Base de dados : MEDLINE
Pesquisa : F02.463.425.179 [Categoria DeCS]
Referências encontradas : 12455 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1246 ir para página                         

  1 / 12455 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
[PMID]:29365346
[Au] Autor:Hodder RK; Stacey FG; O'Brien KM; Wyse RJ; Clinton-McHarg T; Tzelepis F; James EL; Bartlem KM; Nathan NK; Sutherland R; Robson E; Yoong SL; Wolfenden L
[Ad] Endereço:Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, Australia, 2287.
[Ti] Título:Interventions for increasing fruit and vegetable consumption in children aged five years and under.
[So] Source:Cochrane Database Syst Rev;1:CD008552, 2018 01 25.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Insufficient consumption of fruits and vegetables in childhood increases the risk of future chronic diseases, including cardiovascular disease. OBJECTIVES: To assess the effectiveness, cost effectiveness and associated adverse events of interventions designed to increase the consumption of fruit, vegetables or both amongst children aged five years and under. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE and Embase to identify eligible trials on 25 September 2017. We searched Proquest Dissertations and Theses and two clinical trial registers in November 2017. We reviewed reference lists of included trials and handsearched three international nutrition journals. We contacted authors of included studies to identify further potentially relevant trials. SELECTION CRITERIA: We included randomised controlled trials, including cluster-randomised controlled trials and cross-over trials, of any intervention primarily targeting consumption of fruit, vegetables or both among children aged five years and under, and incorporating a dietary or biochemical assessment of fruit or vegetable consumption. Two review authors independently screened titles and abstracts of identified papers; a third review author resolved disagreements. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data and assessed the risks of bias of included studies; a third review author resolved disagreements. Due to unexplained heterogeneity, we used random-effects models in meta-analyses for the primary review outcomes where we identified sufficient trials. We calculated standardised mean differences (SMDs) to account for the heterogeneity of fruit and vegetable consumption measures. We conducted assessments of risks of bias and evaluated the quality of evidence (GRADE approach) using Cochrane procedures. MAIN RESULTS: We included 55 trials with 154 trial arms and 11,108 participants. Thirty-three trials examined the impact of child-feeding practices (e.g. repeated food exposure) in increasing child vegetable intake. Thirteen trials examined the impact of parent nutrition education in increasing child fruit and vegetable intake. Eight studies examined the impact of multicomponent interventions (e.g. parent nutrition education and preschool policy changes) in increasing child fruit and vegetable intake. One study examined the effect of a nutrition intervention delivered to children in increasing child fruit and vegetable intake.We judged 14 of the 55 included trials as free from high risks of bias across all domains; performance, detection and attrition bias were the most common domains judged at high risk of bias for the remaining studies.Meta-analysis of trials examining child-feeding practices versus no intervention revealed a positive effect on child vegetable consumption (SMD 0.38, 95% confidence interval (CI) 0.15 to 0.61; n = 1509; 11 studies; very low-quality evidence), equivalent to a mean difference of 4.03 g of vegetables. There were no short-term differences in child consumption of fruit and vegetables in meta-analyses of trials examining parent nutrition education versus no intervention (SMD 0.11, 95% CI -0.05 to 0.28; n = 3023; 10 studies; very low-quality evidence) or multicomponent interventions versus no intervention (SMD 0.28, 95% CI -0.06 to 0.63; n = 1861; 4 studies; very low-quality evidence).Insufficient data were available to assess long-term effectiveness, cost effectiveness and unintended adverse consequences of interventions. Studies reported receiving governmental or charitable funds, except for three studies reporting industry funding. AUTHORS' CONCLUSIONS: Despite identifying 55 eligible trials of various intervention approaches, the evidence for how to increase children's fruit and vegetable consumption remains sparse. There was very low-quality evidence that child-feeding practice interventions are effective in increasing vegetable consumption in children aged five years and younger, however the effect size was very small and long-term follow-up is required. There was very low-quality evidence that parent nutrition education and multicomponent interventions are not effective in increasing fruit and vegetable consumption in children aged five years and younger. All findings should be considered with caution, given most included trials could not be combined in meta-analyses. Given the very low-quality evidence, future research will very likely change estimates and conclusions. Such research should adopt more rigorous methods to advance the field.This is a living systematic review. Living systematic reviews offer a new approach to review updating, in which the review is continually updated, incorporating relevant new evidence as it becomes available. Please refer to the Cochrane Database of Systematic Reviews for the current status of this review.
