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[PMID]:29203741
[Au] Autor:Medvedovska NV; Bukhanovska TM; Shevchyk AA
[Ad] Endereço:Shupyk National Medical Academy Of Postgraduate Education, Kyiv, Ukraine.
[Ti] Título:[Studying of life's quality changes among children of the first three year of life with visual analyzer's congenital pathology as instrument of their social adaptation's formation in the future became a research objective].
[So] Source:Wiad Lek;70(5):917-920, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:ukr
[Ab] Resumo:INTRODUCTION: The study of the composite qualities of life is an important component of the quality of provided medical aid. The way of our investigation that was chosen by us, the quality of life of the children of first years of life with the congenital pathology of vision arises the significant problem of assessment of its changes, because children of these ages can't take part in an interview and we adapted the standard questionnaire "Children Visual Function Questionnaire" (CVFQ) with its help the components of quality of the children of first years of life assess their parents. THE AIM: Studying of life's quality changes among children of the first three year of life with visual analyzer's congenital pathology as instrument of their social adaptation's formation in the future became a research objective. MATERIALS AND METHODS: Out-patient and polyclinic units of Kyiv's healthcare institutions in which the medical care is provided to children of the first three years of life, particularly with congenital ophthalmic pathology (3 institutions) were scientific base of a research. We have been used the adapted version of the standardized questionnaire of Children's Visual Function Questionnaire (CVFQ) Felius et al were primary material. (2004) - 498 questionnaires, from them 398 of the main group and 100 of control. The purpose of a research required using the complex of research methods, a basis for which is a system approach, namely: medico-statistical and sociological (the respondents were informed about the purpose and research problems and timely gave the oral voluntary agreement in anonymous poll before the filling of questionnaires) methods. RESULTS: The results of a research has established that parents of children from control group have estimated the general condition of children's vision totally in 89,75 ± 1,33 points vs 60,25 ± 1,96 points according to a total score of children's parents from the main group (the difference was 32,87%, at Ñ€<0,001). In general, the total number of points was 64,89 ± 1,01 vs 84,67 ± 0,92, with a difference in 23,4% (Ñ€<0,001) in the main group, according to life's quality total score of early years children's parents. Our research proves existence of children's life quality changes at the presence of visual violations among them that substantiates expediency of strengthening of early identification and treatment measures of visual function's violations at children, within the approved medico-technological documents. CONCLUSION: Interaction in form of cooperation between the family doctor and children's ophthalmologist within the competences on maintaining children with visual analyzer's violation of functions from the first days of life, allows to perform effective long observation of a family, preventing development of medico-social disadaptation both the child, and a family in which it appeared. Research results of life's quality components changes are informative for a future social functioning of the child, his family, the parent's attitude to a child's disease and it's treatments, and performance of disease's treatment.
[Mh] Termos MeSH primário: Adaptação Psicológica
Comportamento Infantil/psicologia
Relações Pais-Filho
Qualidade de Vida
Transtornos da Visão/psicologia
Acuidade Visual
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Pré-Escolar
Seres Humanos
Lactente
Recém-Nascido
Comportamento Social
Inquéritos e Questionários
Ucrânia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:28463420
[Au] Autor:Chang YC; Cole TB; Costa LG
[Ad] Endereço:Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
[Ti] Título:Behavioral Phenotyping for Autism Spectrum Disorders in Mice.
[So] Source:Curr Protoc Toxicol;72:11.22.1-11.22.21, 2017 May 02.
[Is] ISSN:1934-9262
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorder (ASD) represents a heterogeneous group of disorders characterized by alterations in three behavioral symptom domains: Social interactions, verbal and nonverbal communication, and repetitive behaviors. Increasing prevalence of ASD in recent years suggests that exposure to environmental toxicants may be critical in modulating etiology of this disease. As clinical diagnosis of autism still relies on behavioral evaluation, it is important to be able to assess similar behavioral traits in animal models, to provide biological plausibility of associations between environmental exposures and ASD. Rodents naturally exhibit a large number of behaviors that can be linked to similar behaviors in human. In this unit, behavioral tests are described that are relevant to the domains affected in ASD. For the repetitive domain, the T-maze spontaneous alternation test and marble burying test are described. For the communication domain, neonatal ultrasonic vocalization and olfactory habituation test toward social and non-social odor are described. Finally, for the sociability domain, the three-chambered social preference test and the reciprocal interaction test are presented. © 2017 by John Wiley & Sons, Inc.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Comportamento Animal
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Modelos Animais de Doenças
Habituação Psicofisiológica
Camundongos
Transtorno Obsessivo-Compulsivo/psicologia
Odorantes
Fenótipo
Olfato
Comportamento Social
Urina/química
Vocalização Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cptx.19


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[PMID]:28470439
[Au] Autor:Clement S; Bollinger R
[Ad] Endereço:John Templeton Foundation, West Conshohocken, PA, USA. sclement@templeton.org.
[Ti] Título:Accelerating Progress: A New Era of Research on Character Development.
[So] Source:J Youth Adolesc;46(6):1240-1245, 2017 Jun.
[Is] ISSN:1573-6601
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adolescent character development is a high priority for educators, policymakers, and front-line youth workers. To meet this growing demand, and as exemplified in the five articles in this special section, character development scholars are drawing from a range of academic disciplines to push beyond the traditional boundaries of the science of character development. These articles highlight important trends in character research, including the co-development of a subset of character strengths, the articulation of developmental trajectories of character, the use of advanced methodological approaches, and the implications for education. Studies such as these are critically important for establishing the research base that will be used to design the character development programs of tomorrow.
[Mh] Termos MeSH primário: Comportamento do Adolescente
Desenvolvimento do Adolescente
Caráter
Desenvolvimento Moral
Desenvolvimento da Personalidade
[Mh] Termos MeSH secundário: Adolescente
Seres Humanos
Grupo Associado
Pesquisa
Comportamento Social
Meio Social
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s10964-017-0681-9


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[PMID]:28448987
[Au] Autor:Weitekamp CA; Solomon-Lane TK; Del Valle P; Triki Z; Nugent BM; Hofmann HA
[Ad] Endereço:Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.
[Ti] Título:A Role for Oxytocin-Like Receptor in Social Habituation in a Teleost.
[So] Source:Brain Behav Evol;89(3):153-161, 2017.
[Is] ISSN:1421-9743
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Oxytocin (OT) mediates social habituation in rodent model systems, but its role in mediating this effect in other vertebrates is unknown. We used males of the African cichlid fish, Astatotilapia burtoni, to investigate two aspects of isotocin (IT; an OT homolog) signaling in social habituation. First, we examined the expression of IT receptor 2 (ITR2) as well as two immediate early genes in brain regions implicated in social recognition. Next, we examined IT neuron activity using immunohistochemistry. Patterns of gene expression in homologs of the amygdala and hippocampus implicate IT signaling in these regions in social habituation to a territorial neighbor. In the preoptic area, the expression of the ITR2 subtype and IT neuron activity respond to the presence of a male, independent of familiarity. Our results implicate IT in mediating social habituation in a teleost.
[Mh] Termos MeSH primário: Ciclídeos/genética
Ocitocina/análogos & derivados
[Mh] Termos MeSH secundário: Agressão/fisiologia
Tonsila do Cerebelo
Animais
Comportamento Animal/fisiologia
Encéfalo/metabolismo
Ciclídeos/fisiologia
Feminino
Hibridização In Situ
Masculino
Ocitocina/metabolismo
Ocitocina/fisiologia
Área Pré-Óptica/metabolismo
Receptores de Ocitocina/fisiologia
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Oxytocin); 50-56-6 (Oxytocin); 550-21-0 (isotocin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1159/000464098


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[PMID]:29385179
[Au] Autor:Theadom A; Starkey N; Barker-Collo S; Jones K; Ameratunga S; Feigin V; BIONIC4you Research Group
[Ad] Endereço:National Institute for Stroke and Applied Neuroscience, Auckland University of Technology, Auckland, New Zealand.
[Ti] Título:Population-based cohort study of the impacts of mild traumatic brain injury in adults four years post-injury.
[So] Source:PLoS One;13(1):e0191655, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is increasing evidence that some people can experience persistent symptoms for up to a year following mild TBI. However, few longitudinal studies of mild TBI exist and the longer-term impact remains unclear. The purpose of this study is to determine if there are long-term effects of mild traumatic brain injury (TBI) four-years later. Adults (aged ≥16 years) identified as part of a TBI incidence study who experienced a mild-TBI four-years ago (N = 232) were compared to age-sex matched controls (N = 232). Sociodemographic variables, prior TBI and symptoms were assessed at the time of injury. Four years post-injury participants completed the Rivermead Post-Concussion Symptom Questionnaire, Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index and the Participation Assessment with Recombined Tools. Analysis of covariance was used to compare differences between TBI cases four years post-injury and controls, controlling for prior TBI and depression. A multiple regression model was used to identify the predictors of increased symptoms and reduced participation. The mild-TBI sample experienced significantly increased self-reported cognitive symptoms (F = 19.90, p = <0.01) four years post-injury than controls. There were no differences between the groups for somatic (F = 0.02, p = 0.89) or emotional symptoms (F = 0.31, p = 0.58). Additionally, the mild-TBI group reported significantly poorer community participation across all three domains: productivity (F = 199.07, p = <0.00), social relations (F = 13.93, p = <0.00) and getting out and about (F = 364.69, p = <0.00) compared to controls. A regression model accounting for 41% of the variance in cognitive symptoms in TBI cases revealed a history of TBI, receiving acute medical attention and baseline cognitive symptoms, sleep quality, anxiety and depression were predictive of outcome. The results indicate that whilst somatic and emotional symptoms resolve over time, cognitive symptoms can become persistent and that mild TBI can impact longer-term community participation. Early intervention is needed to reduce the longer-term impact of cognitive symptoms and facilitate participation.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/psicologia
[Mh] Termos MeSH secundário: Adulto
Ansiedade/etiologia
Lesões Encefálicas Traumáticas/complicações
Estudos de Casos e Controles
Disfunção Cognitiva/etiologia
Estudos de Coortes
Depressão/etiologia
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Nova Zelândia
Autorrelato
Transtornos do Sono-Vigília/etiologia
Comportamento Social
Inquéritos e Questionários
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191655


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[PMID]:28468634
[Au] Autor:Ito N; Hirose E; Ishida T; Hori A; Nagai T; Kobayashi Y; Kiyohara H; Oikawa T; Hanawa T; Odaguchi H
[Ad] Endereço:Department of Clinical Research, Oriental Medicine Research Center, Kitasato University, Tokyo, Japan. ito-n@insti.kitasato-u.ac.jp.
[Ti] Título:Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice.
[So] Source:J Neuroinflammation;14(1):98, 2017 May 03.
[Is] ISSN:1742-2094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence for the antidepressant efficacy of kososan and potential mechanisms are lacking. Recently, it has been recognized that stress triggers neuroinflammation and suppresses adult neurogenesis, leading to depression and anxiety. Here, we examined whether kososan extract affected social behavior in mice exposed to chronic social defeat stress (CSDS), an animal model of prolonged psychosocial stress, and neuroinflammation induced by CSDS. METHODS: In the CSDS paradigm, C57BL/6J mice were exposed to 10 min of social defeat stress from an aggressive CD-1 mouse for 10 consecutive days (days 1-10). Kososan extract (1.0 g/kg) was administered orally once daily for 12 days (days 1-12). On day 11, the social avoidance test was performed to examine depressive- and anxious-like behaviors. To characterize the impacts of kososan on neuroinflammation and adult neurogenesis, immunochemical analyses and ex vivo microglial stimulation assay with lipopolysaccharide (LPS) were performed on days 13-15. RESULTS: Oral administration of kososan extract alleviated social avoidance, depression- and anxiety-like behaviors, caused by CSDS exposure. CSDS exposure resulted in neuroinflammation, as indicated by the increased accumulation of microglia, the resident immune cells of the brain, and their activation in the hippocampus, which was reversed to normal levels by treatment with kososan extract. Additionally, in ex vivo studies, CSDS exposure potentiated the microglial pro-inflammatory response to a subsequent LPS challenge, an effect that was also blunted by kososan extract treatment. Indeed, the modulatory effect of kososan extract on neuroinflammation appears to be due to a hippocampal increase in an anti-inflammatory phenotype of microglia while sparing an increased pro-inflammatory phenotype of microglia caused by CSDS. Moreover, reduced adult hippocampal neurogenesis in defeated mice was recovered by kososan extract treatment. CONCLUSIONS: Our findings suggest that kososan extract prevents a social avoidant behavior in socially defeated mice that is partially mediated by the downregulation of hippocampal neuroinflammation, presumably by the relative increased anti-inflammatory microglia and regulation of adult hippocampal neurogenesis. Our present study also provides novel evidence for the beneficial effects of kososan on depression/anxiety and the possible underlying mechanisms.
[Mh] Termos MeSH primário: Aprendizagem da Esquiva/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Mediadores da Inflamação/antagonistas & inibidores
Medicina Kampo
Extratos Vegetais/farmacologia
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva/fisiologia
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/uso terapêutico
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Hipocampo/patologia
Mediadores da Inflamação/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Estresse Psicológico/tratamento farmacológico
Estresse Psicológico/metabolismo
Estresse Psicológico/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Inflammation Mediators); 0 (Plant Extracts); 0 (koso-san)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0876-8


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[PMID]:29282542
[Au] Autor:Bode NWF; Seitz MJ
[Ad] Endereço:Department of Engineering Mathematics, University of Bristol, Bristol, BS8 1UB, UK. nikolai.bode@bristol.ac.uk.
[Ti] Título:Using Hidden Markov Models to characterise intermittent social behaviour in fish shoals.
[So] Source:Naturwissenschaften;105(1-2):7, 2017 Dec 27.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The movement of animals in groups is widespread in nature. Understanding this phenomenon presents an important problem in ecology with many applications that range from conservation to robotics. Underlying all group movements are interactions between individual animals and it is therefore crucial to understand the mechanisms of this social behaviour. To date, despite promising methodological developments, there are few applications to data of practical statistical techniques that inferentially investigate the extent and nature of social interactions in group movement. We address this gap by demonstrating the usefulness of a Hidden Markov Model approach to characterise individual-level social movement in published trajectory data on three-spined stickleback shoals (Gasterosteus aculeatus) and novel data on guppy shoals (Poecilia reticulata). With these models, we formally test for speed-mediated social interactions and verify that they are present. We further characterise this inferred social behaviour and find that despite the substantial shoal-level differences in movement dynamics between species, it is qualitatively similar in guppies and sticklebacks. It is intermittent, occurring in varying numbers of individuals at different time points. The speeds of interacting fish follow a bimodal distribution, indicating that they are either stationary or move at a preferred mean speed, and social fish with more social neighbours move at higher speeds, on average. Our findings and methodology present steps towards characterising social behaviour in animal groups.
[Mh] Termos MeSH primário: Modelos Biológicos
Poecilia/fisiologia
Smegmamorpha/fisiologia
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Cadeias de Markov
Atividade Motora
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1534-9


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[PMID]:27773352
[Au] Autor:Torres-Berrío A; Lopez JP; Bagot RC; Nouel D; Dal Bo G; Cuesta S; Zhu L; Manitt C; Eng C; Cooper HM; Storch KF; Turecki G; Nestler EJ; Flores C
[Ad] Endereço:Integrated Program in Neuroscience, Montréal, Québec, Canada; Douglas Mental Health University Institute; Montréal, Québec, Canada.
[Ti] Título:DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218.
[So] Source:Biol Psychiatry;81(4):306-315, 2017 02 15.
[Is] ISSN:1873-2402
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUD: Variations in the expression of the Netrin-1 guidance cue receptor DCC (deleted in colorectal cancer) appear to confer resilience or susceptibility to psychopathologies involving prefrontal cortex (PFC) dysfunction. METHODS: With the use of postmortem brain tissue, mouse models of defeat stress, and in vitro analysis, we assessed microRNA (miRNA) regulation of DCC and whether changes in DCC levels in the PFC lead to vulnerability to depression-like behaviors. RESULTS: We identified miR-218 as a posttranscriptional repressor of DCC and detected coexpression of DCC and miR-218 in pyramidal neurons of human and mouse PFC. We found that exaggerated expression of DCC and reduced levels of miR-218 in the PFC are consistent traits of mice susceptible to chronic stress and of major depressive disorder in humans. Remarkably, upregulation of Dcc in mouse PFC pyramidal neurons causes vulnerability to stress-induced social avoidance and anhedonia. CONCLUSIONS: These data are the first demonstration of microRNA regulation of DCC and suggest that, by regulating DCC, miR-218 may be a switch of susceptibility versus resilience to stress-related disorders.
[Mh] Termos MeSH primário: Transtorno Depressivo Maior/metabolismo
MicroRNAs/metabolismo
Córtex Pré-Frontal/metabolismo
Células Piramidais/metabolismo
Receptores de Superfície Celular/metabolismo
Proteínas Supressoras de Tumor/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Receptor DCC
Transtorno Depressivo Maior/etiologia
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
RNA Mensageiro/metabolismo
Comportamento Social
Estresse Psicológico/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (DCC Receptor); 0 (DCC protein, human); 0 (MIRN218 microRNA, human); 0 (MicroRNAs); 0 (RNA, Messenger); 0 (Receptors, Cell Surface); 0 (Tumor Suppressor Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28744972
[Au] Autor:Neat FC
[Ad] Endereço:Marine Scotland - Science, 375 Victoria Road, Aberdeen AB11 9DB, U.K.
[Ti] Título:Aggregating behaviour, social interactions and possible spawning in the deep-water fish Coryphaenoides rupestris.
[So] Source:J Fish Biol;91(3):975-980, 2017 Sep.
[Is] ISSN:1095-8649
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A dense aggregation of the roundnose grenadier Coryphaenoides rupestris was observed with a towed camera at a depth of 1500 m in the Rockall Trough during September. The density of fish was 100 times greater than other sites. Within the aggregation the fish showed directional alignment, rapid swimming actions, mid-water swimming and social interactions similar to those associated with spawning in other Gadiformes.
[Mh] Termos MeSH primário: Comportamento Animal
Gadiformes/fisiologia
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Oceano Atlântico
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1111/jfb.13386


  10 / 42644 MEDLINE  
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[PMID]:29346444
[Au] Autor:Tran BX; Nguyen LH; Tran TT; Latkin CA
[Ad] Endereço:Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam.
[Ti] Título:Social and structural barriers for adherence to methadone maintenance treatment among Vietnamese opioid dependence patients.
[So] Source:PLoS One;13(1):e0190941, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Methadone maintenance treatment (MMT) services may reduce the risk of HIV transmission if patients completely adhere to the treatment. Identifying adherence patterns and potential related factors is vital for the sustainability of MMT program in Vietnam. This study examined social and structural factors associated with adherence to MMT among patients in different service delivery models. MATERIALS AND METHODS: A total of 510 patients at three MMT clinics in Hanoi were interviewed. Measures of self-reported adherence included the number of missed doses in the past 7 days and the level of adherence in the past 30 days using a visual analog scale (VAS) scoring from 0 (non-adherence) to 100 (perfect adherence). Multivariate regressions were employed to identify factors associated with non-adherence to MMT. RESULTS: A total of 17.7% of participants reported incomplete MMT adherence in the last 30 days and 8.3% reported missing a dose in the last seven days, respectively. Living with HIV/AIDS, poor self-care and usual activities, and disclosure of health issues to spouses or intimate partners were associated with non-adherence. Those patients with pain or depression were more likely to report better adherence. Disclosing health status to spouse/partner increased the risk of incomplete adherence, while disclosing to friends reduced the number of missed dose in the last seven days. Patients attending clinics with comprehensive services had a lower VAS score of adherence compared to those enrolling in clinics with only MMT and general health care. CONCLUSIONS: Sustaining the compliance of patients to MMT is principal in the rapid expansion of this service in Vietnam. It is necessary to address the complexity of health care demands of drug users, their difficulties to be rehabilitated into workforce and society, and the stigmatization to maximize the outcomes of MMT program.
[Mh] Termos MeSH primário: Metadona/administração & dosagem
Tratamento de Substituição de Opiáceos
Transtornos Relacionados ao Uso de Opioides/tratamento farmacológico
Cooperação do Paciente
Comportamento Social
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Seres Humanos
Masculino
Transtornos Relacionados ao Uso de Opioides/psicologia
Estigma Social
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190941



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