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[PMID]:29240813
[Au] Autor:Yashar A; Denison RN
[Ad] Endereço:Department of Psychology and Center for Neural Science, New York University, New York, New York, United States of America.
[Ti] Título:Feature reliability determines specificity and transfer of perceptual learning in orientation search.
[So] Source:PLoS Comput Biol;13(12):e1005882, 2017 12.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Training can modify the visual system to produce a substantial improvement on perceptual tasks and therefore has applications for treating visual deficits. Visual perceptual learning (VPL) is often specific to the trained feature, which gives insight into processes underlying brain plasticity, but limits VPL's effectiveness in rehabilitation. Under what circumstances VPL transfers to untrained stimuli is poorly understood. Here we report a qualitatively new phenomenon: intrinsic variation in the representation of features determines the transfer of VPL. Orientations around cardinal are represented more reliably than orientations around oblique in V1, which has been linked to behavioral consequences such as visual search asymmetries. We studied VPL for visual search of near-cardinal or oblique targets among distractors of the other orientation while controlling for other display and task attributes, including task precision, task difficulty, and stimulus exposure. Learning was the same in all training conditions; however, transfer depended on the orientation of the target, with full transfer of learning from near-cardinal to oblique targets but not the reverse. To evaluate the idea that representational reliability was the key difference between the orientations in determining VPL transfer, we created a model that combined orientation-dependent reliability, improvement of reliability with learning, and an optimal search strategy. Modeling suggested that not only search asymmetries but also the asymmetric transfer of VPL depended on preexisting differences between the reliability of near-cardinal and oblique representations. Transfer asymmetries in model behavior also depended on having different learning rates for targets and distractors, such that greater learning for low-reliability distractors facilitated transfer. These findings suggest that training on sensory features with intrinsically low reliability may maximize the generalizability of learning in complex visual environments.
[Mh] Termos MeSH primário: Orientação/fisiologia
Transferência de Experiência (Psicologia)/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Adulto
Encéfalo/fisiologia
Biologia Computacional
Feminino
Seres Humanos
Aprendizagem/fisiologia
Masculino
Modelos Neurológicos
Modelos Psicológicos
Plasticidade Neuronal/fisiologia
Estimulação Luminosa
Reprodutibilidade dos Testes
Aprendizagem Espacial/fisiologia
Análise e Desempenho de Tarefas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005882


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Texto completo SciELO Brasil
[PMID]:29340521
[Au] Autor:Oliveira AR; Campos Neto AA; de Andrade MJO; de Medeiros PCB; Dos Santos NA
[Ad] Endereço:Departamento de Psicologia, Universidade Federal de Campina Grande, Campina Grande, PB, Brasil.
[Ti] Título:Organic solvent exposure and contrast sensitivity: comparing men and women.
[So] Source:Braz J Med Biol Res;51(3):e6568, 2018 Jan 11.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The goal of this study was to compare the visual contrast sensitivity (CS) of men and women exposed and not exposed to organic solvents. Forty-six volunteers of both genders aged between 18 and 41 years (mean±SD=27.72±6.28) participated. Gas station attendants were exposed to gas containing 46.30 ppm of solvents at a temperature of 304±274.39 K, humidity of 62.25±7.59% and ventilation of 0.69±0.46 m/s (a passive gas chromatography-based sampling method was used considering the microclimate variables). Visual CS was measured via the psychophysical method of two-alternative forced choice using vertical sinusoidal gratings with spatial frequencies of 0.2, 0.5, 1.0, 2.0, 5.0, 10.0, and 16.0 cpd (cycles per degree) and an average luminance of 34.4 cd/m2. The results showed that visual CS was significantly lower (P<0.05) in the following groups: i) exposed men compared to unexposed men at frequencies of 0.2, 0.5, 1.0, and 2.0 cpd; ii) exposed women compared to unexposed women at a frequency of 5.0 cpd; and iii) exposed women compared to exposed men at a frequency of 0.5 cpd, even at exposures below the tolerance limit (300 ppm). These results suggest that the visual CS of exposed men was impaired over a wider range of spatial frequencies than that of exposed women. This difference may have been due to the higher body fat content of women compared to that of men, suggesting that body fat in women can serve as a protective factor against neurotoxic effects.
