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  1 / 10398 MEDLINE  
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[PMID]:27770254
[Au] Autor:Fiechter JL; Benjamin AS
[Ad] Endereço:University of Illinois at Urbana-Champaign, Urbana, IL, USA. fiechte2@illinois.edu.
[Ti] Título:Updating metacognitive control in response to expected retention intervals.
[So] Source:Mem Cognit;45(3):347-361, 2017 04.
[Is] ISSN:1532-5946
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In five experiments, we investigated whether expected retention intervals affect subjects' encoding strategies. In the first four experiments, our subjects studied paired associates consisting of words from the Graduate Record Exam and a synonym. They were told to expect a test on a word pair after either a short or a longer interval. Subjects were tested on most pairs after the expected retention interval. For some pairs, however, subjects were tested after the other retention interval, allowing for a comparison of performance at a given retention interval conditional upon the expected retention interval. No effect of the expected retention interval was found for 1 min versus 4 min (Exp. 1), 30 s versus 3 min (Exp. 2), and 30 s versus 10 min (Exps. 3 and 4), even when subjects were given complete control over the pacing of study items (Exp. 4). However, when the difference between the expected retention intervals was increased massively (10 min vs. 24 h; Exp. 5), subjects remembered more items that they expected to be tested sooner, an effect consistent with the idea that they traded off efforts to remember items for the later test versus items that were about to be tested. Overall, this set of results accords with much of the test-expectancy literature, revealing that subjects are often reluctant to adjust encoding strategies on an item-by-item basis, and when they do, they usually make quantitative, rather than qualitative, adjustments.
[Mh] Termos MeSH primário: Função Executiva/fisiologia
Rememoração Mental/fisiologia
Metacognição/fisiologia
Retenção (Psicologia)/fisiologia
Aprendizagem Verbal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.3758/s13421-016-0664-1


  2 / 10398 MEDLINE  
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[PMID]:28460315
[Au] Autor:Davis MT; DellaGioia N; Matuskey D; Harel B; Maruff P; Pietrzak RH; Esterlis I
[Ad] Endereço:Yale University School of Medicine, Departments of Psychiatry and Diagnostic Radiology, USA. Electronic address: margaret.t.davis@yale.edu.
[Ti] Título:Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures.
[So] Source:J Affect Disord;218:82-85, 2017 Aug 15.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cognitive deficits are common in individuals with major depressive disorder (MDD), and are associated with treatment non-responsiveness and poorer functional outcomes. Characterization of the nature and magnitude of deficits in this population has been limited in part by lack of brief, practical, and well-validated assessment measures. The goal of this study was to use a brief, practical, and repeatable computerized cognitive test battery from Cogstate to examine differences in cognitive functioning between individuals with MDD and healthy controls. METHODS: Forty participants (22 healthy controls (HCs), 18 with MDD) completed a battery of six cognitive measures, as well as measures of intellectual functioning (intellect) and depressive symptom severity. A multivariate analysis of covariance (MANCOVA) was conducted to compare cognitive test performance across groups while controlling for intellect. RESULTS: Individuals with MDD had lower full-scale IQ scores on average, and performed worse on measures of visual attention (d=1.04), verbal learning (d=1.22) and memory (d=1.22), and visuospatial problem solving (d=0.80) than HCs after adjustment for differences in intellect. Psychomotor speed, visual memory, and working memory did not differ between groups. CONCLUSIONS: Cogstate measures appear to be sensitive in assessing deficits in attention, verbal learning and memory, and executive function in individuals with MDD. Further research will be useful in establishing the utility of Cogstate measures for standard use in research and clinical practice.
[Mh] Termos MeSH primário: Disfunção Cognitiva/diagnóstico
Transtorno Depressivo Maior/psicologia
Testes Neuropsicológicos
[Mh] Termos MeSH secundário: Adulto
Atenção
Estudos de Casos e Controles
Cognição
Disfunção Cognitiva/psicologia
Função Executiva
Feminino
Seres Humanos
Masculino
Memória de Curto Prazo
Meia-Idade
Análise Multivariada
Resolução de Problemas
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Aprendizagem Verbal
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  3 / 10398 MEDLINE  
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[PMID]:27776568
[Au] Autor:Lindbergh CA; Mewborn CM; Hammond BR; Renzi-Hammond LM; Curran-Celentano JM; Miller LS
[Ad] Endereço:1Department of Psychology,University of Georgia,Athens,Georgia.