[Mh] Termos MeSH primário: Ingestão de Alimentos
Comportamento Alimentar
Frutas
Verduras
[Mh] Termos MeSH secundário: Pré-Escolar
Condicionamento (Psicologia)
Visita Domiciliar
Seres Humanos
Lactente
Ensaios Clínicos Controlados Aleatórios como Assunto
Recompensa
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD008552.pub4


  2 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29253878
[Au] Autor:Asam K; Staniszewski A; Zhang H; Melideo SL; Mazzeo A; Voronkov M; Huber KL; Pérez E; Stock M; Stock JB; Arancio O; Nicholls RE
[Ad] Endereço:Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America.
[Ti] Título:Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.
[So] Source:PLoS One;12(12):e0189413, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soluble forms of oligomeric beta-amyloid (Aß) are thought to play a central role in Alzheimer's disease (AD). Transgenic manipulation of methylation of the serine/threonine protein phosphatase, PP2A, was recently shown to alter the sensitivity of mice to AD-related impairments resulting from acute exposure to elevated levels of Aß. In addition, eicosanoyl-5-hydroxytryptamide (EHT), a naturally occurring component from coffee beans that modulates PP2A methylation, was shown to confer therapeutic benefits in rodent models of AD and Parkinson's disease. Here, we tested the hypothesis that EHT protects animals from the pathological effects of exposure to elevated levels of soluble oligomeric Aß. We treated mice with EHT-containing food at two different doses and assessed the sensitivity of these animals to Aß-induced behavioral and electrophysiological impairments. We found that EHT administration protected animals from Aß-induced cognitive impairments in both a radial-arm water maze and contextual fear conditioning task. We also found that both chronic and acute EHT administration prevented Aß-induced impairments in long-term potentiation. These data add to the accumulating evidence suggesting that interventions with pharmacological agents, such as EHT, that target PP2A activity may be therapeutically beneficial for AD and other neurological conditions.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Peptídeos beta-Amiloides/química
Transtornos Cognitivos/prevenção & controle
Serotonina/análogos & derivados
[Mh] Termos MeSH secundário: Doença de Alzheimer/patologia
Animais
Café
Cognição/efeitos dos fármacos
Condicionamento (Psicologia)
Modelos Animais de Doenças
Eletrofisiologia
Medo
Feminino
Potenciação de Longa Duração
Masculino
Aprendizagem em Labirinto
Metilação
Camundongos
Camundongos Endogâmicos C57BL
Doenças do Sistema Nervoso/tratamento farmacológico
Doenças do Sistema Nervoso/patologia
Plasticidade Neuronal
Fosforilação
Serotonina/farmacologia
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Coffee); 0 (eicosanoyl-5-hydroxytryptamide); 333DO1RDJY (Serotonin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189413


  3 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29374173
[Au] Autor:Shin JH; Kim D; Jung MW
[Ad] Endereço:Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea.
[Ti] Título:Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways.
[So] Source:Nat Commun;9(1):404, 2018 01 26.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The direct and indirect pathways of the basal ganglia have long been thought to mediate behavioral promotion and inhibition, respectively. However, this classic dichotomous model has been recently challenged. To better understand neural processes underlying reward-based learning and movement control, we recorded from direct (dSPNs) and indirect (iSPNs) pathway spiny projection neurons in the dorsomedial striatum of D1-Cre and D2-Cre mice performing a probabilistic Pavlovian conditioning task. dSPNs tend to increase activity while iSPNs decrease activity as a function of reward value, suggesting the striatum represents value in the relative activity levels of dSPNs versus iSPNs. Lick offset-related activity increase is largely dSPN selective, suggesting dSPN involvement in suppressing ongoing licking behavior. Rapid responses to negative outcome and previous reward-related responses are more frequent among iSPNs than dSPNs, suggesting stronger contributions of iSPNs to outcome-dependent behavioral adjustment. These findings provide new insights into striatal neural circuit operations.
