Base de dados : MEDLINE
Pesquisa : F01.393.398 [Categoria DeCS]
Referências encontradas : 1427 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 143 ir para página                         

  1 / 1427 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27776266
[Au] Autor:Davis PR; Giannini G; Rudolph K; Calloway N; Royer CM; Beckett TL; Murphy MP; Bresch F; Pagani D; Platt T; Wang X; Donovan AS; Sudduth TL; Lou W; Abner E; Kryscio R; Wilcock DM; Barrett EG; Head E
[Ad] Endereço:Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
[Ti] Título:Aß vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aß, and microhemorrhages.
[So] Source:Neurobiol Aging;49:86-99, 2017 Jan.
[Is] ISSN:1558-1497
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Beta-amyloid (Aß) immunotherapy is a promising intervention to slow Alzheimer's disease. Aging dogs naturally accumulate Aß and show cognitive decline. An active vaccine against fibrillar Aß 1-42 (VAC) in aged beagles resulted in maintenance but not improvement of cognition along with reduced brain Aß. Behavioral enrichment (ENR) led to cognitive benefits but no reduction in Aß. We hypothesized cognitive outcomes could be improved by combining VAC with ENR in aged dogs. Aged dogs (11-12 years) were placed into 4 groups: (1) control/control (C/C); (2) control/VAC (C/V); (3) ENR/control (E/C); and (4) ENR/VAC (E/V) and treated for 20 months. VAC decreased brain Aß, pyroglutamate Aß, increased cerebrospinal fluid Aß 42 and brain-derived neurotrophic factor RNA levels but also increased microhemorrhages. ENR reduced brain Aß and prevented microhemorrhages. The combination treatment resulted in a significant maintenance of learning over time, reduced Aß, and increased brain-derived neurotrophic factor mRNA despite increased microhemorrhages; however, there were no benefits to memory. These results suggest that the combination of immunotherapy with behavioral enrichment leads to cognitive maintenance associated with reduced neuropathology that may benefit people with Alzheimer's disease.
[Mh] Termos MeSH primário: Envelhecimento/metabolismo
Envelhecimento/psicologia
Doença de Alzheimer/terapia
Vacinas contra Alzheimer/uso terapêutico
Peptídeos beta-Amiloides/imunologia
Peptídeos beta-Amiloides/metabolismo
Hemorragia Cerebral/prevenção & controle
Cognição
Terapia Cognitiva/métodos
Imunoterapia
Fragmentos de Peptídeos/imunologia
Fragmentos de Peptídeos/metabolismo
[Mh] Termos MeSH secundário: Doença de Alzheimer/etiologia
Doença de Alzheimer/patologia
Peptídeos beta-Amiloides/líquido cefalorraquidiano
Animais
Encéfalo/metabolismo
Encéfalo/patologia
Fator Neurotrófico Derivado do Encéfalo/genética
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Cães
Desamparo Aprendido
Fragmentos de Peptídeos/líquido cefalorraquidiano
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alzheimer Vaccines); 0 (Amyloid beta-Peptides); 0 (Brain-Derived Neurotrophic Factor); 0 (Peptide Fragments); 0 (RNA, Messenger); 0 (amyloid beta-protein (1-42))
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29219903
[Au] Autor:Gibson TL; Lloyd SL
[Ad] Endereço:Author Affiliations: Associate Professor (Dr Gibson), Department of Nursing, Southwestern Adventist University, Keene, Texas; Associate Professor (Dr Lloyd), Associate Dean, Graduate Program in Nursing School of Graduate Nursing, Loma Linda University, California.
[Ti] Título:Nursing Staff Perceptions of Fall Risk: The Emergence of Learned Helplessness as a Theme.
[So] Source:J Nurs Adm;48(1):5-7, 2018 Jan.
[Is] ISSN:1539-0721
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nurses and unlicensed assistive personnel on 2 medical-surgical units were asked about their perceptions regarding patient falls. Their responses reflect learned helplessness and a lack of nurse empowerment that are relevant findings as nurse executives work to decrease patient falls.
[Mh] Termos MeSH primário: Acidentes por Quedas/prevenção & controle
Atitude do Pessoal de Saúde
Desamparo Aprendido
Auxiliares de Enfermagem/psicologia
Recursos Humanos de Enfermagem no Hospital/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1097/NNA.0000000000000562


