Base de dados : MEDLINE
Pesquisa : F01.145.209.530.538 [Categoria DeCS]
Referências encontradas : 821 [refinar]
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[PMID]:28334943
[Au] Autor:Perry A; Saunders SN; Stiso J; Dewar C; Lubell J; Meling TR; Solbakk AK; Endestad T; Knight RT
[Ad] Endereço:University of California, Berkeley, CA 94720, USA.
[Ti] Título:Effects of prefrontal cortex damage on emotion understanding: EEG and behavioural evidence.
[So] Source:Brain;140(4):1086-1099, 2017 Apr 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Humans are highly social beings that interact with each other on a daily basis. In these complex interactions, we get along by being able to identify others' actions and infer their intentions, thoughts and feelings. One of the major theories accounting for this critical ability assumes that the understanding of social signals is based on a primordial tendency to simulate observed actions by activating a mirror neuron system. If mirror neuron regions are important for action and emotion recognition, damage to regions in this network should lead to deficits in these domains. In the current behavioural and EEG study, we focused on the lateral prefrontal cortex including dorsal and ventral prefrontal cortex and utilized a series of task paradigms, each measuring a different aspect of recognizing others' actions or emotions from body cues. We examined 17 patients with lesions including (n = 8) or not including (n = 9) the inferior frontal gyrus, a core mirror neuron system region, and compared their performance to matched healthy control subjects (n = 18), in behavioural tasks and in an EEG observation-execution task measuring mu suppression. Our results provide support for the role of the lateral prefrontal cortex in understanding others' emotions, by showing that even unilateral lesions result in deficits in both accuracy and reaction time in tasks involving the recognition of others' emotions. In tasks involving the recognition of actions, patients showed a general increase in reaction time, but not a reduction in accuracy. Deficits in emotion recognition can be seen by either direct damage to the inferior frontal gyrus, or via damage to dorsal lateral prefrontal cortex regions, resulting in deteriorated performance and less EEG mu suppression over sensorimotor cortex.
[Mh] Termos MeSH primário: Compreensão
Eletroencefalografia
Emoções
Córtex Pré-Frontal/lesões
Percepção Social
[Mh] Termos MeSH secundário: Adulto
Neoplasias Encefálicas/cirurgia
Sinais (Psicologia)
Feminino
Gestos
Seres Humanos
Processamento de Imagem Assistida por Computador
Cinésica
Masculino
Meia-Idade
Neurônios-Espelho
Percepção de Movimento
Córtex Pré-Frontal/diagnóstico por imagem
Desempenho Psicomotor
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx031


  2 / 821 MEDLINE  
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[PMID]:28287675
[Au] Autor:King C
[Ti] Título:Psychiatric Nurses' Views on Caring: Patients and Canine Companions.
[So] Source:J Psychosoc Nurs Ment Health Serv;55(3):46-52, 2017 Mar 01.
[Is] ISSN:0279-3695
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Psychiatric nurses are expert care providers for individuals with mental health needs. The art of caring spans across multiple species, is important to understand, and is universal whether intentions are toward individuals or animals. Pets are often cared for and viewed as family members. The current research examined psychiatric nurses' views on the similarities and differences of caring for patients and their pet dogs. Twenty-five nurses were interviewed. Similarities of caring for patients and canines included trusting relationships, companionship, daily basic needs, and improved communication through monitored body language. Differences in caring included personal expectations, unconditional love, and professional boundaries. Understanding the concepts of caring for patients and pet dogs will provide the opportunity for insight into familial versus professional relationships, improve communication with others, and strengthen the human-animal bond. [Journal of Psychosocial Nursing and Mental Health Services, 55(3), 46-52.].
[Mh] Termos MeSH primário: Cinésica
Relações Enfermeiro-Paciente
Cuidados de Enfermagem/psicologia
Enfermagem Psiquiátrica
Confiança
[Mh] Termos MeSH secundário: Adulto
Animais
Comunicação
Cães
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.3928/02793695-20170301-06


  3 / 821 MEDLINE  
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[PMID]:28285180
[Au] Autor:Suchowski K; Pöschinger T; Rehemtulla A; Stürzl M; Scheuer W
[Ad] Endereço:Discovery Oncology, Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany. Electronic address: Karina.Suchowski@roche.com.
[Ti] Título:Noninvasive Bioluminescence Imaging of AKT Kinase Activity in Subcutaneous and Orthotopic NSCLC Xenografts: Correlation of AKT Activity with Tumor Growth Kinetics.
[So] Source:Neoplasia;19(4):310-320, 2017 Apr.
[Is] ISSN:1476-5586
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aberrant signaling through the AKT kinase mediates oncogenic phenotypes including cell proliferation, survival, and therapeutic resistance. Here, we utilize a bioluminescence reporter for AKT kinase activity (BAR) to noninvasively assess the therapeutic efficacy of the EGFR inhibitor erlotinib in KRAS-mutated lung cancer therapy. A549 non-small cell lung cancer cell line, engineered to express BAR, enabled the evaluation of compounds targeting the EGFR/PI3K/AKT pathway in vitro as well as in mouse models. We found that erlotinib treatment of resistant A549 subcutaneous and orthotopic xenografts resulted in significant AKT inhibition as determined by an 8- to 13-fold (P < .0001) increase in reporter activity 3 hours after erlotinib (100 mg/kg) administration compared to the control. This was confirmed by a 25% (P < .0001) decrease in pAKT ex vivo and a decrease in tumor growth. Treatment of the orthotopic xenograft with varying doses of erlotinib (25, 50, and 100 mg/kg) revealed a dose- and time-dependent increase in reporter activity (10-, 12-, and 23-fold). Correspondingly, a decrease in phospho-AKT levels (0%, 16%, and 28%, respectively) and a decrease in the AKT dependent proliferation marker PCNA (0%, 50%, and 50%) were observed. We applied µ-CT imaging for noninvasive longitudinal quantification of lung tumor load which revealed a corresponding decrease in tumor growth in a dose-dependent manner. These findings demonstrate the utility of BAR to noninvasively monitor AKT activity in preclinical studies in response to AKT modulating agents. These results also demonstrate that BAR can be applied to study drug dosing, drug combinations, and treatment efficacy in orthotopic mouse lung tumor models.
[Mh] Termos MeSH primário: Medições Luminescentes
Imagem Molecular
Neoplasias/metabolismo
Neoplasias/patologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
[Mh] Termos MeSH secundário: Animais
Caspase 3/metabolismo
Linhagem Celular Tumoral
Modelos Animais de Doenças
Ativação Enzimática
Expressão Gênica
Genes Reporter
Xenoenxertos
Seres Humanos
Cinésica
Medições Luminescentes/métodos
Camundongos
Modelos Biológicos
Imagem Molecular/métodos
Neoplasias/diagnóstico por imagem
Fosfatidilinositol 3-Quinases/metabolismo
Fosforilação
Inibidores de Proteínas Quinases/farmacologia
Proteínas Proto-Oncogênicas c-akt/genética
Receptor do Fator de Crescimento Epidérmico/metabolismo
Transdução de Sinais
Carga Tumoral
Microtomografia por Raio-X
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  4 / 821 MEDLINE  
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[PMID]:27702450
[Au] Autor:Birch I; Birch T; Bray D
[Ad] Endereço:Sheffield Teaching Hospitals NHS Foundation Trust, Jordanthorpe Health Centre, 1 Dyche Close, Sheffield, S8 8DJ, England, United Kingdom. Electronic address: ivanbirch@btinternet.com.
[Ti] Título:The identification of emotions from gait.
[So] Source:Sci Justice;56(5):351-356, 2016 Sep.
[Is] ISSN:1355-0306
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Emoções
Psiquiatria Legal
Marcha
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Cinésica
Masculino
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE


  5 / 821 MEDLINE  
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[PMID]:27399688
[Au] Autor:Choi JY; Iacobazzi RM; Perrone M; Margiotta N; Cutrignelli A; Jung JH; Park do D; Moon BS; Denora N; Kim SE; Lee BC
[Ad] Endereço:Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea. cjy0929@snu.ac.kr.
[Ti] Título:Synthesis and Evaluation of Tricarbonyl (99m)Tc-Labeled 2-(4-Chloro)phenyl-imidazo[1,2-a]pyridine Analogs as Novel SPECT Imaging Radiotracer for TSPO-Rich Cancer.
[So] Source:Int J Mol Sci;17(7), 2016 Jul 07.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The 18-kDa translocator protein (TSPO) levels are associated with brain, breast, and prostate cancer progression and have emerged as viable targets for cancer therapy and imaging. In order to develop highly selective and active ligands with a high affinity for TSPO, imidazopyridine-based TSPO ligand (CB256, 3) was prepared as the precursor. (99m)Tc- and Re-CB256 (1 and 2, respectively) were synthesized in high radiochemical yield (74.5% ± 6.4%, decay-corrected, n = 5) and chemical yield (65.6%) by the incorporation of the [(99m)Tc(CO)3(H2O)3]⁺ and (NEt4)2[Re(CO)3Br3] followed by HPLC separation. Radio-ligand 1 was shown to be stable (>99%) when incubated in human serum for 4 h at 37 °C with a relatively low lipophilicity (logD = 2.15 ± 0.02). The rhenium-185 and -187 complex 2 exhibited a moderate affinity (Ki = 159.3 ± 8.7 nM) for TSPO, whereas its cytotoxicity evaluated on TSPO-rich tumor cell lines was lower than that observed for the precursor. In vitro uptake studies of 1 in C6 and U87-MG cells for 60 min was found to be 9.84% ± 0.17% and 7.87% ± 0.23% ID, respectively. Our results indicated that (99m)Tc-CB256 can be considered as a potential new TSPO-rich cancer SPECT imaging agent and provides the foundation for further in vivo evaluation.
[Mh] Termos MeSH primário: Piridinas/química
Compostos Radiofarmacêuticos/síntese química
Receptores de GABA/metabolismo
Tecnécio/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Células Hep G2
Seres Humanos
Cinésica
Células MCF-7
Neoplasias/diagnóstico por imagem
Piridinas/metabolismo
Piridinas/toxicidade
Compostos Radiofarmacêuticos/metabolismo
Compostos Radiofarmacêuticos/toxicidade
Ratos
Receptores de GABA/química
Tomografia Computadorizada de Emissão de Fóton Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pyridines); 0 (Radiopharmaceuticals); 0 (Receptors, GABA); 0 (TSPO protein, human); 7440-26-8 (Technetium); G18ZBV2HXA (imidazo(1,2-a)pyridine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE


  6 / 821 MEDLINE  
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[PMID]:27210846
[Au] Autor:Sher D; Sher M
[Ad] Endereço:The Tavistock Institute of Human Relations, 30 Tabernacle Street, London, EC2A 4UE, United Kingdom. Electronic address: sherdanny@hotmail.com.
[Ti] Título:Understanding and working with the psychodynamics of practitioner-patient relationships in the manual therapies.
[So] Source:J Bodyw Mov Ther;20(2):293-9, 2016 Apr.
[Is] ISSN:1532-9283
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this paper, we argue that practitioner-patient relationships in the manual therapies would be strengthened by a deeper understanding of the psychodynamics and emotions of those relationships. We suggest that in many cases, a purely bio-mechanical approach may neglect underlying psychological and emotional reasons of the patient's presenting condition, and consequently, lead to a less than adequate outcome for the patient. We offer easily adopted suggestions that could enhance the practice of practitioners of manual therapies as well as other professions that rely on the application of physical methods of diagnosis and treatment. These suggestions could lead to improved prognosis and increased professional satisfaction for practitioners. This paper describes five key dynamics that characterize practitioner-patient relationships: (i) pain as a form of communication; (ii) the 'heart-sink' patient; (iii) dependency; (iv) the erotic transference; (v) endings and loss.
[Mh] Termos MeSH primário: Comunicação
Emoções
Manipulações Musculoesqueléticas/psicologia
Relações Profissional-Paciente
[Mh] Termos MeSH secundário: Seres Humanos
Cinésica
Dor/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE


  7 / 821 MEDLINE  
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[PMID]:27025242
[Au] Autor:de Borst AW; de Gelder B
[Ad] Endereço:Department of Cognitive Neuroscience, Brain and Emotion Laboratory, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands aline.deborst@maastrichtuniversity.nl.
[Ti] Título:Clear signals or mixed messages: inter-individual emotion congruency modulates brain activity underlying affective body perception.
[So] Source:Soc Cogn Affect Neurosci;11(8):1299-309, 2016 Aug.
[Is] ISSN:1749-5024
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The neural basis of emotion perception has mostly been investigated with single face or body stimuli. However, in daily life one may also encounter affective expressions by groups, e.g. an angry mob or an exhilarated concert crowd. In what way is brain activity modulated when several individuals express similar rather than different emotions? We investigated this question using an experimental design in which we presented two stimuli simultaneously, with same or different emotional expressions. We hypothesized that, in the case of two same-emotion stimuli, brain activity would be enhanced, while in the case of two different emotions, one emotion would interfere with the effect of the other. The results showed that the simultaneous perception of different affective body expressions leads to a deactivation of the amygdala and a reduction of cortical activity. It was revealed that the processing of fearful bodies, compared with different-emotion bodies, relied more strongly on saliency and action triggering regions in inferior parietal lobe and insula, while happy bodies drove the occipito-temporal cortex more strongly. We showed that this design could be used to uncover important differences between brain networks underlying fearful and happy emotions. The enhancement of brain activity for unambiguous affective signals expressed by several people simultaneously supports adaptive behaviour in critical situations.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/fisiologia
Mapeamento Encefálico/métodos
Córtex Cerebral/fisiologia
Emoções/fisiologia
Cinésica
Percepção Social
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Ira/fisiologia
Feminino
Felicidade
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Percepção Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE
[do] DOI:10.1093/scan/nsw039


  8 / 821 MEDLINE  
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[PMID]:27008052
[Au] Autor:Lange C
[Ad] Endereço:Clint Lange is a registered nurse in San Antonio, Tex.
[Ti] Título:Nursing and the importance of body language.
[So] Source:Nursing;46(4):48-9, 2016 Apr.
[Is] ISSN:1538-8689
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Enfermagem de Cuidados Críticos
Cinésica
Relações Enfermeiro-Paciente
Recursos Humanos de Enfermagem no Hospital/psicologia
[Mh] Termos MeSH secundário: Ansiedade
Seres Humanos
Aprendizagem
Postura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160324
[Lr] Data última revisão:
160324
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.1097/01.NURSE.0000481421.03964.34


  9 / 821 MEDLINE  
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[PMID]:26974742
[Au] Autor:Rajhans P; Jessen S; Missana M; Grossmann T
[Ad] Endereço:Early Social Development Group, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1A, 04103 Leipzig, Germany. Electronic address: rajhans@cbs.mpg.de.
[Ti] Título:Putting the face in context: Body expressions impact facial emotion processing in human infants.
[So] Source:Dev Cogn Neurosci;19:115-21, 2016 Jun.
[Is] ISSN:1878-9307
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Body expressions exert strong contextual effects on facial emotion perception in adults. Specifically, conflicting body cues hamper the recognition of emotion from faces, as evident on both the behavioral and neural level. We examined the developmental origins of the neural processes involved in emotion perception across body and face in 8-month-old infants by measuring event-related brain potentials (ERPs). We primed infants with body postures (fearful, happy) that were followed by either congruent or incongruent facial expressions. Our results revealed that body expressions impact facial emotion processing and that incongruent body cues impair the neural discrimination of emotional facial expressions. Priming effects were associated with attentional and recognition memory processes, as reflected in a modulation of the Nc and Pc evoked at anterior electrodes. These findings demonstrate that 8-month-old infants possess neural mechanisms that allow for the integration of emotion across body and face, providing evidence for the early developmental emergence of context-sensitive facial emotion perception.
[Mh] Termos MeSH primário: Emoções/fisiologia
Expressão Facial
Comportamento do Lactente/fisiologia
Cinésica
Estimulação Luminosa/métodos
[Mh] Termos MeSH secundário: Adulto
Atenção/fisiologia
Encéfalo/crescimento & desenvolvimento
Sinais (Psicologia)
Bases de Dados Factuais
Potenciais Evocados Visuais/fisiologia
Face
Medo/fisiologia
Medo/psicologia
Feminino
Seres Humanos
Lactente
Comportamento do Lactente/psicologia
Masculino
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE


  10 / 821 MEDLINE  
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[PMID]:26558850
[Au] Autor:Sluzki CE
[Ad] Endereço:Department of Psychiatry, George Washington University Medical School, Washington, DC.
[Ti] Título:Proxemics in Couple Interactions: Rekindling an Old Optic.
[So] Source:Fam Process;55(1):7-15, 2016 Mar.
[Is] ISSN:1545-5300
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Utilizing as a lens the interpersonal implications of physical interpersonal distances in social contexts (a set of variables present during the professional discourse during the 1960s and 1970s, to then fade away), this article explores interactive process displayed by the protagonic couple in Bela Bartok's opera "Bluebeard Castle," an exercise aimed at underlining the value of maintaining proxemics as an explicit level of observation for clinical practice and interpersonal research.
[Mh] Termos MeSH primário: Relações Interpessoais
Cinésica
Distância Social
[Mh] Termos MeSH secundário: Ciências do Comportamento
Características Culturais
Terapia Familiar
Seres Humanos
Metáfora
Música
Espaço Pessoal
Canto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151113
[St] Status:MEDLINE
[do] DOI:10.1111/famp.12196



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