[Mh] Termos MeSH primário: Condicionamento (Psicologia)/fisiologia
Corpo Estriado/fisiologia
Vias Neurais/fisiologia
Neurônios/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpo Estriado/citologia
Sinais (Psicologia)
Eletrodos Implantados
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Monoterpenos
Movimento
Odorantes/análise
Percepção Olfatória/fisiologia
Optogenética
Pentanóis
Receptores de Dopamina D1/fisiologia
Receptores de Dopamina D2/fisiologia
Recompensa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Pentanols); 0 (Receptors, Dopamine D1); 0 (Receptors, Dopamine D2); 75GK9XIA8I (carvone); T7EU0O9VPP (citral); Z135787824 (isoamyl acetate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180128
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02817-1


  4 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29352183
[Au] Autor:Zhang TY; Keown CL; Wen X; Li J; Vousden DA; Anacker C; Bhattacharyya U; Ryan R; Diorio J; O'Toole N; Lerch JP; Mukamel EA; Meaney MJ
[Ad] Endereço:Sackler Program for Epigenetics and Psychobiology, McGill University, Montréal, H4H 1R3, Canada. tieyuan.zhang@mcgill.ca.
[Ti] Título:Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus.
[So] Source:Nat Commun;9(1):298, 2018 01 19.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus. The hippocampal dentate gyrus (DG) is a major site for experience-dependent plasticity associated with sustained transcriptional alterations, potentially mediated by epigenetic modifications. Here, we report comprehensive DNA methylome, hydroxymethylome and transcriptome data sets from mouse dorsal and ventral DG. We find genome-wide transcriptional and methylation differences between dorsal and ventral DG, including at key developmental transcriptional factors. Peripubertal environmental enrichment increases hippocampal volume and enhances dorsal DG-specific differences in gene expression. Enrichment also enhances dorsal-ventral differences in DNA methylation, including at binding sites of the transcription factor NeuroD1, a regulator of adult neurogenesis. These results indicate a dorsal-ventral asymmetry in transcription and methylation that parallels well-known functional and anatomical differences, and that may be enhanced by environmental enrichment.
[Mh] Termos MeSH primário: Condicionamento (Psicologia)/fisiologia
Giro Denteado/metabolismo
Epigênese Genética
Interação Gene-Ambiente
Proteínas do Tecido Nervoso/genética
Neurogênese/genética
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética
Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo
Sítios de Ligação
DNA/genética
DNA/metabolismo
Metilação de DNA
Giro Denteado/anatomia & histologia
Giro Denteado/diagnóstico por imagem
Giro Denteado/crescimento & desenvolvimento
Regulação da Expressão Gênica no Desenvolvimento
Imagem por Ressonância Magnética
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Proteínas do Tecido Nervoso/metabolismo
Plasticidade Neuronal/fisiologia
Neurônios/citologia
Neurônios/fisiologia
Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Nerve Tissue Proteins); 0 (Neurod1 protein, mouse); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02748-x


  5 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29223397
[Au] Autor:Cao B; Ni HY; Li J; Zhou Y; Bian XL; Tao Y; Cai CY; Qin C; Wu HY; Chang L; Luo CX; Zhu DY
[Ad] Endereço:Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
[Ti] Título:(+)-Borneol suppresses conditioned fear recall and anxiety-like behaviors in mice.
[So] Source:Biochem Biophys Res Commun;495(2):1588-1593, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fear- and anxiety-related psychiatric disorders have been one of the major chronic diseases afflicting patients for decades, and new compounds for treating such disorders remain to be developed. (+)-Borneol, a bicyclic monoterpene found in several species of Artemisia and Dipterocarpaceae, is widely used for anxiety, pain and anesthesia in Chinese medicine. Meanwhile, it can potentiate GABA (γ-aminobutyric acid) activity directly in recombinant GABAA receptors. The present study was to investigate the effects of (+)-Borneol on both contextual and cued fear recall. Interestingly, microinjection of (+)-Borneol into the dorsal hippocampus inhibited 24 h and 7 d contextual fear, whereas its infusion into ventral hippocampus only reduced 24 h cued fear responses. Moreover, microinjection of (+)-Borneol into dorsal but not ventral hippocampus suppressed anxiety-like behaviors in the open field test, light/dark exploration and the elevated plus maze test. As selective GABA receptor antagonist bicuculline reversed the effect of (+)-Borneol on contextual fear paradigm and the drug potentiated GABA-evoked currents in acute hippocampus slices, modulation of the GABAergic neurotransmission may explain the effects of (+)-Borneol. Our findings suggest that (+)-Borneol can serve as a new therapeutic in fear- and anxiety-related disorders.
