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Pesquisa : F01.658.556 [Categoria DeCS]
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[PMID]:28161326
[Au] Autor:Rödel HG; Bautista A; Roder M; Gilbert C; Hudson R
[Ad] Endereço:Laboratoire d'Ethologie Expérimentale et Comparée E.A. 4443 (LEEC), Université Paris 13, Sorbonne Paris Cité, F-93430 Villetaneuse, France; Department of Animal Physiology, University of Bayreuth, D-93440 Bayreuth, Germany. Electronic address: heiko.rodel@leec.univ-paris13.fr.
[Ti] Título:Early development and the emergence of individual differences in behavior among littermates of wild rabbit pups.
[So] Source:Physiol Behav;173:101-109, 2017 May 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ontogeny of associated individual differences in behavior and physiology during early postnatal life, and in particular the emergence of such differences among litter siblings, has been hardly explored in mammals under natural conditions. We studied such within-litter differences in behavior in European rabbit pups Oryctolagus cuniculus prior to weaning, and whether and how these differences co-varied with other individual characteristics such as postnatal body temperature and early growth. The study was conducted under semi-natural conditions in a colony of rabbits of wild origin, where the young were born and developed in nursery burrows. We equipped two siblings per litter with interscapular skin temperature loggers on postnatal day 2 and recorded temperature profiles for 48h. Individual body (skin) temperatures of pups within litters were repeatable across time, indicating the existence of consistent individual differences. Such differences within litters were associated with relative differences in pre-weaning growth, revealing that relatively warmer pups showed a greater increase in body mass during the nest period. Between postnatal days 12 and 17, after the pups had reached a developmental stage of greater mobility, we carried out different behavioral tests: a handling-restraint test, an open field test and a jump-down test from a platform. Individual responses in the former two tests were associated, as those pups showing a quicker struggling response to restraint during handling also exhibited greater exploratory activity in the open field. This correlation across contexts suggests the existence of personality types in wild rabbits at an early developmental stage. Furthermore, pups' behavioral responses were strongly associated with their relative within-litter body mass at testing. Animals with a lower body mass compared to their siblings showed a relatively quicker struggle response to handling restraint and covered a relatively larger distance in the open field, suggesting greater reactivity and responsiveness of relatively lighter pups in these tests. In contrast, relatively heavier pups jumped sooner from the platform, which may have been due to their greater physical maturation. In conclusion, our study shows that individual differences in behavior and associated differences in body temperature and growth are already present during early postnatal life, although such relationships can be easily overlooked, as they predominantly emerge as relative differences among littermates.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Temperatura Corporal/fisiologia
Individualidade
Tamanho da Ninhada de Vivíparos/fisiologia
Coelhos/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Animais Recém-Nascidos
Índice de Massa Corporal
Comportamento Exploratório
Manejo (Psicologia)
Atividade Motora/fisiologia
Tempo de Reação/fisiologia
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


  2 / 1803 MEDLINE  
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[PMID]:27956122
[Au] Autor:Horiquini-Barbosa E; Gibb R; Kolb B; Bray D; Lachat JJ
[Ad] Endereço:Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Neuroanatomy, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: horiquini
[Ti] Título:Tactile stimulation partially prevents neurodevelopmental changes in visual tract caused by early iron deficiency.
[So] Source:Brain Res;1657:130-139, 2017 Feb 15.
[Is] ISSN:1872-6240
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Iron deficiency has a critical impact on maturational mechanisms of the brain and the damage related to neuroanatomical parameters is not satisfactorily reversed after iron replacement. However, emerging evidence suggest that enriched early experience may offer great therapeutic efficacy in cases of nutritional disorders postnatally, since the brain is remarkably responsive to its interaction with the environment. Given the fact that tactile stimulation (TS) treatment has been previously shown to be an effective therapeutic approach and with potential application to humans, here we ask whether exposure to TS treatment, from postnatal day (P) 1 to P32 for 3min/day, could also be employed to prevent neuroanatomical changes in the optic nerve of rats maintained on an iron-deficient diet during brain development. We found that iron deficiency changed astrocyte, oligodendrocyte, damaged fiber, and myelinated fiber density, however, TS reversed the iron-deficiency-induced alteration in oligodendrocyte, damaged fiber and myelinated fiber density, but failed to reverse astrocyte density. Our results suggest that early iron deficiency may act by disrupting the timing of key steps in visual system development thereby modifying the normal progression of optic nerve maturation. However, optic nerve development is sensitive to enriching experiences, and in the current study we show that this sensitivity can be used to prevent damage from postnatal iron deficiency during the critical period.