[Ti] Título:Relationship of Lutein and Zeaxanthin Levels to Neurocognitive Functioning: An fMRI Study of Older Adults.
[So] Source:J Int Neuropsychol Soc;23(1):11-22, 2017 Jan.
[Is] ISSN:1469-7661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: It is well known that the carotenoids lutein (L) and zeaxanthin (Z) improve eye health and an accumulating evidence base suggests cognitive benefits as well. The present study investigated underlying neural mechanisms using functional magnetic resonance imaging (fMRI). It was hypothesized that lower L and Z concentrations would be associated with neurobiological inefficiency (i.e., increased activation) during cognitive performance. METHODS: Forty-three community-dwelling older adults (mean age=72 years; 58% female; 100% Caucasian) were asked to learn and recall pairs of unrelated words in an fMRI-adapted paradigm. L and Z levels were measured in retina (macular pigment optical density) and serum using validated procedures. RESULTS: Following first-level contrasts of encoding and retrieval trials minus control trials (p<.05, family-wise error corrected, minimum voxel cluster=8), L and Z were found to significantly and negatively relate to blood-oxygen-level-dependent signal in central and parietal operculum cortex, inferior frontal gyrus, supramarginal gyrus, planum polare, frontal and middle temporal gyrus, superior parietal lobule, postcentral gyrus, precentral gyrus, occipital cortex bilaterally, and cerebellar regions. CONCLUSIONS: To the authors' knowledge, the present study represents the first attempt to investigate neural mechanisms underlying the relation of L and Z to cognition using fMRI. The observed results suggest that L and Z promote cognitive functioning in old age by enhancing neural efficiency. (JINS, 2017, 23, 11-22).
[Mh] Termos MeSH primário: Envelhecimento/sangue
Encéfalo/diagnóstico por imagem
Envelhecimento Cognitivo
Luteína/sangue
Imagem por Ressonância Magnética
Zeaxantinas/sangue
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Envelhecimento/patologia
Mapeamento Encefálico
Depressão/sangue
Depressão/diagnóstico por imagem
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Vida Independente
Pigmento Macular/metabolismo
Masculino
Testes Neuropsicológicos
Oxigênio/sangue
Leitura
Aprendizagem Verbal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Macular Pigment); 0 (Zeaxanthins); S88TT14065 (Oxygen); X72A60C9MT (Lutein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1017/S1355617716000850


  4 / 10398 MEDLINE  
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[PMID]:28460299
[Au] Autor:Laing CE
[Ad] Endereço:Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA. Electronic address: catherine.laing@duke.edu.
[Ti] Título:A perceptual advantage for onomatopoeia in early word learning: Evidence from eye-tracking.
[So] Source:J Exp Child Psychol;161:32-45, 2017 Sep.
[Is] ISSN:1096-0457
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A perceptual advantage for iconic forms in infant language learning has been widely reported in the literature, termed the "sound symbolism bootstrapping hypothesis" by Imai and Kita (2014). However, empirical research in this area is limited mainly to sound symbolic forms, which are very common in languages such as Japanese but less so in Indo-European languages such as English. In this study, we extended this body of research to onomatopoeia-words that are thought to be present across most of the world's languages and that are known to be dominant in infants' early lexicons. In a picture-mapping task, 10- and 11-month-old infants showed a processing advantage for onomatopoeia (e.g., woof woof) over their conventional counterparts (e.g., doggie). However, further analysis suggests that the input may play a key role in infants' experience and processing of these forms.
[Mh] Termos MeSH primário: Desenvolvimento da Linguagem
Fonética
Aprendizagem Verbal/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Movimentos Oculares/fisiologia
Feminino
Seres Humanos
Lactente
Simbolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  5 / 10398 MEDLINE  
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[PMID]:28459262
[Au] Autor:Ginsburg V; Archambeau K; van Dijck JP; Chetail F; Gevers W
[Ad] Endereço:Center for Research in Cognition and Neurosciences, Université Libre de Bruxelles.
[Ti] Título:Coding of serial order in verbal, visual and spatial working memory.
[So] Source:J Exp Psychol Gen;146(5):632-650, 2017 May.
[Is] ISSN:1939-2222
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the domain of working memory, recent theories postulate that the maintenance of serial order is driven by position marking. According to this idea, serial order is maintained though associations of each item with an independent representation of the position that the item constitutes in the sequence. Recent studies suggest that those position markers are spatial in nature, with the beginning items associated with left side and the end elements with the right side of space (i.e., the ordinal position effect). So far however, it is unclear whether serial order is coded along the same principles in the verbal and the visuospatial domain. The aim of the current study was to investigate whether serial order is coded in a domain general fashion or not. To unravel this question, 6 experiments were conducted. The first 3 experiments revealed that the ordinal position effect is found with verbal but not with spatial information. In the subsequent experiments, the authors isolated the origin of this dissociation and conclude that to obtain spatial coding of serial order, it is not the nature of the encoded information (verbal, visual, or spatial) that is crucial, but whether the memoranda are semantically processed or not. This work supports the idea that serial order is coded in a domain general fashion, but suggests that position markers are only spatially coded when the to-be-remembered information is processed at the semantic level. (PsycINFO Database Record
[Mh] Termos MeSH primário: Memória de Curto Prazo/fisiologia
Aprendizagem Seriada/fisiologia
Memória Espacial/fisiologia
Aprendizagem Verbal/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Masculino
Testes Neuropsicológicos
Tempo de Reação/fisiologia
Semântica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1037/xge0000278


  6 / 10398 MEDLINE  
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[PMID]:27776264
[Au] Autor:Christidi F; Karavasilis E; Zalonis I; Ferentinos P; Giavri Z; Wilde EA; Xirou S; Rentzos M; Zouvelou V; Velonakis G; Toulas P; Efstathopoulos E; Poulou L; Argyropoulos G; Athanasakos A; Zambelis T; Levin HS; Karandreas N; Kelekis N; Evdokimidis I
[Ad] Endereço:First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: christidi.f.a@gmail.com.
[Ti] Título:Memory-related white matter tract integrity in amyotrophic lateral sclerosis: an advanced neuroimaging and neuropsychological study.
[So] Source:Neurobiol Aging;49:69-78, 2017 Jan.
[Is] ISSN:1558-1497
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We aimed to investigate structural changes in vivo in memory-related white matter tracts (i.e., perforant pathway zone [PPZ]; uncinate fasciculus [UF]; fornix) using diffusion tensor tractography and evaluate possible associations with memory performance in nondemented patients with amyotrophic lateral sclerosis (ALS). Forty-two ALS patients and 25 healthy controls (HCs) underwent a 30-directional diffusion-weighted imaging on a 3T MR scanner, followed by tractography of PPZ, UF, and fornix and analysis of fractional anisotropy (FA), axial diffusivity and radial diffusivity (Dr). Patients were administered neuropsychological measures of verbal (list learning via Rey Auditory Verbal Learning Test [RAVLT] and prose memory via Babcock Story Recall Test) and nonverbal (Rey's Complex Figure Test) episodic memory. After correcting for multiple comparisons, ALS patients showed increased Dr in the left PPZ compared to HC. We then fitted a multivariate general linear model within ALS patients with neuropsychological measures as dependent variables and age, age , gender, verbal IQ, and diffusion tensor tractography metrics with at least medium effect size differences between ALS and HC as independent variables. We found that (1) left PPZ FA, gender, and verbal IQ contributed to RAVLT-Total Learning; (2) left PPZ FA, left UF Dr, and gender contributed to RAVLT-Immediate Recall; and (3) left PPZ FA and left UF axial diffusivity contributed to Babcock Story Recall Test-Immediate and Delayed Recall. Advanced neuroimaging techniques verified in this study previously reported neuropathological findings regarding PPZ degeneration in ALS. We also detected a unique contribution of microstructural changes in hippocampal and frontotemporal white matter tracts on patients' memory profile.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/patologia
Esclerose Amiotrófica Lateral/psicologia
Neuroimagem
Substância Branca/diagnóstico por imagem
Substância Branca/patologia
[Mh] Termos MeSH secundário: Idoso
Anisotropia
Imagem de Difusão por Ressonância Magnética
Imagem de Tensor de Difusão
Feminino
Hipocampo/diagnóstico por imagem
Hipocampo/patologia
Seres Humanos
Masculino
Memória Episódica
Meia-Idade
Testes Neuropsicológicos
Aprendizagem Verbal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  7 / 10398 MEDLINE  
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[PMID]:28926629
[Au] Autor:Bollegala D; Hayashi K; Kawarabayashi KI
[Ad] Endereço:Department of Computer Science, University of Liverpool, Liverpool, United Kingdom.
[Ti] Título:Learning linear transformations between counting-based and prediction-based word embeddings.
[So] Source:PLoS One;12(9):e0184544, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the growing interest in prediction-based word embedding learning methods, it remains unclear as to how the vector spaces learnt by the prediction-based methods differ from that of the counting-based methods, or whether one can be transformed into the other. To study the relationship between counting-based and prediction-based embeddings, we propose a method for learning a linear transformation between two given sets of word embeddings. Our proposal contributes to the word embedding learning research in three ways: (a) we propose an efficient method to learn a linear transformation between two sets of word embeddings, (b) using the transformation learnt in (a), we empirically show that it is possible to predict distributed word embeddings for novel unseen words, and
[Mh] Termos MeSH primário: Aprendizagem Verbal
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Teóricos
Semântica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184544


  8 / 10398 MEDLINE  
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[PMID]:28922397
[Au] Autor:Alkozei A; Smith R; Dailey NS; Bajaj S; Killgore WDS
[Ad] Endereço:Department of Psychiatry, University of Arizona College of Medicine, Tucson, Arizona, United States of America.
[Ti] Título:Acute exposure to blue wavelength light during memory consolidation improves verbal memory performance.
[So] Source:PLoS One;12(9):e0184884, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acute exposure to light within the blue wavelengths has been shown to enhance alertness and vigilance, and lead to improved speed on reaction time tasks, possibly due to activation of the noradrenergic system. It remains unclear, however, whether the effects of blue light extend beyond simple alertness processes to also enhance other aspects of cognition, such as memory performance. The aim of this study was to investigate the effects of a thirty minute pulse of blue light versus placebo (amber light) exposure in healthy normally rested individuals in the morning during verbal memory consolidation (i.e., 1.5 hours after memory acquisition) using an abbreviated version of the California Verbal Learning Test (CVLT-II). At delayed recall, individuals who received blue light (n = 12) during the consolidation period showed significantly better long-delay verbal recall than individuals who received amber light exposure (n = 18), while controlling for the effects of general intelligence, depressive symptoms and habitual wake time. These findings extend previous work demonstrating the effect of blue light on brain activation and alertness to further demonstrate its effectiveness at facilitating better memory consolidation and subsequent retention of verbal material. Although preliminary, these findings point to a potential application of blue wavelength light to optimize memory performance in healthy populations. It remains to be determined whether blue light exposure may also enhance performance in clinical populations with memory deficits.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Luz
Consolidação da Memória/efeitos da radiação
Aprendizagem Verbal/efeitos da radiação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184884


  9 / 10398 MEDLINE  
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[PMID]:28768650
[Au] Autor:Qin B; Xun P; Jacobs DR; Zhu N; Daviglus ML; Reis JP; Steffen LM; Van Horn L; Sidney S; He K
[Ad] Endereço:Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.
[Ti] Título:Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
[So] Source:Am J Clin Nutr;106(4):1032-1040, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife. We hypothesize that higher intake of these B vitamins in young adulthood is associated with better cognition later in life. This study comprised a community-based multicenter cohort of black and white men and women aged 18-30 y in 1985-1986 (year 0, i.e., baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study ( = 3136). We examined participants' CARDIA diet history at years 0, 7, and 20 to assess nutrient intake, including dietary and supplemental B vitamins. We measured cognitive function at year 25 (mean ± SD age: 50 ± 4 y) through the use of the Rey Auditory Verbal Learning Test (RAVLT) for verbal memory, the Digit Symbol Substitution Test (DSST) for psychomotor speed, and a modified Stroop interference test for executive function. Higher RAVLT and DSST scores and a lower Stroop score indicated better cognitive function. We used multivariable-adjusted linear regressions to estimate mean differences in cognitive scores and 95% CIs. Comparing the highest quintile with the lowest (quintile 5 compared with quintile 1), cumulative total intake of niacin was significantly associated with 3.92 more digits on the DSST (95% CI: 2.28, 5.55; -trend < 0.01) and 1.89 points lower interference score on the Stroop test (95% CI: -3.10, -0.68; -trend = 0.05). Total folate was associated with 2.56 more digits on the DSST (95% CI: 0.82, 4.31; -trend = 0.01). We also found that higher intakes of vitamin B-6 (quartile 5 compared with quartile 1: 2.62; 95% CI: 0.97, 4.28; -trend = 0.02) and vitamin B-12 (quartile 5 compared with quartile 1: 2.08; 95% CI: 0.52, 3.65; -trend = 0.02) resulted in better psychomotor speed measured by DSST scores. Higher intake of B vitamins throughout young adulthood was associated with better cognitive function in midlife.
[Mh] Termos MeSH primário: Transtornos Cognitivos/prevenção & controle
Cognição/efeitos dos fármacos
Ácido Fólico/administração & dosagem
Niacina/administração & dosagem
Vitamina B 12/administração & dosagem
Vitamina B 6/administração & dosagem
Complexo Vitamínico B/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Doença de Alzheimer/etiologia
Doença de Alzheimer/prevenção & controle
Transtornos Cognitivos/etiologia
Estudos de Coortes
Dieta
Suplementos Nutricionais
Função Executiva
Feminino
Ácido Fólico/farmacologia
Seres Humanos
Estudos Longitudinais
Masculino
Memória
Meia-Idade
Niacina/farmacologia
Desempenho Psicomotor
Aprendizagem Verbal
Vitamina B 12/farmacologia
Vitamina B 6/farmacologia
Complexo Vitamínico B/farmacologia
Deficiência de Vitaminas do Complexo B/etiologia
Deficiência de Vitaminas do Complexo B/prevenção & controle
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
12001-76-2 (Vitamin B Complex); 2679MF687A (Niacin); 8059-24-3 (Vitamin B 6); 935E97BOY8 (Folic Acid); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.157834


  10 / 10398 MEDLINE  
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[PMID]:28704424
[Au] Autor:Siffredi V; Barrouillet P; Spencer-Smith M; Vaessen M; Anderson V; Vuilleumier P
[Ad] Endereço:University of Geneva, Geneva, Switzerland.
[Ti] Título:Examining distinct working memory processes in children and adolescents using fMRI: Results and validation of a modified Brown-Peterson paradigm.
[So] Source:PLoS One;12(7):e0179959, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Verbal working memory (WM) comprises different processes (encoding, maintenance, retrieval) that are often compromised in brain diseases, but their neural correlates have not yet been examined in childhood and adolescence. To probe WM processes and associated neural correlates in developmental samples, and obtain comparable effects across different ages and populations, we designed an adapted Brown-Peterson task (verbal encoding and retrieval combined with verbal and visual concurrent tasks during maintenance) to implement during functional magnetic resonance imaging (fMRI). In a sample of typically developing children and adolescents (n = 16), aged 8 to 16 years, our paradigm successfully identified distinct patterns of activation for encoding, maintenance, and retrieval. While encoding activated perceptual systems in posterior and ventral visual regions, retrieval activated fronto-parietal regions associated with executive control and attention. We found a different impact of verbal versus visual concurrent processing during WM maintenance: at retrieval, the former condition evoked greater activations in visual cortex, as opposed to selective involvement of language-related areas in left temporal cortex in the latter condition. These results are in accord with WM models, suggesting greater competition for processing resources when retrieval follows within-domain compared with cross-domain interference. This pattern was found regardless of age. Our study provides a novel paradigm to investigate distinct WM brain systems with reliable results across a wide age range in developmental populations, and suitable for participants with different WM capacities.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética/métodos
Memória de Curto Prazo/fisiologia
Lobo Parietal/diagnóstico por imagem
Lobo Temporal/diagnóstico por imagem
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Atenção
Mapeamento Encefálico/métodos
Criança
Função Executiva
Feminino
Seres Humanos
Masculino
Testes Neuropsicológicos
Aprendizagem Verbal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179959



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