[Mh] Termos MeSH primário: Ansiedade/tratamento farmacológico
Bornanos/farmacologia
Medo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ansiedade/fisiopatologia
Ansiedade/psicologia
Condicionamento (Psicologia)/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Medo/fisiologia
Agonistas de Receptores de GABA-A/farmacologia
Hipocampo/anatomia & histologia
Hipocampo/efeitos dos fármacos
Hipocampo/fisiologia
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Rememoração Mental/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Plantas Medicinais
Transmissão Sináptica/efeitos dos fármacos
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bornanes); 0 (Drugs, Chinese Herbal); 0 (GABA-A Receptor Agonists); 56-12-2 (gamma-Aminobutyric Acid); L88RA8N5EG (isoborneol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


  6 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29184202
[Au] Autor:Yu K; Ahrens S; Zhang X; Schiff H; Ramakrishnan C; Fenno L; Deisseroth K; Zhao F; Luo MH; Gong L; He M; Zhou P; Paninski L; Li B
[Ad] Endereço:Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
[Ti] Título:The central amygdala controls learning in the lateral amygdala.
[So] Source:Nat Neurosci;20(12):1680-1685, 2017 Dec.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Experience-driven synaptic plasticity in the lateral amygdala is thought to underlie the formation of associations between sensory stimuli and an ensuing threat. However, how the central amygdala participates in such a learning process remains unclear. Here we show that PKC-δ-expressing central amygdala neurons are essential for the synaptic plasticity underlying learning in the lateral amygdala, as they convey information about the unconditioned stimulus to lateral amygdala neurons during fear conditioning.
[Mh] Termos MeSH primário: Núcleo Central da Amígdala/fisiologia
Aprendizagem/fisiologia
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva
Condicionamento (Psicologia)
Ingestão de Alimentos
Medo/psicologia
Imuno-Histoquímica
Camundongos
Camundongos Endogâmicos C57BL
Plasticidade Neuronal/fisiologia
Optogenética
Técnicas de Patch-Clamp
Proteína Quinase C-delta/biossíntese
Proteína Quinase C-delta/genética
Transmissão Sináptica/fisiologia
Tálamo/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.1.- (Prkcd protein, mouse); EC 2.7.11.13 (Protein Kinase C-delta)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/s41593-017-0009-9


  7 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28987617
[Au] Autor:Goodfellow MJ; Shin YJ; Lindquist DH
[Ad] Endereço:Department of Psychology, The Ohio State University, 1835 Neil Ave., Columbus, OH 43210, USA. Electronic address: mgoodfellow@som.umaryland.edu.
[Ti] Título:Mitigation of postnatal ethanol-induced neuroinflammation ameliorates trace fear memory deficits in juvenile rats.
[So] Source:Behav Brain Res;338:28-31, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4-9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats. Phosphate buffered saline vehicle (VEH) or IBU was injected 2h following ethanol exposure over PD4-9, followed by quantification of inflammation-related genes in the dorsal hippocampus of PD10 rats. The 5E-VEH rats exhibited significant increases in Il1b and Tnf, but not Itgam or Gfap, relative to NC, SI-VEH, and 5E-IBU rats. In separate groups of PD31-33 rats, conditioned fear (freezing) was significantly reduced in 5E-VEH rats during TFC testing, but not acquisition, compared to SI-VEH and, critically, 5E-IBU rats. Results suggest neuroimmune activation in response to ethanol within the neonate hippocampus contributes to later-life cognitive dysfunction.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Encéfalo/efeitos dos fármacos
Citocinas/metabolismo
Etanol/administração & dosagem
Transtornos do Espectro Alcoólico Fetal/metabolismo
Ibuprofeno/uso terapêutico
Transtornos da Memória/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Condicionamento (Psicologia)/efeitos dos fármacos
Condicionamento (Psicologia)/fisiologia
Citocinas/genética
Modelos Animais de Doenças
Medo/efeitos dos fármacos
Medo/fisiologia
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Transtornos da Memória/metabolismo
Ratos
Ratos Long-Evans
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 3K9958V90M (Ethanol); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  8 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28450301
[Au] Autor:Egawa J; Schilling JM; Cui W; Posadas E; Sawada A; Alas B; Zemljic-Harpf AE; Fannon-Pavlich MJ; Mandyam CD; Roth DM; Patel HH; Patel PM; Head BP
[Ad] Endereço:Veterans Affairs San Diego Healthcare System, San Diego, California, USA.
[Ti] Título:Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma.
[So] Source:FASEB J;31(8):3403-3411, 2017 08.
[Is] ISSN:1530-6860
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies and demonstrate that membrane/lipid rafts and caveolin (Cav) organize progrowth receptors, and, when overexpressed specifically in neurons, Cav-1 augments neuronal signaling and growth and improves cognitive function in adult and aged mice; however, whether neuronal Cav-1 overexpression can preserve motor and cognitive function in the brain trauma setting is unknown. Here, we generated a neuron-targeted Cav-1-overexpressing transgenic (Tg) mouse [synapsin-driven Cav-1 (SynCav1 Tg)] and subjected it to a controlled cortical impact model of brain trauma and measured biochemical, anatomic, and behavioral changes. SynCav1 Tg mice exhibited increased hippocampal expression of Cav-1 and membrane/lipid raft localization of postsynaptic density protein 95, NMDA receptor, and tropomyosin receptor kinase B. When subjected to a controlled cortical impact, SynCav1 Tg mice demonstrated preserved hippocampus-dependent fear learning and memory, improved motor function recovery, and decreased brain lesion volume compared with wild-type controls. Neuron-targeted overexpression of Cav-1 in the adult brain prevents hippocampus-dependent learning and memory deficits, restores motor function after brain trauma, and decreases brain lesion size induced by trauma. Our findings demonstrate that neuron-targeted Cav-1 can be used as a novel therapeutic strategy to restore brain function and prevent trauma-associated maladaptive plasticity.-Egawa, J., Schilling, J. M., Cui, W., Posadas, E., Sawada, A., Alas, B., Zemljic-Harpf, A. E., Fannon-Pavlich, M. J., Mandyam, C. D., Roth, D. M., Patel, H. H., Patel, P. M., Head, B. P. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/metabolismo
Caveolina 1/metabolismo
Memória/fisiologia
Neurônios/metabolismo
[Mh] Termos MeSH secundário: Animais
Lesões Encefálicas Traumáticas/fisiopatologia
Caveolina 1/genética
Condicionamento (Psicologia)
Medo
Regulação da Expressão Gênica/fisiologia
Terapia Genética
Genótipo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Plasticidade Neuronal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Caveolin 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1096/fj.201601288RRR


  9 / 12455 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743603
[Au] Autor:Corrales A; Parisotto EB; Vidal V; García-Cerro S; Lantigua S; Diego M; Wilhem Filho D; Sanchez-Barceló EJ; Martínez-Cué C; Rueda N
[Ad] Endereço:Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, Santander, Spain.
[Ti] Título:Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.
