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[PMID]:29441971
[Au] Autor:Rutkowska M; Slupski W; Trocha M; Szandruk M; Rymaszewska J
[Ti] Título:The anxiolytic activity of n-3 PUFAs enriched egg yolk phospholipids in rat behavioral studies.
[So] Source:Pharmazie;71(11):655-659, 2016 11 02.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phospholipids play an important role in the biochemical and physiological processes of cells. An association between disturbed phospholipids metabolism in neuronal tissue and anxiety it was shown. The aim of this study was to examine the anxiolytic properties of phospholipids obtained from a new generation of eggs enriched in n-3 PUFA and its effect on locomotor activity in rat behavioral studies N-3 PUFA-enriched egg yolk phospholipids ("super lecithin") were added to the standard feed. Rats were fed by chow without (control group) or with (experimental group) addition of phospholipids. After six weeks of supplementation, the effect of phospholipids on locomotor activity in the open field test and anxiolytic properties in elevated plus maze and Vogel conflict test were examined. In the open field test the total distance traveled in the experimental group was similar to the control group. In the elevated plus maze test a six weeks phospholipids' administration significantly prolonged the time spent on the open arms by rats from experimental group compared to control group. The number of entries into the open arms was also increased but the difference was not statistically significant. The number of punished drinking water in the Vogel conflict test increased significantly in experimental versus control group. The obtained results suggest that the phospholipids isolated from n-3 PUFA enriched egg yolk have a specific anxiolytic effect, without general sedative influence.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Comportamento Animal/efeitos dos fármacos
Gema de Ovo/química
Ácidos Graxos Ômega-3/farmacologia
Fosfolipídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Conflito (Psicologia)
Comportamento Exploratório/efeitos dos fármacos
Masculino
Atividade Motora/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Fatty Acids, Omega-3); 0 (Phospholipids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6646


  2 / 13503 MEDLINE  
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[PMID]:29254287
[Au] Autor:Jiang L; Li H; Zhao N
[Ad] Endereço:Department of Anesthesiology, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi, China.
[Ti] Título:Thymoquinone protects against cobalt chloride-induced neurotoxicity via Nrf2/GCL-regulated glutathione homeostasis.
[So] Source:J Biol Regul Homeost Agents;31(4):843-853, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The prevalence of neurodegenerative diseases worldwide has increased dramatically in the last decades. Hypoxia and oxidative stress play a central role in the pathogenesis of neurodegenerative diseases. Thymoquinone (TQ) is a monoterpenoid hydrocarbon compound that possesses potent antioxidant activity. In the current study, we investigated the neuroprotective effects of TQ against CoCl2, a widely used hypoxia-inducing agent. We found that TQ inhibited CoCl2-indcued cytotoxicity in vitro, as reflected by an increase of cell viability and decrease of apoptosis in CoCl2-treated PC12 cells. TQ exhibited a potent protective effect against CoCl2-induced neurotoxicity in vivo, as evidenced by decreased time spent to find the platform site in the Probe trials, reduced escape latencies, decreased traveling distance and reduction of apoptotic cell death in brains in CoCl2-treated rats. CoCl2-resulted decrease of glutathione (GSH) and increase of malondialdehyde (MDA) levels were significantly inhibited by TQ. Inhibition of GSH synthesis by buthionine sulphoximine (BSO) significantly attenuated TQ-induced neuroprotective effects against CoCl2 in rats and in PC12 cells. TQ could upregulate nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/glutamate-cysteine ligase catalytic subunit (GCLc) and Nrf2/glutamate-cysteine ligase modifier subunit (GCLm) pathway which contributed to antioxidant and neuroprotective effects of TQ. In summary, we found that TQ exhibited protective effects against neurotoxicity via upregulation of Nrf2/GCL signaling. Upregulation of Nrf2/GCL signaling promoted the synthesis of GSH and contributed to attenuation of oxidative stress, neuronal cell apoptosis and neurotoxicity. These data have appointed a new path toward the understanding of the neuroprotective activities of TQ.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Benzoquinonas/farmacologia
Cobalto/farmacologia
Hipóxia/prevenção & controle
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Butionina Sulfoximina/antagonistas & inibidores
Butionina Sulfoximina/farmacologia
Hipóxia Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Comportamento Exploratório/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Glutamato-Cisteína Ligase/genética
Glutamato-Cisteína Ligase/metabolismo
Glutationa/agonistas
Glutationa/metabolismo
Seres Humanos
Hipóxia/induzido quimicamente
Hipóxia/genética
Hipóxia/patologia
Masculino
Malondialdeído/antagonistas & inibidores
Malondialdeído/metabolismo
Fator 2 Relacionado a NF-E2/genética
Fator 2 Relacionado a NF-E2/metabolismo
Células PC12
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzoquinones); 0 (NF-E2-Related Factor 2); 0 (Neuroprotective Agents); 0 (Nfe2l2 protein, rat); 3G0H8C9362 (Cobalt); 490-91-5 (thymoquinone); 4Y8F71G49Q (Malondialdehyde); 5072-26-4 (Buthionine Sulfoximine); EC 6.3.2.2 (GCLM protein, rat); EC 6.3.2.2 (Glutamate-Cysteine Ligase); EC 6.3.2.2. (GCLC protein, rat); EVS87XF13W (cobaltous chloride); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  3 / 13503 MEDLINE  
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[PMID]:29304159
[Au] Autor:Brandner J; Cerwenka AF; Schliewen UK; Geist J
[Ad] Endereço:Wasserwirtschaftsamt Regensburg, Regensburg, Germany.
[Ti] Título:Invasion strategies in round goby (Neogobius melanostomus): Is bigger really better?
[So] Source:PLoS One;13(1):e0190777, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Few studies have systematically investigated mid- or long-term temporal changes of biological characteristics in invasive alien species considering the different phases of an invasion. We studied the invasion performance of one of the most invasive species worldwide, the round goby Neogobius melanostomus, from total absence over first occurrence until establishment from 2010 to 2015 in the upper Danube River. After an upstream movement of the invasion front of about 30 river km within four years, the pattern that round goby pioneering populations significantly differ from longer established ones has been confirmed: Pioneering populations at the invasion front comprised more females than males, and adult specimens with a larger body size compared to those at longer inhabited areas. On the population-level, the proportion of juveniles increased with time since invasion. The results of this study provide support for the previously postulated ´bigger is better´ and ´individual trait utility´ hypotheses explaining invasion success in round goby. Pioneering invaders with their greater exploratory behavior, highly adaptive phenotypic plasticity and increased competitive ability seem to act as prime emperors of new habitats, strongly following and benefiting from man-made river-bank structures.
[Mh] Termos MeSH primário: Espécies Introduzidas
Perciformes
Rios
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Tamanho Corporal
Europa (Continente)
Comportamento Exploratório
Feminino
Masculino
Perciformes/anatomia & histologia
Fenótipo
Dinâmica Populacional
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190777


  4 / 13503 MEDLINE  
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[PMID]:29107713
[Au] Autor:Fish EW; Wieczorek LA; Rumple A; Suttie M; Moy SS; Hammond P; Parnell SE
[Ad] Endereço:The Bowles Center for Alcohol Studies (EWF, LAW, SEP), Department of Cell Biology and Physiology (SEP), Department of Psychiatry (AR, SSM), and Carolina Institute for Developmental Disabilities (SSM, SEP), University of North Carolina, Chapel Hill, NC 27599, United States. Electronic address: efish@
[Ti] Título:The enduring impact of neurulation stage alcohol exposure: A combined behavioral and structural neuroimaging study in adult male and female C57BL/6J mice.
[So] Source:Behav Brain Res;338:173-184, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Prenatal alcohol exposure (PAE) can cause behavioral and brain alterations over the lifespan. In animal models, these effects can occur following PAE confined to critical developmental periods, equivalent to the third and fourth weeks of human gestation, before pregnancy is usually recognized. The current study focuses on PAE during early neurulation and examines the behavioral and brain structural consequences that appear in adulthood. On gestational day 8 C57BL/6J dams received two alcohol (2.8g/kg, i.p), or vehicle, administrations, four hours apart. Male and female offspring were reared to adulthood and examined for performance on the elevated plus maze, rotarod, open field, Morris water maze, acoustic startle, social preference (i.e. three-chambered social approach test), and the hot plate. A subset of these mice was later evaluated using magnetic resonance imaging to detect changes in regional brain volumes and shapes. In males, PAE increased exploratory behaviors on the elevated plus maze and in the open field; these changes were associated with increased fractional anisotropy in the anterior commissure. In females, PAE reduced social preference and the startle response, and decreased cerebral cortex and brain stem volumes. Vehicle-treated females had larger pituitaries than did vehicle-treated males, but PAE attenuated this sex difference. In males, pituitary size correlated with open field activity, while in females, pituitary size correlated with social activity. These findings indicate that early neurulation PAE causes sex specific behavioral and brain changes in adulthood. Changes in the pituitary suggest that this structure is especially vulnerable to neurulation stage PAE.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Etanol/farmacologia
Comportamento Exploratório/efeitos dos fármacos
Neurulação/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal/diagnóstico por imagem
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Encéfalo/diagnóstico por imagem
Encéfalo/patologia
Feminino
Imagem por Ressonância Magnética
Masculino
Camundongos
Tamanho do Órgão/efeitos dos fármacos
Gravidez
Efeitos Tardios da Exposição Pré-Natal/patologia
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE


  5 / 13503 MEDLINE  
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[PMID]:29037661
[Au] Autor:Donaldson TN; Jennings KT; Cherep LA; McNeela AM; Depreux FF; Jodelka FM; Hastings ML; Wallace DG
[Ad] Endereço:Northern Illinois University, Department of Psychology, DeKalb, IL 60115, United States.
[Ti] Título:Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice.
[So] Source:Behav Brain Res;338:76-87, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Usher syndrome, Type 1C (USH1C) is an autosomal recessive inherited disorder in which a mutation in the gene encoding harmonin is associated with multi-sensory deficits (i.e., auditory, vestibular, and visual). USH1C (Usher) mice, engineered with a human USH1C mutation, exhibit these multi-sensory deficits by circling behavior and lack of response to sound. Administration of an antisense oligonucleotide (ASO) therapeutic that corrects expression of the mutated USH1C gene, has been shown to increase harmonin levels, reduce circling behavior, and improve vestibular and auditory function. The current study evaluates the organization of exploratory movements to assess spatial organization in Usher mice and determine the efficacy of ASO therapy in attenuating any such deficits. Usher and heterozygous mice received the therapeutic ASO, ASO-29, or a control, non-specific ASO treatment at postnatal day five. Organization of exploratory movements was assessed under dark and light conditions at two and six-months of age. Disruptions in exploratory movement organization observed in control-treated Usher mice were consistent with impaired use of self-movement and environmental cues. In general, ASO-29 treatment rescued organization of exploratory movements at two and six-month testing points. These observations are consistent with ASO-29 rescuing processing of multiple sources of information and demonstrate the potential of ASO therapies to ameliorate topographical disorientation associated with other genetic disorders.
[Mh] Termos MeSH primário: Proteínas de Transporte/genética
Comportamento Exploratório/efeitos dos fármacos
Movimento/efeitos dos fármacos
Oligonucleotídeos Antissenso/farmacologia
Síndromes de Usher/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Proteínas de Transporte/metabolismo
Masculino
Camundongos
Síndromes de Usher/genética
Síndromes de Usher/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Oligonucleotides, Antisense); 0 (Ush1c protein, mouse)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE


  6 / 13503 MEDLINE  
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[PMID]:27776994
[Au] Autor:Kokhan VS; Matveeva MI; Bazyan AS; Kudrin VS; Mukhametov A; Shtemberg AS
[Ad] Endereço:Laboratory of Extreme Physiology, Institute of Medico-Biological Problems RAS, Moscow, Russia. Electronic address: viktor_kohan@hotmail.com.
[Ti] Título:Combined effects of antiorthostatic suspension and ionizing radiation on the behaviour and neurotransmitters changes in different brain structures of rats.
[So] Source:Behav Brain Res;320:473-483, 2017 03 01.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Space flight factors (SFF) significantly affect the operating activity of astronauts during deep space missions. In contrast to an orbital flight, leaving the Earth's magnetic field is fraught with the dangers of exposure to ionizing radiation and more specifically, the high-energy nuclei component of galactic cosmic rays. Microgravity, just another critical non-radiation factor, significantly affects the normal functioning of the CNS. Some morphological structures of the brain, such as the prefrontal cortex and the hippocampus, that are rich in monoaminergic and acetylcholinergic neurones, are the most sensitive to the effects of ionizing radiation and non-radiation spaceflight factors (SFF). In this work we have studied the combined effects of microgravity (in antiorthostatic suspension model, AS) and irradiation (γ-ray and protons in spread-out Bragg peak) on the behaviour, cognitive abilities, and metabolism of monoamines and acetylcholine in the key structures of the rat's brain. Irradiation (as independently as combined with AS) resulted in the decrease of thigmotaxis in rats. Learning problems, caused by the malfunctioning of the working memory but not the spatial memory, were observed in response to AS as well as to the SFF in combination. Analysis of monoamines metabolism showed that the serotoninergic system was the most affected by the SFF. Concentration of acetylcholine in the hippocampus significantly increased in the groups of irradiated rats, and in the groups which were exposed to the SFF in combination, compared to the rats exposed only to AS.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos da radiação
Encéfalo/metabolismo
Encéfalo/efeitos da radiação
Gravitação
Neurotransmissores/metabolismo
Radiação Ionizante
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva/fisiologia
Aprendizagem da Esquiva/efeitos da radiação
Comportamento Animal/fisiologia
Comportamento Exploratório/efeitos da radiação
Masculino
Aprendizagem em Labirinto/fisiologia
Aprendizagem em Labirinto/efeitos da radiação
Ratos
Ratos Wistar
Voo Espacial
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Neurotransmitter Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  7 / 13503 MEDLINE  
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[PMID]:28459875
[Au] Autor:Minami C; Shimizu T; Mitani A
[Ad] Endereço:Laboratory of Physiology, Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
[Ti] Título:Neural activity in the prelimbic and infralimbic cortices of freely moving rats during social interaction: Effect of isolation rearing.
[So] Source:PLoS One;12(5):e0176740, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sociability promotes a sound daily life for individuals. Reduced sociability is a central symptom of various neuropsychiatric disorders, and yet the neural mechanisms underlying reduced sociability remain unclear. The prelimbic cortex (PL) and infralimbic cortex (IL) have been suggested to play an important role in the neural mechanisms underlying sociability because isolation rearing in rats results in impairment of social behavior and structural changes in the PL and IL. One possible mechanism underlying reduced sociability involves dysfunction of the PL and IL. We made a wireless telemetry system to record multiunit activity in the PL and IL of pairs of freely moving rats during social interaction and examined the influence of isolation rearing on this activity. In group-reared rats, PL neurons increased firing when the rat showed approaching behavior and also contact behavior, especially when the rat attacked the partner. Conversely, IL neurons increased firing when the rat exhibited leaving behavior, especially when the partner left on its own accord. In social interaction, the PL may be involved in active actions toward others, whereas the IL may be involved in passive relief from cautionary subjects. Isolation rearing altered social behavior and neural activity. Isolation-reared rats showed an increased frequency and decreased duration of contact behavior. The increased firing of PL neurons during approaching and contact behavior, observed in group-reared rats, was preserved in isolation-reared rats, whereas the increased firing of IL neurons during leaving behavior, observed in group-reared rats, was suppressed in isolation-reared rats. This result indicates that isolation rearing differentially alters neural activity in the PL and IL during social behavior. The differential influence of isolation rearing on neural activity in the PL and IL may be one of the neural bases of isolation rearing-induced behavior.
[Mh] Termos MeSH primário: Córtex Cerebral/fisiopatologia
Neurônios/fisiologia
Comportamento Social
Isolamento Social/psicologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Comportamento de Escolha/fisiologia
Eletrodos Implantados
Comportamento Exploratório/fisiologia
Abrigo para Animais
Masculino
Atividade Motora/fisiologia
Ratos Sprague-Dawley
Telemetria
Fatores de Tempo
Tecnologia sem Fio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176740


  8 / 13503 MEDLINE  
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[PMID]:28452114
[Au] Autor:Keijzers G
[Ad] Endereço:Department of Emergency Medicine, Gold Coast University Hospital, Gold Coast, Queensland, Australia.
[Ti] Título:Critical thinking, curiosity and parsimony in (emergency) medicine: 'Doing nothing' as a quality measure?
[So] Source:Emerg Med Australas;29(3):360-362, 2017 Jun.
[Is] ISSN:1742-6723
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Current medical decision-making is influenced by many factors, such as competing interests, distractions, as well as fear of missing an important diagnosis. This can result in ordering tests or providing treatments that can be harmful. Unnecessary tests are more likely to lead to false positive diagnosis or incidental findings that are of uncertain clinical relevance. Estimates indicate that almost one-third of all health spending is wasteful. The 'Choosing Wisely' campaign has identified many of these wasteful tests and treatments. This perspective proposes some suggestions to focus on our critical thinking, embrace shared decision-making and stay curious about the patient we are treating. Most importantly, 'doing nothing' could be a quality indicator for EDs, and ACEM supported audits and research to develop benchmarks for certain tests and procedures in the ED are important to achieve a cultural change.
[Mh] Termos MeSH primário: Tomada de Decisões
Medicina de Emergência/recursos humanos
Comportamento Exploratório
Pensamento
[Mh] Termos MeSH secundário: Serviço Hospitalar de Emergência/organização & administração
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/1742-6723.12782


  9 / 13503 MEDLINE  
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[PMID]:29020028
[Au] Autor:Rivera-Gutierrez HF; Martens T; Pinxten R; Eens M
[Ad] Endereço:Grupo Ecología y Evolución de Vertebrados, Instituto de Biología, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Medellin, Colombia.
[Ti] Título:Learning speed is affected by personality and reproductive investment in a songbird.
[So] Source:PLoS One;12(10):e0185410, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Individuals from different taxa, including songbirds, differ consistently in behaviour and personality when facing different situations. Although our understanding of animal behaviour has increased, knowledge about between-individual differences in cognitive abilities is still limited. By using an experimental approach and a free-living songbird (Parus major) as a model, we attempted to understand between-individual differences in habituation to playbacks (as a proxy of learning speed), by investigating the role of personality, age and reproductive investment (clutch size). Pre-breeding males were tested for exploration (a proxy of personality) in standardized conditions. In addition, the same individuals were exposed to three playbacks in the field during incubation. Birds significantly moved less, stayed further away and overlapped less the playback with successive playback stimulation. While a decrease in the locomotor behaviour can be explained by personality, differences in habituation of overlapping were predicted by both reproductive investment and personality. Fast explorers habituated less. Moreover, males paired to females with larger clutches did not vary the intensity of overlapping. Since habituation requires information for recognition of non-threatening signals, personality may bias information gathering. While fast explorers may collect less information from the environment, slow explorers (reactive birds) seem to pay attention to environmental clues and collect detailed information. We provided evidence that the rate of habituation of behavioural responses, a proxy of cognitive abilities, may be affected by different factors and in a complex way.
[Mh] Termos MeSH primário: Aprendizagem
Personalidade
Reprodução/fisiologia
Aves Canoras/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Tamanho da Ninhada
Meio Ambiente
Comportamento Exploratório/fisiologia
Habituação Psicofisiológica
Modelos Lineares
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185410


  10 / 13503 MEDLINE  
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[PMID]:28881029
[Au] Autor:Berezniuk I; Rodriguiz RM; Zee ML; Marcus DJ; Pintar J; Morgan DJ; Wetsel WC; Fricker LD
[Ad] Endereço:Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
[Ti] Título:ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.
[So] Source:J Neurochem;143(3):268-281, 2017 Nov.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To identify neuropeptides that are regulated by cocaine, we used a quantitative peptidomic technique to examine the relative levels of neuropeptides in several regions of mouse brain following daily intraperitoneal administration of 10 mg/kg cocaine or saline for 7 days. A total of 102 distinct peptides were identified in one or more of the following brain regions: nucleus accumbens, caudate putamen, frontal cortex, and ventral tegmental area. None of the peptides detected in the caudate putamen or frontal cortex were altered by cocaine administration. Three peptides in the nucleus accumbens and seven peptides in the ventral tegmental area were significantly decreased in cocaine-treated mice. Five of these ten peptides are derived from proSAAS, a secretory pathway protein and neuropeptide precursor. To investigate whether proSAAS peptides contribute to the physiological effects of psychostimulants, we examined acute responses to cocaine and amphetamine in the open field with wild-type (WT) and proSAAS knockout (KO) mice. Locomotion was stimulated more robustly in the WT compared to mutant mice for both psychostimulants. Behavioral sensitization to amphetamine was not maintained in proSAAS KO mice and these mutants failed to sensitize to cocaine. To determine whether the rewarding effects of cocaine were altered, mice were tested in conditioned place preference (CPP). Both WT and proSAAS KO mice showed dose-dependent CPP to cocaine that was not distinguished by genotype. Taken together, these results suggest that proSAAS-derived peptides contribute differentially to the behavioral sensitization to psychostimulants, while the rewarding effects of cocaine appear intact in mice lacking proSAAS.
[Mh] Termos MeSH primário: Cocaína/farmacologia
Inibidores da Captação de Dopamina/farmacologia
Hipercinese/induzido quimicamente
Locomoção/efeitos dos fármacos
Proteínas do Tecido Nervoso/metabolismo
[Mh] Termos MeSH secundário: Anfetamina/farmacologia
Animais
Condicionamento Operante/efeitos dos fármacos
Relação Dose-Resposta a Droga
Comportamento Exploratório/efeitos dos fármacos
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/genética
Masculino
Espectrometria de Massas
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Proteínas do Tecido Nervoso/genética
Núcleo Accumbens/efeitos dos fármacos
Área Tegmentar Ventral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dopamine Uptake Inhibitors); 0 (Nerve Tissue Proteins); 0 (Pcsk1n protein, mouse); CK833KGX7E (Amphetamine); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14209



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