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  1 / 1904 MEDLINE  
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[PMID]:28659274
[Au] Autor:Calvin CM; Batty GD; Der G; Brett CE; Taylor A; Pattie A; Cukic I; Deary IJ
[Ad] Endereço:Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK I.Deary@ed.ac.uk catherine.calvin@psych.ox.ac.uk.
[Ti] Título:Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study.
[So] Source:BMJ;357:j2708, 2017 Jun 28.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To examine the association between intelligence measured in childhood and leading causes of death in men and women over the life course. Prospective cohort study based on a whole population of participants born in Scotland in 1936 and linked to mortality data across 68 years of follow-up. Scotland. 33 536 men and 32 229 women who were participants in the Scottish Mental Survey of 1947 (SMS1947) and who could be linked to cause of death data up to December 2015. Cause specific mortality, including from coronary heart disease, stroke, specific cancer types, respiratory disease, digestive disease, external causes, and dementia. Childhood intelligence was inversely associated with all major causes of death. The age and sex adjusted hazard ratios (and 95% confidence intervals) per 1 SD (about 15 points) advantage in intelligence test score were strongest for respiratory disease (0.72, 0.70 to 0.74), coronary heart disease (0.75, 0.73 to 0.77), and stroke (0.76, 0.73 to 0.79). Other notable associations (all P<0.001) were observed for deaths from injury (0.81, 0.75 to 0.86), smoking related cancers (0.82, 0.80 to 0.84), digestive disease (0.82, 0.79 to 0.86), and dementia (0.84, 0.78 to 0.90). Weak associations were apparent for suicide (0.87, 0.74 to 1.02) and deaths from cancer not related to smoking (0.96, 0.93 to 1.00), and their confidence intervals included unity. There was a suggestion that childhood intelligence was somewhat more strongly related to coronary heart disease, smoking related cancers, respiratory disease, and dementia in women than men (P value for interactions <0.001, 0.02, <0.001, and 0.02, respectively).Childhood intelligence was related to selected cancer presentations, including lung (0.75, 0.72 to 0.77), stomach (0.77, 0.69 to 0.85), bladder (0.81, 0.71 to 0.91), oesophageal (0.85, 0.78 to 0.94), liver (0.85, 0.74 to 0.97), colorectal (0.89, 0.83 to 0.95), and haematopoietic (0.91, 0.83 to 0.98). Sensitivity analyses on a representative subsample of the cohort observed only small attenuation of the estimated effect of intelligence (by 10-26%) after adjustment for potential confounders, including three indicators of childhood socioeconomic status. In a replication sample from Scotland, in a similar birth year cohort and follow-up period, smoking and adult socioeconomic status partially attenuated (by 16-58%) the association of intelligence with outcome rates. In a whole national population year of birth cohort followed over the life course from age 11 to age 79, higher scores on a well validated childhood intelligence test were associated with lower risk of mortality ascribed to coronary heart disease and stroke, cancers related to smoking (particularly lung and stomach), respiratory diseases, digestive diseases, injury, and dementia.
[Mh] Termos MeSH primário: Causas de Morte
Inteligência/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Seguimentos
Inquéritos Epidemiológicos
Seres Humanos
Longevidade/fisiologia
Masculino
Meia-Idade
Carência Psicossocial
Medição de Risco
Escócia/epidemiologia
Fatores Socioeconômicos
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j2708


  2 / 1904 MEDLINE  
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[PMID]:28615374
[Au] Autor:Larson LM; Young MF; Ramakrishnan U; Webb Girard A; Verma P; Chaudhuri I; Srikantiah S; Martorell R
[Ad] Endereço:Nutrition and Health Sciences Program, Laney Graduate School and leila.larson@emory.edu.
[Ti] Título:A Cross-Sectional Survey in Rural Bihar, India, Indicates That Nutritional Status, Diet, and Stimulation Are Associated with Motor and Mental Development in Young Children.
[So] Source:J Nutr;147(8):1578-1585, 2017 Aug.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many malnourished children in resource-poor settings fail to fulfill their developmental potential. The objectives of this analysis were to examine the nutritional, psychosocial, environmental, and household correlates of child development in Bihar, India, and identify mediators between dietary diversity and mental development. Using 2-stage cluster randomized sampling, we surveyed 4360 households with children 6-18 mo of age in the West Champaran district of Bihar. We measured motor and mental development with the use of the Developmental Milestones Checklist II. In a random subsample ( = 2838), we measured anthropometric characteristics and hemoglobin. Cluster-adjusted multiple linear regression analysis was used to examine the associations between nutrition indicators and development scores. Sobel's test was used to assess significant mediators in the association between diet diversity and development scores. Analyses were stratified by children 6-11 and 12-18 mo of age. In all children, length-for-age score (LAZ), dietary diversity, and psychosocial stimulation were significant ( < 0.05) correlates of motor development scores [(ß coefficient ± SE) in children 6-11 mo: LAZ = 0.46 ± 0.08, dietary diversity = 0.43 ± 0.09, and stimulation = 0.15 ± 0.04; in children 12-18 mo: LAZ = 0.73 ± 0.07, dietary diversity = 0.30 ± 0.09, and stimulation = 0.31 ± 0.05] and mental development scores [(ß coefficient ± SE) in children 6-11 mo: LAZ = 0.57 ± 0.10, dietary diversity = 0.84 ± 0.13, and stimulation = 0.54 ± 0.07; in children 12-18 mo: LAZ = 0.54 ± 0.11, dietary diversity = 0.40 ± 0.16, and stimulation = 0.62 ± 0.09]. Stimulation, gross motor development, and fine motor development were significant mediators in the relation between dietary diversity and mental development. Strategies to improve dietary diversity and psychosocial stimulation could have important implications for child development of young North Indian children. This trial was registered at clinicaltrials.gov as NCT02593136.
[Mh] Termos MeSH primário: Desenvolvimento Infantil
Dieta
Comportamento Alimentar
Fenômenos Fisiológicos da Nutrição do Lactente
Destreza Motora
Estado Nutricional
Carência Psicossocial
[Mh] Termos MeSH secundário: Fatores Etários
Estudos Transversais
Dieta/normas
Feminino
Seres Humanos
Índia
Lactente
Masculino
Meio Social
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.251231


  3 / 1904 MEDLINE  
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[PMID]:28236340
[Au] Autor:Béjot Y; Guilloteau A; Joux J; Lannuzel A; Mimeau E; Mislin-Tritsch C; Fournel I; Bonithon-Kopp C; INDIA Study Group
[Ad] Endereço:Neurology Department and Dijon Stroke Registry, University Hospital of Dijon, Dijon.
[Ti] Título:Social deprivation and stroke severity on admission: a French cohort study in Burgundy and the West Indies - Guyana region.
[So] Source:Eur J Neurol;24(5):694-702, 2017 May.
[Is] ISSN:1468-1331
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Although there is growing and convincing evidence that socially deprived patients are at higher risk of stroke and worse outcomes, it remains controversial whether or not they suffer more severe stroke. This study aimed to evaluate the influence of social deprivation on initial clinical severity in patients with stroke. METHODS: A total of 1536 consecutive patients with an acute first-ever stroke (both ischaemic stroke and intracerebral hemorrhage) were prospectively enrolled from six French study centers. Stroke severity on admission was measured by the National Institutes of Health Stroke Scale score. Social deprivation was assessed at the individual level by the Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examen de Santé (EPICES) score, a validated multidimensional questionnaire, and several additional single socioeconomic indicators. Polytomous logistic regression analyses were performed to evaluate the association between social deprivation and stroke severity. RESULTS: In univariate analysis, the EPICES score (P = 0.039) and level of education (P = 0.018) were the only two socioeconomic variables associated with stroke severity. Multivariate analysis of the association between EPICES and National Institutes of Health Stroke Scale scores showed that more deprived patients presented a significantly higher risk of both mild and moderate/severe stroke (odds ratio for mild versus minor stroke, 1.39; 95% confidence interval, 1.06-1.84; odds ratio for moderate/severe versus minor stroke, 1.44; 95% confidence interval, 1.09-1.92). A non-significant trend towards a higher risk of both mild and moderate/severe stroke in less educated patients was observed. CONCLUSIONS: Social deprivation was associated with a more severe clinical presentation in patients with stroke. These findings may contribute to the worse outcome after stroke in deprived patients, and underline the need for strategies to reduce social inequalities for stroke.
[Mh] Termos MeSH primário: Carência Psicossocial
Acidente Vascular Cerebral/etnologia
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Isquemia Encefálica/complicações
Hemorragia Cerebral/etiologia
Estudos de Coortes
Feminino
França/etnologia
Guiana Francesa/etnologia
Seres Humanos
Masculino
Meia-Idade
Índias Ocidentais/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE
[do] DOI:10.1111/ene.13271


  4 / 1904 MEDLINE  
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[PMID]:28215283
[Au] Autor:Warner TD; Settersten RA
[Ad] Endereço:University of Nebraska-Lincoln, Lincoln, NE, United States. Electronic address: twarner2@unl.edu.
[Ti] Título:Why Neighborhoods (and How We Study Them) Matter for Adolescent Development.
[So] Source:Adv Child Dev Behav;52:105-152, 2017.
[Is] ISSN:0065-2407
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adolescence is a sensitive developmental period marked by significant changes that unfold across multiple contexts. As a central context of development, neighborhoods capture-in both physical and social space-the stratification of life chances and differential distribution of resources and risks. For some youth, neighborhoods are springboards to opportunities; for others, they are snares that constrain progress and limit the ability to avoid risks. Despite abundant research on "neighborhood effects," scant attention has been paid to how neighborhoods are a product of social stratification forces that operate simultaneously to affect human development. Neighborhoods in the United States are the manifestation of three intersecting social structural cleavages: race/ethnicity, socioeconomic class, and geography. Many opportunities are allocated or denied along these three cleavages. To capture these joint processes, we advocate a "neighborhood-centered" approach to study the effects of neighborhoods on adolescent development. Using nationally representative data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), we demonstrate the complex ways that these three cleavages shape specific neighborhood contexts and can result in stark differences in well-being. A neighborhood-centered approach demands more rigorous and sensitive theories of place, as well as multidimensional classification and measures. We discuss an agenda to advance the state of theories and research, drawing explicit attention to the stratifying forces that bring about distinct neighborhood types that shape developmental trajectories during adolescence and beyond.
[Mh] Termos MeSH primário: Desenvolvimento do Adolescente
Distribuição Espacial da População
[Mh] Termos MeSH secundário: Adolescente
Comportamento do Adolescente/psicologia
Aspirações (Psicologia)
Vítimas de Crime/psicologia
Grupos Étnicos/psicologia
Seres Humanos
Acontecimentos que Mudam a Vida
Pobreza/psicologia
Carência Psicossocial
Controles Informais da Sociedade
Meio Social
Facilitação Social
Apoio Social
Valores Sociais
Socialização
Violência/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


  5 / 1904 MEDLINE  
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[PMID]:27936361
[Au] Autor:Ng Fat L; Scholes S; Jivraj S
[Ad] Endereço:Department of Epidemiology & Public Health, Institute of Epidemiology & Health Care, University College London, London, England.
[Ti] Título:The Relationship Between Drinking Pattern, Social Capital, and Area-Deprivation: Findings From the Health Survey for England.
[So] Source:J Stud Alcohol Drugs;78(1):20-29, 2017 Jan.
[Is] ISSN:1938-4114
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study was to establish the relationships between heavy episodic and drinking frequency with area-deprivation and social capital in England. METHOD: Using the Health Survey for England 2002-2006, a nationally representative crosssectional survey (N = 54,422), multilevel logistic regression models with individuals nested within primary sampling units were carried out, stratified by sex, on (a) drinkers versus nondrinkers, (b) heavy episodic drinking versus drinking less (on the heaviest drinking day), and (c) fewer than 2 drink-free days versus at least 2 drink-free days. Key exposures were individual social capital variables (social trust, active civic participation, social support, neighborhood perception). Models adjusted for age, area-deprivation, economic activity, education, ethnicity, longstanding illness, marital status, and children in the household. RESULTS: Lack of social support (men: OR = 0.69, 95% CI [0.60, 0.79]; women: OR = 0.77, 95% CI [0.69, 0.86]) and no civic participation (men: OR = 0.75, 95% CI [0.67, 0.83]; women: OR = 0.73, 95% CI [0.68, 0.78]) decreased the odds of being a drinker versus a nondrinker. Among men, low social trust increased (OR = 1.16, 95% CI [1.04, 1.30]) and no civic participation decreased (OR = 0.81, 95% CI [0.74, 0.89]) the odds of heavy episodic drinking; among women, good overall neighborhood perception decreased the odds (OR = 0.91, 95% CI [0.86, 0.97]). Lack of social support (men: OR = 1.25, 95% CI [1.14, 1.36]; women: OR = 1.20, 95% CI [1.02, 1.40]) and no civic participation (men: OR = 1.25, 95% CI [1.14, 1.36]; women: OR = 1.37, 95% CI [1.25, 1.51]) increased the odds of having fewer than 2 drink-free days. Men and women living in the most deprived areas were less likely to drink, more likely to engage in heavy episodic drinking, and more likely to have at least 2 alcohol-free days, after social capital variables were adjusted for. CONCLUSIONS: Social capital is associated with drinking alcohol, and low forms is associated with heavy episodic and frequent drinking. Interventions to reduce heavy episodic consumption should be targeted at those with low social capital and those living in deprived areas where heavy drinking is normalized. Drink-free days recommended in guidelines could be further targeted at those lacking social support.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/psicologia
Capital Social
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Estudos Transversais
Inglaterra
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Meia-Idade
Carência Psicossocial
Fatores de Risco
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE


  6 / 1904 MEDLINE  
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[PMID]:27926743
[Au] Autor:Rice F; Sellers R; Hammerton G; Eyre O; Bevan-Jones R; Thapar AK; Collishaw S; Harold GT; Thapar A
[Ad] Endereço:Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales.
[Ti] Título:Antecedents of New-Onset Major Depressive Disorder in Children and Adolescents at High Familial Risk.
[So] Source:JAMA Psychiatry;74(2):153-160, 2017 Feb 01.
[Is] ISSN:2168-6238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Early-onset major depressive disorder (MDD) is common in individuals at high familial risk of depression and is associated with poor long-term mental health, social, and educational outcomes. Objectives: To examine the developmental pathways that lead to first-episode adolescent-onset MDD (incident cases) in those at high familial risk and to postulate a theoretically informed model that enables simultaneous testing of different pathways to incident adolescent-onset MDD composed of contributions from familial/genetic and social risk factors, as well as effects via specific clinical antecedents. Design, Setting, and Participants: This investigation was a 4-year longitudinal study (April 2007 to March 2011) among offspring of depressed parents in the general community. Analyses were conducted between September 1, 2015, and May 27, 2016. Participants were 337 families in whom the index parent (315 mothers and 22 fathers) had experienced at least 2 episodes of MDD (recruited through primary care) and among whom there was a biologically related child in the age range of 9 to 17 years living with the index parent (197 girls and 140 boys with a mean [SD] age of 12.4 [2.0] years) at baseline. Offspring with MDD before the study or at baseline (n = 27), offspring with an episode of MDD that had remitted by follow-up (n = 4), and offspring with missing baseline MDD data (n = 2) were excluded. Ninety-two percent (279 of 304) of families completed the follow-up. Main Outcomes and Measures: The primary outcome was new-onset offspring MDD, and the secondary outcome was the total DSM-IV MDD symptom score. Results: On average, children and adolescents had a mean (SD) of 1.85 (1.74) (range, 0-8.5) DSM-IV symptoms of MDD at follow-up. Twenty (6 males and 14 females) had new-onset MDD, with a mean (SD) age at onset of 14.4 (2.0) years (range, 10-18 years). Irritability (ß = 0.12, P = .03) and fear and/or anxiety (ß = 0.38, P < .001) were significant independent clinical antecedents of new adolescent-onset MDD, but disruptive behavior (ß = -0.08, P = .14) and low mood (ß = -0.03, P = .65) were not. The results were similar for the DSM-IV symptom count at follow-up. All the measured familial/genetic and social risk indicators directly influenced risk for new-onset MDD rather than indirectly through acting on dimensional clinical antecedents. Conclusions and Relevance: There are multiple pathways to first-onset adolescent depression in individuals at familial risk. Irritability and fear/anxiety may be additional clinical phenomena to be included as targets in primary preventive interventions focusing on the child. In addition to targeting these phenomena in parents and children, depression prevention methods in high-risk groups may need to take into consideration social risks, such as poverty and psychosocial adversity.
[Mh] Termos MeSH primário: Transtorno Depressivo Maior/genética
Predisposição Genética para Doença/genética
[Mh] Termos MeSH secundário: Adolescente
Criança
Transtorno Depressivo Maior/diagnóstico
Transtorno Depressivo Maior/psicologia
Manual Diagnóstico e Estatístico de Transtornos Mentais
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Pobreza/psicologia
Estudos Prospectivos
Carência Psicossocial
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1001/jamapsychiatry.2016.3140


  7 / 1904 MEDLINE  
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[PMID]:27866498
[Au] Autor:Cummings EM; Merrilees C; Taylor LK; Goeke-Morey M; Shirlow P
[Ad] Endereço:University of Notre Dame.
[Ti] Título:Emotional insecurity about the community: A dynamic, within-person mediator of child adjustment in contexts of political violence.
[So] Source:Dev Psychopathol;29(1):27-36, 2017 Feb.
[Is] ISSN:1469-2198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Over 1 billion children worldwide are exposed to political violence and armed conflict. The current conclusions are qualified by limited longitudinal research testing sophisticated process-oriented explanatory models for child adjustment outcomes. In this study, consistent with a developmental psychopathology perspective emphasizing the value of process-oriented longitudinal study of child adjustment in developmental and social-ecological contexts, we tested emotional insecurity about the community as a dynamic, within-person mediating process for relations between sectarian community violence and child adjustment. Specifically, this study explored children's emotional insecurity at a person-oriented level of analysis assessed over 5 consecutive years, with child gender examined as a moderator of indirect effects between sectarian community violence and child adjustment. In the context of a five-wave longitudinal research design, participants included 928 mother-child dyads in Belfast (453 boys, 475 girls) drawn from socially deprived, ethnically homogenous areas that had experienced political violence. Youth ranged in age from 10 to 20 years and were 13.24 (SD = 1.83) years old on average at the initial time point. Greater insecurity about the community measured over multiple time points mediated relations between sectarian community violence and youth's total adjustment problems. The pathway from sectarian community violence to emotional insecurity about the community was moderated by child gender, with relations to emotional insecurity about the community stronger for girls than for boys. The results suggest that ameliorating children's insecurity about community in contexts of political violence is an important goal toward improving adolescents' well-being and adjustment. These results are discussed in terms of their translational research implications, consistent with a developmental psychopathology model for the interface between basic and intervention research.
[Mh] Termos MeSH primário: Adaptação Psicológica
Transtornos de Adaptação/psicologia
Conflitos Armados/psicologia
Dissidências e Disputas
Ajustamento Emocional
Individualidade
Distribuição Espacial da População
Violência/psicologia
[Mh] Termos MeSH secundário: Transtornos de Adaptação/diagnóstico
Adolescente
Criança
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Relações Mãe-Filho
Irlanda do Norte
Psicopatologia
Carência Psicossocial
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1017/S0954579416001097


  8 / 1904 MEDLINE  
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[PMID]:27109625
[Au] Autor:Troller-Renfree S; McLaughlin KA; Sheridan MA; Nelson CA; Zeanah CH; Fox NA
[Ad] Endereço:Department of Human Development and Quantitative Methodology, University of Maryland, College Park, United States. Electronic address: str@umd.edu.
[Ti] Título:The beneficial effects of a positive attention bias amongst children with a history of psychosocial deprivation.
[So] Source:Biol Psychol;122:110-120, 2017 Jan.
[Is] ISSN:1873-6246
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Children raised in institutions experience psychosocial deprivation that has detrimental influences on attention and mental health. The current study examined patterns of attention biases in children from institutions who were randomized at approximately 21.6 months to receive either a high-quality foster care intervention or care-as-usual. At age 12, children performed a dot-probe task and indices of attention bias were calculated. Additionally, children completed a social stress paradigm and cortisol reactivity was computed. Children randomized into foster care (N=40) exhibited an attention bias toward positive stimuli but not threat, whereas children who received care-as-usual (N=40) and a never-institutionalized comparison group (N=47) showed no bias. Stability of foster care placement was related to positive bias, while instability of foster care placement was related to threat bias. The magnitude of the positive bias was associated with fewer internalizing problems and better coping mechanisms. Within the foster care group, positive attention bias was related to less blunted cortisol reactivity.
[Mh] Termos MeSH primário: Nível de Alerta
Viés de Atenção
Criança Institucionalizada/psicologia
Emoções
Cuidados no Lar de Adoção/psicologia
Controle Interno-Externo
Carência Psicossocial
[Mh] Termos MeSH secundário: Adaptação Psicológica/fisiologia
Nível de Alerta/fisiologia
Viés de Atenção/fisiologia
Criança
Intervenção Precoce (Educação)
Emoções/fisiologia
Feminino
Seres Humanos
Hidrocortisona/sangue
Masculino
Comportamento Social
Estresse Psicológico/sangue
Estresse Psicológico/complicações
Estresse Psicológico/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE


  9 / 1904 MEDLINE  
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[PMID]:27690663
[Au] Autor:Vitiello B; Ordóñez AE
[Ad] Endereço:a Treatment and Preventive Intervention Research Branch, Division of Services and Intervention Research , National Institute of Mental Health , Bethesda , MD , USA.
[Ti] Título:Pharmacological treatment of children and adolescents with depression.
[So] Source:Expert Opin Pharmacother;17(17):2273-2279, 2016 Dec.
[Is] ISSN:1744-7666
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Despite an increasing number of studies, there is debate whether antidepressants have a favorable benefit/risk balance in depressed youth. Areas covered: A systematic search identified 23 systematic reviews and meta-analyses published between 2010-2016. More than 30 controlled clinical trials were conducted in adolescents, but only a few in pre-pubertal patients. About one-third of the trials were severely statistically underpowered. Most studies failed to detect differences from placebo, but a few found fluoxetine effective. Although no suicide occurred in these studies, antidepressants increased suicidality risk (including suicidal ideation and behavior) versus placebo (OR = 2.39). Only two placebo-controlled trials with acceptable statistical power were publicly funded: both showed efficacy of fluoxetine, and one found a higher incidence of suicidality (OR = 3.7, 95% C.I. 1.00-13.7). Expert opinion: In youth, antidepressants have, on average, a small therapeutic effect. The high placebo response is exacerbated by the large number of sites in many industry-funded studies. There is evidence that fluoxetine leads to greater and faster improvement than placebo or psychotherapy in adolescents. Considering both the high response to non-specific interventions and safety concerns, antidepressants should be used cautiously in youth, and limited to patients with moderate-to-severe depression for whom psychosocial interventions are either ineffective or not feasible.
[Mh] Termos MeSH primário: Antidepressivos/uso terapêutico
Transtorno Depressivo Maior/tratamento farmacológico
Fluoxetina/uso terapêutico
Inibidores da Captação de Serotonina/uso terapêutico
Suicídio
[Mh] Termos MeSH secundário: Adolescente
Antidepressivos/administração & dosagem
Antidepressivos/efeitos adversos
Criança
Ensaios Clínicos como Assunto/estatística & dados numéricos
Interpretação Estatística de Dados
Fluoxetina/administração & dosagem
Fluoxetina/efeitos adversos
Seres Humanos
Carência Psicossocial
Psicoterapia/métodos
Medição de Risco
Inibidores da Captação de Serotonina/administração & dosagem
Inibidores da Captação de Serotonina/efeitos adversos
Suicídio/prevenção & controle
Suicídio/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Serotonin Uptake Inhibitors); 01K63SUP8D (Fluoxetine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:27647049
[Au] Autor:Zeanah CH; Sonuga-Barke EJ
[Ti] Título:Editorial: The effects of early trauma and deprivation on human development - from measuring cumulative risk to characterizing specific mechanisms.
[So] Source:J Child Psychol Psychiatry;57(10):1099-102, 2016 Oct.
[Is] ISSN:1469-7610
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Science is not a linear process of accumulating knowledge. To the contrary, progress in understanding is most likely to occur, especially in less 'mature' disciplines, when healthy debate between opposing points of view create a dialectic in which thesis and antithesis force a new synthesis. In developmental psychopathology, such tension between opposing schools of thought continue to play a vital role in driving discovery across a wide range of topics.
[Mh] Termos MeSH primário: Adultos Sobreviventes de Eventos Adversos na Infância/psicologia
Desenvolvimento Infantil/fisiologia
Transtornos Mentais/psicologia
Trauma Psicológico/psicologia
Carência Psicossocial
[Mh] Termos MeSH secundário: Adulto
Criança
Seres Humanos
Transtornos Mentais/etiologia
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1111/jcpp.12642



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