[So] Source:Behav Brain Res;334:142-154, 2017 09 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome. Here, we investigated the effects of pre- and post-natal melatonin treatment on behavioral and cognitive abnormalities and on several neuromorphological alterations (hypocellularity, neurogenesis impairment and increased oxidative stress) that appear during the early developmental stages in TS mice. Pregnant TS females were orally treated with melatonin or vehicle from the time of conception until the weaning of the offspring, and the pups continued to receive the treatment from weaning until the age of 5 months. Melatonin administered during the pre- and post-natal periods did not improve the cognitive impairment of TS mice as measured by the Morris Water maze or fear conditioning tests. Histological alterations, such as decreased proliferation (Ki67+ cells) and hippocampal hypocellularity (DAPI+ cells), which are typical in TS mice, were not prevented by melatonin. However, melatonin partially regulated brain oxidative stress by modulating the activity of the primary antioxidant enzymes (superoxide dismutase in the cortex and catalase in the cortex and hippocampus) and slightly decreasing the levels of lipid peroxidation in the hippocampus of TS mice. These results show the inability of melatonin to prevent cognitive impairment in TS mice when it is administered at pre- and post-natal stages. Additionally, our findings suggest that to induce pro-cognitive effects in TS mice during the early stages of development, in addition to attenuating oxidative stress, therapies should aim to improve other altered processes, such as hippocampal neurogenesis and/or hypocellularity.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Cognição/efeitos dos fármacos
Síndrome de Down/tratamento farmacológico
Melatonina/administração & dosagem
Fármacos Neuroprotetores/administração & dosagem
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Encéfalo/metabolismo
Encéfalo/patologia
Catalase/metabolismo
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/fisiologia
Cognição/fisiologia
Condicionamento (Psicologia)/efeitos dos fármacos
Condicionamento (Psicologia)/fisiologia
Modelos Animais de Doenças
Síndrome de Down/metabolismo
Síndrome de Down/patologia
Medo/efeitos dos fármacos
Medo/fisiologia
Antígeno Ki-67/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Peroxidação de Lipídeos/fisiologia
Aprendizagem em Labirinto/efeitos dos fármacos
Aprendizagem em Labirinto/fisiologia
Melatonina/sangue
Atividade Motora/efeitos dos fármacos
Atividade Motora/fisiologia
Fármacos Neuroprotetores/sangue
Estresse Oxidativo/fisiologia
Distribuição Aleatória
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ki-67 Antigen); 0 (Neuroprotective Agents); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  10 / 12455 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28464876
[Au] Autor:Lan A; Kalimian M; Amram B; Kofman O
[Ad] Endereço:Department of Psychology, Ben-Gurion University of the Negev, P.O.B. 653, Beer-Sheva, 84105, Israel.
[Ti] Título:Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6/J mice.
[So] Source:Environ Health;16(1):43, 2017 05 02.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Children are at daily risk for exposure to organophosphate insecticides, of which the most common is chlorpyrifos (CPF). Exposure of pregnant women to CPF was linked to decreased birth weight, abnormal reflexes, reduction in IQ, as well as increased maternal reports of signs of pervasive developmental disorder. The aim of current study was to examine the long term effects of prenatal exposure to CPF in C57BL/6 J (B6) mice with specific focus on social and repetitive behavior. METHODS: B6 female mice were treated with vehicle, 2.5 mg/kg CPF or 5 mg/kg of CPF on gestational days 12-15 by oral gavage. On postnatal days (PND's) 6-12 early development and neuromotor ability were assessed by measuring 3 neonatal reflexes in the offspring. In adulthood, PND 90, social behavior was investigated using the social preference, social novelty and social conditioned place preference tasks. Object recognition and restricted interest, measured by the repetitive novel object contact task (RNOC), were also assessed on PN D 90. In order to rule out the possibility that CPF administration induced alterations in maternal care, the dams' behavior was evaluated via the maternal retrieval task. RESULTS: CPF treatment resulted in delayed development of neonatal reflexes on PND's 6-12. On PND 90, mice treated prenatally with the 5.0 mg/kg dose exhibited reduced preference towards an unfamiliar conspecific in the social preference test and reduced social conditioned place preference. In the RNOC task, mice exposed prenatally to 2.5 mg/kg dose of CPF showed enhanced restricted interest. CPF administration did not impair dams' behavior and did not cause memory or recognition deficit as was observed in the object recognition task. CONCLUSIONS: Our data indicate that gestational exposure to CPF has long-term deleterious effects on social behavior and limits exploration of novel objects.
[Mh] Termos MeSH primário: Transtorno Autístico/etiologia
Clorpirifos/toxicidade
Inseticidas/toxicidade
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Condicionamento (Psicologia)/efeitos dos fármacos
Feminino
Masculino
Comportamento Materno/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Gravidez
Reflexo/efeitos dos fármacos
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); JCS58I644W (Chlorpyrifos)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12940-017-0251-3



página 1 de 1246 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde