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[PMID]:29480848
[Au] Autor:Yammine L; Kosten TR; Cinciripini PM; Green CE; Meininger JC; Minnix JA; Newton TF
[Ad] Endereço:University of Texas Health Science Center at Houston.
[Ti] Título:Exenatide once weekly for smoking cessation: study protocol for a randomized clinical trial.
[So] Source:Medicine (Baltimore);97(2):e9567, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cigarette smoking is the greatest preventable cause of morbidity and premature mortality in the United States. Approved pharmacological treatments for smoking cessation are marginally effective, underscoring the need for improved pharmacotherapies. A novel approach might use glucagon-like peptide-1 (GLP-1) agonists, which reduce alcohol and drug use in preclinical studies. GLP-1 is produced in the intestinal L-cells and in the hindbrain. The peptide maintains glucose homeostasis and reduces food intake. Several GLP-1 agonists are used clinically to treat type 2 diabetes and obesity, but none have been tested in humans to reduce smoking. AIMS: We will examine whether extended-release exenatide reduces smoking, craving, and withdrawal symptoms, as well as cue-induced craving for cigarettes. METHODS: We will enroll prediabetic and/or overweight treatment seeking smokers (n = 90) into a double-blind, placebo-controlled, randomized clinical trial. Participants will be randomized in a 1:1 ratio to receive exenatide or placebo. All participants will receive transdermal nicotine replacement therapy (NRT) and behavioral counseling. Abstinence from smoking (verified via expired CO level of ≤5 ppm), craving (Questionnaire of Smoking Urges score), and withdrawal symptoms (Wisconsin Scale of Withdrawal Symptoms score) will be assessed weekly during 6 weeks of treatment and at 1 and 4 weeks posttreatment. Cue-induced craving for cigarettes will be assessed at baseline and at 3 weeks of treatment following virtual reality exposure. EXPECTED OUTCOMES: We hypothesize that exenatide will increase the number of participants able to achieve complete smoking abstinence above that achieved via standard NRT and that exenatide will reduce craving and withdrawal symptoms, as well as cue-induced craving for cigarettes.
[Mh] Termos MeSH primário: Peptídeo 1 Semelhante ao Glucagon/agonistas
Peptídeos/administração & dosagem
Abandono do Hábito de Fumar
Fumar/tratamento farmacológico
Peçonhas/administração & dosagem
[Mh] Termos MeSH secundário: Administração Cutânea
Adolescente
Adulto
Idoso
Aconselhamento
Fissura/efeitos dos fármacos
Preparações de Ação Retardada
Método Duplo-Cego
Esquema de Medicação
Seres Humanos
Meia-Idade
Abandono do Hábito de Fumar/métodos
Síndrome de Abstinência a Substâncias/tratamento farmacológico
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Peptides); 0 (Venoms); 89750-14-1 (Glucagon-Like Peptide 1); 9P1872D4OL (exenatide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009567


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[PMID]:29251980
[Au] Autor:Stamates AL; Lau-Barraco C
[Ad] Endereço:Department of Psychology, Old Dominion University.
[Ti] Título:Environmental context effects on craving among consumers of caffeinated alcohol beverages: Associations with aspects of impulsivity.
[So] Source:Exp Clin Psychopharmacol;25(6):503-511, 2017 12.
[Is] ISSN:1936-2293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study primarily sought to (a) determine the effects of environmental context on subjective ratings of craving for alcohol and caffeinated alcohol beverages (CAB) and (b) test inhibitory control, a state behavioral aspect of impulsivity, as a mediator of the association between context and craving in a sample of consumers of CAB. A secondary aim was to examine the associations between trait impulsivity and subjective craving for alcohol and CAB. Participants were 143 (67.1% female) college CAB drinkers. Participants were randomized into either a simulated bar context condition or neutral context condition and completed measures of alcohol use, CAB use, trait impulsivity, inhibitory control on a go/no-go task, and subjective craving for alcohol and CAB. Findings revealed that participants in the simulated bar condition, as compared with those in the neutral condition, reported more subjective craving for alcohol and for CAB; however, alcohol and CAB-specific craving were not different overall or as a function of context. The association between context and subjective craving for alcohol was not mediated by inhibitory control. Trait impulsivity was positively associated with alcohol and CAB-specific craving at baseline and post context exposure, and this finding was similar across both conditions. Therefore, the current investigation suggests that consumers of CAB may be sensitive to alcohol contexts as indicated by greater responses in alcohol and CAB-specific craving. However, inhibitory control did not explain this association. Future research may benefit from examining other potential mechanisms that explain the relationship between context and craving among CAB consumers. (PsycINFO Database Record
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/psicologia
Bebidas
Cafeína
Fissura
Meio Ambiente
Comportamento Impulsivo/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Sinais (Psicologia)
Feminino
Seres Humanos
Inibição (Psicologia)
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3G6A5W338E (Caffeine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1037/pha0000160


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[PMID]:29385147
[Au] Autor:Trigo JM; Soliman A; Quilty LC; Fischer B; Rehm J; Selby P; Barnes AJ; Huestis MA; George TP; Streiner DL; Staios G; Le Foll B
[Ad] Endereço:Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Canada.
[Ti] Título:Nabiximols combined with motivational enhancement/cognitive behavioral therapy for the treatment of cannabis dependence: A pilot randomized clinical trial.
[So] Source:PLoS One;13(1):e0190768, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The current lack of pharmacological treatments for cannabis use disorder (CUD) warrants novel approaches and further investigation of promising pharmacotherapy. We previously showed that nabiximols (27 mg/ml Δ9-tetrahydrocannabinol (THC)/ 25 mg/ml cannabidiol (CBD), Sativex®) can decrease cannabis withdrawal symptoms. Here, we assessed in a pilot study the tolerability and safety of self-titrated nabiximols vs. placebo among 40 treatment-seeking cannabis-dependent participants. METHODS: Subjects participated in a double blind randomized clinical trial, with as-needed nabiximols up to 113.4 mg THC/105 mg CBD or placebo daily for 12 weeks, concurrently with Motivational Enhancement Therapy and Cognitive Behavioral Therapy (MET/CBT). Primary outcome measures were tolerability and abstinence, secondary outcome measures were days and amount of cannabis use, withdrawal, and craving scores. Participants received up to CDN$ 855 in compensation for their time. RESULTS: Medication was well tolerated and no serious adverse events (SAEs) were observed. Rates of adverse events did not differ between treatment arms (F1,39 = 0.205, NS). There was no significant change in abstinence rates at trial end. Participants were not able to differentiate between subjective effects associated with nabiximols or placebo treatments (F1,40 = 0.585, NS). Cannabis use was reduced in the nabiximols (70.5%) and placebo groups (42.6%). Nabiximols reduced cannabis craving but no significant differences between the nabiximols and placebo groups were observed on withdrawal scores. CONCLUSIONS: Nabiximols in combination with MET/CBT was well tolerated and allowed for reduction of cannabis use. Future clinical trials should explore the potential of high doses of nabiximols for cannabis dependence.
[Mh] Termos MeSH primário: Canabidiol/uso terapêutico
Terapia Cognitiva
Dronabinol/uso terapêutico
Abuso de Maconha/terapia
Motivação
[Mh] Termos MeSH secundário: Adulto
Fissura
Método Duplo-Cego
Combinação de Medicamentos
Feminino
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Placebos
Síndrome de Abstinência a Substâncias/terapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Placebos); 19GBJ60SN5 (Cannabidiol); 7J8897W37S (Dronabinol); K4H93P747O (nabiximols)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190768


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[PMID]:29338020
[Au] Autor:Moretta T; Buodo G
[Ad] Endereço:Department of General Psychology, University of Padova, Padova, Italy.
[Ti] Título:Autonomic stress reactivity and craving in individuals with problematic Internet use.
[So] Source:PLoS One;13(1):e0190951, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The link between autonomic stress reactivity and subjective urge/craving has been less systematically examined in behavioral addictions (i.e. problematic Internet use) than in substance use disorders. The present study investigated whether problematic Internet users (PU) show enhanced autonomic stress reactivity than non-PU, indexed by lower Heart Rate Variability (HRV) and higher Skin Conductance Level (SCL) reactivity during the Trier Social Stress Test (TSST), whether greater reactivity is related to stronger Internet craving, and whether problematic Internet usage is associated with some dysfunctional psychological features. Based on their Internet Addiction Test scores, participants were divided into PU (N = 24) and non-PU (N = 21). Their heart rate and skin conductance were continuously recorded during baseline, social stressors, and recovery. Craving for Internet usage were collected using a Likert scale before and after the TSST. The SDNN, an overall measure of HRV, was significantly lower in PU than non-PU during baseline, but not during and after stressful task. Furthermore, only among PU a significant negative correlation emerged between SDNN during recovery and craving ratings after the test. No group differences emerged for SCL. Lastly, PU endorsed more mood, obsessive-compulsive, and alcohol-related problems. Our findings suggest that problems in controlling one's use of the Internet may be related to reduced autonomic balance at rest. Moreover, our results provide new insights into the characterization of craving in PIU, indicating the existence of a relationship between craving for Internet usage and reduced autonomic flexibility.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/fisiopatologia
Comportamento Aditivo/fisiopatologia
Fissura/fisiologia
Internet
[Mh] Termos MeSH secundário: Adulto
Afeto
Feminino
Resposta Galvânica da Pele
Frequência Cardíaca
Seres Humanos
Masculino
Modelos Neurológicos
Modelos Psicológicos
Estresse Fisiológico
Estresse Psicológico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190951


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[PMID]:28457110
[Au] Autor:Munter G; Brivik Y; Freier-Dror Y; Zevin S
[Ad] Endereço:Department of Internal Medicine C, Shaare Zedek Medical Center, affiliated with Hadassah-Hebrew University Medical School, Jerusalem, Israel.
[Ti] Título:Nicotine Addiction and Withdrawal among Orthodox Jews: the Effect of Sabbath Abstinence.
[So] Source:Isr Med Assoc J;19(1):25-29, 2017 Jan.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cigarette smoking is a widespread problem around the world. In Israel, the prevalence of smoking is 23%. Smokers who are Orthodox abstain from smoking during the Sabbath, i.e., from sundown Friday to sundown Saturday, due to a religious prohibition. The prevalence of smoking among Orthodox men is 13%. However, there are no data on patterns of smoking or on the addiction profiles in this population. OBJECTIVES: To explore the smoking patterns, motivation for smoking and nicotine addiction among Orthodox Jewish men, compared to non-Orthodox men, as well as the differences in the urge to smoke and withdrawal symptoms on Saturday versus weekdays in the Orthodox group. METHODS: The participants completed the Fagerstrom test for nicotine dependence, questionnaires on reasons for smoking and smoking patterns, as well as two brief questionnaires on the urge to smoke and withdrawal symptoms after overnight abstinence on a weekday and after the end of the Sabbath. RESULTS: Both groups were strongly addicted to nicotine and there were no differences in the reasons for smoking, withdrawal symptoms and nicotine craving after an overnight abstinence on weekdays. However, religious smokers had low levels of craving for nicotine and few withdrawal symptoms during Sabbath abstinence when compared to weekdays. CONCLUSIONS: Although we found no difference in the baseline characteristics with regard to nicotine addiction, smoking motivation, urge to smoke and withdrawal symptoms between religious and non-religious groups, the former are able to abstain from smoking during 25 hours of the Sabbath every week with significantly fewer withdrawal symptoms compared to week days.
[Mh] Termos MeSH primário: Fissura
Judaísmo
Abandono do Hábito de Fumar/etnologia
Síndrome de Abstinência a Substâncias/etiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Seres Humanos
Israel
Judeus
Masculino
Fumar/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:27771313
[Au] Autor:Sudan R; Sudan R; Lyden E; Thompson JS
[Ad] Endereço:Duke University, Durham, North Carolina.
[Ti] Título:Food cravings and food consumption after Roux-en-Y gastric bypass versus cholecystectomy.
[So] Source:Surg Obes Relat Dis;13(2):220-226, 2017 Feb.
[Is] ISSN:1878-7533
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Food cravings and consumption of craved foods after Roux-en-Y gastric bypass (RYGB) are poorly understood. Food cravings after bariatric surgery may explain why some patients fail to change eating behaviors after RYGB, and understanding these cravings may provide better information for nutritional counseling to either enhance weight loss or prevent weight regain. OBJECTIVES: To study cravings in RYGB patients and compare them with cholecystectomy (CC) control patients. SETTING: This study took place in a university hospital. METHODS: RYGB patients (n = 50) and CC control patients (n = 38) completed a validated food craving inventory before surgery and at 2 and 6 weeks postoperatively. In addition, RYGB patients completed the food craving inventory at 12, 24, 36, and 52 weeks postoperatively. A linear mixed-effect model with a first-order autoregressive structure for correlations was used to evaluate changes in food consumption and food cravings between visits. Correlations between food cravings and body mass index (BMI) or weight changes before and after RYGB were assessed with Spearman correlation coefficients. P<.05 was considered statistically significant. RESULTS: After RYGB, food consumption decreased significantly compared with CC control patients and was lowest at 2 weeks. Consumption progressively increased over time in the first year but remained significantly less than that from presurgery. In addition, a higher preoperative BMI was found to correlate moderately with higher preoperative cravings of the total of all 4 food groups studied (r = .3, P = .04); high-fat foods (r = .3, P = .04); and sweets (r = .3, P = .03). However, with the exception of preoperative cravings for high-fat foods, these scores were not predictive of changes in BMI after surgery. Overall, RYGB did not significantly affect food cravings after surgery compared with CC control patients. CONCLUSION: These findings indicate that RYGB may limit food consumption but does not affect the drive to consume certain types of food. Because food cravings are high in patients with obesity before surgery and remain high after surgery, these findings suggest a possible reason for noncompliance with dietary recommendations after RYGB.
[Mh] Termos MeSH primário: Colecistectomia
Fissura/fisiologia
Dependência de Alimentos/etiologia
Derivação Gástrica
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Índice de Massa Corporal
Estudos de Casos e Controles
Ingestão de Alimentos/psicologia
Comportamento Alimentar/psicologia
Feminino
Preferências Alimentares
Seres Humanos
Masculino
Obesidade Mórbida/psicologia
Obesidade Mórbida/cirurgia
Cooperação do Paciente
Cuidados Pós-Operatórios
Estudos Prospectivos
Inquéritos e Questionários
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28767647
[Au] Autor:Petit G; Luminet O; Cordovil de Sousa Uva M; Zorbas A; Maurage P; de Timary P
[Ad] Endereço:Research Institute for Psychological Sciences, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
[Ti] Título:Differential spontaneous recovery across cognitive abilities during detoxification period in alcohol-dependence.
[So] Source:PLoS One;12(8):e0176638, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: There is a lack of consensus regarding the extent to which cognitive dysfunctions may recover upon cessation of alcohol intake by alcohol-dependents (AD), and the divergent findings are most likely due to methodological differences between the various studies. The present study was aimed at conducting a very strict longitudinal study of cognitive recovery in terms of assessment points, the duration of abstinence, control of age and duration of the addiction, and by use of individual analyses in addition to mean group comparisons. Our study further focused on the 2-3 week phase of alcohol detoxification that is already known to positively affect many biological, emotional, motivational, as well as neural variables, followed by longer-term therapies for which good cognitive functioning is needed. METHODS: 41 AD inpatients undergoing a detoxification program, and 41 matched controls, were evaluated twice in terms of five cognitive functions (i.e., short-term memory, working memory, inhibition, cognitive flexibility, and verbal fluency) within a three-week interval [on the first day (T1) and the 18th day (T2) of abstinence for AD patients]. Emotional (positive and negative affectivity and depression) and motivational (craving) variables were also measured at both evaluation times. RESULTS: Although verbal fluency, short-term memory, and cognitive flexibility did not appear to be affected, the patients exhibited impaired inhibition and working memory at T1. While no recovery of inhibition was found to occur, the average working memory performance of the patients was comparable to that of the controls at T2. Improvements in emotional and motivational dimensions were also observed, although they did not correlate with the ones in working memory. Individual analysis showed that not all participants were impaired or recover the same functions. CONCLUSIONS: While inhibition deficits appear to persist after 18 days of detoxification, deficits in working memory, which is a central component of cognition, are greatly reduced after alcohol detoxification. Individual differences in the trajectory of recovery do arise however, and it might be worth implementing individual assessments of impaired functions at the end of the detoxification phase in order to maximize the chances of success in longer-term treatments and abstinence.
[Mh] Termos MeSH primário: Alcoolismo/fisiopatologia
Cognição/fisiologia
[Mh] Termos MeSH secundário: Adulto
Alcoolismo/tratamento farmacológico
Benzodiazepinas/uso terapêutico
Estudos de Casos e Controles
Fissura
Emoções
Feminino
Seres Humanos
Inativação Metabólica
Estudos Longitudinais
Masculino
Memória de Curto Prazo
Meia-Idade
Testes Neuropsicológicos
Avaliação de Programas e Projetos de Saúde
Tempo de Reação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12794-10-4 (Benzodiazepines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176638


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[PMID]:28723930
[Au] Autor:Hormes JM; Niemiec MA
[Ad] Endereço:University at Albany, State University of New York, Albany, New York, United States of America.
[Ti] Título:Does culture create craving? Evidence from the case of menstrual chocolate craving.
[So] Source:PLoS One;12(7):e0181445, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Craving is considered a key characteristic of diverse pathologies, but evidence suggests it may be a culture-bound construct. Almost 50% of American women crave chocolate specifically around the onset of menstruation. Research does not support popular accounts implicating physiological factors in menstrual chocolate craving etiology. We tested the novel hypothesis that greater menstrual craving prevalence in the U.S. is the product of internalized cultural norms. Women of diverse backgrounds (n = 275) reported on craving frequency and triggers and completed validated measures of acculturation. Foreign-born women were significantly less likely to endorse menstrual chocolate craving (17.3%), compared to women born to U.S.-born parents (32.7%, p = .03) and second generation immigrants (40.9%, p = .001). Second generation immigrant and foreign-born women endorsing menstrual chocolate craving reported significantly greater U.S. acculturation and lower identification with their native culture than non-menstrual cravers (all p < .001). Findings inform our understanding of food cravings, with important implications for the study of cravings in other domains.
[Mh] Termos MeSH primário: Chocolate
Fissura
Cultura
Preferências Alimentares/psicologia
Menstruação/psicologia
[Mh] Termos MeSH secundário: Aculturação
Adolescente
Feminino
Preferências Alimentares/fisiologia
Seres Humanos
Menstruação/fisiologia
Inquéritos e Questionários
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181445


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[PMID]:28703474
[Au] Autor:Persson PB; Bondke Persson A
[Ad] Endereço:Corporate Member of Freie Universität Berlin, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
[Ti] Título:Hunger, craving and appetite.
[So] Source:Acta Physiol (Oxf);221(1):3-5, 2017 09.
[Is] ISSN:1748-1716
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Apetite
Fome
[Mh] Termos MeSH secundário: Fissura
Ingestão de Alimentos
Comportamento Alimentar
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1111/apha.12917


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[PMID]:28682103
[Au] Autor:Conklin CA; Soreca I; Kupfer DJ; Cheng Y; Salkeld RP; Mumma JM; Jakicic JM; Joyce CJ
[Ad] Endereço:Department of Psychiatry, University of Pittsburgh.
[Ti] Título:Exercise attenuates negative effects of abstinence during 72 hours of smoking deprivation.
[So] Source:Exp Clin Psychopharmacol;25(4):265-272, 2017 Aug.
[Is] ISSN:1936-2293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exercise is presumed to be a potentially helpful smoking cessation adjunct reputed to attenuate the negative effects of deprivation. The present study examined the effectiveness of moderate within-session exercise to reduce 4 key symptoms of smoking deprivation during 3 72-hr nicotine abstinence blocks in both male and female smokers. Forty-nine (25 male, 24 female) sedentary smokers abstained from smoking for 3 consecutive days on 3 separate occasions. At each session, smokers' abstinence-induced craving, cue-induced craving, negative mood, and withdrawal symptom severity were assessed prior to and after either exercise (a.m. exercise, p.m. exercise) or a sedentary control activity (magazine reading). Abstinence-induced craving and negative mood differed as a function of condition, F(2, 385) = 21, p < .0001; and, F(2, 385) = 3.38, p = .03. Planned contrasts revealed no difference between a.m. and p.m. exercise, but exercise overall led to greater pre-post reduction in abstinence-induced craving, t(385) = 6.23, p < .0001, effect size Cohen's d = 0.64; and negative mood, t(385) = 2.25, p = .03, d = 0.23. Overall exercise also led to a larger pre-post reduction in cue-induced craving in response to smoking cues, F(2, 387) = 8.94, p = .0002; and withdrawal severity, F(2, 385) = 3.8, p = .02. Unlike the other 3 measures, p.m. exercise reduced withdrawal severity over control, t(385) = 2.64, p = .009, d = 0.27, whereas a.m. exercise did not. The results support the clinical potential of exercise to assist smokers in managing common and robust negative symptoms experienced during the first 3 days of abstinence. (PsycINFO Database Record
[Mh] Termos MeSH primário: Exercício/fisiologia
Abandono do Hábito de Fumar/métodos
Prevenção do Hábito de Fumar
Tabagismo/reabilitação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Afeto/fisiologia
Fissura
Sinais (Psicologia)
Feminino
Seres Humanos
Masculino
Meia-Idade
Síndrome de Abstinência a Substâncias/prevenção & controle
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1037/pha0000128



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