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[PMID]:28462758
[Au] Autor:Haynes BI; Bauermeister S; Bunce D
[Ad] Endereço:1School of Psychology,University of Leeds,Leeds,United Kingdom.
[Ti] Título:A Systematic Review of Longitudinal Associations Between Reaction Time Intraindividual Variability and Age-Related Cognitive Decline or Impairment, Dementia, and Mortality.
[So] Source:J Int Neuropsychol Soc;23(5):431-445, 2017 May.
[Is] ISSN:1469-7661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Intraindividual variability (IIV) in reaction time refers to the trial-to-trial fluctuations in responding across a given cognitive task. Cross-sectional research suggests that IIV increases with normal and neuropathological ageing and it may serve as a marker of neurobiological integrity. This raises the possibility that IIV may also predict future cognitive decline and, indeed, neuropathology. Therefore, we conducted a systematic review to address these issues. METHODS: A search of electronic databases Embase, Medline, PsycINFO, and Web of Science was completed on May 17, 2016 that identified longitudinal investigations of IIV in middle-aged or older adults. RESULTS: A total of 688 studies were initially identified of which 22 met the inclusion criteria. Nine included longitudinal IIV measures and 17 predicted subsequent outcome (cognitive decline or impairment, dementia, mortality) from baseline IIV. The results suggested IIV increased over time, particularly in participants aged over 75 years. Greater baseline IIV was consistently associated with increased risk of adverse outcomes including cognitive decline or impairment, and mortality. CONCLUSIONS: Increased IIV over time is associated with normal ageing. However, further increases in IIV over and above those found in normal ageing may be a risk factor for future cognitive impairment or mortality. Measures of IIV may, therefore, have considerable potential as a supplement to existing clinical assessment to aid identification of individuals at risk of adverse outcomes such as dementia or death. (JINS, 2017, 23, 431-445).
[Mh] Termos MeSH primário: Envelhecimento
Disfunção Cognitiva
Demência
Individualidade
Tempo de Reação/fisiologia
[Mh] Termos MeSH secundário: Disfunção Cognitiva/mortalidade
Disfunção Cognitiva/patologia
Disfunção Cognitiva/fisiopatologia
Bases de Dados Bibliográficas/estatística & dados numéricos
Demência/mortalidade
Demência/patologia
Demência/fisiopatologia
Seres Humanos
Estudos Longitudinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1017/S1355617717000236


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[PMID]:29237616
[Au] Autor:Obermeyer Z; Samra JK; Mullainathan S
[Ad] Endereço:Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA zobermeyer@bwh.harvard.edu.
[Ti] Título:Individual differences in normal body temperature: longitudinal big data analysis of patient records.
[So] Source:BMJ;359:j5468, 2017 12 13.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To estimate individual level body temperature and to correlate it with other measures of physiology and health. DESIGN: Observational cohort study. SETTING: Outpatient clinics of a large academic hospital, 2009-14. PARTICIPANTS: 35 488 patients who neither received a diagnosis for infections nor were prescribed antibiotics, in whom temperature was expected to be within normal limits. MAIN OUTCOME MEASURES: Baseline temperatures at individual level, estimated using random effects regression and controlling for ambient conditions at the time of measurement, body site, and time factors. Baseline temperatures were correlated with demographics, medical comorbidities, vital signs, and subsequent one year mortality. RESULTS: In a diverse cohort of 35 488 patients (mean age 52.9 years, 64% women, 41% non-white race) with 243 506 temperature measurements, mean temperature was 36.6°C (95% range 35.7-37.3°C, 99% range 35.3-37.7°C). Several demographic factors were linked to individual level temperature, with older people the coolest (-0.021°C for every decade, P<0.001) and African-American women the hottest (versus white men: 0.052°C, P<0.001). Several comorbidities were linked to lower temperature (eg, hypothyroidism: -0.013°C, P=0.01) or higher temperature (eg, cancer: 0.020, P<0.001), as were physiological measurements (eg, body mass index: 0.002 per m/kg , P<0.001). Overall, measured factors collectively explained only 8.2% of individual temperature variation. Despite this, unexplained temperature variation was a significant predictor of subsequent mortality: controlling for all measured factors, an increase of 0.149°C (1 SD of individual temperature in the data) was linked to 8.4% higher one year mortality (P=0.014). CONCLUSIONS: Individuals' baseline temperatures showed meaningful variation that was not due solely to measurement error or environmental factors. Baseline temperatures correlated with demographics, comorbid conditions, and physiology, but these factors explained only a small part of individual temperature variation. Unexplained variation in baseline temperature, however, strongly predicted mortality.
