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[PMID]:29300763
[Au] Autor:Parmentier FBR; Pacheco-Unguetti AP; Valero S
[Ad] Endereço:Neuropsychology & Cognition Group, Department of Psychology and Research Institute for Health Sciences (iUNICS), University of the Balearic Islands, Palma, Balearic Islands, Spain.
[Ti] Título:Food words distract the hungry: Evidence of involuntary semantic processing of task-irrelevant but biologically-relevant unexpected auditory words.
[So] Source:PLoS One;13(1):e0190644, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rare changes in a stream of otherwise repeated task-irrelevant sounds break through selective attention and disrupt performance in an unrelated visual task by triggering shifts of attention to and from the deviant sound (deviance distraction). Evidence indicates that the involuntary orientation of attention to unexpected sounds is followed by their semantic processing. However, past demonstrations relied on tasks in which the meaning of the deviant sounds overlapped with features of the primary task. Here we examine whether such processing is observed when no such overlap is present but sounds carry some relevance to the participants' biological need to eat when hungry. We report the results of an experiment in which hungry and satiated participants partook in a cross-modal oddball task in which they categorized visual digits (odd/even) while ignoring task-irrelevant sounds. On most trials the irrelevant sound was a sinewave tone (standard sound). On the remaining trials, deviant sounds consisted of spoken words related to food (food deviants) or control words (control deviants). Questionnaire data confirmed state (but not trait) differences between the two groups with respect to food craving, as well as a greater desire to eat the food corresponding to the food-related words in the hungry relative to the satiated participants. The results of the oddball task revealed that food deviants produced greater distraction (longer response times) than control deviants in hungry participants while the reverse effect was observed in satiated participants. This effect was observed in the first block of trials but disappeared thereafter, reflecting semantic saturation. Our results suggest that (1) the semantic content of deviant sounds is involuntarily processed even when sharing no feature with the primary task; and that (2) distraction by deviant sounds can be modulated by the participants' biological needs.
[Mh] Termos MeSH primário: Estimulação Acústica
Percepção Auditiva
Fome
[Mh] Termos MeSH secundário: Seres Humanos
Análise e Desempenho de Tarefas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190644


  2 / 4272 MEDLINE  
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[PMID]:29024666
[Au] Autor:Beutler LR; Chen Y; Ahn JS; Lin YC; Essner RA; Knight ZA
[Ad] Endereço:Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Center for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
[Ti] Título:Dynamics of Gut-Brain Communication Underlying Hunger.
[So] Source:Neuron;96(2):461-475.e5, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Communication between the gut and brain is critical for homeostasis, but how this communication is represented in the dynamics of feeding circuits is unknown. Here we describe nutritional regulation of key neurons that control hunger in vivo. We show that intragastric nutrient infusion rapidly and durably inhibits hunger-promoting AgRP neurons in awake, behaving mice. This inhibition is proportional to the number of calories infused but surprisingly independent of macronutrient identity or nutritional state. We show that three gastrointestinal signals-serotonin, CCK, and PYY-are necessary or sufficient for these effects. In contrast, the hormone leptin has no acute effect on dynamics of these circuits or their sensory regulation but instead induces a slow modulation that develops over hours and is required for inhibition of feeding. These findings reveal how layers of visceral signals operating on distinct timescales converge on hypothalamic feeding circuits to generate a central representation of energy balance.
[Mh] Termos MeSH primário: Química Encefálica/fisiologia
Encéfalo/fisiologia
Comportamento Alimentar/fisiologia
Trato Gastrointestinal/fisiologia
Fome/fisiologia
Rede Nervosa/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Trato Gastrointestinal/química
Trato Gastrointestinal/inervação
Masculino
Camundongos
Camundongos da Linhagem 129
Camundongos Endogâmicos C57BL
Camundongos Obesos
Camundongos Transgênicos
Rede Nervosa/química
Vias Neurais/química
Vias Neurais/fisiologia
Optogenética/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


  3 / 4272 MEDLINE  
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[PMID]:28869131
[Au] Autor:Püschel F; Muñoz-Pinedo C
[Ad] Endereço:Cell Death Regulation Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
[Ti] Título:In the Hunger Games, the Winner Takes Everything.
[So] Source:Trends Biochem Sci;42(10):763-764, 2017 Oct.
[Is] ISSN:0968-0004
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Entosis is an atypical form of cell death that occurs when a cell engulfs and kills another cell. A recent article by Overholtzer and colleagues indicates that glucose deprivation promotes entosis. AMP-activated protein kinase (AMPK) activation in the loser cells triggers their engulfment and elimination by winner cells, which endure starvation.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP
Fome
[Mh] Termos MeSH secundário: Morte Celular
Glucose
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.11.31 (AMP-Activated Protein Kinases); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


  4 / 4272 MEDLINE  
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[PMID]:28766953
[Au] Autor:Christensen BJ; Hillersdal L; Holm L
[Ad] Endereço:a Faculty of Science , Institute of Food and Resource Economics, University of Copenhagen , Frederiksberg , Denmark.
[Ti] Título:Working with a fractional object: enactments of appetite in interdisciplinary work in anthropology and biomedicine.
[So] Source:Anthropol Med;24(2):221-235, 2017 Aug.
[Is] ISSN:1469-2910
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper explores the productive tensions occurring in an interdisciplinary research project on weight loss after obesity surgery. The study was a bio-medical/anthropological collaboration investigating to what extent eating patterns, the subjective experience of hunger and physiological mechanisms are involved in appetite regulation that might determine good or poor response to the surgery. Linking biomedical and anthropological categories and definitions of central concepts about the body turned out to be a major challenge in the collaborative analysis. Notably, the conception of what constitutes 'appetite' was a key concern, as each discipline has its particular definition and operationalization of the term. In response, a material-semiotic approach was chosen which allowed for a reconceptualization of appetite as a 'fractional object', engaged in multiple relations and enacted differently in each instance. This perspective produced creative contrasts and offered alternative explorations of both scientific knowledge production and anthropological practices. The paper thereby explores the interfaces between anthropology and medical science by attending to the challenges and opportunities that result from destabilising an assumed fixed and well-defined concept associated with the body.
[Mh] Termos MeSH primário: Apetite/etnologia
Pesquisa Biomédica
Obesidade
Perda de Peso/etnologia
[Mh] Termos MeSH secundário: Antropologia Médica
Alimentos
Seres Humanos
Fome/etnologia
Estudos Interdisciplinares
Obesidade/etnologia
Obesidade/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1080/13648470.2017.1322846


  5 / 4272 MEDLINE  
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[PMID]:28753423
[Au] Autor:Nectow AR; Schneeberger M; Zhang H; Field BC; Renier N; Azevedo E; Patel B; Liang Y; Mitra S; Tessier-Lavigne M; Han MH; Friedman JM
[Ad] Endereço:Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA. Electronic address: anectow@princeton.edu.
[Ti] Título:Identification of a Brainstem Circuit Controlling Feeding.
[So] Source:Cell;170(3):429-442.e11, 2017 Jul 27.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hunger, driven by negative energy balance, elicits the search for and consumption of food. While this response is in part mediated by neurons in the hypothalamus, the role of specific cell types in other brain regions is less well defined. Here, we show that neurons in the dorsal raphe nucleus, expressing vesicular transporters for GABA or glutamate (hereafter, DRN and DRN neurons), are reciprocally activated by changes in energy balance and that modulating their activity has opposite effects on feeding-DRN neurons increase, whereas DRN neurons suppress, food intake. Furthermore, modulation of these neurons in obese (ob/ob) mice suppresses food intake and body weight and normalizes locomotor activity. Finally, using molecular profiling, we identify druggable targets in these neurons and show that local infusion of agonists for specific receptors on these neurons has potent effects on feeding. These data establish the DRN as an important node controlling energy balance. PAPERCLIP.
[Mh] Termos MeSH primário: Regulação do Apetite
Núcleo Dorsal da Rafe/metabolismo
Neurônios/metabolismo
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Encéfalo/fisiologia
Núcleo Dorsal da Rafe/citologia
Eletrofisiologia
Jejum
Fome
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Obesos
Optogenética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE


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[PMID]:28703474
[Au] Autor:Persson PB; Bondke Persson A
[Ad] Endereço:Corporate Member of Freie Universität Berlin, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
[Ti] Título:Hunger, craving and appetite.
[So] Source:Acta Physiol (Oxf);221(1):3-5, 2017 09.
[Is] ISSN:1748-1716
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Apetite
Fome
[Mh] Termos MeSH secundário: Fissura
Ingestão de Alimentos
Comportamento Alimentar
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1111/apha.12917


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[PMID]:28506206
[Au] Autor:Pandulli-Alonso I; Quaglia A; Albo MJ
[Ad] Endereço:Laboratorio de Etología, Ecología y Evolución, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia, 3318, Montevideo, Uruguay.
[Ti] Título:Females of a gift-giving spider do not trade sex for food gifts: a consequence of male deception?
[So] Source:BMC Evol Biol;17(1):112, 2017 May 15.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Polyandry is commonly maintained by direct benefits in gift-giving species, so females may remate as an adaptive foraging strategy. However, the assumption of a direct benefit fades in mating systems where male gift-giving behaviour has evolved from offering nutritive to worthless (non-nutritive) items. In the spider Paratrechalea ornata, 70% of gifts in nature are worthless. We therefore predicted female receptivity to be independent of hunger in this species. We exposed poorly-fed and well-fed females to multiple males offering nutritive gifts and well-fed females to males offering worthless gifts. RESULTS: Though the treatments strongly affected fecundity, females of all groups had similar number of matings. This confirms that female receptivity is independent of their nutritional state, i.e. polyandry does not prevail as a foraging strategy. CONCLUSIONS: In the spider Pisaura mirabilis, in which the majority (62%) of gifts in nature are nutritive, female receptivity depends on hunger. We therefore propose that the dependence of female receptivity on hunger state may have evolved in species with predominantly nutritive gifts but is absent in species with predominantly worthless gifts.
[Mh] Termos MeSH primário: Comportamento Sexual Animal
Aranhas/fisiologia
[Mh] Termos MeSH secundário: Animais
Canibalismo
Feminino
Fertilidade
Alimentos
Fome
Masculino
Aranhas/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-017-0953-8


  8 / 4272 MEDLINE  
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[PMID]:28369078
[Au] Autor:Belinova L; Kahleova H; Malinska H; Topolcan O; Windrichova J; Oliyarnyk O; Kazdova L; Hill M; Pelikanova T
[Ad] Endereço:Department of Diabetology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
[Ti] Título:The effect of meal frequency in a reduced-energy regimen on the gastrointestinal and appetite hormones in patients with type 2 diabetes: A randomised crossover study.
[So] Source:PLoS One;12(4):e0174820, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Appetite and gastrointestinal hormones (GIHs) participate in energy homeostasis, feeding behavior and regulation of body weight. We demonstrated previously the superior effect of a hypocaloric diet regimen with lower meal frequency (B2) on body weight, hepatic fat content, insulin sensitivity and feelings of hunger compared to the same diet divided into six smaller meals a day (A6). Studies with isoenergetic diet regimens indicate that lower meal frequency should also have an effect on fasting and postprandial responses of GIHs. The aim of this secondary analysis was to explore the effect of two hypocaloric diet regimens on fasting levels of appetite and GIHs and on their postprandial responses after a standard meal. It was hypothesized that lower meal frequency in a reduced-energy regimen leading to greater body weight reduction and reduced hunger would be associated with decreased plasma concentrations of GIHs: gastric inhibitory peptide (GIP), glucagon-like peptide-1(GLP-1), peptide YY(PYY), pancreatic polypeptide (PP) and leptin and increased plasma concentration of ghrelin. The postprandial response of satiety hormones (GLP-1, PYY and PP) and postprandial suppression of ghrelin will be improved. METHODS: In a randomized crossover study, 54 patients suffering from type 2 diabetes (T2D) underwent both regimens. The concentrations of GLP-1, GIP, PP, PYY, amylin, leptin and ghrelin were determined using multiplex immunoanalyses. RESULTS: Fasting leptin and GIP decreased in response to both regimens with no difference between the treatments (p = 0.37 and p = 0.83, respectively). Fasting ghrelin decreased in A6 and increased in B2 (with difference between regimens p = 0.023). Fasting PP increased in B2with no significant difference between regimens (p = 0.17). Neither GLP-1 nor PYY did change in either regimen. The decrease in body weight correlated negatively with changes in fasting ghrelin (r = -0.4, p<0.043) and the postprandial reduction of ghrelin correlated positively with its fasting level (r = 0.9, p<0.001). The postprandial responses of GIHs and appetite hormones were similar after both diet regimens. CONCLUSIONS: Both hypocaloric diet regimens reduced fasting leptin and GIP and postprandial response of GIP comparably. The postprandial responses of GIHs and appetite hormones were similar after both diet regimens. Eating only breakfast and lunch increased fasting plasma ghrelin more than the same caloric restriction split into six meals. The changes in fasting ghrelin correlated negatively with the decrease in body weight. These results suggest that for type 2 diabetic patients on a hypocaloric diet, eating larger breakfast and lunch may be more efficient than six smaller meals during the day.
[Mh] Termos MeSH primário: Restrição Calórica/métodos
Diabetes Mellitus Tipo 2/dietoterapia
Diabetes Mellitus Tipo 2/fisiopatologia
Refeições
[Mh] Termos MeSH secundário: Adulto
Idoso
Peso Corporal
Estudos Cross-Over
Diabetes Mellitus Tipo 2/patologia
Diabetes Mellitus Tipo 2/psicologia
Feminino
Polipeptídeo Inibidor Gástrico/sangue
Grelina/sangue
Peptídeo 1 Semelhante ao Glucagon/sangue
Seres Humanos
Fome/fisiologia
Resistência à Insulina
Leptina/sangue
Masculino
Refeições/fisiologia
Refeições/psicologia
Meia-Idade
Polipeptídeo Pancreático/sangue
Peptídeo YY/sangue
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Ghrelin); 0 (Leptin); 106388-42-5 (Peptide YY); 59392-49-3 (Gastric Inhibitory Polypeptide); 59763-91-6 (Pancreatic Polypeptide); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174820


  9 / 4272 MEDLINE  
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[PMID]:28324096
[Au] Autor:Chalela JA
[Ad] Endereço:Neurosurgery Department, Medical University of South Carolina, Charleston; and 218th Maneuver Enhancement Brigade, South Carolina Army National Guard, Charleston.
[Ti] Título:Medical Care of Detainees in US Military Facilities: Unspeakable Kindness.
[So] Source:JAMA;317(11):1119-1120, 2017 Mar 21.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pessoal Técnico de Saúde
Assistência à Saúde/normas
Empatia
Instalações Militares/normas
Medicina Militar/normas
Prisioneiros de Guerra
[Mh] Termos MeSH secundário: Afeganistão
Barreiras de Comunicação
Tomada de Decisões
Seres Humanos
Fome
Relações Interprofissionais
Meios de Comunicação de Massa
Instalações Militares/organização & administração
Medicina Militar/ética
Autonomia Profissional
Relações Profissional-Paciente
Senso de Humor e Humor como Assunto
[Pt] Tipo de publicação:PERSONAL NARRATIVES
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.16798


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[PMID]:28294985
[Au] Autor:Sanchez M; Darimont C; Panahi S; Drapeau V; Marette A; Taylor VH; Doré J; Tremblay A
[Ad] Endereço:Faculty of Medicine, Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada. marina.sanchez@criucpq.ulaval.ca.
[Ti] Título:Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals.
[So] Source:Nutrients;9(3), 2017 Mar 15.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This study evaluated the impact of probiotic supplementation (Lactobacillus rhamnosus CGMCC1.3724 (LPR)) on appetite sensations and eating behaviors in the context of a weight-reducing program. Obese men ( = 45) and women ( = 60) participated in a double-blind, randomized, placebo-controlled trial that included a 12-week weight loss period (Phase 1) based on moderate energy restriction, followed by 12 weeks of weight maintenance (Phase 2). During the two phases of the program, each subject consumed two capsules per day of either a placebo or a LPR formulation (10 mg of LPR equivalent to 1.6 108 CFU/capsule, 210 mg of oligofructose, and 90 mg of inulin). The LPR supplementation increased weight loss in women that was associated with a greater increase in the fasting desire to eat ( = 0.03). On the other hand, satiety efficiency (satiety quotient for desire to eat) at lunch increased ( = 0.02), whereas disinhibition ( = 0.05) and hunger ( = 0.02) scores decreased more in the LPR-treated women, when compared with the female control group. Additionally, the LPR female group displayed a more pronounced decrease in food craving ( = 0.05), and a decrease in the Beck Depression Inventory score ( = 0.05) that was significantly different from the change noted in the placebo group ( = 0.02), as well as a higher score in the Body Esteem Scale questionnaire ( = 0.06). In men, significant benefits of LPR on fasting fullness and cognitive restraint were also observed. Taken together, these observations lend support to the hypothesis that the gut-brain axis may impact appetite control and related behaviors in obesity management.
[Mh] Termos MeSH primário: Dieta Redutora/psicologia
Comportamentos Relacionados com a Saúde
Probióticos/administração & dosagem
Saciação/fisiologia
Perda de Peso
[Mh] Termos MeSH secundário: Adolescente
Adulto
Apetite
Manutenção do Peso Corporal
Método Duplo-Cego
Exercício
Feminino
Seres Humanos
Fome/fisiologia
Lactobacillus rhamnosus/metabolismo
Masculino
Meia-Idade
Obesidade/dietoterapia
Obesidade/psicologia
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE



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