[Mh] Termos MeSH primário: Sensibilidades de Contraste/efeitos dos fármacos
Exposição Ocupacional/efeitos adversos
Solventes/efeitos adversos
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Tecido Adiposo/anatomia & histologia
Adolescente
Adulto
Brasil/epidemiologia
Escolaridade
Feminino
Seres Humanos
Masculino
Microclima
Exposição Ocupacional/estatística & dados numéricos
Limiar Sensorial/fisiologia
Fatores Sexuais
Aprendizagem Espacial/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solvents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


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[PMID]:28457905
[Au] Autor:Radabaugh HL; LaPorte MJ; Greene AM; Bondi CO; Lajud N; Kline AE
[Ad] Endereço:Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
[Ti] Título:Refining environmental enrichment to advance rehabilitation based research after experimental traumatic brain injury.
[So] Source:Exp Neurol;294:12-18, 2017 08.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The typical environmental enrichment (EE) paradigm, which consists of continuous exposure after experimental traumatic brain injury (TBI), promotes behavioral and histological benefits. However, rehabilitation is often abbreviated in the clinic and administered in multiple daily sessions. While recent studies have demonstrated that a once daily 6-hr bout of EE confers benefits comparable to continuous EE, breaking the therapy into two shorter sessions may increase novelty and ultimately enhance recovery. Hence, the aim of the study was to test the hypothesis that functional and histological outcomes will be significantly improved by daily preclinical neurorehabilitation consisting of two 3-hr periods of EE vs. a single 6-hr session. Anesthetized adult male rats received a controlled cortical impact of moderate-to-severe injury (2.8mm tissue deformation at 4m/s) or sham surgery and were then randomly assigned to groups receiving standard (STD) housing, a single 6-hr session of EE, or two 3-hr sessions of EE daily for 3weeks. Motor function (beam-balance/traversal) and acquisition of spatial learning/memory retention (Morris water maze) were assessed on post-operative days 1-5 and 14-19, respectively. Cortical lesion volume was quantified on day 21. Both EE conditions improved motor function and acquisition of spatial learning, and reduced cortical lesion volume relative to STD housing (p<0.05), but did not differ from one another in any endpoint (p>0.05). The findings replicate previous work showing that 6-hr of EE daily is sufficient to confer behavioral and histological benefits after TBI and extend the findings by demonstrating that the benefits are comparable regardless of how the 6-hrs of EE are accrued. The relevance of the finding is that it can be extrapolated to the clinic and may benefit patients who cannot endure a single extended period of neurorehabilitation.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/reabilitação
Meio Ambiente
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Lesões Encefálicas Traumáticas/fisiopatologia
Modelos Animais de Doenças
Masculino
Exame Neurológico
Desempenho Psicomotor/fisiologia
Ratos
Ratos Sprague-Dawley
Recuperação de Função Fisiológica
Retenção (Psicologia)/fisiologia
Aprendizagem Espacial/fisiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29326274
[Au] Autor:Omer DB; Maimon SR; Las L; Ulanovsky N
[Ti] Título:Social place-cells in the bat hippocampus.
[So] Source:Science;359(6372):218-224, 2018 01 12.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Social animals have to know the spatial positions of conspecifics. However, it is unknown how the position of others is represented in the brain. We designed a spatial observational-learning task, in which an observer bat mimicked a demonstrator bat while we recorded hippocampal dorsal-CA1 neurons from the observer bat. A neuronal subpopulation represented the position of the other bat, in allocentric coordinates. About half of these "social place-cells" represented also the observer's own position-that is, were place cells. The representation of the demonstrator bat did not reflect self-movement or trajectory planning by the observer. Some neurons represented also the position of inanimate moving objects; however, their representation differed from the representation of the demonstrator bat. This suggests a role for hippocampal CA1 neurons in social-spatial cognition.
[Mh] Termos MeSH primário: Região CA1 Hipocampal/fisiologia
Quirópteros/fisiologia
Neurônios/fisiologia
Células de Lugar/fisiologia
Percepção Espacial
Comportamento Espacial
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Região CA1 Hipocampal/citologia
Voo Animal
Masculino
Aprendizagem Espacial
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1126/science.aao3474


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[PMID]:29030082
[Au] Autor:Marszalek-Grabska M; Gibula-Bruzda E; Bodzon-Kulakowska A; Suder P; Gawel K; Talarek S; Listos J; Kedzierska E; Danysz W; Kotlinska JH
[Ad] Endereço:Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland.
[Ti] Título:ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats.
[So] Source:Behav Brain Res;338:9-16, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Repeated exposure to and withdrawal from ethanol induces deficits in spatial reversal learning. Data indicate that metabotropic glutamate 5 (mGlu5) receptors are implicated in synaptic plasticity and learning and memory. These receptors functionally interact with N-methyl-d-aspartate (NMDA) receptors, and activation of one type results in the activation of the other. We examined whether (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-piperidin-1-yl (ADX-47273), a positive allosteric modulator (PAM) of mGlu5 receptor, attenuates deficits in reversal learning induced by withdrawal (11-13days) from 'binge-like' ethanol input (5.0g/kg, i.g. for 5days) in the Barnes maze (a spatial learning) task in rats. We additionally examined the effects of ADX-47273 on the expression of the NMDA receptors subunit, GluN2B, in the hippocampus and prefrontal cortex, on the 13th day of ethanol withdrawal. Herein, withdrawal from repeated ethanol administration impaired reversal learning, but not the probe trial. Moreover, ADX-47273 (30mg/kg, i.p.) given prior to the first reversal learning trial for 3days in the Barnes maze, significantly enhanced performance in the ethanol-treated group. The 13th day of ethanol abstinence decreased the expression of the GluN2B subunit in the selected brain regions, but ADX-47273 administration increased it. In conclusion, positive allosteric modulation of mGlu5 receptors recovered spatial reversal learning impairment induced by withdrawal from 'binge-like' ethanol exposure. Such effect seems to be correlated with the mGlu5 receptors mediated potentiation of GluN2B-NMDA receptor mediated responses in the hippocampus and prefrontal cortex. Thus, our results emphasize the role of mGlu5 receptor PAM in the adaptive learning impaired by ethanol exposure.
[Mh] Termos MeSH primário: Cognição/efeitos dos fármacos
Etanol/administração & dosagem
Oxidiazóis/farmacologia
Piperidinas/farmacologia
Receptor de Glutamato Metabotrópico 5/metabolismo
Reversão de Aprendizagem/efeitos dos fármacos
Aprendizagem Espacial/efeitos dos fármacos
Síndrome de Abstinência a Substâncias/psicologia
[Mh] Termos MeSH secundário: Regulação Alostérica/efeitos dos fármacos
Animais
Masculino
Atividade Motora/efeitos dos fármacos
Ratos
Ratos Wistar
Síndrome de Abstinência a Substâncias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxadiazoles); 0 (Piperidines); 0 (Receptor, Metabotropic Glutamate 5); 0 (S-(4-fluorophenyl)-(3-(3-(4-fluorophenyl)-(1,2,4)-oxadiazol-5-yl)piperidin-1-yl)methanone); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:27775905
[Au] Autor:Leo F; Cocchi E; Brayda L
[Ti] Título:The Effect of Programmable Tactile Displays on Spatial Learning Skills in Children and Adolescents of Different Visual Disability.
[So] Source:IEEE Trans Neural Syst Rehabil Eng;25(7):861-872, 2017 07.
[Is] ISSN:1558-0210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vision loss has severe impacts on physical, social and emotional well-being. The education of blind children poses issues as many scholar disciplines (e.g., geometry, mathematics) are normally taught by heavily relying on vision. Touch-based assistive technologies are potential tools to provide graphical contents to blind users, improving learning possibilities and social inclusion. Raised-lines drawings are still the golden standard, but stimuli cannot be reconfigured or adapted and the blind person constantly requires assistance. Although much research concerns technological development, little work concerned the assessment of programmable tactile graphics, in educative and rehabilitative contexts. Here we designed, on programmable tactile displays, tests aimed at assessing spatial memory skills and shapes recognition abilities. Tests involved a group of blind and a group of low vision children and adolescents in a four-week longitudinal schedule. After establishing subject-specific difficulty levels, we observed a significant enhancement of performance across sessions and for both groups. Learning effects were comparable to raised paper control tests: however, our setup required minimal external assistance. Overall, our results demonstrate that programmable maps are an effective way to display graphical contents in educative/rehabilitative contexts. They can be at least as effective as traditional paper tests yet providing superior flexibility and versatility.
[Mh] Termos MeSH primário: Cegueira/fisiopatologia
Cegueira/reabilitação
Auxiliares Sensoriais
Memória Espacial
Análise e Desempenho de Tarefas
Tato
Interface Usuário-Computador
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Seres Humanos
Masculino
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Aprendizagem Espacial
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1109/TNSRE.2016.2619742


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[PMID]:28459599
[Au] Autor:Hedge C; Weaver R; Schnall S
[Ad] Endereço:1 School of Psychology, Cardiff University , Cardiff, United Kingdom .
[Ti] Título:Spatial Learning and Wayfinding in an Immersive Environment: The Digital Fulldome.
[So] Source:Cyberpsychol Behav Soc Netw;20(5):327-333, 2017 May.
[Is] ISSN:2152-2723
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous work has examined whether immersive technologies can benefit learning in virtual environments, but the potential benefits of technology in this context are confounded by individual differences such as spatial ability. We assessed spatial knowledge acquisition in male and female participants using a technology not previously examined empirically: the digital fulldome. Our primary aim was to examine whether performance on a test of survey knowledge was better in a fulldome (N = 28, 12 males) relative to a large, flat screen display (N = 27, 13 males). Regression analysis showed that, compared to a flat screen display, males showed higher levels of performance on a test of survey knowledge after learning in the fulldome, but no benefit occurred for females. Furthermore, performance correlated with spatial visualization ability in male participants, but not in female participants. Thus, the digital fulldome is a potentially useful learning aid, capable of accommodating multiple users, but individual differences and use of strategy need to be considered.
[Mh] Termos MeSH primário: Aprendizagem Espacial
Interface Usuário-Computador
Realidade Virtual
[Mh] Termos MeSH secundário: Simulação por Computador
Terminais de Computador
Feminino
Seres Humanos
Individualidade
Masculino
Análise de Regressão
Fatores Sexuais
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1089/cyber.2016.0399


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[PMID]:28747485
[Au] Autor:Al-Harbi AN; Khan KM; Rahman A
[Ad] Endereço:Department of Food Science and Nutrition, College of Life Sciences, and.
[Ti] Título:Developmental Vitamin D Deficiency Affects Spatial Learning in Wistar Rats.
[So] Source:J Nutr;147(9):1795-1805, 2017 09.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin D deficiency is a global problem. Recent evidence suggests that vitamin D is involved in brain development and function. Vitamin D deficiency has been associated with poor cognitive function in adults, but the effect of developmental vitamin D deficiency (DVDD) on cognitive function and brain development in children has not been well established. We explored the effects of DVDD on cognitive functions and brain morphology of rat pups. Wistar rat pups born to control and vitamin D-deficient dams were divided into 4 groups: control (C), deficient during gestation (dG), deficient during lactation (dL), and deficient during gestation and lactation (dGL). Spatial learning and memory were assessed by the Morris water maze test at postnatal day (PND) 24 and PND 45. Cortical thickness at the level of the hippocampus was measured at PND 63, and synapses were counted in specified areas of the hippocampus at PND 32 and PND 63. Repeated-measures ANOVA revealed that at PND 24, learning (escape latency) was impaired (by 42%) in the dGL group, whereas at PND 45, both the dL and the dGL groups showed learning impairment (by 47% and 45%, respectively) compared with their respective C groups ( < 0.05). Short-term or long-term memory was largely unaffected by DVDD either at PND 24 or PND 45. Compared with the C group, all the DVDD groups had fewer synapses in the molecular layer of the hippocampus ( < 0.001). The synapse number decreased by 54% in the dGL group at PND 33 and by 70% in the dL and dGL groups at PND 63. All the DVDD groups at PND 63 showed a reduced cortical thickness (by 22%) compared with the C group ( < 0.05). These results suggest that a combined prenatal and postnatal DVDD for ≥6 wk in rat pups affects learning but not memory.
[Mh] Termos MeSH primário: Cognição
Hipocampo/crescimento & desenvolvimento
Transtornos de Aprendizagem/etiologia
Fenômenos Fisiológicos da Nutrição Materna
Memória
Aprendizagem Espacial
Deficiência de Vitamina D/complicações
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal
Animais
Animais Recém-Nascidos
Feminino
Lactação
Transtornos de Aprendizagem/sangue
Masculino
Aprendizagem em Labirinto
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Ratos Wistar
Sinapses
Vitamina D/sangue
Deficiência de Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1406-16-2 (Vitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.249953


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[PMID]:28700627
[Au] Autor:Suzuki Y; Imayoshi I
[Ad] Endereço:Medical Innovation Center/SK Project, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
[Ti] Título:Network analysis of exploratory behaviors of mice in a spatial learning and memory task.
[So] Source:PLoS One;12(7):e0180789, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Barnes maze is one of the main behavioral tasks used to study spatial learning and memory. The Barnes maze is a task conducted on "dry land" in which animals try to escape from a brightly lit exposed circular open arena to a small dark escape box located under one of several holes at the periphery of the arena. In comparison with another classical spatial learning and memory task, the Morris water maze, the negative reinforcements that motivate animals in the Barnes maze are less severe and less stressful. Furthermore, the Barnes maze is more compatible with recently developed cutting-edge techniques in neural circuit research, such as the miniature brain endoscope or optogenetics. For this study, we developed a lift-type task start system and equipped the Barnes maze with it. The subject mouse is raised up by the lift and released into the maze automatically so that it can start navigating the maze smoothly from exactly the same start position across repeated trials. We believe that a Barnes maze test with a lift-type task start system may be useful for behavioral experiments when combined with head-mounted or wire-connected devices for online imaging and intervention in neural circuits. Furthermore, we introduced a network analysis method for the analysis of the Barnes maze data. Each animal's exploratory behavior in the maze was visualized as a network of nodes and their links, and spatial learning in the maze is described by systematic changes in network structures of search behavior. Network analysis was capable of visualizing and quantitatively analyzing subtle but significant differences in an animal's exploratory behavior in the maze.
[Mh] Termos MeSH primário: Comportamento Exploratório/fisiologia
Memória/fisiologia
Aprendizagem Espacial/fisiologia
[Mh] Termos MeSH secundário: Animais
Masculino
Aprendizagem em Labirinto/fisiologia
Camundongos
Camundongos Endogâmicos C57BL
Tempo de Reação/fisiologia
Percepção Espacial/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180789


  10 / 588 MEDLINE  
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[PMID]:28698031
[Au] Autor:Free KE; Greene AM; Bondi CO; Lajud N; de la Tremblaye PB; Kline AE
[Ad] Endereço:Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
[Ti] Título:Comparable impediment of cognitive function in female and male rats subsequent to daily administration of haloperidol after traumatic brain injury.
[So] Source:Exp Neurol;296:62-68, 2017 Oct.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antipsychotic drugs, such as haloperidol (HAL), are prescribed in the clinic to manage traumatic brain injury (TBI)-induced agitation. While preclinical studies have consistently shown that once-daily administration of HAL hinders functional recovery after TBI in male rats, its effects in females are unknown. Hence, the objective of this study was to directly compare neurobehavioral and histological outcomes in both sexes to determine whether the reported deleterious effects of HAL extend to females. Anesthetized adult female and male rats received either a controlled cortical impact (CCI) or sham injury and then were randomly assigned to a dosing regimen of HAL (0.5mg/kg, i.p.) or vehicle (VEH; 1mL/kg, i.p.) that was initiated 24h after injury and continued once daily for 19 consecutive days. Motor function was tested using established beam-balance/walk protocols on post-operative days 1-5 and acquisition of spatial learning was assessed with a well-validated Morris water maze task on days 14-19. Cortical lesion volume was quantified at 21days. No statistical differences were revealed between the HAL and VEH-treated sham groups and thus they were pooled for each sex. HAL only impaired motor recovery in males (p<0.05), but significantly diminished spatial learning in both sexes (p<0.05). Females, regardless of treatment, exhibited smaller cortical lesions vs VEH-treated males (p<0.05). Taken together, the data show that daily HAL does not prohibit motor recovery in females, but does negatively impact cognition. These task-dependent differential effects of HAL in female vs male rats may have clinical significance as they can direct therapy.
[Mh] Termos MeSH primário: Antipsicóticos/efeitos adversos
Lesões Encefálicas Traumáticas/tratamento farmacológico
Lesões Encefálicas Traumáticas/fisiopatologia
Cognição/efeitos dos fármacos
Haloperidol/efeitos adversos
Caracteres Sexuais
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Modelos Animais de Doenças
Ciclo Estral/efeitos dos fármacos
Feminino
Masculino
Atividade Motora/efeitos dos fármacos
Exame Neurológico
Desempenho Psicomotor/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Retenção (Psicologia)/efeitos dos fármacos
Aprendizagem Espacial/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); J6292F8L3D (Haloperidol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE



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