[Mh] Termos MeSH primário: Ferro/deficiência
Manipulações Musculoesqueléticas
Nervo Óptico/crescimento & desenvolvimento
Vias Visuais/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Astrócitos/metabolismo
Astrócitos/patologia
Peso Corporal
Dieta
Modelos Animais de Doenças
Manejo (Psicologia)
Masculino
Fibras Nervosas Mielinizadas/metabolismo
Fibras Nervosas Mielinizadas/patologia
Neuroproteção
Oligodendroglia/metabolismo
Oligodendroglia/patologia
Nervo Óptico/irrigação sanguínea
Nervo Óptico/metabolismo
Nervo Óptico/patologia
Estimulação Física
Distribuição Aleatória
Ratos Wistar
Vias Visuais/irrigação sanguínea
Vias Visuais/metabolismo
Vias Visuais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


  3 / 1803 MEDLINE  
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[PMID]:27737780
[Au] Autor:Arroyo L; Carreras R; Valent D; Peña R; Mainau E; Velarde A; Sabrià J; Bassols A
[Ad] Endereço:Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain.
[Ti] Título:Effect of handling on neurotransmitter profile in pig brain according to fear related behaviour.
[So] Source:Physiol Behav;167:374-381, 2016 Dec 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemical neurotransmitters (NT) are principal actors in all neuronal networks of animals. The central nervous system plays an important role in stress susceptibility and organizes the response to a stressful situation through the interaction of the dopaminergic and the serotonergic pathways, leading to the activation of the hypothalamus-pituitary-adrenal axis (HPA). This study was designed to investigate: a) the effects of stressful handling of pigs at the slaughterhouse on the neurotransmitter profile in four brain areas: amygdala, prefrontal cortex (PFC), hippocampus and hypothalamus, and b) whether the alterations in the brain NT profile after stressful handling were associated with fear, determined by the tonic immobility (TI) test. In the first place, the characterization of the NT profile allowed to distinguish the four brain areas in a principal component analysis. The most crucial pathway involved in the reaction of pigs to a stressful handling was the serotonergic system, and changes were observed in the amygdala with a decrease in serotonin (5-HT) and total indoleamines, and in the hippocampus, where this pathway was activated. Fearful and non-fearful pigs did not show significant differences in their NT profile in control conditions, but when subjected to a stressful handling in the slaughterhouse, fearful animals showed a significant variation in the serotonin pathway and, in a lesser extent, the dopamine (DA) pathway. In conclusion, the existence of an underlying biological trait - possibly fearfulness - may be involved in the pig's response toward stressful challenges, and the serotonergic system seems to play a central role in this response.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Medo/fisiologia
Manejo (Psicologia)
Neurotransmissores/metabolismo
[Mh] Termos MeSH secundário: Aminas/metabolismo
Animais
Encéfalo/anatomia & histologia
Masculino
Análise de Componente Principal
Restrição Física
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Neurotransmitter Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE


  4 / 1803 MEDLINE  
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[PMID]:27717870
[Au] Autor:Couto-Pereira NS; Ferreira CF; Lampert C; Arcego DM; Toniazzo AP; Bernardi JR; da Silva DC; Von Poser Toigo E; Diehl LA; Krolow R; Silveira PP; Dalmaz C
[Ad] Endereço:Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: natividade.pereira@gmail.com.
[Ti] Título:Neonatal interventions differently affect maternal care quality and have sexually dimorphic developmental effects on corticosterone secretion.
[So] Source:Int J Dev Neurosci;55:72-81, 2016 Dec.
[Is] ISSN:1873-474X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neonatal handling (H) and maternal separation (MS) both induce changes in maternal care, but the contribution of these changes to the behavioral and neurochemical outcomes of the offspring remains unclear, as studies often find opposite results concerning the frequency of maternal behaviors, particularly in the MS paradigm. In this study, behavior displayed by H, MS and non-handled (NH) Wistar rat dams were observed during the first 10days after birth. A tentative assessment of the quality of maternal care was made, using a previously reported score that reflects behavior fragmentation and inconsistency. Central oxytocin levels and hippocampal synaptic plasticity markers were also evaluated in dams, immediately after litter weaning. In adulthood, male and female offspring were subjected to a contextual stress-induced corticosterone challenge to provide further information on the impact of early interventions on neuroendocrine parameters. We found that while both H and MS interventions induced an increase in the amount of pup-directed behavior, MS dams displayed a more fragmented and inconsistent pattern of care, reflecting poorer maternal care quality. Interestingly, an increase in oxytocin levels was observed only in H dams. While H offspring did not differ from NH, MS males and females showed marked differences in corticosterone secretion compared to controls. Our results suggest that briefly removing the pups from the nest alters maternal care quantity but not quality and increases central oxytocin, while long separations appear to increase low quality maternal care and change neuroendocrine responses in adult offspring in a sex-specific manner.
[Mh] Termos MeSH primário: Corticosterona/sangue
Manejo (Psicologia)
Privação Materna
Caracteres Sexuais
[Mh] Termos MeSH secundário: Fatores Etários
Análise de Variância
Animais
Animais Recém-Nascidos
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Feminino
Hipocampo/metabolismo
Masculino
Transtornos Mentais/sangue
Transtornos Mentais/etiologia
Ocitocina/líquido cefalorraquidiano
Medição da Dor
Gravidez
Ratos
Ratos Wistar
Sinaptofisina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Synaptophysin); 50-56-6 (Oxytocin); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


  5 / 1803 MEDLINE  
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[PMID]:27534000
[Au] Autor:Miller RM
[Ti] Título:Shaping cattle behavior.
[So] Source:J Am Vet Med Assoc;248(9):990, 2016 May 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Animais Recém-Nascidos/fisiologia
Comportamento Animal/fisiologia
Bovinos/fisiologia
Manejo (Psicologia)
Fixação Instintiva (Psicologia)
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos/psicologia
Bovinos/psicologia
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


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[PMID]:27222349
[Au] Autor:Beck ML; Davies S; Moore IT; Schoenle LA; Kerman K; Vernasco BJ; Sewall KB
[Ad] Endereço:2125 Derring Hall, Department of Biology, Virginia Tech, Blacksburg, VA 24061-0406, USA. Electronic address: beckmic@vt.edu.
[Ti] Título:Beeswax corticosterone implants produce long-term elevation of plasma corticosterone and influence condition.
[So] Source:Gen Comp Endocrinol;233:109-114, 2016 Jul 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glucocorticoids can play a critical role in modulating life-history trade-offs. However, studying the effects of glucocorticoids on life-history often requires experimentally elevating plasma glucocorticoid concentrations for several weeks within normal physiological limits and without repeated handling of the animal. Recently, implants made of beeswax and testosterone (T) were shown to have release dynamics superior to some currently available T implants, and these beeswax implants dissolved, eliminating the need to recapture the animal. We evaluated the utility of beeswax implants containing four different dosages of corticosterone (CORT; the primary glucocorticoid in birds) and their effect on several condition indices in a captive colony of zebra finches (Taeniopygia guttata). The three implants with the greatest CORT doses (0.05, 0.1, and 0.5mg) produced spikes in plasma CORT concentrations 20h after treatment, but were within the limits that zebra finches may normally experience. The 0.5mg CORT implant elevated plasma CORT between typical baseline and restraint stress levels reported in other studies of zebra finches for the entire 35day experiment. Birds in the 0.5mg implant group were heavier, had greater furcular fat scores, and had lower hematocrit than birds in the control and other CORT implant groups. Beeswax CORT implants are a low cost method of elevating plasma CORT for a prolonged time. Furthermore, because there is no need to remove these implants at the end of a study, this method may be amenable to studies of free-ranging animals.
[Mh] Termos MeSH primário: Corticosterona/administração & dosagem
Corticosterona/sangue
Implantes de Medicamento/química
Tentilhões
Ceras/química
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Tentilhões/sangue
Tentilhões/fisiologia
Glucocorticoides/sangue
Manejo (Psicologia)
Hematócrito
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Implants); 0 (Glucocorticoids); 0 (Waxes); 3XMK78S47O (Testosterone); 8012-89-3 (beeswax); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE


  7 / 1803 MEDLINE  
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[PMID]:27214261
[Au] Autor:Hampson MC; Schwitzer C
[Ad] Endereço:Bristol Zoological Society, Bristol, United Kingdom.
[Ti] Título:Effects of Hand-Rearing on Reproductive Success in Captive Large Cats Panthera tigris altaica, Uncia uncia, Acinonyx jubatus and Neofelis nebulosa.
[So] Source:PLoS One;11(5):e0155992, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Species Survival Plans and European Endangered Species Programmes have been developed for several species of endangered felids in order to build up captive reserve populations and support their conservation in the wild. The Siberian tiger (Panthera tigris altaica), snow leopard (Uncia uncia), cheetah (Acinonyx jubatus) and clouded leopard (Neofelis nebulosa) are managed in such ex situ conservation programmes. Many zoological institutions hand-rear offspring if rearing by the mother fails. Hand-rearing can cause behavioural problems, resulting in decreased copulation and lower breeding success in some species. In this study, studbook data subsets were examined: from 1901 to 2011; and 2000 to 2011. We analysed records from 4273 Siberian tigers, 2045 snow leopards, 3435 cheetahs, and 804 clouded leopards. We assessed the number of offspring produced, litter size, age at first reproduction, longevity, infant mortality and generational rearing of hand-reared versus parent-reared individuals. Hand-reared Siberian tigers (p<0.01; p = 0.0113), snow leopards (p<0.01), male cheetahs (p<0.01) and female clouded leopards (p<0.01) produced fewer offspring than parent-reared individuals. Hand-reared snow leopard breeding pairs had larger litters than parent-reared pairs (p = 0.0404). Hand-reared snow leopard females reproduced later in life (p<0.01). Hand-reared female Siberian tigers lived shorter lives, while hand-reared cheetahs lived longer (p<0.01; p = 0.0107). Infant mortality was higher in hand-reared snow leopards (p<0.01) and male cheetahs (p = 0.0395) in the 1901-2011 dataset and lower in hand-reared female Siberian tiger and male snow leopard cubs (p = 0.0404; p = 0.0349) in the 2000-2011 dataset. The rearing of the mother and subsequent rearing of offspring showed a significant relationship for all species (p<0.01 for Siberian tiger and snow leopard cubs; p<0.001 for cheetah and snow leopard cubs). Taking into account the limited carrying capacity of zoos, the results of this study highlight that careful consideration should be taken when deciding whether or not to hand-rear individuals that are part of Species Survival Plans and European Endangered Species Programmes.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/métodos
Felidae/fisiologia
Manejo (Psicologia)
Reprodução/fisiologia
[Mh] Termos MeSH secundário: Acinonyx/fisiologia
Animais
Animais de Zoológico
Gatos
Espécies em Perigo de Extinção
Felidae/classificação
Felis/fisiologia
Feminino
Tamanho da Ninhada de Vivíparos
Masculino
Panthera/fisiologia
Comportamento Sexual Animal/fisiologia
Tigres/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0155992


  8 / 1803 MEDLINE  
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[PMID]:27065128
[Au] Autor:Frese DA; Reinhardt CD; Bartle SJ; Rethorst DN; Hutcheson JP; Nichols WT; Depenbusch BE; Corrigan ME; Thomson DU
[Ti] Título:Cattle handling technique can induce fatigued cattle syndrome in cattle not fed a beta adrenergic agonist.
