Base de dados : MEDLINE
Pesquisa : F01.829.263.065 [Categoria DeCS]
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[PMID]:28463711
[Au] Autor:Sands A; Thompson EJ; Gaysina D
[Ad] Endereço:EDGE Lab, School of Psychology, University of Sussex, UK.
[Ti] Título:Long-term influences of parental divorce on offspring affective disorders: A systematic review and meta-analysis.
[So] Source:J Affect Disord;218:105-114, 2017 Aug 15.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prevalence of divorce in Western countries has increased in recent decades. However, there is no recent systematic review and/or meta-analysis of studies testing for long-term effects of parental divorce on offspring affective disorders. The present study conducted a systematic review and meta-analysis of studies published since 1980 testing for the association between parental divorce and offspring depression and anxiety in adulthood. METHOD: PUBMED, Science Direct, Medline, PsychInfo, and PsychArticles databases were searched for eligible studies. Random-effect meta-analyses were used to synthesize effect sizes and to test whether associations of parental divorce with offspring affective disorders differed among three publication periods (i.e., before 1996, 1996-2005, 2006-2015). RESULTS: In total, 29 studies were eligible for the systematic review, and 18 studies were included in the meta-analyses (depression: n=21,581; anxiety: n=2472). There was significant association between parental divorce and offspring depression (OR=1.56; 95%CI [1.31, 1.86]), but not anxiety (OR=1.16; 95%CI [0.98, 1.38]). The effect of parental divorce on offspring depression was not weaker in the reports published in more recent decades. LIMITATIONS: There is limited research in relation to offspring anxiety in adulthood. CONCLUSIONS: Parental divorce is associated with an increased risk of adult offspring depression, with no indication of the effect being weaker in recent publications.
[Mh] Termos MeSH primário: Crianças Adultas/psicologia
Ansiedade/psicologia
Depressão/psicologia
Divórcio/psicologia
Transtornos do Humor/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Pais/psicologia
Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28844163
[Au] Autor:Benkel I; Molander U
[Ad] Endereço:1 University of Gothenburg, Sweden.
[Ti] Título:A Qualitative Study of the Experiences of Parents With an Adult Child Who Has a Severe Disease: Existential Questions Will Be Raised.
[So] Source:Inquiry;54:46958017727107, 2017 Jan 01.
[Is] ISSN:1945-7243
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A prominent existential concept is that elderly parents should naturally become severely ill or die before a younger person does. If the reverse should happen, it may influence the parent's existential view of life. The aim of this study was to investigate the existential issues during illness time. This was a qualitative study with in-depth interviews and was conducted in a University Hospital in western Sweden. Eleven parents agreed to participate in individual interviews at baseline and 1 year later. The total number of interviews completed was 19. The study identified 5 areas according to an existential perspective: life took the wrong path, the age of the child, difficult to see the child as sick, worrying about the child, and the relationship with the adult child. Existential questions are often present in those circumstances and can be raised in conversations with parents. Existential questions began to arise for the parent when the child was diagnosed with the severe illness. The situation of having a severely ill child caused both fear and anxiety that the worst-case scenario they could imagine, that the child will die, might happen. Further research is required on this rarely investigated subject of having an adult child with a severe disease.
[Mh] Termos MeSH primário: Crianças Adultas
Existencialismo/psicologia
Neoplasias/mortalidade
Pais/psicologia
[Mh] Termos MeSH secundário: Adaptação Psicológica
Atitude Frente à Morte
Seres Humanos
Entrevistas como Assunto
Relações Pais-Filho
Pesquisa Qualitativa
Índice de Gravidade de Doença
Suécia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1177/0046958017727107


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[PMID]:28575259
[Au] Autor:Dong X; Li G; Simon MA
[Ad] Endereço:Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois.
[Ti] Título:The Association Between Childhood Abuse and Elder Abuse Among Chinese Adult Children in the United States.
[So] Source:J Gerontol A Biol Sci Med Sci;72(suppl_1):S69-S75, 2017 Jul 01.
[Is] ISSN:1758-535X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: The previous researchers have postulated that an abused child may abuse his or her abuser parent when the parent is getting old, also known as the intergenerational transmission of violence. However, few studies use data to support this model, and it has yet to be examined in the U.S. Chinese community. This study aims to examine the association between childhood abuse and elder abuse reported by Chinese adult children in the United States. Methods: Guided by a community-based participatory research approach, 548 Chinese adult children aged 21 years and older participated in this study. Childhood abuse was assessed by four-item Hurt-Insult-Threaten-Scream (HITS) scale. Elder abuse was assessed by a 10-item instrument derived from the Caregiver Abuse Screen (CASE). Logistic regression analysis was performed. Results: Childhood abuse was associated with caregiver abuse screen results (odds ratio = 1.92, 95% confidence interval = 1.24-2.95). Being physically hurt (r = .13, p < .01), insulted (r = .15, p < .001), threatened (r = .12, p < .01), and screamed at (r = .18, p < .001) as a child were significantly correlated with caregiver abuse screen results. Conclusion: This study suggests that childhood abuse is associated with increased risk of elder abuse among Chinese adult children in the United States. Longitudinal research should be conducted to explore the mechanisms through which childhood abuse and its subtypes links with elder abuse.
[Mh] Termos MeSH primário: Crianças Adultas/etnologia
Americanos Asiáticos/estatística & dados numéricos
Cuidadores/estatística & dados numéricos
Maus-Tratos Infantis/etnologia
Maus-Tratos ao Idoso/etnologia
Pais
[Mh] Termos MeSH secundário: Adulto
Crianças Adultas/estatística & dados numéricos
Idoso
Chicago/epidemiologia
Criança
Maus-Tratos Infantis/estatística & dados numéricos
Estudos Transversais
Maus-Tratos ao Idoso/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Prevalência
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1093/gerona/glw205


  4 / 1024 MEDLINE  
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[PMID]:28560924
[Au] Autor:Laidlaw J
[Ad] Endereço:Ashford, Kent.
[Ti] Título:Anguish at outliving our adult children.
[So] Source:Nurs Older People;29(5):15, 2017 May 31.
[Is] ISSN:1472-0795
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:'Old age ain't no place for sissies', film star Bette Davis (pictured) once said, and how right she was.
[Mh] Termos MeSH primário: Crianças Adultas
Luto
Pais/psicologia
Estresse Psicológico/psicologia
[Mh] Termos MeSH secundário: Enfermagem Geriátrica
Seres Humanos
Casas de Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.7748/nop.29.5.15.s21


  5 / 1024 MEDLINE  
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[PMID]:28535172
[Au] Autor:Manson JE; Bassuk SS
[Ti] Título:Invited Commentary: The Framingham Offspring Study-A Pioneering Investigation Into Familial Aggregation of Cardiovascular Risk.
[So] Source:Am J Epidemiol;185(11):1103-1108, 2017 Jun 01.
[Is] ISSN:1476-6256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Launched in 1948, the Framingham Heart Study was a seminal prospective cohort study of 5,209 adult residents of Framingham, Massachusetts, that was designed to uncover the determinants and natural history of coronary heart disease. Data from this original cohort established the cardiac threat posed by high blood pressure, high cholesterol, smoking, obesity, physical inactivity, diabetes, and other factors. In the late 1960s, investigators conceived the innovative idea of assembling a second cohort that comprised the adult children of the original study population (and these children's spouses). From 1971 to 1975, a total of 5,124 individuals were recruited to form the Offspring Cohort. Studying successive generations in this fashion provided an efficient method for examining secular trends in cardiovascular disease and its risk factors, as well as an opportunity to assess familial aggregation of risk without the threat of recall bias. In a paper published in the September 1979 issue of the Journal, then study director William Kannel et al. (Am J Epidemiol. 1979;110(3):281-290) described the sampling design of the Offspring Study and presented selected baseline characteristics of the cohort. The scientific questions addressed by this research provided the impetus for a decades-long effort-still in full force today both within the Framingham Study itself and in the broader cardiovascular epidemiologic community-to quantify the independent and synergistic effects of genetic, lifestyle, and other environmental factors on cardiovascular outcomes.
[Mh] Termos MeSH primário: Crianças Adultas
Doenças Cardiovasculares/epidemiologia
Estudos Epidemiológicos
[Mh] Termos MeSH secundário: Doenças Cardiovasculares/genética
Doença das Coronárias/epidemiologia
Diabetes Mellitus/epidemiologia
Meio Ambiente
Métodos Epidemiológicos
Predisposição Genética para Doença
Seres Humanos
Hipercolesterolemia/epidemiologia
Hipertensão/epidemiologia
Estilo de Vida
Obesidade/epidemiologia
Estudos Prospectivos
Fatores de Risco
Estilo de Vida Sedentário
Fumar/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1093/aje/kwx068


  6 / 1024 MEDLINE  
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[PMID]:28430851
[Au] Autor:Lix LM; Leslie WD; Yang S; Yan L; Walld R; Morin SN; Majumdar SR; Roos LL
[Ti] Título:Accuracy of Offspring-Reported Parental Hip Fractures: A Novel Population-Based Parent-Offspring Record Linkage Study.
[So] Source:Am J Epidemiol;185(10):974-981, 2017 May 15.
[Is] ISSN:1476-6256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to test the validity of offspring-reported parental hip fracture in a unique bone mineral density (BMD) registry linked to administrative databases spanning 4 decades. Population-based data were from Manitoba, Canada, and included hospital abstracts, health insurance registrations, and the provincewide BMD registry. The cohort included individuals aged ≥40 years with BMD tests and self-reports of parental hip fracture between 2006 and 2014. Population registry data for 1966-2014 were used to link offspring with their parents, and hospital records were used to ascertain parental fractures. Overall, 8,112 offspring met the inclusion criteria; 13.6% had a parental hip fracture diagnosis in administrative data during an average of 32.9 years of follow-up. Agreement between parental hip fracture from offspring reports and diagnoses in administrative data was good (κ = 0.68). The sensitivity of offspring reports was 0.70 (95% confidence interval: 0.67, 0.73), and specificity was 0.96 (95% confidence interval: 0.96, 0.97). Offspring characteristics associated with disagreement included male sex, northern rural residence, early BMD test year, and longer interval between BMD test and parental hip fracture diagnosis. This proof-of-concept study focused on hip fractures, but use of record linkage techniques to validate offspring-reported parental information can be extended to other conditions.
[Mh] Termos MeSH primário: Crianças Adultas/estatística & dados numéricos
Densidade Óssea
Fraturas do Quadril/epidemiologia
Registro Médico Coordenado/normas
Sistema de Registros/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Manitoba
Meia-Idade
Reprodutibilidade dos Testes
Distribuição Espacial da População
Fatores Sexuais
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1093/aje/kww197


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[PMID]:28417203
[Au] Autor:Tometich DB; Mosher CE; Winger JG; Badr HJ; Snyder DC; Sloane RJ; Demark-Wahnefried W
[Ad] Endereço:Department of Psychology, Indiana University-Purdue University Indianapolis, 402 North Blackford Street, LD 133, Indianapolis, IN, 46202, USA. dbtometi@iupui.edu.
[Ti] Título:Effects of diet and exercise on weight-related outcomes for breast cancer survivors and their adult daughters: an analysis of the DAMES trial.
[So] Source:Support Care Cancer;25(8):2559-2568, 2017 Aug.
[Is] ISSN:1433-7339
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Few trials have aimed to promote diet and exercise behaviors in both cancer survivors and their family members and examine their associations with weight-related outcomes. We conducted a secondary analysis to examine associations between change in diet and exercise behaviors and weight-related outcomes for overweight breast cancer survivors and their overweight adult daughters in the Daughters And MothErS Against Breast Cancer (DAMES) randomized trial. METHODS: The DAMES trial assessed the impact of two iteratively tailored, mailed print diet and exercise interventions against standard brochures over a 12-month period. This analysis examined change in diet and exercise behaviors and weight-related variables from baseline to post-intervention for the 50 breast cancer survivors and their adult daughters randomized to the intervention arms. To reduce the potential for type II error in this pilot, p values <0.10 were considered statistically significant. RESULTS: For mothers, change in diet quality was uniquely related to change in BMI (ß = -0.12, p = 0.082), weight (ß = -0.12, p = 0.060), and waist circumference (ß = -0.38, p = 0.001), whereas change in caloric intake was related to waist circumference (ß = 0.21, p = 0.002). For daughters, change in caloric intake was related to change in waist circumference (ß = 0.12, p = 0.055). However, change in diet quality was not associated with weight-related outcomes in daughters. Additionally, change in exercise was not associated with weight-related outcomes in mothers or daughters. CONCLUSIONS: Findings support mail-based and other tailored interventions for weight loss in this population, with an emphasis on diet quality for breast cancer survivors and caloric intake for their adult daughters.
[Mh] Termos MeSH primário: Neoplasias da Mama/complicações
Sobreviventes/psicologia
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Adulto
Crianças Adultas
Peso Corporal
Dieta
Exercício
Feminino
Seres Humanos
Meia-Idade
Mães
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1007/s00520-017-3665-0


  8 / 1024 MEDLINE  
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[PMID]:28413567
[Au] Autor:Houshmand-Oeregaard A; Hansen NS; Hjort L; Kelstrup L; Broholm C; Mathiesen ER; Clausen TD; Damm P; Vaag A
[Ad] Endereço:Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, Dept. 7821, Blegdamsvej 9, 2100 Copenhagen, Denmark.
[Ti] Título:Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy.
[So] Source:Clin Epigenetics;9:37, 2017.
[Is] ISSN:1868-7083
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: , , ) play key roles in the pathophysiology of T2DM. We hypothesized that offspring exposed to maternal diabetes exhibit alterations in epigenetic regulation of subcutaneous adipose tissue (SAT) adipokine transcription. We studied adipokine plasma levels, SAT gene expression, and DNA methylation of , , and in adult offspring of women with gestational diabetes (O-GDM, = 82) or type 1 diabetes (O-T1DM, = 67) in pregnancy, compared to offspring of women from the background population (O-BP, = 57). RESULTS: Compared to O-BP, we found elevated plasma leptin and resistin levels in O-T1DM, decreased gene expression of all adipokines in O-GDM, decreased expression in O-T1DM, and increased and methylation in O-GDM. In multivariate regression analysis, O-GDM remained associated with increased methylation and decreased and gene expression and O-T1DM remained associated with decreased expression after adjustment for potential confounders and mediators. CONCLUSIONS: In conclusion, offspring of women with diabetes in pregnancy exhibit increased DNA methylation and decreased and gene expression in SAT. However, altered methylation and expression levels were not reflected in plasma protein levels, and the functional implications of these findings remain uncertain.
[Mh] Termos MeSH primário: Adiponectina/genética
Metilação de DNA
Diabetes Mellitus Tipo 2/genética
Leptina/genética
Exposição Materna/efeitos adversos
Resistina/genética
Gordura Subcutânea/metabolismo
[Mh] Termos MeSH secundário: Adiponectina/sangue
Adiponectina/metabolismo
Crianças Adultas
Diabetes Mellitus Tipo 1/epidemiologia
Diabetes Gestacional/epidemiologia
Epigênese Genética
Feminino
Seguimentos
Regulação da Expressão Gênica
Predisposição Genética para Doença
Seres Humanos
Leptina/sangue
Gravidez
Resistina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (ADIPOQ protein, human); 0 (Adiponectin); 0 (Leptin); 0 (RETN protein, human); 0 (Resistin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1186/s13148-017-0338-2


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[PMID]:28346066
[Au] Autor:Greene N; McGovern K
[Ad] Endereço:a Clinical Psychology Program , The Wright Institute , Berkeley , California , USA.
[Ti] Título:Gratitude, psychological well-being, and perceptions of posttraumatic growth in adults who lost a parent in childhood.
[So] Source:Death Stud;41(7):436-446, 2017 08.
[Is] ISSN:1091-7683
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Findings from an online survey of 350 adults who experienced early parental death showed that current dispositional gratitude was positively correlated with psychological well-being and posttraumatic growth and negatively correlated with depression. Further, 281 participants produced textual responses indicating they could remember the time following their parent's death. Increases in gratitude attributable to the experience of losing a parent were reported by 79% of these participants. They associated their increased gratitude with a newfound belief that life is precious and with greater appreciation for loved ones. Direction of change in gratitude was associated with psychological well-being, posttraumatic growth, and depression.
[Mh] Termos MeSH primário: Crianças Adultas/psicologia
Ajustamento Emocional
Relações Pais-Filho
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Luto
Morte
Emoções
Feminino
Seres Humanos
Masculino
Meia-Idade
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1080/07481187.2017.1296505


  10 / 1024 MEDLINE  
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[PMID]:28325769
[Au] Autor:Rajendran M; Nachbagauer R; Ermler ME; Bunduc P; Amanat F; Izikson R; Cox M; Palese P; Eichelberger M; Krammer F
[Ad] Endereço:Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
[Ti] Título:Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin.
[So] Source:MBio;8(2), 2017 Mar 21.
[Is] ISSN:2150-7511
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity to a panel of N1, N2, and influenza B virus neuraminidases in different age groups, including children, adults, and the elderly. Using enzyme-linked immunosorbent assays (ELISA), we determined the breadth, magnitude, and isotype distribution of neuraminidase antibody responses to historic, current, and avian strains, as well as to recent isolates to which these individuals have not been exposed. It appears that antibody levels against N1 neuraminidases were lower than those against N2 or B neuraminidases. The anti-neuraminidase antibody levels increased with age and were, in general, highest against strains that circulated during the childhood of the tested individuals, providing evidence for "original antigenic sin." Titers measured by ELISA correlated well with titers measured by the neuraminidase inhibition assays. However, in the case of the 2009 pandemic H1N1 virus, we found evidence of interference from antibodies binding to the conserved stalk domain of the hemagglutinin. In conclusion, we found that antibodies against the neuraminidase differ in magnitude and breadth between subtypes and age groups in the human population. (This study has been registered at ClinicalTrials.gov under registration no. NCT00336453, NCT00539981, and NCT00395174.) Anti-neuraminidase antibodies can afford broad protection from influenza virus infection in animal models and humans. However, little is known about the breadth and magnitude of the anti-neuraminidase response in the human population. Here we assessed antibody levels of children, adults, and the elderly against a panel of N1, N2, and type B influenza virus neuraminidases. We demonstrated that antibody levels measured by ELISA correlate well with functional neuraminidase inhibition titers. This is an important finding since ELISA is a simpler method than functional assays and can be implemented in high-throughput settings to analyze large numbers of samples. Furthermore, we showed that low titers of broadly cross-reactive antibodies against neuraminidase are prevalent in humans. By the use of an appropriate vaccination strategy, these titers could potentially be boosted to levels that might provide broad protection from influenza virus infection.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Neuraminidase/imunologia
Proteínas Virais/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Crianças Adultas
Fatores Etários
Idoso
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Lactente
Meia-Idade
Neuraminidase/análise
Ensaios Clínicos Controlados Aleatórios como Assunto
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Viral Proteins); EC 3.2.1.18 (NA protein, influenza A virus); EC 3.2.1.18 (NA protein, influenza B virus); EC 3.2.1.18 (Neuraminidase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE



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