Base de dados : MEDLINE
Pesquisa : F01.829.458.205.250 [Categoria DeCS]
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[Au] Autor:McMillan F
[So] Source:Aust Nurs Midwifery J;24(7):28, 2017 02.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:If the Close the Gap Campaign is working to achieve health and life expectation equality, are we creating an ageing health workforce to work with older Aboriginal and Torres Strait Islander people?
[Mh] Termos MeSH primário: Necessidades e Demandas de Serviços de Saúde
Serviços de Saúde do Indígena
Envelhecimento Saudável
[Mh] Termos MeSH secundário: Austrália
Disparidades nos Níveis de Saúde
Seres Humanos
Grupo com Ancestrais Oceânicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE

  2 / 4 MEDLINE  
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[Au] Autor:Pismenetskaya IU; Butters TD
[Ti] Título:Serum glycomarkers of endoplasmic reticulum and lysosomal-endosomal system stress in human healthy aging and diseases.
[So] Source:Ukr Biochem J;89(1):59-70, 2017 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:To verify the idea that extracellular free oligosaccharides might be able to reflect the functional status of the endoplasmic reticulum (ER) and lysosomal-endosomal system, HPLC-profiles of serum-derived free oligosaccharides (FOS) in human healthy aging, acute myeloproliferative neoplasms, and cardiovascular pathologies were compared with intracellular glycans. After plasma deproteinization and FOS purification the oligosaccharides were labelled with anthranilic acid, separated into the neutral and charged with QAE Sephadex (Q25-120) chromatography and analysed using high-performance liquid chromatography (HPLC). The charged FOS were digested with a sialidase and compared with free oligosaccharides from transferrin for structural decoding. HPLC-profiles of serum-derived FOS revealed mild delay of the dolichol phosphate cycle in ER, moderate intensification of ER-associated degradation (ERAD) and degradation in endosomal-lysosomal system with aging; an inhibition of the dolichol phosphate cycle, intensification of ERAD and increasing of lysosomal exocytosis in acute myeloproliferative neoplasms; intensification of ERAD and glycocojugate degradation with endosomal-lysosomal system in cardiovascular diseases. As serum free oligosaccharides are able to reflect specifically perturbations in ER and endosomal-lysosomal system under wide range of stressors they can serve as extracellular markers of functionality of these organelles.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/sangue
Fosfatos de Dolicol/sangue
Degradação Associada com o Retículo Endoplasmático
Envelhecimento Saudável/sangue
Transtornos Mieloproliferativos/sangue
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Sequência de Carboidratos
Doenças Cardiovasculares/diagnóstico
Estudos de Casos e Controles
Retículo Endoplasmático/metabolismo
Seres Humanos
Transtornos Mieloproliferativos/diagnóstico
Coloração e Rotulagem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dolichol Phosphates); 0 (Glycoconjugates); 0 (Oligosaccharides); 0 (ortho-Aminobenzoates); 0YS975XI6W (anthranilic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj89.01.059

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[Au] Autor:Strandberg T; Kivipelto M
[Ti] Título:Healthy habits - healthy brain.
[So] Source:Duodecim;133(2):195-200, 2017.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:A multifactorial memory disease with old-age onset forms a continuum having at one end a "clear" Alzheimer-type form, with a pathophysiology involving a central role played by the accumulation of amyloid protein, and a purely arterial disease at the other end. Most of the cases exhibit a mixed form. As the options of prevention of arterial diseases are well known, this will also provide possibilities for extensive prevention of memory diseases. Central measures include physical activity, a healthy diet and intervention in risk factors - early enough, of course. What is good for the heart is generally good for the brain as well.
[Mh] Termos MeSH primário: Transtornos Cerebrovasculares/prevenção & controle
Transtornos Cerebrovasculares/fisiopatologia
Envelhecimento Saudável/fisiologia
Dieta Saudável
Estilo de Vida Saudável
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE

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[Au] Autor:Guadalupe-Grau A; Carnicero JA; Losa-Reyna J; Tresguerres J; Gómez-Cabrera MD; Castillo C; Alfaro-Acha A; Rosado-Artalejo C; Rodriguez-Mañas L; García-García FJ
[Ad] Endereço:ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences-INEF, Technical University of Madrid, Madrid, Spain; Hospital Virgen del Valle (Complejo Hospitalario de Toledo), Red Española de Investigación en Fragilidad y Envejecimiento (RETICEF),
[Ti] Título:Endocrinology of Aging From a Muscle Function Point of View: Results From the Toledo Study for Healthy Aging.
[So] Source:J Am Med Dir Assoc;18(3):234-239, 2017 Mar 01.
[Is] ISSN:1538-9375
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Aging is a process that involves a reduction in muscle strength and anabolic hormone concentrations, which impacts significantly on health. AIM: To study the hormone/total strength (H/TS) ratio as a proxy of anabolic insensitivity status in elders, and its relationship with disability, hospitalization, and mortality risk. DESIGN: A total of 1462 persons aged ≥65 years from the Toledo Study of Healthy Aging participated in this study. Serum concentrations of insulin like growth factor 1, total and free testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and 17ß-estradiol were measured. Total maximal voluntary isometric strength was obtained (handgrip, shoulder, hip, and knee) using standardized techniques and equipment. Physical activity was recorded by physical activity scale for the elderly questionnaire. Associations of the H/TS ratio with hospitalization and mortality were assessed using logistic regression models, and participants stratified into quartiles for each H/TS ratio. RESULTS: In women, all individual ratio H/TS models showed a strong to moderate increased risk for death and hospitalization. In men, all models revealed a significant positive association of the ratio H/TS with mortality rate but not for hospitalization (P < .01). Participants who have 2 or more H/TS ratios in the worst quartile increased the risk of hospitalization and mortality at least by 2-fold. CONCLUSIONS: We demonstrate the main role that muscle function plays in the relationship between the hormonal status and hospitalization and mortality risk; this could be taken into consideration as a way to classify patients for hormonal therapy.
[Mh] Termos MeSH primário: Sistema Endócrino/metabolismo
Envelhecimento Saudável
Força Muscular/fisiologia
Músculo Esquelético/metabolismo
Músculo Esquelético/fisiologia
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE

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