Base de dados : MEDLINE
Pesquisa : F01.145.527.100 [Categoria DeCS]
Referências encontradas : 2498 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 250 ir para página                         

  1 / 2498 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29024649
[Au] Autor:Scholl J; Rushworth MFS
[Ad] Endereço:Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK. Electronic address: jacqueline.scholl@cantab.net.
[Ti] Título:Obsessing about Uncertainty?
[So] Source:Neuron;96(2):250-252, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A striking observation in obsessive-compulsive disorder is that patients know that their obsessions and compulsions are excessive, but their symptoms nevertheless persist. Drawing on computational models from basic neuroscience, Vaghi and colleagues (2017) suggest a quantitative account of this clinical finding.
[Mh] Termos MeSH primário: Comportamento Obsessivo
Transtorno Obsessivo-Compulsivo
[Mh] Termos MeSH secundário: Comportamento Compulsivo
Seres Humanos
Incerteza
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


  2 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28965997
[Au] Autor:Vaghi MM; Luyckx F; Sule A; Fineberg NA; Robbins TW; De Martino B
[Ad] Endereço:Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK; Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge CB2 3EB, UK. Electronic address: matilde.vaghi@gmail.com.
[Ti] Título:Compulsivity Reveals a Novel Dissociation between Action and Confidence.
[So] Source:Neuron;96(2):348-354.e4, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Confidence and actions are normally tightly interwoven-if I am sure that it is going to rain, I will take an umbrella-therefore, it is difficult to understand their interplay. Stimulated by the ego-dystonic nature of obsessive-compulsive disorder (OCD), where compulsive actions are recognized as disproportionate, we hypothesized that action and confidence might be independently updated during learning. Participants completed a predictive-inference task designed to identify how action and confidence evolve in response to surprising changes in the environment. While OCD patients (like controls) correctly updated their confidence according to changes in the environment, their actions (unlike those of controls) mostly disregarded this knowledge. Therefore, OCD patients develop an accurate, internal model of the environment but fail to use it to guide behavior. Results demonstrated a novel dissociation between confidence and action, suggesting a cognitive architecture whereby confidence estimates can accurately track the statistic of the environment independently from performance.
[Mh] Termos MeSH primário: Tomada de Decisões/fisiologia
Aprendizagem/fisiologia
Transtorno Obsessivo-Compulsivo/psicologia
Estimulação Luminosa/métodos
Desempenho Psicomotor/fisiologia
[Mh] Termos MeSH secundário: Adulto
Comportamento Compulsivo/fisiopatologia
Comportamento Compulsivo/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtorno Obsessivo-Compulsivo/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