  3 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28843434
[Au] Autor:Berry LL; Danaher TS; Beckham D; Awdish RLA; Mate KS
[Ad] Endereço:Department of Marketing, Mays Business School, Texas A&M University, College Station, TX; Institute for Healthcare Improvement, Cambridge, MA. Electronic address: BerryLe@tamu.edu.
[Ti] Título:When Patients and Their Families Feel Like Hostages to Health Care.
[So] Source:Mayo Clin Proc;92(9):1373-1381, 2017 Sep.
[Is] ISSN:1942-5546
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Patients are often reluctant to assert their interests in the presence of clinicians, whom they see as experts. The higher the stakes of a health decision, the more entrenched the socially sanctioned roles of patient and clinician can become. As a result, many patients are susceptible to "hostage bargaining syndrome" (HBS), whereby they behave as if negotiating for their health from a position of fear and confusion. It may manifest as understating a concern, asking for less than what is desired or needed, or even remaining silent against one's better judgment. When HBS persists and escalates, a patient may succumb to learned helplessness, making his or her authentic involvement in shared decision making almost impossible. To subvert HBS and prevent learned helplessness, clinicians must aim to be sensitive to the power imbalance inherent in the clinician-patient relationship. They should then actively and mindfully pursue shared decision making by helping patients trust that it is safe to communicate their concerns and priorities, ask questions about the available clinical options, and contribute knowledge of self to clinical decisions about their care. Hostage bargaining syndrome is an insidious psychosocial dynamic that can compromise quality of care, but clinicians often have the power to arrest it and reverse it by appreciating, paradoxically, how patients' perceptions of their power as experts play a central role in the care they provide.
[Mh] Termos MeSH primário: Atitude Frente à Saúde
Tomada de Decisões
Desamparo Aprendido
Poder (Psicologia)
Relações Profissional-Família
Relações Profissional-Paciente
[Mh] Termos MeSH secundário: Empatia
Seres Humanos
Confiança
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170828
[St] Status:MEDLINE


  4 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27919695
[Au] Autor:Zhou X; Liu L; Zhang Y; Pu J; Yang L; Zhou C; Yuan S; Zhang H; Xie P
[Ad] Endereço:Department of Neurology and Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
[Ti] Título:Metabolomics identifies perturbations in amino acid metabolism in the prefrontal cortex of the learned helplessness rat model of depression.
[So] Source:Neuroscience;343:1-9, 2017 Feb 20.
[Is] ISSN:1873-7544
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Major depressive disorder is a serious psychiatric condition associated with high rates of suicide and is a leading cause of health burden worldwide. However, the underlying molecular mechanisms of major depression are still essentially unclear. In our study, a non-targeted gas chromatography-mass spectrometry-based metabolomics approach was used to investigate metabolic changes in the prefrontal cortex of the learned helplessness (LH) rat model of depression. Body-weight measurements and behavioral tests including the active escape test, sucrose preference test, forced swimming test, elevated plus-maze and open field test were used to assess changes in the behavioral spectrum after inescapable footshock stress. Rats in the stress group exhibited significant learned helpless and depression-like behaviors, while without any significant change in anxiety-like behaviors. Using multivariate and univariate statistical analysis, a total of 18 differential metabolites were identified after the footshock stress protocol. Ingenuity Pathways Analysis and MetaboAnalyst were applied for predicted pathways and biological functions analysis. "Amino Acid Metabolism, Molecule Transport, Small Molecule Biochemistry" was the most significantly altered network in the LH model. Amino acid metabolism, particularly glutamate metabolism, cysteine and methionine metabolism, arginine and proline metabolism, was significantly perturbed in the prefrontal cortex of LH rats.
[Mh] Termos MeSH primário: Aminoácidos/metabolismo
Transtorno Depressivo Maior/metabolismo
Metaboloma
Córtex Pré-Frontal/metabolismo
[Mh] Termos MeSH secundário: Animais
Ansiedade/metabolismo
Modelos Animais de Doenças
Eletrochoque
Cromatografia Gasosa-Espectrometria de Massas
Desamparo Aprendido
Masculino
Metabolômica
Distribuição Aleatória
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


  5 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27908838
[Au] Autor:Meints SM; Stout M; Abplanalp S; Hirsh AT
[Ad] Endereço:Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana.
[Ti] Título:Pain-Related Rumination, But Not Magnification or Helplessness, Mediates Race and Sex Differences in Experimental Pain.
[So] Source:J Pain;18(3):332-339, 2017 Mar.
[Is] ISSN:1528-8447
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Compared with white individuals and men, black individuals and women show a lower tolerance for experimental pain stimuli. Previous studies suggest that pain catastrophizing is important in this context, but little is known about which components of catastrophizing contribute to these race and sex differences. The purpose of the current study was to examine the individual components of catastrophizing (rumination, magnification, and helplessness) as candidate mediators of race and sex differences in experimental pain tolerance. Healthy undergraduates (N = 172, 74% female, 43.2% black) participated in a cold pressor task and completed a situation-specific version of the Pain Catastrophizing Scale. Black and female participants showed a lower pain tolerance than white (P < .01, d = .70) and male (P < .01, d = .55) participants, respectively. Multiple mediation analyses indicated that these race and sex differences were mediated by the rumination component of catastrophizing (indirect effect = -7.13, 95% confidence interval (CI), -16.20 to -1.96, and 5.75, 95% CI, .81-15.57, respectively) but not by the magnification (95% CI, -2.91 to 3.65 and -1.54 to 1.85, respectively) or helplessness (95% CI, -5.53 to 3.31 and -.72 to 5.38, respectively) components. This study provides new information about race and sex differences in pain and suggests that treatments targeting the rumination component of catastrophizing may help mitigate pain-related disparities. PERSPECTIVE: This study suggests that differences in pain-related rumination, but not magnification or helplessness, are important contributors to race and sex differences in the pain experience. Interventions that target this maladaptive cognitive style may help reduce disparities in pain.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano/psicologia
Grupo com Ancestrais do Continente Europeu/psicologia
Transtornos de Alimentação na Infância/etiologia
Limiar da Dor/etnologia
Dor
Caracteres Sexuais
[Mh] Termos MeSH secundário: Adolescente
Adulto
Grupo com Ancestrais do Continente Africano/etnologia
Catastrofização/etnologia
Temperatura Baixa/efeitos adversos
Grupo com Ancestrais do Continente Europeu/etnologia
Transtornos de Alimentação na Infância/etnologia
Feminino
Desamparo Aprendido
Seres Humanos
Masculino
Dor/complicações
Dor/etnologia
Dor/psicologia
Medição da Dor
Percepção da Dor/fisiologia
Pressão/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


  6 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27542584
[Au] Autor:Grieco SF; Cheng Y; Eldar-Finkelman H; Jope RS; Beurel E
[Ad] Endereço:Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, United States; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United States.
[Ti] Título:Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition.
[So] Source:Prog Neuropsychopharmacol Biol Psychiatry;72:49-54, 2017 Jan 04.
[Is] ISSN:1878-4216
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An antidepressant dose of the rapidly-acting ketamine inhibits glycogen synthase kinase-3 (GSK3) in mouse hippocampus, and this inhibition is required for the antidepressant effect of ketamine in learned helplessness depression-like behavior. Here we report that treatment with an antidepressant dose of ketamine (10mg/kg) increased expression of insulin-like growth factor 2 (IGF2) in mouse hippocampus, an effect that required ketamine-induced inhibition of GSK3. Ketamine also inhibited hippocampal GSK3 and increased expression of hippocampal IGF2 in mice when administered after the induction of learned helplessness. Treatment with the specific GSK3 inhibitor L803-mts was sufficient to up-regulate hippocampal IGF2 expression. Administration of IGF2 siRNA reduced ketamine's antidepressant effect in the learned helplessness paradigm. Mice subjected to the learned helplessness paradigm were separated into two groups, those that were resilient (non-depressed) and those that were susceptible (depressed). Non-depressed resilient mice displayed higher expression of IGF2 than susceptible mice. These results indicate that IGF2 contributes to ketamine's antidepressant effect and that IGF2 may confer resilience to depression-like behavior.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Quinase 3 da Glicogênio Sintase/metabolismo
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Fator de Crescimento Insulin-Like II/metabolismo
Ketamina/farmacologia
Regulação para Cima/efeitos dos fármacos
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Feminino
Quinase 3 da Glicogênio Sintase/genética
Desamparo Aprendido
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Oligopeptídeos/farmacologia
RNA Mensageiro/metabolismo
RNA Interferente Pequeno/metabolismo
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (N-myristoyl-glycyl-lysyl-glutamyl-alanyl-prolyl-prolyl-alanyl-prolyl-prolyl-glutaminyl-phosphoseryl-proline); 0 (Oligopeptides); 0 (RNA, Messenger); 0 (RNA, Small Interfering); 67763-97-7 (Insulin-Like Growth Factor II); 690G0D6V8H (Ketamine); EC 2.7.11.26 (Glycogen Synthase Kinase 3)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160821
[St] Status:MEDLINE


  7 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27480092
[Au] Autor:Shirayama Y; Hashimoto K
[Ad] Endereço:Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan.
[Ti] Título:Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression.
[So] Source:Eur Arch Psychiatry Clin Neurosci;267(2):177-182, 2017 Mar.
[Is] ISSN:1433-8491
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Effects of a single bilateral infusion of R-enantiomer of ketamine in rat brain regions of learned helplessness model of depression were examined. A single bilateral infusion of R-ketamine into infralimbic (IL) portion of medial prefrontal cortex (mPFC), CA3 and dentate gyrus (DG) of the hippocampus showed antidepressant effects. By contrast, a single bilateral infusion of R-ketamine into prelimbic (PL) portion of mPFC, shell and core of nucleus accumbens, basolateral amygdala and central nucleus of the amygdala had no effect. This study suggests that IL of mPFC, CA3 and DG of hippocampus might be involved in the antidepressant actions of R-ketamine.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Depressão/tratamento farmacológico
Desamparo Aprendido
Hipocampo/efeitos dos fármacos
Ketamina/farmacologia
Córtex Pré-Frontal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/efeitos dos fármacos
Animais
Antidepressivos/administração & dosagem
Modelos Animais de Doenças
Ketamina/administração & dosagem
Masculino
Núcleo Accumbens/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 690G0D6V8H (Ketamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1007/s00406-016-0718-1


  8 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27095187
[Au] Autor:Vergara F; Rosa J; Orozco C; Bertiller E; Gallardo MA; Bravo M; Catay E; Collado V; Gómez G; Sabelli M; García MV; Rosemffet MG; Citera G; Schneeberger EE; Catoggio LJ; Soriano ER
[Ad] Endereço:a Rheumatology Unit, Internal Medicine Service , Hospital Italiano , Buenos Aires , Argentina.
[Ti] Título:Evaluation of learned helplessness, self-efficacy and disease activity, functional capacity and pain in Argentinian patients with rheumatoid arthritis.
[So] Source:Scand J Rheumatol;46(1):17-21, 2017 Jan.
[Is] ISSN:1502-7732
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the association between learned helplessness (LH) and self-efficacy (SE) with disease activity, functional capacity, and level of pain in patients with rheumatoid arthritis (RA) and to compare LH and SE between patients in remission and patients with active disease. METHOD: This multicentre, cross-sectional study included consecutive patients (aged ≥ 18 years) with RA according to 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria. LH was measured by the Rheumatology Attitude Index (RAI), Spanish version; SE with the Arthritis Self-efficacy Scale (ASES), Spanish version; functional capacity with the Health Assessment Questionnaire, Argentinian version (HAQ-A); and perceived pain by the visual analogue scale (VAS). Disease activity was measured by the Clinical Disease Activity Index (CDAI). RESULTS: A total of 115 patients (82% females) with a mean (± sd) age of 58 ± 13 years were included. We found a significantly positive correlation between LH and perceived pain (p < 0.001), HAQ-A score (p < 0.001), and CDAI (p < 0.001) and a significantly negative correlation between SE and perceived pain (p < 0.001), HAQ-A score (p < 0.001), and CDAI (p < 0.001). We found greater levels of SE and lower grades of LH in patients in remission compared to those with active disease (median 76 vs. 58; p < 0.001 and 6 vs. 11; p < 0.001, respectively). CONCLUSIONS: LH and SE correlated significantly with disease activity, functional capacity, and perceived pain. Levels of SE were higher in patients in remission compared to those with active disease as opposed to levels of LH, which were lower in patients in remission compared to those with active disease. These results show that cognitive factors are related to disease activity and their modifications may have importance in the management of RA.
[Mh] Termos MeSH primário: Artrite Reumatoide/psicologia
Desamparo Aprendido
Percepção da Dor
Autoeficácia
[Mh] Termos MeSH secundário: Idoso
Argentina
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE
[do] DOI:10.3109/03009742.2016.1155643


  9 / 1427 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27769904
[Au] Autor:Iwata M; Ishida H; Kaneko K; Shirayama Y
[Ad] Endereço:Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan.
[Ti] Título:Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine.
[So] Source:Pharmacol Biochem Behav;150-151:138-146, 2016 Nov - Dec.
[Is] ISSN:1873-5177
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An accumulating body of evidence has demonstrated that inflammation is associated with the pathology of depression. We recently found that psychological stress induces inflammation in the hippocampus of the rat brain through the inflammasome, a component of the innate immune system. Microglia, the resident macrophages in the brain, play a central role in the innate immune system and express inflammasomes; thus, we hypothesized that hippocampal microglia would be key mediators in the development of depression via stress-induced inflammation. To test this hypothesis and to determine how antidepressants modulate microglial function, we used immunohistochemistry to examine the morphological changes that occur in the hippocampal microglia of rats exposed to the learned helplessness (LH) paradigm. We noted significantly increased numbers of activated microglia in the granule cell layer, hilus, CA1, and CA3 regions of the hippocampi of LH rats. Conversely, administering imipramine to LH rats for 7days produced a significant decrease in the number of activated microglia in the hilus, but not in the other examined regions. Nonetheless, there were no significant differences in the combined number of activated and non-activated microglia either in LH or LH+imipramine rats relative to control rats. In addition, treating the naïve rats with imipramine or fluvoxamine produced no discernible microglial changes. These data suggest that stress activates hippocampal microglia, while certain antidepressants decrease the number of activated microglia in the hilus, but not in other hippocampal regions. Therefore, the hilus represents a candidate target region for the antidepressant imipramine.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Desamparo Aprendido
Hipocampo/fisiologia
Imipramina/farmacologia
Microglia/fisiologia
[Mh] Termos MeSH secundário: Animais
Masculino
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); OGG85SX4E4 (Imipramine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


  10 / 1427 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27494716
[Au] Autor:Svenningsen K; Venø MT; Henningsen K; Mallien AS; Jensen L; Christensen T; Kjems J; Vollmayr B; Wiborg O
[Ad] Endereço:Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, Denmark.
[Ti] Título:MicroRNA Profiling in the Medial and Lateral Habenula of Rats Exposed to the Learned Helplessness Paradigm: Candidate Biomarkers for Susceptibility and Resilience to Inescapable Shock.
[So] Source:PLoS One;11(8):e0160318, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Depression is a highly heterogeneous disorder presumably caused by a combination of several factors ultimately causing the pathological condition. The genetic liability model of depression is likely to be of polygenic heterogeneity. miRNAs can regulate multiple genes simultaneously and therefore are candidates that align with this model. The habenula has been linked to depression in both clinical and animal studies, shifting interest towards this region as a neural substrate in depression. The goal of the present study was to search for alterations in miRNA expression levels in the medial and lateral habenula of rats exposed to the learned helplessness (LH) rat model of depression. Ten miRNAs showed significant alterations associating with their response to the LH paradigm. Of these, six and four miRNAs were significantly regulated in the MHb and LHb, respectively. In the MHb we identified miR-490, miR-291a-3p, MiR-467a, miR-216a, miR-18b, and miR-302a. In the LHb miR-543, miR-367, miR-467c, and miR-760-5p were significantly regulated. A target gene analysis showed that several of the target genes are involved in MAPK signaling, neutrophin signaling, and ErbB signaling, indicating that neurotransmission is affected in the habenula as a consequence of exposure to the LH paradigm.
[Mh] Termos MeSH primário: Habênula/fisiologia
Desamparo Aprendido
MicroRNAs/genética
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Eletrochoque
Perfilação da Expressão Gênica
Marcadores Genéticos
Masculino
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers); 0 (MicroRNAs)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160318



página 1 de 143 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde