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  1 / 20422 MEDLINE  
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[PMID]:29379958
[Au] Autor:Emanuel EJ; Gudbranson E
[Ad] Endereço:Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
[Ti] Título:Does Medicine Overemphasize IQ?
[So] Source:JAMA;319(7):651-652, 2018 Feb 20.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Teste de Admissão Acadêmica
Educação de Graduação em Medicina
Inteligência Emocional
Inteligência
Médicos/psicologia
Critérios de Admissão Escolar
[Mh] Termos MeSH secundário: Educação de Graduação em Medicina/métodos
Seres Humanos
Relações Interpessoais
Entrevistas como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.20141


  2 / 20422 MEDLINE  
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[PMID]:28743040
[Au] Autor:Furlong MA; Herring A; Buckley JP; Goldman BD; Daniels JL; Engel LS; Wolff MS; Chen J; Wetmur J; Barr DB; Engel SM
[Ad] Endereço:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, United States. Electronic address: mfurlong@email.arizona.edu.
[Ti] Título:Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.
[So] Source:Environ Res;158:737-747, 2017 10.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopmental outcomes. Additionally, Bayesian hierarchical modeling can account for confounding by collinear co-exposures. We use this framework to examine associations between prenatal exposure to OPs and behavior, executive functioning, and IQ assessed at age 6-9 years in a cohort of 404 mother/infant pairs recruited during pregnancy. We derived phenotypes of neurodevelopment with a factor analysis, and estimated associations between OP metabolites and these phenotypes in Bayesian hierarchical models for exposure mixtures. We report seven factors: 1) Impulsivity and Externalizing, 2) Executive Functioning, 3) Internalizing, 4) Perceptual Reasoning, 5) Adaptability, 6) Processing Speed, and 7) Verbal Intelligence. These, along with the Working Memory Index, were standardized and scaled so that positive values reflected positive attributes and negative values represented adverse outcomes. Standardized dimethylphosphate metabolites were negatively associated with Internalizing factor scores (ß^ - 0.13, 95% CI - 0.26, 0.00) but positively associated with Executive Functioning factor scores (ß^ 0.18, 95% CI 0.04, 0.31). Standardized diethylphosphate metabolites were negatively associated with the Working Memory Index (ß^ - 0.17, 95% CI - 0.33, - 0.03). Associations with factor scores were generally stronger and more precise than associations with individual instrument-specific items. Factor analysis of outcomes may provide some advantages in etiological studies of childhood neurodevelopment by incorporating information across scales to reduce dimensionality and improve precision.
[Mh] Termos MeSH primário: Comportamento Infantil/efeitos dos fármacos
Desenvolvimento Infantil/efeitos dos fármacos
Poluentes Ambientais/toxicidade
Função Executiva/efeitos dos fármacos
Inteligência/efeitos dos fármacos
Compostos Organofosforados/toxicidade
Efeitos Tardios da Exposição Pré-Natal/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Feminino
Seres Humanos
Testes de Inteligência
Estudos Longitudinais
Masculino
Exposição Materna
Cidade de Nova Iorque/epidemiologia
Praguicidas/toxicidade
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Organophosphorus Compounds); 0 (Pesticides)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180303
[Lr] Data última revisão:
180303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  3 / 20422 MEDLINE  
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[PMID]:29390291
[Au] Autor:Al Kaissi A; Kuranova M; Pleskach N; Kenis V; Nassib NM; Grill F; Ganger R; Gerit Kircher S
[Ad] Endereço:Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, First Medical Department, Hanusch Hospital.
[Ti] Título:Are parents of children with Cockayne syndrome manifesting features of the disorder?: Case reports.
[So] Source:Medicine (Baltimore);96(50):e8970, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Postnatal growth failure and progressive neurologic dysfunction and increasing multiorgan involvement are the main clinical features of Cockayne syndrome (CS). CS is a rare autosomal recessive disorder of the group of DNA repair diseases. Usually, genetic carriers, such as parents of patients, are not at risk for developing the disease. PATIENT CONCERNS: A series of 14 family subjects (6 children with age range from 6 months to 4 years with CS) and 9 parents (aged from 23 to 34 years) from consanguineous families is reported. DIAGNOSES: Ultraviolet irradiation studies were performed on these children and were indicative of CS. INTERVENTIONS: Cells of skin fibroblast from these children with the disease showed a symmetrical accumulation of chromosomal aberrations and the nuclear lamina aberrations. Our results showed a significant and simultaneous increase of percent of blebbs and invaginations of the nuclear lamina in all cases CS. The pronounced changes in 12.6 times at atypical form (girl); in 8.5 times at severe form (boy) and in 5.6 times at light form (boy). Percentage of metaphases with chromosomal aberration is significantly higher in CS cells: in 4 times at atypical form, in 3 times at hard form, and in 2 times at light form. The parents of these families (consanguineous families) were intellectually variable between normal/borderline intelligence, though most manifested a constellation of skeletal and extraskeletal abnormalities and notably, the characteristic cachectic facial appearance. The parents were considered as manifesting the mild type of CS, because they showed no abnormalities of DNA repair. OUTCOMES: Clinical manifestations in heterozygote carriers of an autosomal recessive disorders is a rare phenomenon as carriers are usually healthy. LESSONS: The interesting finding of the families studied is that there appeared to be a multitude of carriers manifesting with normal to borderline intelligence but with a wide spectrum of skeletal and extraskeletal abnormalities.
[Mh] Termos MeSH primário: Síndrome de Cockayne/genética
Pais
[Mh] Termos MeSH secundário: Adulto
Pré-Escolar
Consanguinidade
Feminino
Predisposição Genética para Doença
Heterozigoto
Seres Humanos
Lactente
Inteligência
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008970