  3 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28539422
[Au] Autor:Qualls-Creekmore E; Yu S; Francois M; Hoang J; Huesing C; Bruce-Keller A; Burk D; Berthoud HR; Morrison CD; Münzberg H
[Ad] Endereço:Neurobiology of Nutrition and Metabolism, and Heike.Munzberg@pbrc.edu Emily.Qualls-Creekmore@pbrc.edu.
[Ti] Título:Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion.
[So] Source:J Neurosci;37(25):6053-6065, 2017 Jun 21.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The lateral hypothalamus (LHA) integrates reward and appetitive behavior and is composed of many overlapping neuronal populations. Recent studies associated LHA GABAergic neurons (LHA ), which densely innervate the ventral tegmental area (VTA), with modulation of food reward and consumption; yet, LHA projections to the VTA exclusively modulated food consumption, not reward. We identified a subpopulation of LHA neurons that coexpress the neuropeptide galanin (LHA ). These LHA neurons also modulate food reward, but lack direct VTA innervation. We hypothesized that LHA neurons may represent a subpopulation of LHA neurons that mediates food reward independent of direct VTA innervation. We used chemogenetic activation of LHA or LHA neurons in mice to compare their role in feeding behavior. We further analyzed locomotor behavior to understand how differential VTA connectivity and transmitter release in these LHA neurons influences this behavior. LHA or LHA neuronal activation both increased operant food-seeking behavior, but only activation of LHA neurons increased overall chow consumption. Additionally, LHA or LHA neuronal activation similarly induced locomotor activity, but with striking differences in modality. Activation of LHA neurons induced compulsive-like locomotor behavior; while LHA neurons induced locomotor activity without compulsivity. Thus, LHA neurons define a subpopulation of LHA neurons without direct VTA innervation that mediate noncompulsive food-seeking behavior. We speculate that the striking difference in compulsive-like locomotor behavior is also based on differential VTA innervation. The downstream neural network responsible for this behavior and a potential role for galanin as neuromodulator remains to be identified. The lateral hypothalamus (LHA) regulates motivated feeding behavior via GABAergic LHA neurons. The molecular identity of LHA neurons is heterogeneous and largely undefined. Here we introduce LHA neurons as a subset of LHA neurons that lack direct innervation of the ventral tegmental area (VTA). LHA neurons are sufficient to drive motivated feeding and locomotor activity similar to LHA neurons, but without inducing compulsive-like behaviors, which we propose to require direct VTA innervation. Our study integrates galanin-expressing LHA neurons into our current understanding of the neuronal circuits and molecular mechanisms of the LHA that contribute to motivated feeding behaviors.
[Mh] Termos MeSH primário: Galanina/biossíntese
Região Hipotalâmica Lateral/fisiologia
Atividade Motora/fisiologia
Neurônios/fisiologia
Recompensa
Ácido gama-Aminobutírico/fisiologia
[Mh] Termos MeSH secundário: Animais
Antipsicóticos/farmacologia
Clozapina/farmacologia
Comportamento Compulsivo
Condicionamento Operante/efeitos dos fármacos
Condicionamento Operante/fisiologia
Metabolismo Energético/fisiologia
Alimentos
Região Hipotalâmica Lateral/citologia
Região Hipotalâmica Lateral/metabolismo
Masculino
Camundongos
Atividade Motora/efeitos dos fármacos
Rede Nervosa/citologia
Rede Nervosa/fisiologia
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Neurotransmissores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Neurotransmitter Agents); 56-12-2 (gamma-Aminobutyric Acid); 88813-36-9 (Galanin); J60AR2IKIC (Clozapine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0155-17.2017


  4 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28499521
[Au] Autor:Miner MH; Raymond N; Coleman E; Swinburne Romine R
[Ad] Endereço:Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, USA. Electronic address: miner001@umn.edu.
[Ti] Título:Investigating Clinically and Scientifically Useful Cut Points on the Compulsive Sexual Behavior Inventory.
[So] Source:J Sex Med;14(5):715-720, 2017 May.
[Is] ISSN:1743-6109
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: One of the major obstacles to conducting epidemiologic research and determining the incidence and prevalence of compulsive sexual behavior (CSB) has been the lack of relevant empirically derived cut points on the various instruments that have been used to measure the concept. AIM: To further develop the Compulsive Sexual Behavior Inventory (CSBI) through exploring predictive validity and developing an empirically determined and clinically useful cut point for defining CSB. METHODS: A sample of 242 men who have sex with men was recruited from various sites in a moderate-size Midwestern city. Participants were assigned to a CSB group or a control group using an interview for the diagnosis that was patterned after the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition. The 22-item CSBI was administered as part of a larger battery of self-report inventories. MAIN OUTCOME MEASURES: Receiver operating characteristic analyses were used to compute area-under-the-curve measurements to ascertain the predictive validity of the total scale, the control subscale, and the violence subscale. Cut points were determined through consensus of experts balancing sensitivity and specificity as determined by receiver operating characteristic curves. RESULTS: Analyses indicated that the 22-item CSBI was a good predictor of group membership, as was the 13-item control subscale. The violence subscale added little to the predictive accuracy of the instrument; thus, it likely measures something other than CSB. Two relevant cut points were found, one that minimized false negatives and another, more conservative cut point that minimized false positives. CONCLUSION: The CSBI as currently configured measures two different constructions and only the control subscale is helpful in diagnosing CSB. Therefore, we decided to eliminate the violence subscale and move forward with a 13-item scale that we have named the CSBI-13. Two cut points were developed from this revised scale, one that is useful as a clinical screening tool and the other, more conservative measurement that is useful for etiologic and epidemiologic research. Miner MH, Raymond N, Coleman E, Swinburne Romine R. Investigating Clinically and Scientifically Useful Cut Points on the Compulsive Sexual Behavior Inventory. J Sex Med 2017;14:715-720.
[Mh] Termos MeSH primário: Comportamento Compulsivo/diagnóstico
Homossexualidade Masculina
Comportamento Sexual/psicologia
Inquéritos e Questionários/normas
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Autorrelato
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


  5 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28441394
[Au] Autor:Bruce-Keller AJ; Fernandez-Kim SO; Townsend RL; Kruger C; Carmouche R; Newman S; Salbaum JM; Berthoud HR
[Ad] Endereço:Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States of America.
[Ti] Título:Maternal obese-type gut microbiota differentially impact cognition, anxiety and compulsive behavior in male and female offspring in mice.
[So] Source:PLoS One;12(4):e0175577, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Maternal obesity is known to predispose offspring to metabolic and neurodevelopmental abnormalities. While the mechanisms underlying these phenomena are unclear, high fat diets dramatically alter intestinal microbiota, and gut microbiota can impact physiological function. To determine if maternal diet-induced gut dysbiosis can disrupt offspring neurobehavioral function, we transplanted high fat diet- (HFD) or control low fat diet-associated (CD) gut microbiota to conventionally-housed female mice. Recipient mice were then bred and the behavioral phenotype of male and female offspring was tracked. While maternal behavior was unaffected, neonatal offspring from HFD dams vocalized less upon maternal separation than pups from CD dams. Furthermore, weaned male offspring from HFD dams had significant and selective disruptions in exploratory, cognitive, and stereotypical/compulsive behavior compared to male offspring from CD dams; while female offspring from HFD dams had increases in body weight and adiposity. 16S metagenomic analyses confirmed establishment of divergent microbiota in CD and HFD dams, with alterations in diversity and taxonomic distribution throughout pregnancy and lactation. Likewise, significant alterations in gut microbial diversity and distribution were noted in offspring from HFD dams compared to CD dams, and in males compared to females. Regression analyses of behavioral performance against differentially represented taxa suggest that decreased representation of specific members of the Firmicutes phylum predict behavioral decline in male offspring. Collectively, these data establish that high fat diet-induced maternal dysbiosis is sufficient to disrupt behavioral function in murine offspring in a sex-specific manner. Thus these data reinforce the essential link between maternal diet and neurologic programming in offspring and suggest that intestinal dysbiosis could link unhealthy modern diets to the increased prevalence of neurodevelopmental and childhood disorders.
[Mh] Termos MeSH primário: Ansiedade/etiologia
Cognição
Comportamento Compulsivo/etiologia
Microbioma Gastrointestinal
Obesidade/microbiologia
Efeitos Tardios da Exposição Pré-Natal/etiologia
[Mh] Termos MeSH secundário: Adiposidade
Comunicação Animal
Animais
Animais Recém-Nascidos
Ansiedade/microbiologia
Comportamento Compulsivo/microbiologia
Feminino
Masculino
Fenômenos Fisiológicos da Nutrição Materna
Camundongos Endogâmicos C57BL
Gravidez
Efeitos Tardios da Exposição Pré-Natal/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175577


  6 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28387426
[Au] Autor:Lavender JM; Goodman EL; Culbert KM; Wonderlich SA; Crosby RD; Engel SG; Mitchell JE; Le Grange D; Crow SJ; Peterson CB
[Ad] Endereço:Neuropsychiatric Research Institute, Fargo, ND, USA.
[Ti] Título:Facets of Impulsivity and Compulsivity in Women with Anorexia Nervosa.
[So] Source:Eur Eat Disord Rev;25(4):309-313, 2017 Jul.
[Is] ISSN:1099-0968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study sought to investigate independent associations of impulsivity and compulsivity with eating disorder (ED) symptoms. Women (N = 81) with full or subthreshold Diagnostic and Statistical Manual of Mental Disorders IV anorexia nervosa (AN) completed a semi-structured interview and self-report questionnaires. Multiple regression analyses were conducted using ED symptoms as dependent variables and facets of impulsivity and compulsivity as predictor variables (controlling for body mass index and AN diagnostic subtype). For impulsivity facets, lack of perseverance was uniquely associated with eating concern, shape concern and restraint, whereas negative urgency was uniquely associated with eating concern and frequency of loss of control eating; neither sensation seeking nor lack of premeditation was uniquely associated with any ED variables. Compulsivity was uniquely associated with restraint, eating concern and weight concern. Results support independent associations of impulsivity and compulsivity with ED symptoms in adults with AN, suggesting potential utility in addressing both impulsive and compulsive processes in treatment. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
[Mh] Termos MeSH primário: Anorexia Nervosa/psicologia
Comportamento Compulsivo
Ingestão de Alimentos/psicologia
Comportamento Impulsivo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Autorrelato
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1002/erv.2516


  7 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28350265
[Au] Autor:Meyer D; Cohn A; Robinson B; Muse F; Hughes R
[Ad] Endereço:a Family and Community, Medicine School of Medicine , Saint Louis University , St. Louis , Missouri , USA.
[Ti] Título:Persistent Complications of Child Sexual Abuse: Sexually Compulsive Behaviors, Attachment, and Emotions.
[So] Source:J Child Sex Abus;26(2):140-157, 2017 Feb-Mar.
[Is] ISSN:1547-0679
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Child sexual abuse has the potential to cause distress for the victim across the lifespan. Romantic relationships may be particularly difficult for victims of child sexual abuse. This retrospective study examined differences in adult romantic attachment, sexually compulsive behaviors, and emotion regulation by history of child sexual abuse in a large, nonclinical sample. Those with a history of child sexual abuse reported more attachment anxiety in romantic relationships and engaged in more sexually compulsive behaviors. Overall, males displayed more sexually compulsive behaviors than females regardless of history of sexual abuse. Males with a history of sexual abuse displayed the greatest number of sexually compulsive behaviors. Surprisingly, no differences were observed in emotion regulation or attachment avoidant behaviors by history of child sexual abuse. Future research should seek to replicate current findings and examine emotion regulation difficulties experienced as a result of trauma.
[Mh] Termos MeSH primário: Adultos Sobreviventes de Maus-Tratos Infantis/psicologia
Abuso Sexual na Infância/psicologia
Comportamento Compulsivo/psicologia
Emoções/fisiologia
Apego ao Objeto
Comportamento Sexual/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1080/10538712.2016.1269144


  8 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28325645
[Au] Autor:Turton R; Goodwin H; Meyer C
[Ad] Endereço:Section of Eating Disorders, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom. Electronic address: robert.turton@kcl.ac.uk.
[Ti] Título:Athletic identity, compulsive exercise and eating psychopathology in long-distance runners.
[So] Source:Eat Behav;26:129-132, 2017 Aug.
[Is] ISSN:1873-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Having a high athletic identity is thought to increase vulnerability for compulsive exercise and Eating Disorder (ED) psychopathology. This study examined whether there is an association between athletic identity and levels of compulsive exercise and ED psychopathology in long-distance runners. A sample of 501 long-distance runners completed the Athletic Identity Measurement Scale (AIMS), Compulsive Exercise Test (CET) and Eating Disorders Examination Questionnaire (EDEQ). There was a significant positive association between participants' AIMS and total CET scores (moderate effect size; r=0.34 for males and 0.33 for females). BMI did not influence the relationship between AIMS and CET scores in males. However, for females, AIMS scores were positively associated with levels of Weight Control Exercise when covarying for BMI (small to moderate effect size, r=0.22). No significant associations with EDEQ scores were found (negligible to small effect sizes; r=0.06 for males and r=0.14 for females). Following replication, coaches might need to be vigilant to the welfare of endurance runners that have a strong athletic identity, since this could be linked to them exercising compulsively. Future work should examine whether having a strong athletic identity predicts ED psychopathology when this identity is challenged (e.g., due to injury).
[Mh] Termos MeSH primário: Atletas/psicologia
Comportamento Compulsivo/psicologia
Exercício/psicologia
Transtornos da Alimentação e da Ingestão de Alimentos/psicologia
Corrida/psicologia
Identificação Social
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Atletas/estatística & dados numéricos
Transtornos da Alimentação e da Ingestão de Alimentos/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


  9 / 2498 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28242410
[Au] Autor:Miller ML; Brock RL
[Ad] Endereço:University of Iowa, United States. Electronic address: michelle-miller-2@uiowa.edu.
[Ti] Título:The effect of trauma on the severity of obsessive-compulsive spectrum symptoms: A meta-analysis.
[So] Source:J Anxiety Disord;47:29-44, 2017 Apr.
[Is] ISSN:1873-7897
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:It is important to consider trauma-related sequelae in the etiology and maintenance of psychopathology, namely understudied disorders such as those belonging to the Obsessive-Compulsive Spectrum (OCS). This meta-analysis examined the association between past trauma exposure and current severity of OCS disorder symptoms. A systematic literature search was conducted with 24 (N=4557) articles meeting inclusion criteria. A significant overall effect size was obtained (r=0.20), indicating that exposure to past trauma is associated with a higher severity of OCS symptoms, with a stronger association for females (ß=0.01, p<.001) but not varying as a function of relationship status. Four types of interpersonal trauma (violence, emotional abuse, sexual abuse, and neglect) were associated with OCS symptom severity (r=0.19 -0.24) and past trauma was significantly associated with more severe compulsions (r=0.17), but not obsessions. Results suggest an important link between multiple types of past trauma exposure and OCS symptoms.
[Mh] Termos MeSH primário: Comportamento Compulsivo/psicologia
Comportamento Obsessivo/psicologia
Transtorno Obsessivo-Compulsivo/psicologia
Violência/psicologia
[Mh] Termos MeSH secundário: Adulto
Comportamento Compulsivo/diagnóstico
Feminino
Seres Humanos
Masculino
Comportamento Obsessivo/diagnóstico
Transtorno Obsessivo-Compulsivo/diagnóstico
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE


  10 / 2498 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28193688
[Au] Autor:Martos YV; Braz BY; Beccaria JP; Murer MG; Belforte JE
[Ad] Endereço:Universidad de Buenos Aires. Facultad de Medicina, Departamento de Fisiología, Buenos Aires, Argentina, and CONICET-Universidad de Buenos Aires, Instituto de Fisiología y Biofísica "Bernardo Houssay" (IFIBIO-Houssay), Grupo de Neurociencia de Sistemas, Buenos Aires 1121, Argentina.
[Ti] Título:Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons.
[So] Source:J Neurosci;37(11):2849-2858, 2017 Mar 15.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The mechanisms underlying social dysfunction in neuropsychiatric conditions such as obsessive-compulsive disorder and Tourette syndrome remain uncertain. However, it is known that dysfunctions in basal ganglia, including a reduced number of striatal cholinergic interneurons (SCIN), are involved in their pathophysiology. To explore the role of SCIN in relation to perseverative behaviors, we characterized a new transgenic mouse model in which inducible ablation of SCIN is achieved with high efficiency in a cell-type- and region-specific manner. Mice were subjected to extensive behavioral testing, including assessment of social behaviors, and corticostriatal functional connectivity was evaluated Selective SCIN ablation leads to altered social interactions together with exacerbated spontaneously emitted repetitive behaviors. Lesioned mice showed normal motor coordination, balance, and general locomotion. Interestingly, only environmentally driven, but not self-directed, repetitive behaviors were exacerbated in lesioned mice. Remarkably, in mice with SCIN ablation, the normal pattern of social exploration was replayed continuously. The emerging pattern of social interactions is highly predictable and invariant across time. electrophysiological recordings indicate that SCIN ablation results in an increase of the functional connectivity between different cortical areas and the motor, but not associative, region of the striatum. Our results identify a role of SCIN in suppressing perseverative behaviors, including socially related ones. In sum, SCIN ablation in mice leads to exacerbated ritualistic-like behaviors that affect social performance, providing a link between SCIN dysfunction and the social impairments present in psychiatric disorders. We sought to uncover the impact of striatal cholinergic interneuron (SCIN) degeneration on perseverative behaviors related to obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We found that extensive SCIN ablation results in exacerbated social interactions, in which normal social contacts were replayed continuously in a highly stereotyped, ritualistic pattern. SCIN ablation also leads to an increase in other spontaneously emitted repetitive behaviors without alteration of motor coordination, balance, or locomotion. Moreover, we identify an increase of functional connectivity between frontal cortical areas and the motor region of the striatum as a putative substrate for the observed behavioral alterations. Therefore, perseveration induced by SCIN ablation extends to social performance as occurs in neuropsychiatric conditions such as OCD and TS.
[Mh] Termos MeSH primário: Potenciais de Ação
Neurônios Colinérgicos
Comportamento Compulsivo/fisiopatologia
Corpo Estriado/fisiopatologia
Interneurônios
Transtornos do Comportamento Social/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Comportamento Compulsivo/complicações
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Rede Nervosa/fisiopatologia
Comportamento Social
Transtornos do Comportamento Social/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.3460-16.2017



página 1 de 250 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde