Base de dados : MEDLINE
Pesquisa : F01.145.875 [Categoria DeCS]
Referências encontradas : 6303 [refinar]
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  1 / 6303 MEDLINE  
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[PMID]:29079513
[Au] Autor:Vann SD
[Ad] Endereço:School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, UK. Electronic address: vannsd@cardiff.ac.uk.
[Ti] Título:Lesions within the head direction system reduce retrosplenial c-fos expression but do not impair performance on a radial-arm maze task.
[So] Source:Behav Brain Res;338:153-158, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The lateral mammillary nuclei are a central structure within the head direction system yet there is still relatively little known about how these nuclei contribute to spatial performance. In the present study, rats with selective neurotoxic lesions of the lateral mammillary nuclei were tested on a working memory task in a radial-arm maze. This task requires animals to distinguish between eight radially-oriented arms and remember which arms they have entered within a session. Even though it might have been predicted that this task would heavily tax the head direction system, the lesion rats performed equivalently to their surgical controls on this task; no deficit emerged even when the task was made more difficult by rotating the maze mid-way through testing in order to reduce reliance on intramaze cues. Rats were subsequently tested in the dark to increase the use of internally generated direction cues but the lesion rats remained unimpaired. In contrast, the lateral mammillary nuclei lesions were found to decrease retrosplenial c-Fos levels. These results would suggest that the head direction system is not required for the acquisition of the standard radial-arm maze task. It would also suggest that small decreases in retrosplenial c-Fos are not sufficient to produce behavioural impairments.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Corpos Mamilares/fisiopatologia
Proteínas Proto-Oncogênicas c-fos/metabolismo
Comportamento Espacial/fisiologia
Memória Espacial/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Ácido Ibotênico/toxicidade
Masculino
Corpos Mamilares/efeitos dos fármacos
Memória de Curto Prazo/efeitos dos fármacos
Memória de Curto Prazo/fisiologia
Ratos
Comportamento Espacial/efeitos dos fármacos
Memória Espacial/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-fos); 2552-55-8 (Ibotenic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE


  2 / 6303 MEDLINE  
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[PMID]:29326274
[Au] Autor:Omer DB; Maimon SR; Las L; Ulanovsky N
[Ti] Título:Social place-cells in the bat hippocampus.
[So] Source:Science;359(6372):218-224, 2018 01 12.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Social animals have to know the spatial positions of conspecifics. However, it is unknown how the position of others is represented in the brain. We designed a spatial observational-learning task, in which an observer bat mimicked a demonstrator bat while we recorded hippocampal dorsal-CA1 neurons from the observer bat. A neuronal subpopulation represented the position of the other bat, in allocentric coordinates. About half of these "social place-cells" represented also the observer's own position-that is, were place cells. The representation of the demonstrator bat did not reflect self-movement or trajectory planning by the observer. Some neurons represented also the position of inanimate moving objects; however, their representation differed from the representation of the demonstrator bat. This suggests a role for hippocampal CA1 neurons in social-spatial cognition.
[Mh] Termos MeSH primário: Região CA1 Hipocampal/fisiologia
Quirópteros/fisiologia
Neurônios/fisiologia
Células de Lugar/fisiologia
Percepção Espacial
Comportamento Espacial
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Região CA1 Hipocampal/citologia
Voo Animal
Masculino
Aprendizagem Espacial
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1126/science.aao3474


  3 / 6303 MEDLINE  
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[PMID]:29326273
[Au] Autor:Danjo T; Toyoizumi T; Fujisawa S
[Ad] Endereço:Laboratory for Systems Neurophysiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
[Ti] Título:Spatial representations of self and other in the hippocampus.
[So] Source:Science;359(6372):213-218, 2018 Jan 12.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An animal's awareness of its location in space depends on the activity of place cells in the hippocampus. How the brain encodes the spatial position of others has not yet been identified. We investigated neuronal representations of other animals' locations in the dorsal CA1 region of the hippocampus with an observational T-maze task in which one rat was required to observe another rat's trajectory to successfully retrieve a reward. Information reflecting the spatial location of both the self and the other was jointly and discretely encoded by CA1 pyramidal cells in the observer rat. A subset of CA1 pyramidal cells exhibited spatial receptive fields that were identical for the self and the other. These findings demonstrate that hippocampal spatial representations include dimensions for both self and nonself.
[Mh] Termos MeSH primário: Região CA1 Hipocampal/fisiologia
Células de Lugar/fisiologia
Células Piramidais/fisiologia
Percepção Espacial
Comportamento Espacial
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Região CA1 Hipocampal/citologia
Masculino
Aprendizagem em Labirinto
Modelos Biológicos
Ratos
Ratos Long-Evans
Processamento Espacial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1126/science.aao3898


  4 / 6303 MEDLINE  
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[PMID]:29253015
[Au] Autor:Lallias D; Quillet E; Bégout ML; Aupérin B; Khaw HL; Millot S; Valotaire C; Kernéis T; Labbé L; Prunet P; Dupont-Nivet M
[Ad] Endereço:GABI, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
[Ti] Título:Genetic variability of environmental sensitivity revealed by phenotypic variation in body weight and (its) correlations to physiological and behavioral traits.
[So] Source:PLoS One;12(12):e0189943, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adaptive phenotypic plasticity is a key component of the ability of organisms to cope with changing environmental conditions. Fish have been shown to exhibit a substantial level of phenotypic plasticity in response to abiotic and biotic factors. In the present study, we investigate the link between environmental sensitivity assessed globally (revealed by phenotypic variation in body weight) and more targeted physiological and behavioral indicators that are generally used to assess the sensitivity of a fish to environmental stressors. We took advantage of original biological material, the rainbow trout isogenic lines, which allowed the disentangling of the genetic and environmental parts of the phenotypic variance. Ten lines were characterized for the changes of body weight variability (weight measurements taken every month during 18 months), the plasma cortisol response to confinement stress (3 challenges) and a set of selected behavioral indicators. This study unambiguously demonstrated the existence of genetic determinism of environmental sensitivity, with some lines being particularly sensitive to environmental fluctuations and others rather insensitive. Correlations between coefficient of variation (CV) for body weight and behavioral and physiological traits were observed. This confirmed that CV for body weight could be used as an indicator of environmental sensitivity. As the relationship between indicators (CV weight, risk-taking, exploration and cortisol) was shown to be likely depending on the nature and intensity of the stressor, the joint use of several indicators should help to investigate the biological complexity of environmental sensitivity.
[Mh] Termos MeSH primário: Comportamento Animal
Variação Genética
Hidrocortisona/sangue
Oncorhynchus mykiss/fisiologia
[Mh] Termos MeSH secundário: Adaptação Psicológica
Animais
Variação Biológica da População
Peso Corporal
Meio Ambiente
Feminino
Homozigoto
Análise dos Mínimos Quadrados
Masculino
Fenótipo
Assunção de Riscos
Comportamento Espacial
Estresse Fisiológico/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189943


  5 / 6303 MEDLINE  
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[PMID]:29224779
[Au] Autor:Murugan M; Jang HJ; Park M; Miller EM; Cox J; Taliaferro JP; Parker NF; Bhave V; Hur H; Liang Y; Nectow AR; Pillow JW; Witten IB
[Ad] Endereço:Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
[Ti] Título:Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex.
[So] Source:Cell;171(7):1663-1677.e16, 2017 Dec 14.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Social behaviors are crucial to all mammals. Although the prelimbic cortex (PL, part of medial prefrontal cortex) has been implicated in social behavior, it is not clear which neurons are relevant or how they contribute. We found that PL contains anatomically and molecularly distinct subpopulations that target three downstream regions that have been implicated in social behavior: the nucleus accumbens (NAc), amygdala, and ventral tegmental area. Activation of NAc-projecting PL neurons (PL-NAc), but not the other subpopulations, decreased the preference for a social target. To determine what information PL-NAc neurons convey, we selectively recorded from them and found that individual neurons were active during social investigation, but only in specific spatial locations. Spatially specific manipulation of these neurons bidirectionally regulated the formation of a social-spatial association. Thus, the unexpected combination of social and spatial information within the PL-NAc may contribute to social behavior by supporting social-spatial learning.
[Mh] Termos MeSH primário: Sistema Límbico
Neurônios/citologia
Núcleo Accumbens/citologia
Córtex Pré-Frontal/citologia
Comportamento Social
Comportamento Espacial
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/fisiologia
Animais
Aprendizagem
Camundongos
Vias Neurais
Neurônios/fisiologia
Núcleo Accumbens/fisiologia
Córtex Pré-Frontal/fisiologia
Área Tegmentar Ventral/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  6 / 6303 MEDLINE  
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[PMID]:27772564
[Au] Autor:Leonard M; O'Connell H; Williams O; Awan F; Exton C; O'Connor M; Adamis D; Dunne C; Cullen W; Meagher DJ
[Ad] Endereço:Graduate Entry Medical School, University of Limerick, Ireland; Cognitive Impairment Research Group, Centre for Interventions in Infection, Inflammation & Immunity (4i), Graduate Entry Medical School, University of Limerick, Ireland; Department of Psychiatry, University Hospital Limerick, Irelan
[Ti] Título:Attention, vigilance and visuospatial function in hospitalized elderly medical patients: Relationship to neurocognitive diagnosis.
[So] Source:J Psychosom Res;90:84-90, 2016 11.
[Is] ISSN:1879-1360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Efficient detection of neurocognitive disorders is a key diagnostic challenge. We explored how simple bedside tests of attention, vigilance and visuospatial function might assist in identifying delirium in hospitalized patients. METHODS: Performance on a battery of bedside cognitive tests was compared in elderly medical inpatients with DSM-IV delirium, dementia, comorbid delirium-dementia, and no neurocognitive disorder. RESULTS: 193 patients [mean age 79.9±7.3; 97 male] were assessed with delirium (n=45), dementia (n=33), comorbid delirium-dementia (n=65) and no neurocognitive disorder (NNCD) (n=50). The ability to meaningfully engage with the tests varied from 84% (Spatial Span Forwards) to 57% (Vigilance B test), and was especially problematic among the comorbid delirium-dementia group. The NNCD was distinguished from the delirium groups for most tests, and from the dementia group for the Vigilance B test and the Clock Drawing Test. The dementia group differed from delirium groups in respect of the Months Backward Test, Vigilance A and B tests, Global assessment of visuospatial ability and the Interlocking Pentagons Test. Overall, patients with delirium were best identified by three tests - the Months Backward Test, Vigilance A test and the Global Assessment of visuospatial function with failure to correctly complete any two of these predicting delirium status in 80% of cases. CONCLUSION: Simple bedside tests of attention, vigilance and visuospatial ability can help to distinguish neurocognitive disorders, including delirium, from other presentations. There is a need to develop more accurate methods specifically designed to assess patients with neurocognitive disorder who are unable to engage with conventional tests.
[Mh] Termos MeSH primário: Nível de Alerta
Atenção
Transtornos Cognitivos/psicologia
Hospitalização
Desempenho Psicomotor
Comportamento Espacial
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Nível de Alerta/fisiologia
Atenção/fisiologia
Transtornos Cognitivos/diagnóstico
Transtornos Cognitivos/epidemiologia
Comorbidade
Delírio/diagnóstico
Delírio/epidemiologia
Delírio/psicologia
Demência/diagnóstico
Demência/epidemiologia
Demência/psicologia
Manual Diagnóstico e Estatístico de Transtornos Mentais
Feminino
Seres Humanos
Masculino
Testes Neuropsicológicos/normas
Desempenho Psicomotor/fisiologia
Comportamento Espacial/fisiologia
Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  7 / 6303 MEDLINE  
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[PMID]:28829978
[Au] Autor:Fietzek UM; Stuhlinger L; Plate A; Ceballos-Baumann A; Bötzel K
[Ad] Endereço:Schön Klinik München Schwabing, Dept. of Neurology and Clinical Neurophysiology, Munich, Germany. Electronic address: Urban.Fietzek@Schoen-Kliniken.de.
[Ti] Título:Spatial constraints evoke increased number of steps during turning in Parkinson's disease.
[So] Source:Clin Neurophysiol;128(10):1954-1960, 2017 Oct.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Turning and limitations to step length were shown to trigger progressive shortening of steps, which can lead to freezing of gait. By reducing the base area in which the turn had to take place, we aimed to evaluate the contribution of spatial constraints on 360° axial turns in people with Parkinson's disease with and without freezing. METHODS: We evaluated 40 patients with and without freezing and 16 age-matched healthy subjects. We assessed clinical data, and used body-worn inertial sensors to describe stepping and turn duration of 360° in quadratic squares of different sizes marked on the floor. RESULTS: We found that, when subjects had to perform turns in smaller as compared to larger squares, this spatial constraint strongly affected the turning behavior, i.e. increased the number of steps, and the duration of turns. However, turning was significantly more impaired in patients as compared to controls, and patients with freezing were significantly worse as patients without freezing. CONCLUSION: Our data show that spatial constraint during axial turning has the potential to deteriorate stepping performance, especially in patients reporting freezing of gait. SIGNIFICANCE: The size of the base area needs to be defined in any item or scale that makes diagnostic use of turning.
[Mh] Termos MeSH primário: Transtornos Neurológicos da Marcha/diagnóstico
Transtornos Neurológicos da Marcha/fisiopatologia
Doença de Parkinson/diagnóstico
Doença de Parkinson/fisiopatologia
Comportamento Espacial/fisiologia
Caminhada/fisiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Transtornos Neurológicos da Marcha/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Doença de Parkinson/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


  8 / 6303 MEDLINE  
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[PMID]:28825703
[Au] Autor:Stowers JR; Hofbauer M; Bastien R; Griessner J; Higgins P; Farooqui S; Fischer RM; Nowikovsky K; Haubensak W; Couzin ID; Tessmar-Raible K; Straw AD
[Ad] Endereço:Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria.
[Ti] Título:Virtual reality for freely moving animals.
[So] Source:Nat Methods;14(10):995-1002, 2017 Oct.
[Is] ISSN:1548-7105
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Standard animal behavior paradigms incompletely mimic nature and thus limit our understanding of behavior and brain function. Virtual reality (VR) can help, but it poses challenges. Typical VR systems require movement restrictions but disrupt sensorimotor experience, causing neuronal and behavioral alterations. We report the development of FreemoVR, a VR system for freely moving animals. We validate immersive VR for mice, flies, and zebrafish. FreemoVR allows instant, disruption-free environmental reconfigurations and interactions between real organisms and computer-controlled agents. Using the FreemoVR platform, we established a height-aversion assay in mice and studied visuomotor effects in Drosophila and zebrafish. Furthermore, by photorealistically mimicking zebrafish we discovered that effective social influence depends on a prospective leader balancing its internally preferred directional choice with social interaction. FreemoVR technology facilitates detailed investigations into neural function and behavior through the precise manipulation of sensorimotor feedback loops in unrestrained animals.
[Mh] Termos MeSH primário: Drosophila melanogaster/fisiologia
Camundongos/fisiologia
Atividade Motora
Comportamento Espacial
Interface Usuário-Computador
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Masculino
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE
[do] DOI:10.1038/nmeth.4399


  9 / 6303 MEDLINE  
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[PMID]:28790193
[Au] Autor:Brock AJ; Goody SMG; Mead AN; Sudwarts A; Parker MO; Brennan CH
[Ad] Endereço:School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom (A.J.B., A.S., C.H.B.); Global Safety Pharmacology, Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, Connecticut (S.M.G.G., A.N.M.); and School of Health Scienc
[Ti] Título:Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential.
[So] Source:J Pharmacol Exp Ther;363(1):66-79, 2017 Oct.
[Is] ISSN:1521-0103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Regulatory agencies recommend that centrally active drugs are tested for abuse potential before approval. Standard preclinical assessments are conducted in rats or non-human primates (NHPs). This study evaluated the ability of the zebrafish conditioned place preference (CPP) model to predict human abuse outcomes. Twenty-seven compounds from a variety of pharmacological classes were tested in zebrafish CPP, categorized as positive or negative, and analyzed using standard diagnostic tests of binary classification to determine the likelihood that zebrafish correctly predict robust positive signals in human subjective effects studies (+HSE) and/or Drug Enforcement Administration drug scheduling. Results were then compared with those generated for rat self-administration and CPP, as well as NHP self-administration, using this same set of compounds. The findings reveal that zebrafish concordance and sensitivity values were not significantly different from chance for both +HSE and scheduling. Although significant improvements in specificity and negative predictive values were observed for zebrafish relative to +HSE, specificity without sensitivity provides limited predictive value. Moreover, assessments in zebrafish provided no added value for predicting scheduling. By contrast, rat and NHP models generally possessed significantly improved concordance, sensitivity, and positive predictive values for both clinical measures. Although there may be predictive value with compounds from specific pharmacological classes (e.g., -opioid receptor agonists, psychostimulants) for zebrafish CPP, altogether these data highlight that using the current methodology, the zebrafish CPP model does not add value to the preclinical assessment of abuse potential.
[Mh] Termos MeSH primário: Estimulantes do Sistema Nervoso Central/farmacologia
Condicionamento (Psicologia)
Comportamento Espacial/fisiologia
Transtornos Relacionados ao Uso de Substâncias/fisiopatologia
Transtornos Relacionados ao Uso de Substâncias/psicologia
Peixe-Zebra
[Mh] Termos MeSH secundário: Animais
Estimulantes do Sistema Nervoso Central/administração & dosagem
Condicionamento (Psicologia)/efeitos dos fármacos
Seres Humanos
Locomoção/efeitos dos fármacos
Autoadministração
Comportamento Espacial/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Stimulants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1124/jpet.117.242628


  10 / 6303 MEDLINE  
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[PMID]:28766351
[Au] Autor:Saygin M; Ozguner MF; Onder O; Doguc DK; Ilhan I; Peker Y
[Ti] Título:The impact of sleep deprivation on hippocampal-mediated learning and memory in rats.
[So] Source:Bratisl Lek Listy;118(7):408-416, 2017.
[Is] ISSN:0006-9248
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To examine the impact of different types of sleep deprivation on hippocampal-mediated learning and memory in rats. METHODS: Forty-eight Sprague-Dawley male rats were randomly assigned to 1 of 4 equal-size groups: (1) 12 hours of sleep per day (control). (2) total sleep deprivation (TSD), (3) rapid eye movement (REM) deprivation (RD), and (4) sleep restricted to 4 hours per day (SR). All rats were subjected to swimming training in the Morris water maze (MWM). At the end of the experiments, the rats were decapitated, and hippocampus tissue was analyzed for several neurotransmitters and receptors. RESULTS: The time spent at the target quadrant increased from 20.2 to 30.0 seconds in the control group on the third day of the experiment, whereas corresponding values increased from 20.2 to 21.8 seconds in the TSD group, 22.1 to 25.4 seconds in the RD group, and 21.2 to 32.0 sec in the SR group (p = 0.026). On the seventh day of the experiment, the values decreased to 25.0 seconds in controls, 22.5 in the RD group, and 23.6 in the SR group (p = 0.045). The TSD group demonstrated significant decreases in glutamate and serotonin levels compared with the control group. There was a significant increase in 5-HT2a receptor expression in all intervention groups compared with the controls. CONCLUSIONS: Our results of glutamate levels and 5-HT2a receptor expression in the hippocampus seem to be primarily involved in sleep and memory regulation (Tab. 2, Fig. 4, Ref. 59).
[Mh] Termos MeSH primário: Hipocampo/fisiologia
Memória/fisiologia
Privação do Sono/fisiopatologia
Comportamento Espacial/fisiologia
[Mh] Termos MeSH secundário: Animais
Masculino
Aprendizagem em Labirinto/fisiologia
Ratos
Ratos Sprague-Dawley
Sono
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.4149/BLL_2017_080



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