[So] Source:J Anim Sci;94(2):581-91, 2016 Feb.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Angus crossbred steers (n = 40; 563 ± 44 kg) were used to examine the effects of handling method and fat thickness on the blood chemistry and physiology of market steers. Steers were blocked by backfat (BF) thickness and were randomly assigned to treatment groups: low-stress handling (LSH) and aggressive handling (AH). Cattle were then ran¬domly assigned to one of 5 blocks containing 4 steers from the LSH and AH treatments. Steers in the LSH treatment were walked and AH cattle were run through a course of 1,540 m. Blood samples were obtained via jugular venipuncture before handling (BASE), at 770 m (LAP1), at 1,540 m (LAP2), and at1 h (1H) and 2 h (2H) after finishing the course. Blood samples were analyzed for plasma lactate (LAC), creatinine kinase (CK), base excess (BE), blood pH (pH), serum cortisol (CORT) concentrations, and venous carbon dioxide (PvCO2) and oxygen (PvO2) pressures. Heart rate (HR), respiratory rate (RR), and rectal temperature (TEMP) were measured at the same intervals. Cattle in the AH treatment had greater ( < 0.05) LAC than those in LSH at BASE (4.1 vs. 3.0 mmol/L), LAP1 (16.5 vs. 2.3 mmol/L), LAP2 (22.3 vs. 2.4 mmol/L), 1H (7.2 vs. 2.7 mmol/L), and 2H (4.0 vs. 2.5 mmol/L), respectively. Creatinine kinase and RR were not different (P > 0.14). Blood pH in AH cattle was decreased compared with that in LSH cattle ( < 0.05) at LAP1 (7.25 vs. 7.45) and LAP2 (7.19 vs. 7.48) but was not different ( > 0.13) at BASE, 1H, or 2H. Heart rate and TEMP were increased in AH cattle compared to LSH ( > 0.01). Serum cortisol was increased ( < 0.05) in AH compared to that in LSH cattle at LAP1 (87.5 vs. 58.9 nmol/L), LAP2 (144.4 vs. 93.1 nmol/L), and 1H (113.5 vs. 53.1 nmol/L). Although RR was not differ¬ent between LSH and AH, PvCO2 was decreased in AH compared to that in LSH ( < 0.05) at LAP2 (30.6 vs. 39.3 mmHg) and PvO2 was increased at LAP1 (42.7 vs. 33.5 mmHg) and at LAP2 (51.5 vs. 36.6 mmHg). Lactate was increased in AH cattle in the thicker BF group at 1H ( < 0.05), and blood pH was decreased at LAP1, LAP2, and 1H ( < 0.05) compared to the thinner BF cohorts. Four AH steers became exhausted (EXH) and did not complete the course. Increased CK, decreased PvCO2, and muscle tremors occurred in EXH steers compared to non-exhausted AH cohorts. Results of this study show that AH causes physiologic and blood chemistry changes in steers, which can be potentially detrimental to cattle, emphasizing the need for low-stress handling practices.
[Mh] Termos MeSH primário: Agonistas Adrenérgicos beta/administração & dosagem
Bovinos/fisiologia
Suplementos Nutricionais
Fadiga/veterinária
Manejo (Psicologia)
[Mh] Termos MeSH secundário: Agressão/fisiologia
Criação de Animais Domésticos
Animais
Temperatura Corporal
Bovinos/sangue
Fadiga/prevenção & controle
Ácido Láctico/sangue
Locomoção
Masculino
Condicionamento Físico Animal
Taxa Respiratória
Estresse Fisiológico/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic beta-Agonists); 33X04XA5AT (Lactic Acid)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2015-9824


  9 / 1803 MEDLINE  
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[PMID]:27020142
[Au] Autor:Reis AR; Jacobs S; Menegotto PR; Silveira PP; Lucion AB
[Ad] Endereço:Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Sarmento Leite, 500, Porto Alegre, RS, CEP 90050-170, Brasil. bioadolfo@gmail.com.
[Ti] Título:Neonatal handling alters maternal emotional response to stress.
[So] Source:Dev Psychobiol;58(5):614-22, 2016 07.
