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[PMID]:29386447
[Au] Autor:Mori T; Sawaguchi T
[Ad] Endereço:Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences.
[Ti] Título:[Underlying Mechanisms of Methamphetamine-Induced Self-Injurious Behavior and Lethal Effects in Mice].
[So] Source:Nihon Eiseigaku Zasshi;73(1):51-56, 2018.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Relatively high doses of psychostimulants induce neurotoxicity on the dopaminergic system and self-injurious behavior (SIB) in rodents. However the underlying neuronal mechanisms of SIB remains unclear. Dopamine receptor antagonists, N-methyl-D-aspartic acid (NMDA) receptor antagonists, Nitric Oxide Synthase (NOS) inhibitors and free radical scavengers significantly attenuate methamphetamine-induced SIB. These findings indicate that activation of dopamine as well as NMDA receptors followed by radical formation and oxidative stress, especially when mediated by NOS activation, is associated with methamphetamine-induced SIB. On the other hand, an increase in the incidence of polydrug abuse is a major problem worldwide. Coadministered methamphetamine and morphine induced lethality in more than 80% in mice, accompanied by an increase in the number of poly (ADP-ribose) polymerase (PARP)-immunoreactive cells in the heart, kidney and liver. The lethal effect and the increase in the incidence of rupture or PARP-immunoreactive cells induced by the coadministration of methamphetamine and morphine were significantly attenuated by pretreatment with a phospholipase A2 inhibitor or a radical scavenger, or by cooling of body from 30 to 90 min after drug administration. These results suggest that free radicals play an important role in the increased lethality induced by the coadministration of methamphetamine and morphine. Therefore, free radical scavengers and cooling are beneficial for preventing death that is induced by the coadministration of methamphetamine and morphine. These findings may help us better understand for masochistic behavior, which is a clinical phenomenon on SIB, as well as polydrug-abuse-induced acute toxicity.
[Mh] Termos MeSH primário: Estimulantes do Sistema Nervoso Central/efeitos adversos
Estimulantes do Sistema Nervoso Central/toxicidade
Metanfetamina/efeitos adversos
Metanfetamina/toxicidade
Comportamento Autodestrutivo/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Antagonistas de Dopamina/farmacologia
Antagonistas de Dopamina/uso terapêutico
Neurônios Dopaminérgicos/efeitos dos fármacos
Relação Dose-Resposta a Droga
Interações Medicamentosas
Depuradores de Radicais Livres/farmacologia
Depuradores de Radicais Livres/uso terapêutico
Radicais Livres/efeitos adversos
Radicais Livres/toxicidade
Seres Humanos
Dose Letal Mediana
Metanfetamina/administração & dosagem
Morfina/administração & dosagem
Morfina/efeitos adversos
Morfina/toxicidade
Receptores de N-Metil-D-Aspartato/antagonistas & inibidores
Comportamento Autodestrutivo/etiologia
Transtornos Relacionados ao Uso de Substâncias
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 0 (Dopamine Antagonists); 0 (Free Radical Scavengers); 0 (Free Radicals); 0 (Receptors, N-Methyl-D-Aspartate); 44RAL3456C (Methamphetamine); 76I7G6D29C (Morphine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.73.51


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[PMID]:28451707
[Au] Autor:Kapfhammer HP
[Ad] Endereço:Klinik für Psychiatrie und Psychotherapeutische Medizin, Medizinische Universität Graz, Auenbruggerplatz 31, 8036, Graz, Österreich. Hans-peter.kapfhammer@klinikum-graz.at.
[Ti] Título:[Factitious disorders].
[Ti] Título:Artifizielle Störungen..
[So] Source:Nervenarzt;88(5):549-570, 2017 May.
[Is] ISSN:1433-0407
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Patients with factitious disorders intentionally fabricate, exaggerate or feign physical and/or psychiatric symptoms for various open and covert psychological reasons. There are many issues regarding the diagnostic state and classification of factitious disorders. Both the categorical differentiation of and clinical continuum ranging from somatoform/dissociative disorders to malingering are being controversially debated. Epidemiological studies on the frequency of factitious disorder meet basic methodological difficulties. Reported rates of prevalence and incidence in the professional literature most probably have to be considered underestimations. Illness deception and self-harm as core features of the abnormal illness behaviour in factitious disorder may refer to various highly adverse and traumatic experiences during early development in a subgroup of patients. Chronic courses of illness prevail; however, there are also episodic variants.
[Mh] Termos MeSH primário: Transtornos Dissociativos/diagnóstico
Transtornos Autoinduzidos/diagnóstico
Transtornos Autoinduzidos/psicologia
Simulação de Doença/diagnóstico
Comportamento Autodestrutivo/diagnóstico
Transtornos Somatoformes/diagnóstico por imagem
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Transtornos Dissociativos/psicologia
Transtornos Dissociativos/terapia
Medicina Baseada em Evidências
Transtornos Autoinduzidos/terapia
Seres Humanos
Simulação de Doença/psicologia
Simulação de Doença/terapia
Comportamento Autodestrutivo/prevenção & controle
Comportamento Autodestrutivo/psicologia
Transtornos Somatoformes/psicologia
Transtornos Somatoformes/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s00115-017-0337-8


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[PMID]:28460177
[Au] Autor:Patel BK; Wolfe KS; Hall JB; Kress JP
[Ad] Endereço:1 University of Chicago Chicago, Illinois.
[Ti] Título:A Word of Caution Regarding Patient Self-inflicted Lung Injury and Prophylactic Intubation.
[So] Source:Am J Respir Crit Care Med;196(7):936, 2017 10 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Intubação
Lesão Pulmonar
[Mh] Termos MeSH secundário: Seres Humanos
Comportamento Autodestrutivo
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201702-0410LE


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[PMID]:29173741
[Au] Autor:Wilcox HC; Fullerton JM; Glowinski AL; Benke K; Kamali M; Hulvershorn LA; Stapp EK; Edenberg HJ; Roberts GMP; Ghaziuddin N; Fisher C; Brucksch C; Frankland A; Toma C; Shaw AD; Kastelic E; Miller L; McInnis MG; Mitchell PB; Nurnberger JI
[Ad] Endereço:Johns Hopkins University, Baltimore, MD. Electronic address: hwilcox1@jhmi.edu.
[Ti] Título:Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts.
[So] Source:J Am Acad Child Adolesc Psychiatry;56(12):1073-1080, 2017 Dec.
[Is] ISSN:1527-5418
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Bipolar disorder (BD) is one of the most heritable psychiatric conditions and is associated with high suicide risk. To explore the reasons for this link, this study examined the interaction between traumatic stress and BD polygenic risk score in relation to suicidal ideation, suicide attempt, and nonsuicidal self-injury (NSSI) in adolescent and young adult offspring and relatives of persons with BD (BD-relatives) compared with adolescent and young adult offspring of individuals without psychiatric disorders (controls). METHOD: Data were collected from 4 sites in the United States and 1 site in Australia from 2006 through 2012. Generalized estimating equation models were used to compare rates of ideation, attempts, and NSSI between BD-relatives (n = 307) and controls (n = 166) and to determine the contribution of demographic factors, traumatic stress exposure, lifetime mood or substance (alcohol/drug) use disorders, and BD polygenic risk score. RESULTS: After adjusting for demographic characteristics and mood and substance use disorders, BD-relatives were at increased risk for suicidal ideation and attempts but not for NSSI. Independent of BD-relative versus control status, demographic factors, or mood and substance use disorders, exposure to trauma within the past year (including bullying, sexual abuse, and domestic violence) was associated with suicide attempts (p = .014), and BD polygenic risk score was marginally associated with attempts (p = .061). Importantly, the interaction between BD polygenic risk score and traumatic event exposures was significantly associated with attempts, independent of demographics, relative versus control status, and mood and substance use disorders (p = .041). CONCLUSION: BD-relatives are at increased risk for suicide attempts and ideation, especially if they are exposed to trauma and have evidence of increased genetic vulnerability.
[Mh] Termos MeSH primário: Transtorno Bipolar/genética
Transtorno Bipolar/psicologia
Predisposição Genética para Doença
Trauma Psicológico/genética
Trauma Psicológico/psicologia
Comportamento Autodestrutivo/genética
Comportamento Autodestrutivo/psicologia
[Mh] Termos MeSH secundário: Adolescente
Transtorno Bipolar/diagnóstico
Estudos de Casos e Controles
Criança
Feminino
Seguimentos
Seres Humanos
Masculino
Modelos Estatísticos
Polimorfismo de Nucleotídeo Único
Escalas de Graduação Psiquiátrica
Trauma Psicológico/diagnóstico
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Comportamento Autodestrutivo/diagnóstico
Ideação Suicida
Tentativa de Suicídio/psicologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29304045
[Au] Autor:Lysell H; Dahlin M; Viktorin A; Ljungberg E; D'Onofrio BM; Dickman P; Runeson B
[Ad] Endereço:Department of Clinical Neuroscience, Karolinska Institutet, Centre for psychiatry research, Stockholm, Sweden.
[Ti] Título:Maternal suicide - Register based study of all suicides occurring after delivery in Sweden 1974-2009.
[So] Source:PLoS One;13(1):e0190133, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recent research suggests that having a newborn child is associated with substantially reduced risk for maternal suicide. We studied postpartum suicides in a national cohort of mothers and the role of mental disorder, self-harm and delivery related factors. METHODS: We used a nested case-control design with data from Swedish registries. The cohort consisted of all women given birth in Sweden 1974-2009. Mothers who died by suicide during follow-up were considered cases (n = 1,786) and risk of suicide was estimated with proximity to delivery as the explanatory variable. In a second step, association between suicide during the first year following delivery (n = 145) and mental disorder, self-harm and delivery related variables risk factors were analyzed. RESULTS: The first postpartum year was associated with a lower risk of suicide, compared to later (RR 0.80, 95%CI 0.66-0.96), which was unaltered after adjustment for socio-economic status and history of self-harm (aRR 0.82, 95%CI 0.68-0.99). Compared to living mothers, suicide victims of the postpartum year more often had affective disorders (aRR 133.94, 95%CI 45.93-390.61), psychotic disorders (aRR 83.69, 95%CI 36.99-189.31) and history of self-harm (aRR 47.56, 95%CI 18.24-124.02). The aRR of stillbirth was 2.66 (95%CI 0.63-11.30). CONCLUSIONS: We found only a weak negative association between childbirth during the preceding year and suicide, when using mothers as controls. A severe mental disorder after delivery and a history of self-harm was strongly associated with increased risk of suicide in the postpartum year and may inform the clinical assessment postpartum.
[Mh] Termos MeSH primário: Mães
Período Pós-Parto
Sistema de Registros
Suicídio/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos de Casos e Controles
Estudos de Coortes
Parto Obstétrico
Feminino
Seres Humanos
Gravidez
Fatores de Risco
Comportamento Autodestrutivo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190133


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[PMID]:28456054
[Au] Autor:Ennis CR; Short NA; Moltisanti AJ; Smith CE; Joiner TE; Taylor J
[Ad] Endereço:Florida State University, 1107 W. Call Street, Tallahassee, FL 32306. Electronic address: chelsearennis@gmail.com.
[Ti] Título:Nightmares and nonsuicidal self-injury: The mediating role of emotional dysregulation.
[So] Source:Compr Psychiatry;76:104-112, 2017 07.
[Is] ISSN:1532-8384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Nonsuicidal self-injury (NSSI) is a transdiagnostic behavior associated with significant psychopathology. Research has shown a positive association between sleep disturbances, (e.g., nightmares and insomnia), and suicidal behavior, however, the relation between NSSI and sleep disturbances has yet to be examined. Sleep disturbances have been found to have a causal role in problems with emotional dysfunction. Specifically, sleep disturbances inhibit the emotion processing function of sleep. Importantly, a majority of individuals engage in NSSI to regulate intense emotions, and it is possible that sleep disturbances increase propensity for NSSI by contributing to dysregulated emotions. METHODS: In two cross-sectional studies, the present research examined whether insomnia symptoms and nightmares were related to NSSI in a clinical sample (Study 1, N = 313) and in a university sample (Study 2, N = 152). Furthermore, the hypothesis that emotional dysregulation would atemporally mediate the relationship between sleep disturbances and NSSI was tested in Study 2. RESULTS: Findings showed that nightmares, but not insomnia symptoms, were associated with NSSI while controlling for depressive symptoms. This pattern of findings was consistent across both clinical and university samples, which underscores the robustness of the finding. Further, the relationship between nightmares and NSSI was fully mediated by emotional dysregulation. CONCLUSION: The present research provides initial evidence that nightmares are atemporally associated with an increased propensity for NSSI by contributing to emotional dysregulation, and provides support for the emotion regulation function of dreams.
[Mh] Termos MeSH primário: Emoções
Terrores Noturnos/psicologia
Comportamento Autodestrutivo/psicologia
Distúrbios do Início e da Manutenção do Sono/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Terrores Noturnos/complicações
Comportamento Autodestrutivo/complicações
Distúrbios do Início e da Manutenção do Sono/complicações
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28468644
[Au] Autor:Meszaros G; Horvath LO; Balazs J
[Ad] Endereço:Semmelweis University, Mental Health Sciences School Of Ph.D., Ülloi út 26, Budapest, 1085, Hungary. meszaros.gergely.83@gmail.com.
[Ti] Título:Self-injury and externalizing pathology: a systematic literature review.
[So] Source:BMC Psychiatry;17(1):160, 2017 05 03.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: During the last decade there is a growing scientific interest in nonsuicidal self-injury (NSSI). The aim of the current paper was to review systematically the literature with a special focus on the associations between self-injurious behaviours and externalizing psychopathology. An additional aim was to review terminology and measurements of self-injurious behaviour and the connection between self-injurious behaviours and suicide in the included publications. METHODS: A systematic literature search was conducted on 31st December 2016 in five databases (PubMed, OVID Medline, OVID PsycINFO, Scopus, Web of Science) with two categories of search terms (1. nonsuicidal self-injury, non-suicidal self-injury, NSSI, self-injurious behaviour, SIB, deliberate self-harm, DSH, self-injury; 2. externalizing disorder, attention deficit hyperactivity disorder, ADHD, conduct disorder, CD, oppositional defiant disorder, OD, ODD). RESULTS: Finally 35 papers were included. Eleven different terms were found for describing self-injurious behaviours and 20 methods for measuring it. NSSI has the clearest definition. All the examined externalizing psychopathologies had strong associations with self-injurious behaviours according to: higher prevalence rates in externalizing groups than in control groups, higher externalizing scores on the externalizing scales of questionnaires, higher symptom severity in self-injurious groups. Eight studies investigated the relationship between suicide and self-injurious behaviours and found high overlap between the two phenomena and similar risk factors. CONCLUSIONS: Based on the current findings the association between externalizing psychopathology and self-injurious behaviours has been proven by the scientific literature. Similarly to other reviews on self-injurious behaviours the confusion in terminology and methodology was noticed. NSSI is suggested for use as a distinct term. Further studies should investigate the role of comorbid conditions in NSSI, especially when internalizing and externalizing pathologies are both presented.
[Mh] Termos MeSH primário: Transtorno da Conduta/fisiopatologia
Comportamento Autodestrutivo/fisiopatologia
[Mh] Termos MeSH secundário: Seres Humanos
Fatores de Risco
Tentativa de Suicídio
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-017-1326-y


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[PMID]:28456074
[Au] Autor:Griffin E; Dillon CB; O'Regan G; Corcoran P; Perry IJ; Arensman E
[Ad] Endereço:National Suicide Research Foundation, Cork, Ireland. Electronic address: evegriffin@ucc.ie.
[Ti] Título:The paradox of public holidays: Hospital-treated self-harm and associated factors.
[So] Source:J Affect Disord;218:30-34, 2017 Aug 15.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recent research on the patterns of self-harm around public holidays is lacking. This study used national data to examine the patterns of hospital-treated self-harm during public holidays, and to examine associated factors. METHODS: Data on self-harm presentations to all emergency departments were obtained from the National Self-Harm Registry Ireland. The association between self-harm presentations and public holidays was examined using univariate and multivariate Poisson regression analyses. RESULTS: A total of 104,371 presentations of self-harm were recorded between 2007 and 2015. The mean number of self-harm presentations was 32 on public holidays. St. Patrick's Day had the highest number of presentations compared to all other public holidays, with a daily mean of 44 presentations. Across all years, self-harm presentations during public holidays had a 24% increased risk of involving alcohol consumption compared to all other days and this effect was most pronounced during the Christmas period. The association with alcohol remained significant at a multivariate level. Presentations on public holidays were more likely to attend out of normal working hours. An increase in male presentations involving self-cutting was observed on public holidays and there was an over-representation of males presenting for the first time. LIMITATIONS: It is likely that extent of alcohol involvement in self-harm presentations reported here is an underestimate, as it was dependent on the information being recorded by the attending clinician. CONCLUSIONS: Public holidays are associated with an elevated number of self-harm presentations to hospital, with presentations to hospital involving alcohol significantly increased on these days. Hospital resources should be targeted to address increases during public holidays, including during out-of-hours. Involvement of alcohol may delay delivery of care to these patients in emergency settings.
[Mh] Termos MeSH primário: Férias e Feriados
Comportamento Autodestrutivo/psicologia
[Mh] Termos MeSH secundário: Adulto
Consumo de Bebidas Alcoólicas/psicologia
Serviços Médicos de Emergência/estatística & dados numéricos
Feminino
Seres Humanos
Irlanda
Masculino
Meia-Idade
Sistema de Registros
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29240737
[Au] Autor:Tiatia-Seath J; Lay-Yee R; von Randow M
[Ad] Endereço:Te Wananga o Waipapa, School of Maori Studies and Pacific Studies, University of Auckland, Auckland.
[Ti] Título:Morbidity from intentional self-harm among Pacific peoples in New Zealand 1996-2015.
[So] Source:N Z Med J;130(1467):23-31, 2017 Dec 15.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:AIM: The aim of this study was to describe trends in intentional self-harm for Pacific peoples in New Zealand by reviewing official data over the period 1996-2015. METHOD: Publicly funded hospitalisations where the external cause was intentional self-harm were examined and areas of interest were identified and are presented. RESULTS: Over a 19-year period (1996-2015), there were 1,608 intentional self-harm events for Pacific peoples (2.8%) out of 58,643 intentional self-harm events nationally for New Zealand's total population. CONCLUSION: This study has been able to delineate Pacific ethnic-specific information not previously available for a prolonged period of 19 years. There are differences in Pacific peoples' experiences between ethnic groups. Furthermore, disparities persist between Pacific and non-Pacific. This study exposes priority areas for more targeted interventions according to ethnic, socioeconomic status, gender and age variations.
[Mh] Termos MeSH primário: Hospitalização/estatística & dados numéricos
Grupo com Ancestrais Oceânicos/estatística & dados numéricos
Comportamento Autodestrutivo/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Feminino
Seres Humanos
Masculino
Morbidade/tendências
Nova Zelândia/epidemiologia
Distribuição por Sexo
Classe Social
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:27771563
[Au] Autor:Hawes M; Yaseen Z; Briggs J; Galynker I
[Ad] Endereço:Mount Sinai Beth Israel, Department of Psychiatry, 317 E 17th St, New York, NY 10003, USA.
[Ti] Título:The Modular Assessment of Risk for Imminent Suicide (MARIS): A proof of concept for a multi-informant tool for evaluation of short-term suicide risk.
[So] Source:Compr Psychiatry;72:88-96, 2017 01.
[Is] ISSN:1532-8384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To date, no diagnostic tool has demonstrated clinical value for the assessment of short-term suicide risk among high-risk individuals. To this end we have developed the Modular Assessment of Risk for Imminent Suicide (MARIS), a modular patient and clinician informed risk evaluation instrument. Here we assess its predictive validity for suicidal behavior (SB) in psychiatric patients following discharge from an inpatient unit. METHODS: The MARIS and a psychological test battery were administered to 136 adult psychiatric patients hospitalized for high risk of suicide. Eighty-six participants had complete data at discharge and 59 (69.8%) were reached for follow-up. Logistic regressions were used to assess the predictive validity of the MARIS for SB over the 4-8weeks following hospital discharge and its incremental predictive validity over standard risk factors. RESULTS: Patients who exhibited SB in the period between initial assessment and follow-up had significantly higher MARIS scores. ROC analysis indicated good sensitivity and specificity of MARIS in identifying risk (OR=19). Further, MARIS total score significantly improved predictive validity by the standard risk factors when added to a model comprising global depression severity, hopelessness, and lifetime number of suicide attempts, and was the only factor that approached independent significance. CONCLUSION: The MARIS appears to be a practical and effective tool for detecting short-term suicide risk following hospital discharge, supporting the validity of modular multi-informant approach to suicide risk evaluation. Replication of these findings and further investigation of the applications of such an approach are warranted.
[Mh] Termos MeSH primário: Testes Psicológicos/normas
Ideação Suicida
Tentativa de Suicídio/psicologia
Suicídio/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Alta do Paciente/normas
Medição de Risco
Fatores de Risco
Comportamento Autodestrutivo/diagnóstico
Comportamento Autodestrutivo/epidemiologia
Comportamento Autodestrutivo/psicologia
Sensibilidade e Especificidade
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE



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