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  1 / 7103 MEDLINE  
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[PMID]:28463420
[Au] Autor:Chang YC; Cole TB; Costa LG
[Ad] Endereço:Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
[Ti] Título:Behavioral Phenotyping for Autism Spectrum Disorders in Mice.
[So] Source:Curr Protoc Toxicol;72:11.22.1-11.22.21, 2017 May 02.
[Is] ISSN:1934-9262
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorder (ASD) represents a heterogeneous group of disorders characterized by alterations in three behavioral symptom domains: Social interactions, verbal and nonverbal communication, and repetitive behaviors. Increasing prevalence of ASD in recent years suggests that exposure to environmental toxicants may be critical in modulating etiology of this disease. As clinical diagnosis of autism still relies on behavioral evaluation, it is important to be able to assess similar behavioral traits in animal models, to provide biological plausibility of associations between environmental exposures and ASD. Rodents naturally exhibit a large number of behaviors that can be linked to similar behaviors in human. In this unit, behavioral tests are described that are relevant to the domains affected in ASD. For the repetitive domain, the T-maze spontaneous alternation test and marble burying test are described. For the communication domain, neonatal ultrasonic vocalization and olfactory habituation test toward social and non-social odor are described. Finally, for the sociability domain, the three-chambered social preference test and the reciprocal interaction test are presented. © 2017 by John Wiley & Sons, Inc.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Comportamento Animal
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Modelos Animais de Doenças
Habituação Psicofisiológica
Camundongos
Transtorno Obsessivo-Compulsivo/psicologia
Odorantes
Fenótipo
Olfato
Comportamento Social
Urina/química
Vocalização Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cptx.19


  2 / 7103 MEDLINE  
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[PMID]:28458050
[Au] Autor:Rieth CA; Huber DE
[Ad] Endereço:Pacific Science and Engineering Group, Inc, United States.
[Ti] Título:Comparing different kinds of words and word-word relations to test an habituation model of priming.
[So] Source:Cogn Psychol;95:79-104, 2017 Jun.
[Is] ISSN:1095-5623
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Huber and O'Reilly (2003) proposed that neural habituation exists to solve a temporal parsing problem, minimizing blending between one word and the next when words are visually presented in rapid succession. They developed a neural dynamics habituation model, explaining the finding that short duration primes produce positive priming whereas long duration primes produce negative repetition priming. The model contains three layers of processing, including a visual input layer, an orthographic layer, and a lexical-semantic layer. The predicted effect of prime duration depends both on this assumed representational hierarchy and the assumption that synaptic depression underlies habituation. The current study tested these assumptions by comparing different kinds of words (e.g., words versus non-words) and different kinds of word-word relations (e.g., associative versus repetition). For each experiment, the predictions of the original model were compared to an alternative model with different representational assumptions. Experiment 1 confirmed the prediction that non-words and inverted words require longer prime durations to eliminate positive repetition priming (i.e., a slower transition from positive to negative priming). Experiment 2 confirmed the prediction that associative priming increases and then decreases with increasing prime duration, but remains positive even with long duration primes. Experiment 3 replicated the effects of repetition and associative priming using a within-subjects design and combined these effects by examining target words that were expected to repeat (e.g., viewing the target word 'BACK' after the prime phrase 'back to'). These results support the originally assumed representational hierarchy and more generally the role of habituation in temporal parsing and priming.
[Mh] Termos MeSH primário: Habituação Psicofisiológica/fisiologia
Modelos Psicológicos
Psicolinguística
Priming de Repetição/fisiologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Leitura
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  3 / 7103 MEDLINE  
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[PMID]:28459273
[Au] Autor:Wass SV; Cook C; Clackson K
[Ad] Endereço:Department of Psychology, University of East London.
[Ti] Título:Changes in behavior and salivary cortisol after targeted cognitive training in typical 12-month-old infants.
[So] Source:Dev Psychol;53(5):815-825, 2017 May.
[Is] ISSN:1939-0599
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous research has suggested that early development may be an optimal period to implement cognitive training interventions, particularly those relating to attention control, a basic ability that is essential for the development of other cognitive skills. In the present study, we administered gaze-contingent training (95 min across 2 weeks) targeted at voluntary attention control to a cohort of typical 12-month-old children (N = 24) and sham training to a control group (N = 24). We assessed training effects on (a) tasks involving nontrained aspects of attention control: visual sustained attention, habituation speed, visual recognition memory, sequence learning, and reversal learning; (b) general attentiveness (on-task behaviors during testing); and (c) salivary cortisol levels. Assessments were administered immediately after the cessation of training and at a 6-week follow-up. On the immediate posttest infants showed significantly more sustained visual attention, faster habituation, and improved sequence learning. Significant effects were also found for increased general attentiveness and decreased salivary cortisol. Some of these effects were still evident at the 6-week follow-up (significantly improved sequence learning and marginally improved sustained attention). These findings extend the emerging literature showing that attention training is possible in infancy. (PsycINFO Database Record
[Mh] Termos MeSH primário: Atenção/fisiologia
Hidrocortisona/metabolismo
Comportamento do Lactente/fisiologia
Aprendizagem/fisiologia
Reconhecimento Visual de Modelos/fisiologia
[Mh] Termos MeSH secundário: Assistência ao Convalescente
Feminino
Habituação Psicofisiológica/fisiologia
Seres Humanos
Lactente
Masculino
Recognição (Psicologia)/fisiologia
Reversão de Aprendizagem/fisiologia
Saliva/metabolismo
Aprendizagem Seriada/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1037/dev0000266


  4 / 7103 MEDLINE  
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[PMID]:27770582
[Au] Autor:McCrimmon RJ
[Ad] Endereço:Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
[Ti] Título:RD Lawrence Lecture 2015 Old habits are hard to break: lessons from the study of hypoglycaemia.
[So] Source:Diabet Med;34(2):148-155, 2017 Feb.
[Is] ISSN:1464-5491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Despite the introduction of newer technologies and improved insulin formulations, recurrent hypoglycaemia continues to affect the lives of many people with Type 1 and Type 2 diabetes. Developing strategies or therapies designed to prevent or minimize hypoglycaemia risk is of utmost importance to help individuals safely achieve glycaemic targets. Novel, educational or behavioural approaches need to be based on a clear understanding of the mechanisms underpinning both the detection of hypoglycaemia and why repeated exposure to hypoglycaemia leads to the development of a clinical syndrome referred to as impaired awareness of hypoglycaemia. In the present review, I propose that impaired awareness of hypoglycaemia may represent a form of learning called habituation, a response that, at a cellular level, represents a biological adaptation designed to protect the organism from future exposure to that stressor. In diabetes, this survival response to low glucose is, however, overwhelmed by high systemic insulin levels resulting from exogenous insulin therapy, leading to progressively more severe hypoglycaemia. A recognition of the underlying mechanism means that the development of impaired awareness of hypoglycaemia can perhaps be better understood and explained to individuals with diabetes, and novel therapeutic approaches such as dishabituation or cognitive behavioural therapies can be considered.
[Mh] Termos MeSH primário: Conscientização
Diabetes Mellitus/tratamento farmacológico
Habituação Psicofisiológica
Hipoglicemia/fisiopatologia
Hipoglicemiantes/efeitos adversos
[Mh] Termos MeSH secundário: Terapia Cognitiva
Seres Humanos
Hipoglicemia/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE; LECTURES; REVIEW
[Nm] Nome de substância:
0 (Hypoglycemic Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/dme.13277


  5 / 7103 MEDLINE  
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[PMID]:29020028
[Au] Autor:Rivera-Gutierrez HF; Martens T; Pinxten R; Eens M
[Ad] Endereço:Grupo Ecología y Evolución de Vertebrados, Instituto de Biología, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Medellin, Colombia.
[Ti] Título:Learning speed is affected by personality and reproductive investment in a songbird.
[So] Source:PLoS One;12(10):e0185410, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Individuals from different taxa, including songbirds, differ consistently in behaviour and personality when facing different situations. Although our understanding of animal behaviour has increased, knowledge about between-individual differences in cognitive abilities is still limited. By using an experimental approach and a free-living songbird (Parus major) as a model, we attempted to understand between-individual differences in habituation to playbacks (as a proxy of learning speed), by investigating the role of personality, age and reproductive investment (clutch size). Pre-breeding males were tested for exploration (a proxy of personality) in standardized conditions. In addition, the same individuals were exposed to three playbacks in the field during incubation. Birds significantly moved less, stayed further away and overlapped less the playback with successive playback stimulation. While a decrease in the locomotor behaviour can be explained by personality, differences in habituation of overlapping were predicted by both reproductive investment and personality. Fast explorers habituated less. Moreover, males paired to females with larger clutches did not vary the intensity of overlapping. Since habituation requires information for recognition of non-threatening signals, personality may bias information gathering. While fast explorers may collect less information from the environment, slow explorers (reactive birds) seem to pay attention to environmental clues and collect detailed information. We provided evidence that the rate of habituation of behavioural responses, a proxy of cognitive abilities, may be affected by different factors and in a complex way.
[Mh] Termos MeSH primário: Aprendizagem
Personalidade
Reprodução/fisiologia
Aves Canoras/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Tamanho da Ninhada
Meio Ambiente
Comportamento Exploratório/fisiologia
Habituação Psicofisiológica
Modelos Lineares
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185410


  6 / 7103 MEDLINE  
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[PMID]:28957319
[Au] Autor:Lee JJ; Keramati M
[Ad] Endereço:Gatsby Computational Neuroscience Unit, University College London, London, United Kingdom.
[Ti] Título:Flexibility to contingency changes distinguishes habitual and goal-directed strategies in humans.
[So] Source:PLoS Comput Biol;13(9):e1005753, 2017 Sep.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Decision-making in the real world presents the challenge of requiring flexible yet prompt behavior, a balance that has been characterized in terms of a trade-off between a slower, prospective goal-directed model-based (MB) strategy and a fast, retrospective habitual model-free (MF) strategy. Theory predicts that flexibility to changes in both reward values and transition contingencies can determine the relative influence of the two systems in reinforcement learning, but few studies have manipulated the latter. Therefore, we developed a novel two-level contingency change task in which transition contingencies between states change every few trials; MB and MF control predict different responses following these contingency changes, allowing their relative influence to be inferred. Additionally, we manipulated the rate of contingency changes in order to determine whether contingency change volatility would play a role in shifting subjects between a MB and MF strategy. We found that human subjects employed a hybrid MB/MF strategy on the task, corroborating the parallel contribution of MB and MF systems in reinforcement learning. Further, subjects did not remain at one level of MB/MF behaviour but rather displayed a shift towards more MB behavior over the first two blocks that was not attributable to the rate of contingency changes but rather to the extent of training. We demonstrate that flexibility to contingency changes can distinguish MB and MF strategies, with human subjects utilizing a hybrid strategy that shifts towards more MB behavior over blocks, consequently corresponding to a higher payoff.
[Mh] Termos MeSH primário: Extinção Psicológica/fisiologia
Hábitos
Habituação Psicofisiológica/fisiologia
Modelos Psicológicos
Reforço (Psicologia)
Análise e Desempenho de Tarefas
[Mh] Termos MeSH secundário: Adulto
Tomada de Decisões/fisiologia
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005753


  7 / 7103 MEDLINE  
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[PMID]:28625954
[Au] Autor:Batool Z; Agha F; Ahmad S; Liaquat L; Tabassum S; Khaliq S; Anis L; Sajid I; Emad S; Perveen T; Haider S
[Ad] Endereço:Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan.
[Ti] Título:Attenuation of cadmium-induced decline in spatial, habituation and recognition memory by long-term administration of almond and walnut supplementation: Role of cholinergic function.
[So] Source:Pak J Pharm Sci;30(1 Suppl):273-279, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Excessive exposure of cadmium which is regarded as a neurotoxin can stimulate aging process by inducing abnormality in neuronal function. It has been reported that supplementation of almond and walnut attenuate age-related memory loss. Present study was designed to investigate the weekly administration of cadmium for one month on learning and memory function with relation to cholinergic activity. Cadmium was administered at the dose of 50 mg/kg/week. Whereas, almond and walnut was supplemented at the dose of 400 mg/kg/day along with cadmium administration to separate set of rats. At the end of experiment, memory function was assessed by Morris water maze, open field test and novel object recognition test. Results of the present study showed that cadmium administration significantly reduced memory retention. Reduced acetylcholine levels and elevated acetyl cholinesterase activity were also observed in frontal cortex and hippocampus of cadmium treated rats. Malondialdehyde levels were also significantly increased following the administration of cadmium. Daily supplementation of almond and walnut for 28 days significantly attenuated cadmium-induced memory impairment in rats. Results of the present study are discussed in term of cholinergic activity in cadmium-induced memory loss and its attenuation by nuts supplementation in rats.
[Mh] Termos MeSH primário: Cádmio/administração & dosagem
Colinérgicos/administração & dosagem
Habituação Psicofisiológica/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Transtornos da Memória/induzido quimicamente
Transtornos da Memória/dietoterapia
Memória/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Envelhecimento/efeitos dos fármacos
Animais
Suplementos Nutricionais
Juglans
Aprendizagem em Labirinto/efeitos dos fármacos
Prunus dulcis
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinergic Agents); 00BH33GNGH (Cadmium); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


  8 / 7103 MEDLINE  
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[PMID]:28407522
[Au] Autor:Pollock CL; Carpenter MG; Hunt MA; Gallina A; Vieira TM; Ivanova TD; Garland SJ
[Ad] Endereço:Department of Physical Therapy, University of British Columbia, Vancouver, Canada.
[Ti] Título:Physiological arousal accompanying postural responses to external perturbations after stroke.
[So] Source:Clin Neurophysiol;128(6):935-944, 2017 Jun.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study was to examine simultaneously the level of physiological arousal and the postural response to external perturbations in people post-stroke compared to age-matched controls to build a more comprehensive understanding of the effect of stroke on postural control and balance self-efficacy. METHODS: Participants stood with each foot on separate force platforms. Ten applications of loads of 2% body weight at the hips perturbed the participant anteriorly under two conditions: investigator-triggered or self-triggered (total 20). Electrodermal activity (EDA; measurement of physiological arousal), electromyography (EMG) of the ankle plantarflexor muscles and anterior-posterior center of pressure measurements were taken pre-perturbation (anticipatory) and post-perturbation (response) and compared between the initial (first two) and final (last two) perturbations. RESULTS: Participants post-stroke demonstrated significantly higher levels of anticipatory EDA and anticipatory paretic plantarflexor EMG during both self- and investigator-triggered conditions compared to controls. Anticipatory EDA levels were higher in the final perturbations in participants post-stroke in both conditions, but not in controls. Habituation of the EDA responses post-perturbation was exhibited in the self-triggered perturbations in controls, but not in participants post-stroke. CONCLUSIONS: Physiological arousal and postural control strategies of controls revealed habituation in response to self-triggered perturbations, whereas this was not seen in participants post-stroke. SIGNIFICANCE: Understanding the physiological arousal response to challenges to standing balance post-stroke furthers our understanding of postural control mechanisms post-stroke.
[Mh] Termos MeSH primário: Nível de Alerta
Equilíbrio Postural
Postura
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Antecipação Psicológica
Sistema Nervoso Autônomo/fisiologia
Estudos de Casos e Controles
Feminino
Habituação Psicofisiológica
Seres Humanos
Masculino
Meia-Idade
Contração Muscular
Músculo Esquelético/inervação
Músculo Esquelético/fisiologia
Músculo Esquelético/fisiopatologia
Reabilitação do Acidente Vascular Cerebral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


  9 / 7103 MEDLINE  
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[PMID]:28348135
[Au] Autor:Zaman T; De Oliveira C; Smoka M; Narla C; Poulter MO; Schmid S
[Ad] Endereço:Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada, and.
[Ti] Título:BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.
[So] Source:J Neurosci;37(17):4540-4551, 2017 Apr 26.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Habituation is a basic form of implicit learning and represents a sensory filter that is disrupted in autism, schizophrenia, and several other mental disorders. Despite extensive research in the past decades on habituation of startle and other escape responses, the underlying neural mechanisms are still not fully understood. There is evidence from previous studies indicating that BK channels might play a critical role in habituation. We here used a wide array of approaches to test this hypothesis. We show that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, using patch-clamp recordings and voltage-sensitive dye imaging in slices. Furthermore, positive modulation of BK channels can enhance short-term habituation. Although results using different approaches do not always perfectly align, together they provide convincing evidence for a crucial role of BK channel phosphorylation in synaptic depression underlying short-term habituation of startle. We also show that this mechanism can be targeted to enhance short-term habituation and therefore to potentially ameliorate sensory filtering deficits associated with psychiatric disorders. Short-term habituation is the most fundamental form of implicit learning. Habituation also represents a filter for inundating sensory information, which is disrupted in autism, schizophrenia, and other psychiatric disorders. Habituation has been studied in different organisms and behavioral models and is thought to be caused by synaptic depression in respective pathways. The underlying molecular mechanisms, however, are poorly understood. We here identify, for the first time, a BK channel-dependent molecular synaptic mechanism leading to synaptic depression that is crucial for habituation, and we discuss the significance of our findings for potential treatments enhancing habituation.
[Mh] Termos MeSH primário: Habituação Psicofisiológica/fisiologia
Canais de Potássio Ativados por Cálcio de Condutância Alta/metabolismo
Plasticidade Neuronal/fisiologia
Sinapses/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Técnicas In Vitro
Masculino
Neuroimagem
Técnicas de Patch-Clamp
Fosforilação
Ponte/fisiologia
Ratos
Reflexo de Sobressalto/fisiologia
Imagens com Corantes Sensíveis à Voltagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Large-Conductance Calcium-Activated Potassium Channels)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.3699-16.2017


  10 / 7103 MEDLINE  
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[PMID]:28330446
[Au] Autor:Sarchiapone M; Iosue M; Carli V; Amore M; Baca-Garcia E; Batra A; Cosman D; Courtet P; Di Sciascio G; Gusmao R; Parnowski T; Pestality P; Saiz P; Thome J; Tingström A; Wojnar M; Zeppegno P; Thorell LH
[Ad] Endereço:Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy. marco.sarchiapone@me.com.
[Ti] Título:EUDOR-A multi-centre research program: A naturalistic, European Multi-centre Clinical study of EDOR Test in adult patients with primary depression.
[So] Source:BMC Psychiatry;17(1):108, 2017 Mar 23.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high specificity for suicide. The aims of the present study are to test the effectiveness and the usefulness of the EDOR (ElectroDermal Orienting Reactivity) Test as a support in the suicide risk assessment of depressed patients and to assess the predictive value of electrodermal hyporeactivity, measured through the EDOR Test, for suicide and suicide attempt in adult patients with a primary diagnosis of depression. METHODS AND DESIGN: 1573 patients with a primary diagnosis of depression, whether currently depressed or in remission, have been recruited at 15 centres in 9 different European countries. Depressive symptomatology was evaluated through the Montgomery-Asberg Depression Scale. Previous suicide attempts were registered and the suicide intent of the worst attempt was rated according to the first eight items of the Beck Suicide Intent Scale. The suicide risk was also assessed according to rules and traditions at the centre. The EDOR Test was finally performed. During the EDOR Test, two fingers are put on gold electrodes and direct current of 0.5 V is passed through the epidermis of the fingers according to standards. A moderately strong tone is presented through headphones now and then during the test. The electrodermal responses to the stimuli represent an increase in the conductance due to the increased number of filled sweat ducts that act as conductors through the electrically highly resistant epidermis. Each patient is followed up for one year in order to assess the occurrence of intentional self-harm. DISCUSSION: Based on previous studies, expected results would be that patients realizing a suicide attempt with a strong intent or committing suicide should be electrodermally hyporeactive in most cases and non-hyporeactive patients should show only few indications of death intent or suicides. TRIAL REGISTRATION: The German Clinical Trials Register, DRKS00010082 . Registered May 31 , 2016. Retrospectively registered.
[Mh] Termos MeSH primário: Nível de Alerta/fisiologia
Transtorno Bipolar/diagnóstico
Transtorno Bipolar/fisiopatologia
Transtorno Depressivo/diagnóstico
Transtorno Depressivo/fisiopatologia
Resposta Galvânica da Pele/fisiologia
Transtornos do Humor/diagnóstico
Transtornos do Humor/fisiopatologia
Ideação Suicida
[Mh] Termos MeSH secundário: Adulto
Transtorno Bipolar/psicologia
Depressão
Transtorno Depressivo/psicologia
Europa (Continente)
Feminino
Habituação Psicofisiológica/fisiologia
Seres Humanos
Masculino
Meia-Idade
Transtornos do Humor/psicologia
Valor Preditivo dos Testes
Suicídio
Tentativa de Suicídio
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; PRAGMATIC CLINICAL TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-017-1246-x



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