[Is] ISSN:1098-2302
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neonatal handling is an experimental procedure used to analyze the effects of environmental interventions during early postpartum days (PPD). Long-lasting effects of repeated stress exposure in the neonatal period on the maternal side are poorly studied in this model. The aim of this study was to verify if handling the pups induces enduring effects on damsstress responses, increasing their risk for depression. Dams were divided into two groups (NH-Non-handled and H-Handled) based on the handling procedure (pups were handled for 1 min/per day from PPD1-PPD10) and then subdivided into four groups (NH, NH + S, H, and H + S) based on the exposure or not to restraint stress after weaning (1 hr/per day for 7 days, PPD22-PPD28). We analyzed damsbehavior in the forced swimming test (FST PPD29-PPD30), plasma basal corticosterone and BDNF levels, as well as adrenal weight (PPD31). The results show that handling alters the stress response of dams to acute and chronic stress, as evidenced by dams of the H group having increased immobility in the first day of FST (p < .001), similar to NH + S (p < .01). Dams of the H and H + S groups show decreased levels of corticosterone when compared to NH and NH + S groups (p < .05), but the H + S group shows an increased adrenal weight, suggesting an increased sensibility of the maternal organism to the chronic stress applied after weaning (p < .05). We show that handling may induce a long-lasting effect on maternal stress response; these changes in the damsemotional reactivity increase their susceptibility for the development of psychiatric disorders such as depression. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 614-622, 2016.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Fator Neurotrófico Derivado do Encéfalo/sangue
Corticosterona/sangue
Depressão
Estresse Psicológico
[Mh] Termos MeSH secundário: Glândulas Suprarrenais/anatomia & histologia
Animais
Animais Recém-Nascidos
Depressão/sangue
Depressão/etiologia
Depressão/fisiopatologia
Emoções/fisiologia
Feminino
Manejo (Psicologia)
Masculino
Ratos Wistar
Estresse Psicológico/sangue
Estresse Psicológico/etiologia
Estresse Psicológico/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE
[do] DOI:10.1002/dev.21405


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[PMID]:26999300
[Au] Autor:Bodi CM; Vassoler FM; Byrnes EM
[Ad] Endereço:Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 01536, MA.
[Ti] Título:Adolescent experience affects postnatal ultrasonic vocalizations and gene expression in future offspring.
[So] Source:Dev Psychobiol;58(6):714-23, 2016 09.
[Is] ISSN:1098-2302
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study measured postnatal ultrasonic vocalization (USV) and gene expression to examine potential changes in communication and/or attachment in the offspring of mothers exposed to morphine during adolescence. Offspring of morphine-exposed (Mor-F1), saline-exposed (Sal-F1), or non-handled control (Con-F1) female Sprague-Dawley rats were tested for separation-induced distress calls and maternal potentiation of distress calls during early postnatal development. We also examined relative expression of dopamine D2 receptor and mu opioid receptor (oprm1) mRNA in the nucleus accumbens and hypothalamus in these offspring, as their activity has been implicated in the regulation of postnatal USV in response to maternal separation. The findings indicate that adolescent experiences of future mothers, including their 10 daily saline or morphine injections, can result in significant region-specific differences in gene expression. In addition, these experiences resulted in fewer numbers of separation-induced distress calls produced by offspring. In contrast, augmented maternal potentiation was only observed in Mor-F1 offspring. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58:714-723, 2016.
[Mh] Termos MeSH primário: Peso Corporal/fisiologia
Expressão Gênica/fisiologia
Exposição Materna
Morfina/farmacologia
Entorpecentes/farmacologia
Vocalização Animal/fisiologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Peso Corporal/efeitos dos fármacos
Feminino
Expressão Gênica/efeitos dos fármacos
Manejo (Psicologia)
Hipotálamo/metabolismo
Masculino
Morfina/administração & dosagem
Entorpecentes/administração & dosagem
Núcleo Accumbens/metabolismo
Ratos
Ratos Sprague-Dawley
Receptores de Dopamina D2/metabolismo
Receptores Opioides mu/metabolismo
Vocalização Animal/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (DRD2 protein, rat); 0 (Narcotics); 0 (Oprm1 protein, rat); 0 (Receptors, Dopamine D2); 0 (Receptors, Opioid, mu); 76I7G6D29C (Morphine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160322
[St] Status:MEDLINE
[do] DOI:10.1002/dev.21411



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