  4 / 20422 MEDLINE  
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[PMID]:28453778
[Au] Autor:Caramaschi D; Sharp GC; Nohr EA; Berryman K; Lewis SJ; Davey Smith G; Relton CL
[Ad] Endereço:Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine.
[Ti] Título:Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study.
[So] Source:Hum Mol Genet;26(15):3001-3013, 2017 08 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An adequate intake of vitamin B12 during pregnancy plays an important role in offspring neurodevelopment, potentially via epigenetic processes. We used a two-step Mendelian randomization approach to assess whether DNA methylation plays a mediating and causal role in associations between maternal vitamin B12 status and offspring's cognition. Firstly, we estimated the causal effect of maternal vitamin B12 levels on cord blood DNA methylation using the maternal FUT2 genotypes rs492602:A > G and rs1047781:A > T as proxies for circulating vitamin B12 levels in the Avon Longitudinal Study of Parents and Children (ALSPAC) and we tested the observed associations in a replication cohort. Secondly, we estimated the causal effect of DNA methylation on IQ using the offspring genotype at sites close to the methylated CpG site as a proxy for DNA methylation in ALSPAC and in a replication sample. The first step Mendelian randomization estimated that maternal vitamin B12 had a small causal effect on DNA methylation in offspring at three CpG sites, which was replicated for one of the sites. The second step Mendelian randomization found weak evidence of a causal effect of DNA methylation at two of these sites on childhood performance IQ which was replicated for one of the sites. The findings support a causal effect of maternal vitamin B12 levels on cord blood DNA methylation, and a causal effect of vitamin B12-responsive DNA methylation changes on children's cognition. Some limitations were identified and future studies using a similar approach should aim to overcome such issues.
[Mh] Termos MeSH primário: Inteligência/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal/genética
Vitamina B 12/metabolismo
[Mh] Termos MeSH secundário: Adulto
Criança
Cognição/efeitos dos fármacos
Metilação de DNA/genética
Metilação de DNA/fisiologia
Epigênese Genética/genética
Família
Feminino
Sangue Fetal/metabolismo
Genótipo
Seres Humanos
Testes de Inteligência
Estudos Longitudinais
Masculino
Análise da Randomização Mendeliana
Gravidez
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Distribuição Aleatória
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180225
[Lr] Data última revisão:
180225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx164


  5 / 20422 MEDLINE  
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[PMID]:29220711
[Au] Autor:Duan Q; Jiao J; Chen X; Wang X
[Ad] Endereço:Department of Medical Imaging, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
[Ti] Título:Association between water fluoride and the level of children's intelligence: a dose-response meta-analysis.
[So] Source:Public Health;154:87-97, 2018 Jan.
[Is] ISSN:1476-5616
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Higher fluoride concentrations in water have inconsistently been associated with the levels of intelligence in children. The following study summarizes the available evidence regarding the strength of association between fluoridated water and children's intelligence. STUDY DESIGN: Meta-analysis. METHODS: PubMed, Embase, and Cochrane Library databases were systematically analyzed from November 2016. Observational studies that have reported on intelligence levels in relation to high and low water fluoride contents, with 95% confidence intervals (CIs) were included. Further, the results were pooled using inverse variance methods. The correlation between water fluoride concentration and intelligence level was assessed by a dose-response meta-analysis. RESULTS: Twenty-six studies reporting data on 7258 children were included. The summary results indicated that high water fluoride exposure was associated with lower intelligence levels (standardized mean difference : -0.52; 95% CI: -0.62 to -0.42; P < 0.001). The findings from subgroup analyses were consistent with those from overall analysis. The dose-response meta-analysis suggested a significant association between water fluoride dosage and intelligence (P < 0.001), while increased water fluoride exposure was associated with reduced intelligence levels. CONCLUSIONS: Greater exposure to high levels of fluoride in water was significantly associated with reduced levels of intelligence in children. Therefore, water quality and exposure to fluoride in water should be controlled in areas with high fluoride levels in water.
[Mh] Termos MeSH primário: Fluoretação/estatística & dados numéricos
Fluoretos/efeitos adversos
Inteligência
[Mh] Termos MeSH secundário: Criança
Fluoretos/administração & dosagem
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
Q80VPU408O (Fluorides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  6 / 20422 MEDLINE  
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[PMID]:29329293
[Au] Autor:Ezeamama AE; Bustinduy AL; Nkwata AK; Martinez L; Pabalan N; Boivin MJ; King CH
[Ad] Endereço:Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America.
[Ti] Título:Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis.
[So] Source:PLoS Negl Trop Dis;12(1):e0005524, 2018 01.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits. METHODOLOGY/PRINCIPAL FINDINGS: This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design. CONCLUSION/SIGNIFICANCE: Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits. TRIAL REGISTRATION: ClinicalTrials.gov CRD42016040052.
[Mh] Termos MeSH primário: Disfunção Cognitiva/parasitologia
Transtornos de Aprendizagem/parasitologia
Transtornos da Memória/parasitologia
Esquistossomose/complicações
[Mh] Termos MeSH secundário: Adolescente
Animais
Anti-Helmínticos/uso terapêutico
Criança
Pré-Escolar
Cognição/fisiologia
Seres Humanos
Inteligência/fisiologia
Memória/fisiologia
Testes de Memória e Aprendizagem
Praziquantel/uso terapêutico
Tempo de Reação/fisiologia
Schistosoma/patogenicidade
Esquistossomose/tratamento farmacológico
Esquistossomose/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 6490C9U457 (Praziquantel)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005524


  7 / 20422 MEDLINE  
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[PMID]:28744605
[Au] Autor:Turkheimer E; Beam CR; Sundet JM; Tambs K
[Ad] Endereço:University of Virginia, Charlottesville, VA, USA. ent3c@virginia.edu.
[Ti] Título:Interaction between Parental Education and Twin Correlations for Cognitive Ability in a Norwegian Conscript Sample.
[So] Source:Behav Genet;47(5):507-515, 2017 Sep.
[Is] ISSN:1573-3297
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We examine a sample of Norwegian twin conscripts for evidence of an interaction between parental education and the heritability of general cognitive ability (GA). Ability scores were obtained on 1706 pairs of twins who were conscripted into the Norwegian Armed Forces between 1931and 1960. Education scores were available for mothers and fathers; the majority of the parents had less than a high school education. GA scores were heteroscadistic with respect to mid-parent education, with reduced variability at higher levels of education. Both MZ and DZ twin correlations for GA were linearly and negatively related to mid-parent education, DZ twins substantially more so. When the model was extended to an ACE model consisting of standardized positive ACE variance components, the modification appeared to disappear. Further analysis revealed that this occurred because the steep decline of DZ twin correlations with increasing mid-parent education resulted in a violation of the classical twin model for much of the parameter space. Other phenomena that might result in large declines in DZ twin correlations are considered, along with implications for other studies of socioeconomic interactions with the heritability of GA in European samples.
[Mh] Termos MeSH primário: Inteligência/genética
Gêmeos Dizigóticos/genética
Gêmeos Monozigóticos/genética
[Mh] Termos MeSH secundário: Adulto
Cognição/fisiologia
Educação
Feminino
Interação Gene-Ambiente
Seres Humanos
Masculino
Herança Multifatorial/genética
Noruega
Pais/educação
Gêmeos Dizigóticos/psicologia
Gêmeos Monozigóticos/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1007/s10519-017-9857-z


  8 / 20422 MEDLINE  
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[PMID]:29210884
[Au] Autor:Nahm M; Rousseau D; Greyson B
[Ti] Título:Discrepancy Between Cerebral Structure and Cognitive Functioning: A Review.
[So] Source:J Nerv Ment Dis;205(12):967-972, 2017 Dec.
[Is] ISSN:1539-736X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuroscientists typically assume that human mental functions are generated by the brain and that its structural elements, including the different cell layers and tissues that form the neocortex, play specific roles in this complex process. Different functional units are thought to complement one another to create an integrated self-awareness or episodic memory. Still, findings that pertain to brain dysplasia and brain lesions indicate that in some individuals there is a considerable discrepancy between the cerebral structures and cognitive functioning. This seems to question the seemingly well-defined role of these brain structures. This article provides a review of such remarkable cases. It contains overviews of noteworthy aspects of hydrocephalus, hemihydranencephaly, hemispherectomy, and certain abilities of "savants." We add considerations on memory processing, comment on the assumed role of neural plasticity in these contexts, and highlight the importance of taking such anomalies into account when formulating encompassing models of brain functioning.
[Mh] Termos MeSH primário: Encéfalo/patologia
Encéfalo/fisiologia
Hemisferectomia
Hidranencefalia/patologia
Hidrocefalia/patologia
Inteligência/fisiologia
Memória/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Seres Humanos
Hidranencefalia/fisiopatologia
Hidrocefalia/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1097/NMD.0000000000000752


  9 / 20422 MEDLINE  
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[PMID]:27771566
[Au] Autor:Davis EP; Head K; Buss C; Sandman CA
[Ad] Endereço:Department of Psychology, University of Denver, Denver, CO, 80210, United States; Women and Children's Health and Well-Being Project, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California, 92868, United States. Electronic address: elysia.davis@du.edu.
[Ti] Título:Prenatal maternal cortisol concentrations predict neurodevelopment in middle childhood.
[So] Source:Psychoneuroendocrinology;75:56-63, 2017 Jan.
[Is] ISSN:1873-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Glucocorticoids (cortisol in humans) are the end product of the hypothalamic-pituitary-adrenocortical (HPA) axis and are proposed as a key mechanism for programming fetal brain development. The present prospective longitudinal study evaluates the association between prenatal maternal cortisol concentrations and child neurodevelopment. Participants included a low risk sample of 91 mother-child pairs. Prenatal maternal plasma cortisol concentrations were measured at 19 and 31 gestational weeks. Brain development and cognitive functioning were assessed when children were 6-9 years of age. Structural magnetic resonance imaging scans were acquired and cortical thickness was determined. Child cognitive functioning was evaluated using standardized measures (Wechsler Intelligence Scale for Children IV and Expressive Vocabulary Test, Second Edition). Higher maternal cortisol concentrations during the third trimester were associated with greater child cortical thickness primarily in frontal regions. No significant associations were observed between prenatal maternal cortisol concentrations and child cortical thinning. Elevated third trimester maternal cortisol additionally was associated with enhanced child cognitive performance. Findings in this normative sample of typically developing children suggest that elevated maternal cortisol during late gestation exert lasting benefits for brain development and cognitive functioning 6-9 years later. The benefits of fetal exposure to higher maternal cortisol during the third trimester for child neurodevelopment are consistent with the role cortisol plays in maturation of the human fetus. It is plausible that more extreme elevations in maternal cortisol concentrations late in gestation, as well as exposure to pharmacological levels of synthetic glucocorticoids, may have neurotoxic effects on the developing fetal brain.
[Mh] Termos MeSH primário: Córtex Cerebral/anatomia & histologia
Desenvolvimento Infantil/fisiologia
Cognição/fisiologia
Hidrocortisona/metabolismo
Inteligência/fisiologia
Gravidez/metabolismo
[Mh] Termos MeSH secundário: Córtex Cerebral/diagnóstico por imagem
Córtex Cerebral/crescimento & desenvolvimento
Criança
Feminino
Seres Humanos
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Terceiro Trimestre da Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  10 / 20422 MEDLINE  
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[PMID]:29066580
[Au] Autor:Lopez AS; Lanzieri TM; Claussen AH; Vinson SS; Turcich MR; Iovino IR; Voigt RG; Caviness AC; Miller JA; Williamson WD; Hales CM; Bialek SR; Demmler-Harrison G; Congenital Cytomegalovirus Longitudinal Study Group
[Ad] Endereço:National Center for Immunization and Respiratory Diseases, and.
[Ti] Título:Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection.
[So] Source:Pediatrics;140(5), 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS: We used growth curve modeling to analyze trends in IQ (full-scale, verbal, and nonverbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for patients with normal hearing ( = 78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age ( = 11) and controls ( = 40). RESULTS: Patients with SNHL had full-scale intelligence and receptive vocabulary scores that were 7.0 and 13.1 points lower, respectively, compared with controls, but no significant differences were noted in these scores among patients with normal hearing and controls. No significant differences were noted in scores for verbal and nonverbal intelligence, expressive vocabulary, and academic achievement in math and reading among patients with normal hearing or with SNHL and controls. CONCLUSIONS: Infants with asymptomatic congenital cytomegalovirus infection identified through newborn screening with normal hearing by age 2 years do not appear to have differences in IQ, vocabulary or academic achievement scores during childhood, or adolescence compared with uninfected children.
[Mh] Termos MeSH primário: Doenças Assintomáticas/epidemiologia
Infecções por Citomegalovirus/epidemiologia
Escolaridade
Testes de Inteligência
Inteligência
[Mh] Termos MeSH secundário: Adolescente
Adulto
Doenças Assintomáticas/psicologia
Criança
Pré-Escolar
Infecções por Citomegalovirus/diagnóstico
Infecções por Citomegalovirus/psicologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Estudos Longitudinais
Masculino
Meia-Idade
Triagem Neonatal/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE



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