were found when predicting any substance use; internalizing symptoms was a more robust risk factor for substance use in teens with low (vs. high) conduct problems. CONCLUSIONS: Although internalizing and externalizing problems both generally increase risk of substance use, a closer look reveals important nuances in these risk pathways, particularly among teens with comorbid externalizing and internalizing problems.
[Mh] Termos MeSH primário: Depressão/complicações
Transtornos Mentais/complicações
Comportamento Problema/psicologia
Transtornos Relacionados ao Uso de Substâncias/etiologia
[Mh] Termos MeSH secundário: Adolescente
Depressão/psicologia
Feminino
Seres Humanos
Los Angeles
Masculino
Transtornos Mentais/psicologia
Fatores de Risco
Instituições Acadêmicas
Transtornos Relacionados ao Uso de Substâncias/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:28452584
[Au] Autor:Esbensen AJ; Hooper SR; Fidler D; Hartley SL; Edgin J; d'Ardhuy XL; Capone G; Conners FA; Mervis CB; Abbeduto L; Rafii MS; Krinsky-McHale SJ; Urv T; Outcome Measures Working Group
[Ad] Endereço:Anna J. Esbensen, Cincinnati Children's Hospital Medical Center; Stephen R. Hooper, University of North Carolina - Chapel Hill; Deborah Fidler, Colorado State University; Sigan L. Hartley, University of Wisconsin - Madison; Jamie Edgin, University of Arizona; Xavier Liogier d'Ardhuy, Roche Innovatio
[Ti] Título:Outcome Measures for Clinical Trials in Down Syndrome.
[So] Source:Am J Intellect Dev Disabil;122(3):247-281, 2017 05.
[Is] ISSN:1944-7515
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increasingly individuals with intellectual and developmental disabilities, including Down syndrome, are being targeted for clinical trials. However, a challenge exists in effectively evaluating the outcomes of these new pharmacological interventions. Few empirically evaluated, psychometrically sound outcome measures appropriate for use in clinical trials with individuals with Down syndrome have been identified. To address this challenge, the National Institutes of Health (NIH) assembled leading clinicians and scientists to review existing measures and identify those that currently are appropriate for trials; those that may be appropriate after expansion of age range addition of easier items, and/or downward extension of psychometric norms; and areas where new measures need to be developed. This article focuses on measures in the areas of cognition and behavior.
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto
Síndrome de Down/terapia
Avaliação de Resultados (Cuidados de Saúde)
[Mh] Termos MeSH secundário: Adaptação Psicológica
Comportamento
Cognição
Síndrome de Down/fisiopatologia
Síndrome de Down/psicologia
Função Executiva
Seres Humanos
Linguagem
Aprendizagem
Memória
Comportamento Problema
Autocontrole
Sono
Percepção Social
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1352/1944-7558-122.3.247


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[PMID]:29036206
[Au] Autor:Schmeltz MT; Gamble JL
[Ad] Endereço:ASPPH/EPA Environmental Health Fellowship Program at the United States Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington, DC, United States of America.
[Ti] Título:Risk characterization of hospitalizations for mental illness and/or behavioral disorders with concurrent heat-related illness.
[So] Source:PLoS One;12(10):e0186509, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many studies have found significant associations between high ambient temperatures and increases in heat-related morbidity and mortality. Several studies have demonstrated that increases in heat-related hospitalizations are elevated among individuals with diagnosed mental illnesses and/or behavioral disorders (MBD). However, there are a limited number of studies regarding risk factors associated with specific mental illnesses that contribute, at least in part, to heat-related illnesses (HRI) in the United States. OBJECTIVE: To identify and characterize individual and environmental risk factors associated with MBD hospitalizations with a concurrent HRI diagnosis. METHODS: This study uses hospitalization data from the Nationwide Inpatient Sample (2001-2010). Descriptive analyses of primary and secondary diagnoses of MBDs with an HRI were examined. Risk ratios (RR) were calculated from multivariable models to identify risk factors for hospitalizations among patients with mental illnesses and/or behavioral disorders and HRI. RESULTS: Nondependent alcohol/drug abuse, dementia, and schizophrenia were among the disorders that were associated with increased frequency of HRI hospitalizations among MBD patients. Increased risk of MBD hospitalizations with HRI was observed for Males (RR, 3.06), African Americans (RR, 1.16), Native Americans (RR, 1.70), uninsured (RR, 1.92), and those 40 years and older, compared to MBD hospitalizations alone. CONCLUSIONS: Previous studies outside the U.S. have found that dementia and schizophrenia are significant risk factors for HRI hospitalizations. Our results suggest that hospitalizations among substance abusers may also be an important risk factor associated with heat morbidity. Improved understanding of these relative risks could help inform future public health strategies.
[Mh] Termos MeSH primário: Transtornos de Estresse por Calor/complicações
Hospitalização
Transtornos Mentais/complicações
Comportamento Problema
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Transtornos de Estresse por Calor/psicologia
Transtornos de Estresse por Calor/terapia
Seres Humanos
Lactente
Masculino
Transtornos Mentais/psicologia
Transtornos Mentais/terapia
Meia-Idade
Análise Multivariada
Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186509


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[PMID]:28982350
[Au] Autor:Karmakar A; Goswami R; Saha T; Maitra S; Roychowdhury A; Panda CK; Sinha S; Ray A; Mohanakumar KP; Rajamma U; Mukhopadhyay K
[Ad] Endereço:Manovikas Biomedical Research and Diagnostic Centre, 482, Madudah, Plot: I-24, Sector-J, Manovikas Kendra, E.M. Bypass, Kolkata, 700 107, India.
[Ti] Título:Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands.
[So] Source:BMC Med Genet;18(1):109, 2017 Oct 05.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is an etiologically complex childhood onset neurobehavioral disorder characterized by age-inappropriate inattention, hyperactivity, and impulsivity. Symptom severity varies widely and boys are diagnosed more frequently than girls. ADHD probands were reported to have abnormal transmissions of dopamine, serotonin, and/or noradrenaline. Monoamine oxidase A (MAOA) and B (MAOB), mitochondrial outer membrane bound two isoenzymes, mediate degradation of these neurotransmitters and thus regulating their circulating levels. Case-control analyses in different populations, including Indians, suggested involvement of MAOA and MAOB genes in the etiology of ADHD. Due to high heritability rate of ADHD, we tested familial transmission of MAOA and MAOB variants to ADHD probands in 190 nuclear families having ADHD probands from Indo-Caucasoid ethnicity. METHODS: Subjects were recruited following the Diagnostic and Statistical Manual of Mental Disorders-4th edition (DSM-IV). Appropriate scales were used for measuring the behavioral traits in probands. Genotyping was performed through PCR-based amplification of target sites followed by DNA-sequencing and/or gel-electrophoresis. Data obtained were analyzed by family based statistical methods. RESULTS: Out of 58 variants present in the analyzed sites only 15 were found to be polymorphic (30 bp-uVNTR, rs5906883, rs1465107, rs1465108, rs5905809, rs5906957, rs6323, rs1137070 from MAOA and rs4824562, rs56220155, rs2283728, rs2283727, rs3027441, rs6324, rs3027440 from MAOB). Statistically significant maternal transmission of alleles to male probands was observed for MAOA rs5905809 'G' (p = 0.04), rs5906957 'A' (p = 0.04), rs6323 'G' (p = 0.0001) and MAOB rs56220155 'A' (p = 0.002), rs2283728 'C' (p = 0.0008), rs2283727 'C' (p = 0.0008), rs3027441 'T' (p = 0.003), rs6324 'C' (p = 0.003), rs3027440 'T' (p = 0.0002). Significantly preferential maternal transmissions of different haplotype combinations to male probands were also noticed (p < 0.05), while female probands did not reveal such transmission bias. Behavioral traits of male probands exhibited significant association with gene variants. Age of the mother at pregnancy also revealed association with risk variants of male probands. CONCLUSIONS: It may be inferred that the MAOA and MAOB variants may contribute to the etiology of ADHD in the Indo-Caucasoid population and could be responsible for higher occurrence of ADHD in the boys.
[Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico
Transtorno do Deficit de Atenção com Hiperatividade/genética
Predisposição Genética para Doença
Monoaminoxidase/genética
Comportamento Problema/psicologia
[Mh] Termos MeSH secundário: Alelos
Manual Diagnóstico e Estatístico de Transtornos Mentais
Grupo com Ancestrais do Continente Europeu/genética
Feminino
Técnicas de Genotipagem
Haplótipos
Seres Humanos
Masculino
Projetos Piloto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.4.3.4 (Monoamine Oxidase); EC 1.4.3.4. (monoamine oxidase A, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0469-5


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[PMID]:28809653
[Au] Autor:Jensen L; Padilla R
[Ad] Endereço:Lou Jensen, OTD, OTR/L, is Assistant Professor of Occupational Therapy, Creighton University, Omaha, NE; loujensen@creighton.edu.
[Ti] Título:Effectiveness of Environment-Based Interventions That Address Behavior, Perception, and Falls in People With Alzheimer's Disease and Related Major Neurocognitive Disorders: A Systematic Review.
[So] Source:Am J Occup Ther;71(5):7105180030p1-7105180030p10, 2017 Sep/Oct.
[Is] ISSN:0272-9490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This systematic review evaluated the effectiveness of environment-based interventions that address behavior, perception, and falls in the home and other settings for people with Alzheimer's disease (AD) and related major neurocognitive disorders (NCDs). METHOD: Database searches were limited to outcomes studies published in English in peer-reviewed journals between January 2006 and April 2014. RESULTS: A total of 1,854 articles were initially identified, of which 42 met inclusion criteria. CONCLUSION: Strong evidence indicates that person-centered approaches can improve behavior. Moderate evidence supports noise regulation, environmental design, unobtrusive visual barriers, and environmental relocation strategies to reduce problematic behaviors. Evidence is insufficient for the effectiveness of mealtime ambient music, bright light, proprioceptive input, wander gardens, optical strategies, and sensory devices in improving behavior or reducing wandering and falls. Although evidence supports many environment-based interventions used by occupational therapy practitioners to address behavior, perception, and falls in people with AD and related major NCDs, more studies are needed.
[Mh] Termos MeSH primário: Acidentes por Quedas/prevenção & controle
Doença de Alzheimer/reabilitação
Terapia Ocupacional/métodos
Comportamento Problema
Comportamento Errante
[Mh] Termos MeSH secundário: Seres Humanos
Transtornos Neurocognitivos/reabilitação
Terapias Sensoriais através das Artes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.5014/ajot.2017.027409


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[PMID]:28715786
[Au] Autor:Gump BB; Dykas MJ; MacKenzie JA; Dumas AK; Hruska B; Ewart CK; Parsons PJ; Palmer CD; Bendinskas K
[Ad] Endereço:Department of Public Health, Food Studies, and Nutrition, Syracuse University, United States. Electronic address: bbgump@syr.edu.
[Ti] Título:Background lead and mercury exposures: Psychological and behavioral problems in children.
[So] Source:Environ Res;158:576-582, 2017 10.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The potential harm from exposure to nonessential metals, particularly mercury (Hg) and lead (Pb), has been the focus of research for years. Initial interest focused on relatively high exposures; however, recent evidence suggests that even background exposures might have adverse consequences for child development. Identifying the extent of these consequences is now a priority. METHODS: We assessed blood Pb and Hg levels in a biracial sample of 9-11 year-old children (N = 203). Neurodevelopment and psychological functioning assessments included hostility, disruptive behaviors, emotion regulation, and autism spectrum disorder behaviors. Parasympathetic (vagal) responses to acute stress were indexed by heart rate variability (HRV) at rest and during stress. RESULTS: With increasing Pb levels, children exhibit higher levels of hostile distrust and oppositional defiant behaviors, were more dissatisfied and uncertain about their emotions, and had difficulties with communication. These significant associations were found within a range of blood Pb levels from 0.19 to 3.25µg/dL, well below the "reference value" for children of >5µg/dL. Vagal reactivity interacted with Hg such that increasing Hg was associated with increasing autism spectrum behaviors for those children with sustained vagal tone during acute stress. CONCLUSIONS: This study is the first to demonstrate an association between very low-level Pb exposure and fundamental psychological mechanisms that might explain prior associations with more complex outcomes such as delinquency. Analyses of vagal reactivity yielded entirely novel associations suggesting that Hg may increase autism spectrum behaviors in children with sustained vagal tone during acute stress. The novelty of these later findings requires additional research for confirmation and the cross-sectional nature of the data caution against assumptions of causality without further research.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/epidemiologia
Emoções/efeitos dos fármacos
Exposição Ambiental
Poluentes Ambientais/sangue
Chumbo/sangue
Mercúrio/sangue
Comportamento Problema/psicologia
[Mh] Termos MeSH secundário: Transtorno do Espectro Autista/induzido quimicamente
Criança
Estudos Transversais
Feminino
Hostilidade
Seres Humanos
Masculino
New York/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Environmental Pollutants); 2P299V784P (Lead); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE



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