[Mh] Termos MeSH primário: Variação Biológica da População
Temperatura Corporal
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Coortes
Feminino
Seres Humanos
Individualidade
Estudos Longitudinais
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5468


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[PMID]:28459278
[Au] Autor:Brandmaier AM; Ram N; Wagner GG; Gerstorf D
[Ad] Endereço:Center for Lifespan Psychology, Max Planck Institute for Human Development.
[Ti] Título:Terminal decline in well-being: The role of multi-indicator constellations of physical health and psychosocial correlates.
[So] Source:Dev Psychol;53(5):996-1012, 2017 May.
[Is] ISSN:1939-0599
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Well-being is often relatively stable across adulthood and old age, but typically exhibits pronounced deteriorations and vast individual differences in the terminal phase of life. However, the factors contributing to these differences are not well understood. Using up to 25-year annual longitudinal data obtained from 4,404 now-deceased participants of the nationwide German Socio-Economic Panel Study (SOEP; age at death: M = 73.2 years; SD = 14.3 years; 52% women), we explored the role of multi-indicator constellations of sociodemographic variables, physical health and burden factors, and psychosocial characteristics. Expanding earlier reports, structural equation model (SEM) trees allowed us to identify profiles of variables that were associated with differences in the shape of late-life well-being trajectories. Physical health factors were found to play a major role for well-being decline, but in interaction with psychosocial characteristics such as social participation. To illustrate, for people with low social participation, disability emerged as the strongest correlate of differences in late-life well-being trajectories. However, for people with high social participation, whether or not an individual had spent considerable time in the hospital differentiated high versus low and stable versus declining late-life well-being. We corroborated these results with variable importance measures derived from a set of resampled SEM trees (so-called SEM forests) that provide robust and comparative indicators of the total interactive effects of variables for differential late-life well-being. We discuss benefits and limitations of our approach and consider our findings in the context of other reports about protective factors against terminal decline in well-being. (PsycINFO Database Record
[Mh] Termos MeSH primário: Envelhecimento/psicologia
Nível de Saúde
Satisfação Pessoal
Qualidade de Vida/psicologia
Participação Social/psicologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Alemanha
Seres Humanos
Individualidade
Estudos Longitudinais
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1037/dev0000274


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[PMID]:28470554
[Au] Autor:Adam KCS; Vogel EK
[Ad] Endereço:Department of Psychology, University of Chicago, 5848 S. University Ave., Chicago, IL, 60637, USA. kadam1@uchicago.edu.
[Ti] Título:Confident failures: Lapses of working memory reveal a metacognitive blind spot.
[So] Source:Atten Percept Psychophys;79(5):1506-1523, 2017 Jul.
[Is] ISSN:1943-393X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Working memory performance fluctuates dramatically from trial to trial. On many trials, performance is no better than chance. Here, we assessed participants' awareness of working memory failures. We used a whole-report visual working memory task to quantify both trial-by-trial performance and trial-by-trial subjective ratings of inattention to the task. In Experiment 1 (N = 41), participants were probed for task-unrelated thoughts immediately following 20% of trials. In Experiment 2 (N = 30), participants gave a rating of their attentional state following 25% of trials. Finally, in Experiments 3a (N = 44) and 3b (N = 34), participants reported confidence of every response using a simple mouse-click judgment. Attention-state ratings and off-task thoughts predicted the number of items correctly identified on each trial, replicating previous findings that subjective measures of attention state predict working memory performance. However, participants correctly identified failures on only around 28% of failure trials. Across experiments, participants' metacognitive judgments reliably predicted variation in working memory performance but consistently and severely underestimated the extent of failures. Further, individual differences in metacognitive accuracy correlated with overall working memory performance, suggesting that metacognitive monitoring may be key to working memory success.
[Mh] Termos MeSH primário: Atenção/fisiologia
Julgamento/fisiologia
Memória de Curto Prazo/fisiologia
Metacognição/fisiologia
Estimulação Luminosa/métodos
[Mh] Termos MeSH secundário: Conscientização/fisiologia
Feminino
Seres Humanos
Individualidade
Masculino
Distribuição Aleatória
Pensamento/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.3758/s13414-017-1331-8


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[PMID]:28454917
[Au] Autor:He R; Pagani-Núñez E; Chevallier C; Barnett CRA
[Ad] Endereço:College of Forestry, Guangxi University, Nanning, People's Republic of China.
[Ti] Título:To be so bold: boldness is repeatable and related to within individual behavioural variability in North Island robins.
[So] Source:Behav Processes;140:144-149, 2017 Jul.
[Is] ISSN:1872-8308
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Behavioural research traditionally focusses on the mean responses of a group of individuals rather than variation in behaviour around the mean or among individuals. However, examining the variation in behaviour among and within individuals may also yield important insights into the evolution and maintenance of behaviour. Repeatability is the most commonly used measure of variability among individuals in behavioural research. However, there are other forms of variation within populations that have received less attention. One such measure is intraindividual variation in behaviour (IIV), which is a short-term fluctuation of within-individual behaviour. Such variation in behaviour might be important during interactions because it could decrease the ability of conspecific and heterospecific individuals to predict the behaviour of the subject, thus increasing the cost of the interaction. In this experiment, we made repeated measures of the latency of North Island robins to attack a prey in a novel situation (a form of boldness) and examined (i) repeatability of boldness (the propensity to take a risk), (ii) IIV of boldness, and (iii) whether there was a significant relationship between these two traits (a behavioural syndrome). We found that boldness was highly repeatable, that there were high levels of IIV in boldness, and that there was a negative relationship between boldness and IIV in boldness. This suggests that despite high levels of repeatability for this behaviour, there were also still significant differences in IIV among different individuals within the population. Moreover, bolder individuals had significantly less IIV in their boldness, which suggests that they were forming routines (which reduces behavioural variability) compared to shyer individuals. Our results definitively demonstrate that IIV itself varies across individuals and is linked with key behavioural traits, and we argue for the importance of future studies aimed at understanding its causes and consequences for behavioural interactions.
[Mh] Termos MeSH primário: Agressão/psicologia
Aves Canoras/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Alimentar
Feminino
Individualidade
Masculino
Personalidade
Comportamento Predatório
Reprodutibilidade dos Testes
Timidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29173743
[Au] Autor:Rappaport LM; Sheerin C; Carney DM; Towbin KE; Leibenluft E; Pine DS; Brotman MA; Roberson-Nay R; Hettema JM
[Ad] Endereço:Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond. Electronic address: Lance.Rappaport@vcuhealth.org.
[Ti] Título:Clinical Correlates of Carbon Dioxide Hypersensitivity in Children.
[So] Source:J Am Acad Child Adolesc Psychiatry;56(12):1089-1096.e1, 2017 Dec.
[Is] ISSN:1527-5418
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Hypersensitivity to carbon dioxide (CO )-enriched air may be a promising risk marker for anxiety disorders. Among adult and adolescent samples, heterogeneity in distress response to the CO challenge task indexes 3 underlying classes of individuals, which distinguish between sustained and acute threat response as markers for internalizing disorders, broadly, and anxiety disorders, specifically. The present study examines latent classes in children's response to the CO challenge task to clarify the association of CO hypersensitivity with anxiety and internalizing symptomatology in childhood. METHOD: Healthy children from a community twin sample (N = 538; age 9-13 years) rated anxious distress every 2 minutes while breathing air enriched to 7.5% CO for 8 minutes. Latent growth mixture modeling evaluated potential classes of individuals with characteristic trajectories of distress during the task to clarify the association with internalizing disorder symptoms and related traits (e.g., anxiety sensitivity, irritability). RESULTS: Although all participants reported increased distress during the task, interindividual heterogeneity in distress indexed 3 underlying classes: a consistently low class ("low"), a consistently high class ("high"), and participants who demonstrated markedly increased acute distress ("acute"). Compared to the low class, the high class reported greater internalizing psychopathology, whereas membership in the acute class was associated with experiencing a panic-like event during the task. CONCLUSION: As in older individuals, 3 distinct trajectories emerged to capture interindividual heterogeneity in children's distress during the CO challenge task. These classes were distinguished by clinical validators that reinforce the association of CO hypersensitivity and internalizing disorder phenotypes in children.
[Mh] Termos MeSH primário: Ansiedade/etiologia
Dióxido de Carbono/efeitos adversos
Hipersensibilidade/psicologia
[Mh] Termos MeSH secundário: Adolescente
Ansiedade/diagnóstico
Ansiedade/psicologia
Transtornos de Ansiedade/diagnóstico
Transtornos de Ansiedade/etiologia
Transtornos de Ansiedade/psicologia
Criança
Feminino
Seres Humanos
Hipersensibilidade/diagnóstico
Hipersensibilidade/etiologia
Individualidade
Masculino
Modelos Psicológicos
Modelos Estatísticos
Escalas de Graduação Psiquiátrica
Medição de Risco
Fatores de Risco
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; TWIN STUDY
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28459599
[Au] Autor:Hedge C; Weaver R; Schnall S
[Ad] Endereço:1 School of Psychology, Cardiff University , Cardiff, United Kingdom .
[Ti] Título:Spatial Learning and Wayfinding in an Immersive Environment: The Digital Fulldome.
[So] Source:Cyberpsychol Behav Soc Netw;20(5):327-333, 2017 May.
[Is] ISSN:2152-2723
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous work has examined whether immersive technologies can benefit learning in virtual environments, but the potential benefits of technology in this context are confounded by individual differences such as spatial ability. We assessed spatial knowledge acquisition in male and female participants using a technology not previously examined empirically: the digital fulldome. Our primary aim was to examine whether performance on a test of survey knowledge was better in a fulldome (N = 28, 12 males) relative to a large, flat screen display (N = 27, 13 males). Regression analysis showed that, compared to a flat screen display, males showed higher levels of performance on a test of survey knowledge after learning in the fulldome, but no benefit occurred for females. Furthermore, performance correlated with spatial visualization ability in male participants, but not in female participants. Thus, the digital fulldome is a potentially useful learning aid, capable of accommodating multiple users, but individual differences and use of strategy need to be considered.
[Mh] Termos MeSH primário: Aprendizagem Espacial
Interface Usuário-Computador
Realidade Virtual
[Mh] Termos MeSH secundário: Simulação por Computador
Terminais de Computador
Feminino
Seres Humanos
Individualidade
Masculino
Análise de Regressão
Fatores Sexuais
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1089/cyber.2016.0399


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[PMID]:28464365
[Au] Autor:Estienne V; Stephens C; Boesch C
[Ad] Endereço:Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
[Ti] Título:Extraction of honey from underground bee nests by central African chimpanzees (Pan troglodytes troglodytes) in Loango National Park, Gabon: Techniques and individual differences.
[So] Source:Am J Primatol;79(8), 2017 Aug.
[Is] ISSN:1098-2345
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A detailed analysis of tool use behaviors can disclose the underlying cognitive traits of the users. We investigated the technique used by wild chimpanzees to extract the underground nests of stingless bees (Meliplebeia lendliana), which represent a hard-to-reach resource given their highly undetectable location. Using remote-sensor camera trap footage, we analyzed 151 visits to 50 different bee nests by 18 adult chimpanzees of both sexes. We quantified the degree of complexity and flexibility of this technique by looking at the behavioral repertoire and at its structural organization. We used Generalized Linear Mixed Models to test whether individuals differed in their action repertoire sizes and in their action sequencing patterns, as well as in their preferences of use of different behavioral elements (namely, actions, and grip types). We found that subjects showed non-randomly organized sequences of actions and that the occurrence of certain actions was predicted by the type of the previous action in the sequences. Subjects did not differ in their repertoire sizes, and all used extractive actions involving tools more often than manual digging. As for the type of grip employed, the grip involving the coordinated use of hands and feet together was most frequently used by all subjects when perforating, and we detected significant individual preferences in this domain. Overall, we describe a highly complex and flexible extractive technique, and propose the existence of inter-individual variation in it. We discuss our results in the light of the evolution of higher cognitive abilities in the human lineage.
[Mh] Termos MeSH primário: Comportamento Alimentar
Mel
Pan troglodytes
Comportamento de Utilização de Ferramentas
[Mh] Termos MeSH secundário: Animais
Abelhas
Cognição
Feminino
Gabão
Individualidade
Masculino
Parques Recreativos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/ajp.22672


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[PMID]:28471214
[Au] Autor:Kornadt AE; Kandler C
[Ad] Endereço:Department of Psychology, Bielefeld University.
[Ti] Título:Genetic and environmental sources of individual differences in views on aging.
[So] Source:Psychol Aging;32(4):388-399, 2017 Jun.
[Is] ISSN:1939-1498
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Views on aging are central psychosocial variables in the aging process, but knowledge about their determinants is still fragmental. Thus, the authors investigated the degree to which genetic and environmental factors contribute to individual differences in various domains of views on aging (wisdom, work, fitness, and family), and whether these variance components vary across ages. They analyzed data from 350 monozygotic and 322 dizygotic twin pairs from the Midlife Development in the U.S. (MIDUS) study, aged 25-74. Individual differences in views on aging were mainly due to individual-specific environmental and genetic effects. However, depending on the domain, genetic and environmental contributions to the variance differed. Furthermore, for some domains, variability was larger for older participants; this was attributable to increases in environmental components. This study extends research on genetic and environmental sources of psychosocial variables and stimulates future studies investigating the etiology of views on aging across the life span. (PsycINFO Database Record
[Mh] Termos MeSH primário: Envelhecimento/genética
Meio Ambiente
Individualidade
Gêmeos Dizigóticos
Gêmeos Monozigóticos
[Mh] Termos MeSH secundário: Adulto
Idoso
Envelhecimento/fisiologia
Envelhecimento/psicologia
Feminino
Variação Genética
Seres Humanos
Masculino
Meia-Idade
Meio Social
Gêmeos Dizigóticos/genética
Gêmeos Dizigóticos/psicologia
Gêmeos Monozigóticos/genética
Gêmeos Monozigóticos/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1037/pag0000174


  10 / 12280 MEDLINE  
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[PMID]:29045458
[Au] Autor:Chakrabarti B; Haffey A; Canzano L; Taylor CP; McSorley E
[Ad] Endereço:Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences University of Reading, Whiteknights Campus, Reading, United Kingdom.
[Ti] Título:Individual differences in responsivity to social rewards: Insights from two eye-tracking tasks.
[So] Source:PLoS One;12(10):e0185146, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Humans generally prefer social over nonsocial stimuli from an early age. Reduced preference for social rewards has been observed in individuals with autism spectrum conditions (ASC). This preference has typically been noted in separate tasks that measure orienting toward and engaging with social stimuli. In this experiment, we used two eye-tracking tasks to index both of these aspects of social preference in in 77 typical adults. We used two measures, global effect and preferential looking time. The global effect task measures saccadic deviation toward a social stimulus (related to 'orienting'), while the preferential looking task records gaze duration bias toward social stimuli (relating to 'engaging'). Social rewards were found to elicit greater saccadic deviation and greater gaze duration bias, suggesting that they have both greater salience and higher value compared to nonsocial rewards. Trait empathy was positively correlated with the measure of relative value of social rewards, but not with their salience. This study thus elucidates the relationship of empathy with social reward processing.
[Mh] Termos MeSH primário: Movimentos Oculares/fisiologia
Individualidade
Recompensa
Comportamento Social
Análise e Desempenho de Tarefas
[Mh] Termos MeSH secundário: Viés
Empatia
Feminino
Fixação Ocular/fisiologia
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185146



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