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[PMID]:29287889
[Au] Autor:Cesca F; Bettella E; Polli R; Cama E; Scimemi P; Santarelli R; Murgia A
[Ad] Endereço:Laboratory of Molecular Genetics of Neurodevelopment, Department of Women's and Children's Health, University of Padova, Italy.
[Ti] Título:A novel mutation of the EYA4 gene associated with post-lingual hearing loss in a proband is co-segregating with a novel PAX3 mutation in two congenitally deaf family members.
[So] Source:Int J Pediatr Otorhinolaryngol;104:88-93, 2018 Jan.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This work was aimed at establishing the molecular etiology of hearing loss in a 9-year old girl with post-lingual non-syndromic mild sensorineural hearing loss with a complex family history of clinically heterogeneous deafness. METHODS: The proband's DNA was subjected to NGS analysis of a 59-targeted gene panel, with the use of the Ion Torrent PGM platform. Conventional Sanger sequencing was used for segregation analysis in all the affected relatives. The proband and all the other hearing impaired members of the family underwent a thorough clinical and audiological evaluation. RESULTS: A new likely pathogenic mutation in the EYA4 gene (c.1154C > T; p.Ser385Leu) was identified in the proband and in her 42-year-old father with post-lingual non-syndromic profound sensorineural hearing loss. The EYA4 mutation was also found in the proband's grandfather and uncle, both showing clinical features of Waardenburg syndrome type 1. A novel pathogenic splice-site mutation (c.321+1G > A) of the PAX3 gene was found to co-segregate with the EYA4 mutation in these two subjects. CONCLUSION: The identified novel EYA4 mutation can be considered responsible of the hearing loss observed in the proband and her father, while a dual molecular diagnosis was reached in the relatives co-segregating the EYA4 and the PAX3 mutations. In these two subjects the DFNA10 phenotype was masked by Waardenburg syndrome. The use of NGS targeted gene-panel, in combination with an extensive clinical and audiological examination led us to identify the genetic cause of the hearing loss in members of a family in which different forms of autosomal dominant deafness segregate. These results provide precise and especially important prognostic and follow-up information for the future audiologic management in the youngest affected member.
[Mh] Termos MeSH primário: Surdez/genética
Perda Auditiva Neurossensorial/genética
Fator de Transcrição PAX3/genética
Transativadores/genética
Síndrome de Waardenburg/genética
[Mh] Termos MeSH secundário: Adulto
Audiometria
Criança
Família
Feminino
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Masculino
Mutação
Linhagem
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (EYA4 protein, human); 0 (PAX3 Transcription Factor); 0 (PAX3 protein, human); 0 (Trans-Activators)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  2 / 66424 MEDLINE  
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[PMID]:29214782
[Au] Autor:Lee YH; Shin MH; Nam HS; Park KS; Choi SW; Ryu SY; Kweon SS
[Ad] Endereço:Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
[Ti] Título:Effect of Family History of Diabetes on Hemoglobin A1c Levels among Individuals with and without Diabetes: The Dong-gu Study.
[So] Source:Yonsei Med J;59(1):92-100, 2018 Jan.
[Is] ISSN:1976-2437
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We investigated associations between family history of diabetes (FHD) and hemoglobin A1c (HbA1c) level, among people with and without diabetes. MATERIALS AND METHODS: In total, 7031 people without diabetes and 1918 people with diabetes who participated in the Dong-gu Study were included. Data on FHD in first-degree relatives (father, mother, and siblings) were obtained. Elevated HbA1c levels in people without diabetes and high HbA1c levels in people with diabetes were defined as the highest quintiles of HbA1c ≥5.9% and ≥7.9%, respectively. RESULTS: In people without diabetes, the odds of elevated HbA1c levels [odds ratio (OR) 1.34, 95% confidence interval (CI) 1.13-1.59] were significantly greater in people with any FHD than in those without. Specifically, the odds of elevated HbA1c levels in people without diabetes with an FHD involving siblings were greater than in those without an FHD involving siblings. Additionally, in people with diabetes, the odds of high HbA1c levels (OR 1.33, 95% CI 1.02-1.72) were greater in people with any FHD than in those without such history. Moreover, people with diabetes with maternal FHD had increased odds of high HbA1c levels. CONCLUSION: FHD was associated not only with high HbA1c levels in people with diabetes, but also with elevated HbA1c levels in people without diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus/sangue
Hemoglobina A Glicada/análise
[Mh] Termos MeSH secundário: Idoso
Glicemia/metabolismo
Diabetes Mellitus/epidemiologia
Família
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Prevalência
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Glycated Hemoglobin A)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.3349/ymj.2018.59.1.92


  3 / 66424 MEDLINE  
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[PMID]:29205970
[Au] Autor:Xu WJ; Ji P
[Ad] Endereço:Criminal Police Brigade of Liyang Public Security Bureau, Liyang 213300, China.
[Ti] Título:[Retrospective Analysis of 17 Family Homicide Cases].
[So] Source:Fa Yi Xue Za Zhi;32(6):431-433, 2016 Dec.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To summarize the characteristics of family homicide cases and to provide reference for the analysis and prevention of such cases. METHODS: Seventeen solved family homicide cases in Liyang from 2004 to 2014 were investigated. The original registration information, record of scene investigation, corpse inspection report and case situation were analyzed statistically. RESULTS: The characteristics of the 17 family homicides cases showed that most victims were female and most suspects were male, and spouse infidelity and suspected spouse infidelity have higher proportion in the motives for the killings. Murders by patients with psychosis, camouflage murders and murder-suicides occupied a certain proportion in the family homicide cases. CONCLUSIONS: The family homicide cases are correlated with the family factors such as extramarital sexual intercourse and murder by patients with psychosis. Some suspects suicided after murder. The tools for committing crimes have the features of simplicity, randomness and easy source availability.
[Mh] Termos MeSH primário: Homicídio
Motivação
[Mh] Termos MeSH secundário: Cadáver
Vítimas de Crime
Família
Feminino
Seres Humanos
Masculino
Transtornos Psicóticos
Estudos Retrospectivos
Suicídio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.06.009


  4 / 66424 MEDLINE  
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[PMID]:29188668
[Au] Autor:Xie X; Dong XD
[Ad] Endereço:Criminal Science Office, Suixi Public Security Bureau, Huaibei 235100, China.
[Ti] Título:[Analysis of Forensic Characteristics about 23 Family Homicide Cases].
[So] Source:Fa Yi Xue Za Zhi;32(4):264-265, 2016 Aug.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To provide references for forensic analysis of family homicides cases by analyzing the situations of scene, injuries and individual which were related to the family homicide cases in a county. METHODS: The data of 23 family homicide cases from 2004 to 2013 were collected. The basic situation of individual involved, the relationship between dead and suspect, the cause of death, the motive, the location, time and tools of the crime and the behavior of the suspect after crime etc. were analyzed. RESULTS: The characteristics of the 23 family homicides cases showed that couple relationship was the most common relationship; passion killing was the most common motive; local materials were mostly used as the tools for committing crimes; most crimes were committed in residences; most time of crime was night. CONCLUSIONS: The analysis of family homicide cases should be based on the scene investigation, the examination of the body and combined with the investigation of the situation.
[Mh] Termos MeSH primário: Homicídio
Motivação
[Mh] Termos MeSH secundário: Morte
Família
Ciências Forenses
Seres Humanos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.04.007


  5 / 66424 MEDLINE  
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[PMID]:29178651
[Au] Autor:Laurino MY; Truitt AR; Tenney L; Fisher D; Lindor NM; Veenstra D; Jarvik GP; Newcomb PA; Fullerton SM
[Ad] Endereço:Cancer Prevention Program, Seattle Cancer Care Alliance, Seattle, Washington, USA.
[Ti] Título:Clinical verification of genetic results returned to research participants: findings from a Colon Cancer Family Registry.
[So] Source:Mol Genet Genomic Med;5(6):700-708, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The extent to which participants act to clinically verify research results is largely unknown. This study examined whether participants who received Lynch syndrome (LS)-related findings pursued researchers' recommendation to clinically verify results with testing performed by a CLIA-certified laboratory. METHODS: The Fred Hutchinson Cancer Research Center site of the multinational Colon Cancer Family Registry offered non-CLIA individual genetic research results to select registry participants (cases and their enrolled relatives) from 2011 to 2013. Participants who elected to receive results were counseled on the importance of verifying results at a CLIA-certified laboratory. Twenty-six (76.5%) of the 34 participants who received genetic results completed 2- and 12-month postdisclosure surveys; 42.3% of these (11/26) participated in a semistructured follow-up interview. RESULTS: Within 12 months of result disclosure, only 4 (15.4%) of 26 participants reported having verified their results in a CLIA-certified laboratory; of these four cases, all research and clinical results were concordant. Reasons for pursuing clinical verification included acting on the recommendation of the research team and informing future clinical care. Those who did not verify results cited lack of insurance coverage and limited perceived personal benefit of clinical verification as reasons for inaction. CONCLUSION: These findings suggest researchers will need to address barriers to seeking clinical verification in order to ensure that the intended benefits of returning genetic research results are realized.
[Mh] Termos MeSH primário: Neoplasias Colorretais Hereditárias sem Polipose/diagnóstico
Testes Genéticos
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasias Colorretais Hereditárias sem Polipose/genética
Neoplasias Colorretais Hereditárias sem Polipose/psicologia
Proteínas de Ligação a DNA/genética
Família
Feminino
Pesquisa em Genética
Testes Genéticos/normas
Seres Humanos
Cobertura do Seguro
Laboratórios/normas
Masculino
Meia-Idade
Endonuclease PMS2 de Reparo de Erro de Pareamento/genética
Proteína 1 Homóloga a MutL/genética
Proteína 2 Homóloga a MutS/genética
Sistema de Registros
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (MLH1 protein, human); 0 (Msh6 protein, mouse); EC 3.6.1.- (PMS2 protein, human); EC 3.6.1.3 (MSH2 protein, human); EC 3.6.1.3 (Mismatch Repair Endonuclease PMS2); EC 3.6.1.3 (MutL Protein Homolog 1); EC 3.6.1.3 (MutS Homolog 2 Protein)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.328


  6 / 66424 MEDLINE  
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[PMID]:28460636
[Au] Autor:Saugier-Veber P; Marguet F; Lecoquierre F; Adle-Biassette H; Guimiot F; Cipriani S; Patrier S; Brasseur-Daudruy M; Goldenberg A; Layet V; Capri Y; Gérard M; Frébourg T; Laquerrière A
[Ad] Endereço:Department of Genetics, Normandie Univ, UNIROUEN, INSERM U1245, Normandy Centre for Genomic and Personalized Medicine, Rouen University Hospital, F76000, Rouen, France.
[Ti] Título:Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene.
[So] Source:Acta Neuropathol Commun;5(1):36, 2017 05 01.
[Is] ISSN:2051-5960
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Congenital hydrocephalus is considered as either acquired due to haemorrhage, infection or neoplasia or as of developmental nature and is divided into two subgroups, communicating and obstructive. Congenital hydrocephalus is either syndromic or non-syndromic, and in the latter no cause is found in more than half of the patients. In patients with isolated hydrocephalus, L1CAM mutations represent the most common aetiology. More recently, a founder mutation has also been reported in the MPDZ gene in foetuses presenting massive hydrocephalus, but the neuropathology remains unknown. We describe here three novel homozygous null mutations in the MPDZ gene in foetuses whose post-mortem examination has revealed a homogeneous phenotype characterized by multiple ependymal malformations along the aqueduct of Sylvius, the third and fourth ventricles as well as the central canal of the medulla, consisting in multifocal rosettes with immature cell accumulation in the vicinity of ependymal lining early detached from the ventricular zone. MPDZ also named MUPP1 is an essential component of tight junctions which are expressed from early brain development in the choroid plexuses and ependyma. Alterations in the formation of tight junctions within the ependyma very likely account for the lesions observed and highlight for the first time that primary multifocal ependymal malformations of the ventricular system is genetically determined in humans. Therefore, MPDZ sequencing should be performed when neuropathological examination reveals multifocal ependymal rosette formation within the aqueduct of Sylvius, of the third and fourth ventricles and of the central canal of the medulla.
[Mh] Termos MeSH primário: Proteínas de Transporte/genética
Epêndima/anormalidades
Doenças Fetais/genética
Hidrocefalia/genética
Mutação com Perda de Função
[Mh] Termos MeSH secundário: Adulto
Epêndima/diagnóstico por imagem
Família
Feminino
Doenças Fetais/diagnóstico por imagem
Doenças Fetais/etiologia
Doenças Fetais/patologia
Homozigoto
Seres Humanos
Hidrocefalia/diagnóstico por imagem
Hidrocefalia/etiologia
Hidrocefalia/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (MPDZ protein, human)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s40478-017-0438-4


  7 / 66424 MEDLINE  
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[PMID]:29406647
[Au] Autor:Stokes D
[Ti] Título:Empowering Children with Autism Spectrum Disorder and Their Families within the Healthcare Environment.
[So] Source:Pediatr Nurs;42(5):254-5, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patient and family education is a critical element of diabetes management. Many children with new onset type 1 diabetes present with symptoms of diabetic ketoacidosis (DKA) and are hospitalized at diagnosis. These children and their families receive their initial education in the hospital setting. As soon as blood glucose levels are stabilized and the acidosis is corrected. The patient is discharged home, usually within three days (Nettles, 2005). There is little time to provide the skills and education, as well as emotional support, for a smooth transition to home. It is a challenge to achieve these goals if the only resource person for diabetes education is the clinical nurse specialist (CNS). The CNS for a 14-bed pediatric unit sought to expand the role of the bedside nurse to being the primary educator of patients with diabetes through education and support. All nurses attended an eight-hour workshop on diabetes. A DKA protocol was developed through multidisciplinary collaboration, and nurses were educated on this protocol. Additionally, the CNS organized a diabetes resource cart that contains the tools for diabetes education. The protocol and education materials were uploaded in the Pediatric Share Point site to make them accessible to nurses. Most importantly, the CNS developed a structured patient education plan that is outcome-oriented, and based on review of current literature and practices in the unit. This initiative resulted in an increase in nursing confidence and expertise related to diabetes care as demonstrated by competencies met by nurses and anecdotal evidence from nurses and patients' caregivers.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Crianças com Deficiência/psicologia
Família/psicologia
Pessoal de Saúde/psicologia
Relações Interprofissionais
Poder (Psicologia)
[Mh] Termos MeSH secundário: Adolescente
Adulto
Atitude Frente à Saúde
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  8 / 66424 MEDLINE  
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[PMID]:27776349
[Au] Autor:De Summa S; Guida M; Tommasi S; Strippoli S; Pellegrini C; Fargnoli MC; Pilato B; Natalicchio I; Guida G; Pinto R
[Ad] Endereço:IRCCS Istituto Tumori "Giovanni Paolo II", Molecular Genetics Laboratory, Bari, Italy.
[Ti] Título:Genetic profiling of a rare condition: co-occurrence of albinism and multiple primary melanoma in a Caucasian family.
[So] Source:Oncotarget;8(18):29751-29759, 2017 May 02.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multiple primary melanoma (MPM) is a rare condition, whose genetic basis has not yet been clarified. Only 8-12% of MPM are due to germline mutations of CDKN2A. However, other genes (POT1, BRCA1/2, MC1R, MGMT) have been demonstrated to be involved in predisposition to this pathology.To our knowledge, this is the first family study based on two siblings with the rare coexistence of MPM and oculocutaneous albinism (OCA), an autosomal recessive disease characterized by the absence or decrease in pigmentation in the skin, hair, and eyes.In this study, we evaluated genes involved in melanoma predisposition (CDKN2A, CDK4, MC1R, MITF, POT1, RB1, MGMT, BRCA1, BRCA2), pathogenesis (BRAF, NRAS, PIK3CA, KIT, PTEN), skin/hair pigmentation (MC1R, MITF) and in immune pathways (CTLA4) to individuate alterations able to explain the rare onset of MPM and OCA in indexes and the transmission in their pedigree.From the analysis of the pedigree, we were able to identify a "protective" haplotype with respect to MPM, including MGMT p.I174V alteration. The second generation offspring is under strict follow up as some of them have a higher risk of developing MPM according to our model.
[Mh] Termos MeSH primário: Albinismo/genética
Estudos de Associação Genética
Predisposição Genética para Doença
Mutação em Linhagem Germinativa
Melanoma/genética
Mutação
Neoplasias Primárias Múltiplas/genética
[Mh] Termos MeSH secundário: Albinismo/diagnóstico
Biomarcadores
Biologia Computacional/métodos
Metilação de DNA
Metilases de Modificação do DNA/química
Metilases de Modificação do DNA/genética
Análise Mutacional de DNA
Enzimas Reparadoras do DNA/química
Enzimas Reparadoras do DNA/genética
Família
Feminino
Genótipo
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Masculino
Melanoma/diagnóstico
Meia-Idade
Modelos Moleculares
Anotação de Sequência Molecular
Neoplasias Primárias Múltiplas/diagnóstico
Linhagem
Filogenia
Conformação Proteica
Irmãos
Proteínas Supressoras de Tumor/química
Proteínas Supressoras de Tumor/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Tumor Suppressor Proteins); EC 2.1.1.- (DNA Modification Methylases); EC 2.1.1.63 (MGMT protein, human); EC 6.5.1.- (DNA Repair Enzymes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.12777


  9 / 66424 MEDLINE  
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[PMID]:28470789
[Au] Autor:Kulkarni SS; Vasantha K; Gogri H; Parchure D; Madkaikar M; Férec C; Fichou Y
[Ad] Endereço:National Institute of Immunohaematology, Indian Council of Medical Research (NIIH-ICMR), Mumbai, India.
[Ti] Título:First report of Rh individuals in the Indian population and characterization of the underlying molecular mechanisms.
[So] Source:Transfusion;57(8):1944-1948, 2017 08.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rh phenotype is an extremely rare condition characterized by no expression of Rh antigens at the surface of red blood cells. Although rare, genetic bases of this phenotype are well known and include mutations within either the RH (RHD and RHCE) genes or the RHAG gene. So far Rh has been reported in individuals of Caucasian, African, and Asian origin. Here, we report individuals from two families of Indian origin representing such a rare phenotype. STUDY DESIGN AND METHODS: Serologic analysis was carried out by testing with anti-D, -C, -c, -E, and -e in Rh individuals and their family members. RH genes were analyzed by standard molecular approaches, including Sanger sequencing and quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments. RHAG gene was investigated by exon-specific PCR amplification and Sanger sequencing. RESULTS: In one family, RHAG gene was found to be deleted at the homozygous state in the propositus, suggesting Rh of the regulator type. In the other family, a novel splice site variant in RHCE in cis with whole RHD gene deletion was identified at the homozygous state. Further functional analysis by minigene splicing assay showed that this variation, that is, c.801 + 1G>A, completely impairs normal splicing, then inactivating the expression of RhCE protein. Contrary to the former case, these data suggest Rh of the amorph type. CONCLUSION: Overall, we report for the first time the molecular mechanisms responsible for Rh phenotype in individuals of Indian origin. This study contributes to extend the molecular spectrum of variations in Rh individuals.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Linhagem
Sistema do Grupo Sanguíneo Rh-Hr/genética
[Mh] Termos MeSH secundário: Proteínas Sanguíneas/genética
Família
Feminino
Deleção de Genes
Seres Humanos
Índia/epidemiologia
Masculino
Glicoproteínas de Membrana/genética
Processamento de RNA/genética
Testes Sorológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Membrane Glycoproteins); 0 (RHAG protein, human); 0 (RHCE protein, human); 0 (Rh-Hr Blood-Group System)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14150


  10 / 66424 MEDLINE  
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[PMID]:29292950
[Au] Autor:Barlöv K
[Ti] Título:Anhörigveto försvårar organdonation..
[So] Source:Lakartidningen;114, 2017 11 27.
[Is] ISSN:1652-7518
[Cp] País de publicação:Sweden
[La] Idioma:swe
[Mh] Termos MeSH primário: Consentimento Presumido
Obtenção de Tecidos e Órgãos/legislação & jurisprudência
[Mh] Termos MeSH secundário: Família
Seres Humanos
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde