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[PMID]:29499674
[Au] Autor:Casas P; Ascaso FJ; Vicente E; Tejero-Garcés G; Adiego MI; Cristóbal JA
[Ad] Endereço:Department of Ophthalmology, Hospital Clínico Universitario "Lozano Blesa", San Juan Bosco 15, ES-50009, Zaragoza, Spain. paulacasaspascual@hotmail.com.
[Ti] Título:Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls.
[So] Source:BMC Ophthalmol;18(1):66, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients. RESULTS: OSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters. We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024). CONCLUSIONS: Retinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination.
[Mh] Termos MeSH primário: Fibras Nervosas/patologia
Doenças do Nervo Óptico/etiologia
Células Ganglionares da Retina/patologia
Apneia Obstrutiva do Sono/complicações
Transtornos da Visão/etiologia
Campos Visuais
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Doenças do Nervo Óptico/diagnóstico
Estudos Prospectivos
Apneia Obstrutiva do Sono/diagnóstico
Tomografia de Coerência Óptica
Transtornos da Visão/diagnóstico
Testes de Campo Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0728-z


  2 / 27720 MEDLINE  
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[PMID]:29186723
[Au] Autor:Cennamo G; Tebaldi S; Amoroso F; Arvanitis D; Breve M; Cennamo G
[Ad] Endereço:Eye Clinic, Department of Public Health, Federico II University, Naples, Italy.
[Ti] Título:Optical Coherence Tomography Angiography in Optic Nerve Drusen.
[So] Source:Ophthalmic Res;59(2):76-80, 2018.
[Is] ISSN:1423-0259
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:AIM: To determine the efficacy of optical coherence tomography angiography (OCT-A) in diagnosing optic nerve head flow impairment in patients with optic nerve drusen. METHODS: Patients affected by optic-nerve head drusen (ONHD) attending the Eye Clinic of the Federico II University of Naples were enrolled in this prospective case series between October 2015 and October 2016. Each patient underwent evaluation of best corrected visual acuity (BCVA), Goldman applanation tonometry, slit-lamp biomicroscopy, fundus examination, standard visual-field testing (perimetry), spectral domain (SD)-OCT and OCT-A. RESULTS: Thirteen patients (6 females and 7 males with a mean age of 22.05 ± 7.54 years) with ONHD (19 eyes) were enrolled. Mean BCVA was 0.16 ± 0.21 LogMar and mean intraocular pressure was 15.68 ± 1.66 mm Hg. The control group constituted 16 individuals (24 eyes). Both ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) parameters were lower in patients than in controls. Similarly, the flow index (U = 134, p = 0.021) and vessel density (U = 90, p = 0.001) were significantly lower in eyes affected by ONHD than in normal eyes. Visual-field parameters did not differ between the 2 groups. GCC parameters were significantly correlated with OCT-A parameters (p < 0.05). No correlation was found between RNFL and OCT-A parameters. CONCLUSIONS: Our data suggest that OCT-A could be an objective method, helpful in the analysis of flow changes in patients with ONHD.
[Mh] Termos MeSH primário: Drusas do Disco Óptico/patologia
Disco Óptico/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Pressão Intraocular
Masculino
Fibras Nervosas/patologia
Disco Óptico/diagnóstico por imagem
Drusas do Disco Óptico/diagnóstico por imagem
Drusas do Disco Óptico/fisiopatologia
Estudos Prospectivos
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica
Acuidade Visual
Campos Visuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1159/000481889


  3 / 27720 MEDLINE  
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[PMID]:29378559
[Au] Autor:Anil K; Garip G
[Ad] Endereço:University of Derby Online Learning, Derby, England, United Kingdom. k.anil@soton.ac.uk.
[Ti] Título:Coping strategies, vision-related quality of life, and emotional health in managing retinitis pigmentosa: a survey study.
[So] Source:BMC Ophthalmol;18(1):21, 2018 Jan 30.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Retinitis pigmentosa is a group of genetic progressive retinal dystrophies that may adversely affect daily life. Those with RP should develop adaptive coping strategies to manage their condition. This study investigates the relationship between engaging (ECS) and disengaging coping strategies (DCS), vision-related quality of life (VRQoL), and emotional health, in adults living at home with retinitis pigmentosa. METHOD: One hundred and five participants (70 female; mean of 46.98, SD = 13.77) completed a cross-sectional survey. The questionnaire booklet consisted of the Coping Strategies Inventory - Short Form (32 items), the National Eye Institute Visual Functioning Questionnaire 25 (25 items), Marylands Trait Depression Scale (18 items), the Warwick-Edinburgh Mental Well-being Scale (14 items), and the Subjective Happiness Scale (4 items). RESULTS: Data was analysed with a two-block hierarchical multiple regression, with the first block controlling for the demographic data (age, sex, years since retinitis pigmentosa diagnosis, number of comorbidities, participant-perceived retinitis pigmentosa severity, and knowing RP type) and the second block consisting of primary measures (type of coping strategy, VRQoL, and Emotional Health). Type of coping strategy was found to impact psychosocial variables of VRQoL, not overall VRQoL. These psychosocial VRQoL variables had a positive association with ECS and a negative association with DCS. Emotional Health increased with ECS and decreased with DCS. There was a larger impact of DCS on VRQoL and Emotional Health compared to ECS, that is, VRQoL and Emotional Health decreased more with increasing DCS than VRQoL, and Emotional Health increased with increasing ECS. CONCLUSION: In concordance with previous research, ECS increased with increasing VRQoL and DCS decreased with increasing VRQoL. However, the findings also indicated that DCS had a greater impact than ECS on VRQoL and Emotional Health. This suggests that diminishing DCS should be prioritised over developing ECS to positively influence VRQoL and Emotional Health. Further research should investigate the impact of reducing DCS compared to increasing ECS, and how this may influence VRQoL and Emotional Health.
[Mh] Termos MeSH primário: Adaptação Psicológica
Emoções
Saúde Mental
Qualidade de Vida/psicologia
Retinite Pigmentosa/psicologia
Inquéritos e Questionários
Acuidade Visual
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Retinite Pigmentosa/diagnóstico
Retinite Pigmentosa/fisiopatologia
Autorrelato
Perfil de Impacto da Doença
Campos Visuais
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0689-2


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[PMID]:29298687
[Au] Autor:Aojula A; Mollan SP; Horsburgh J; Yiangou A; Markey KA; Mitchell JL; Scotton WJ; Keane PA; Sinclair AJ
[Ad] Endereço:Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT, Birmingham, UK.
[Ti] Título:Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension.
[So] Source:BMC Ophthalmol;17(1):257, 2018 Jan 04.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. METHODS: Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined. The internal limiting membrane and RNFL thickness of the most severely affected eye was examined for SegE and re-segmented. Using ImageJ, the total area of the RNFL thickness was calculated pre and post re-segmentation and the percentage change was determined. The distribution of RNFL thickness error was qualitatively assessed. RESULTS: Significantly greater SegE (p = 0.009) was present in RNFL thickness total area, assessed using ImageJ, in IIH patients (n = 46, 5% ± 0-58%) compared to controls (n = 14, 1% ± 0-6%). This was particularly evident in moderate to severe optic disc swelling (n = 23, 10% ± 0-58%, p < 0.001). RNFL thickness was unable to be quantified using SDOCT in patients with severe papilloedema. CONCLUSIONS: SegE remain a concern for clinicians using SDOCT to monitor papilloedema in IIH, particularly in the assessment of eyes with moderate to severe oedema. Systematic assessment and manual refinement of SegE is therefore important to ensure the accuracy in longitudinal monitoring of patients.
[Mh] Termos MeSH primário: Fibras Nervosas/patologia
Disco Óptico/patologia
Papiledema/diagnóstico
Pseudotumor Cerebral/diagnóstico
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica/métodos
Campos Visuais
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Papiledema/etiologia
Papiledema/fisiopatologia
Pseudotumor Cerebral/complicações
Pseudotumor Cerebral/fisiopatologia
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0652-7


  5 / 27720 MEDLINE  
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[PMID]:28451634
[Au] Autor:Majima K; Sukhanov P; Horikawa T; Kamitani Y
[Ad] Endereço:Graduate School of Informatics, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
[Ti] Título:Position Information Encoded by Population Activity in Hierarchical Visual Areas.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurons in high-level visual areas respond to more complex visual features with broader receptive fields (RFs) compared to those in low-level visual areas. Thus, high-level visual areas are generally considered to carry less information regarding the position of seen objects in the visual field. However, larger RFs may not imply loss of position information at the population level. Here, we evaluated how accurately the position of a seen object could be predicted (decoded) from activity patterns in each of six representative visual areas with different RF sizes [V1-V4, lateral occipital complex (LOC), and fusiform face area (FFA)]. We collected functional magnetic resonance imaging (fMRI) responses while human subjects viewed a ball randomly moving in a two-dimensional field. To estimate population RF sizes of individual fMRI voxels, RF models were fitted for individual voxels in each brain area. The voxels in higher visual areas showed larger estimated RFs than those in lower visual areas. Then, the ball's position in a separate session was predicted by maximum likelihood estimation using the RF models of individual voxels. We also tested a model-free multivoxel regression (support vector regression, SVR) to predict the position. We found that regardless of the difference in RF size, all visual areas showed similar prediction accuracies, especially on the horizontal dimension. Higher areas showed slightly lower accuracies on the vertical dimension, which appears to be attributed to the narrower spatial distributions of the RF centers. The results suggest that much position information is preserved in population activity through the hierarchical visual pathway regardless of RF sizes and is potentially available in later processing for recognition and behavior.
[Mh] Termos MeSH primário: Percepção Espacial/fisiologia
Córtex Visual/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Campos Visuais
Vias Visuais/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  6 / 27720 MEDLINE  
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[PMID]:29256895
[Au] Autor:Wu Z; Medeiros FA
[Ad] Endereço:Duke Eye Center and Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
[Ti] Título:Recent developments in visual field testing for glaucoma.
[So] Source:Curr Opin Ophthalmol;29(2):141-146, 2018 Mar.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Visual field testing remains one of the most important tools for characterizing and monitoring vision loss in glaucoma. Despite its current mainstream use, new developments continue to emerge on its current use and potentially better methods for its testing and analysis. This review summarizes new developments in visual field testing and, in particular, standard automated perimetry. RECENT FINDINGS: Evidence-based guidance has recently been provided on the impact of testing frequency on the ability to detect visual field progression. An increasing body of evidence also highlights numerous factors that can impact the interpretation of visual field results currently considered reliable (e.g. the reliability indices themselves, fixation tracking parameters, and cognitive decline). More targeted visual field testing paradigms for central and peripheral visual fields have been explored, although further work is needed to understand their role in clinical care. Exploiting retinal imaging during visual field testing with fundus-tracked perimetry shows promise for improving precision. Thresholding algorithms that account for spatial and structural information and novel analytical techniques for longitudinal data could also improve the ability to detect and monitor visual field loss. New promising methods for objective and portable assessment of visual function have also emerged. SUMMARY: New developments in visual field testing shows promise for improving this challenging, yet fundamental, clinical test for glaucoma management.
[Mh] Termos MeSH primário: Glaucoma/diagnóstico
Transtornos da Visão/diagnóstico
Testes de Campo Visual/métodos
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Glaucoma/fisiopatologia
Seres Humanos
Reprodutibilidade dos Testes
Transtornos da Visão/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000461


  7 / 27720 MEDLINE  
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[PMID]:29206653
[Au] Autor:Kang JM; Lin S
[Ad] Endereço:Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
[Ti] Título:Ginkgo biloba and its potential role in glaucoma.
[So] Source:Curr Opin Ophthalmol;29(2):116-120, 2018 Mar.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: This study will review the research on the effect of ginkgo biloba extract (GBE) on patients with glaucoma. RECENT FINDINGS: GBE appears to increase ocular blood flow in those with glaucoma. However, data on visual field outcomes are inconclusive. SUMMARY: GBE has been shown to have antioxidant and vascular effects, making it potentially effective in treating glaucoma. Published data are limited but show an increase in ocular blood flow after GBE administration. Conclusive evidence is lacking regarding the effect of GBE on clinical outcomes in glaucoma patients such as visual field performance.
[Mh] Termos MeSH primário: Terapias Complementares
Glaucoma/tratamento farmacológico
Pressão Intraocular/efeitos dos fármacos
Fitoterapia/métodos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Ginkgo biloba/química
Glaucoma/fisiopatologia
Seres Humanos
Pressão Intraocular/fisiologia
Fluxo Sanguíneo Regional/fisiologia
Campos Visuais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts); 19FUJ2C58T (Ginkgo biloba extract)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000459


  8 / 27720 MEDLINE  
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[PMID]:28743725
[Au] Autor:Hallum LE; Shooner C; Kumbhani RD; Kelly JG; García-Marín V; Majaj NJ; Movshon JA; Kiorpes L
[Ad] Endereço:Center for Neural Science, New York University, New York, New York 10003 hallum@cns.nyu.edu.
[Ti] Título:Altered Balance of Receptive Field Excitation and Suppression in Visual Cortex of Amblyopic Macaque Monkeys.
[So] Source:J Neurosci;37(34):8216-8226, 2017 Aug 23.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In amblyopia, a visual disorder caused by abnormal visual experience during development, the amblyopic eye (AE) loses visual sensitivity whereas the fellow eye (FE) is largely unaffected. Binocular vision in amblyopes is often disrupted by interocular suppression. We used 96-electrode arrays to record neurons and neuronal groups in areas V1 and V2 of six female macaque monkeys ( ) made amblyopic by artificial strabismus or anisometropia in early life, as well as two visually normal female controls. To measure suppressive binocular interactions directly, we recorded neuronal responses to dichoptic stimulation. We stimulated both eyes simultaneously with large sinusoidal gratings, controlling their contrast independently with raised-cosine modulators of different orientations and spatial frequencies. We modeled each eye's receptive field at each cortical site using a difference of Gaussian envelopes and derived estimates of the strength of central excitation and surround suppression. We used these estimates to calculate ocular dominance separately for excitation and suppression. Excitatory drive from the FE dominated amblyopic visual cortex, especially in more severe amblyopes, but suppression from both the FE and AEs was prevalent in all animals. This imbalance created strong interocular suppression in deep amblyopes: increasing contrast in the AE decreased responses at binocular cortical sites. These response patterns reveal mechanisms that likely contribute to the interocular suppression that disrupts vision in amblyopes. Amblyopia is a developmental visual disorder that alters both monocular vision and binocular interaction. Using microelectrode arrays, we examined binocular interaction in primary visual cortex and V2 of six amblyopic macaque monkeys ( ) and two visually normal controls. By stimulating the eyes dichoptically, we showed that, in amblyopic cortex, the binocular combination of signals is altered. The excitatory influence of the two eyes is imbalanced to a degree that can be predicted from the severity of amblyopia, whereas suppression from both eyes is prevalent in all animals. This altered balance of excitation and suppression reflects mechanisms that may contribute to the interocular perceptual suppression that disrupts vision in amblyopes.
[Mh] Termos MeSH primário: Ambliopia/fisiopatologia
Dominância Ocular/fisiologia
Estimulação Luminosa/métodos
Córtex Visual/fisiopatologia
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Macaca nemestrina
Microeletrodos
Estrabismo/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0449-17.2017


  9 / 27720 MEDLINE  
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[PMID]:29433472
[Au] Autor:Adachi S; Yuki K; Awano-Tanabe S; Ono T; Shiba D; Murata H; Asaoka R; Tsubota K
[Ad] Endereço:Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan.
[Ti] Título:Factors associated with developing a fear of falling in subjects with primary open-angle glaucoma.
[So] Source:BMC Ophthalmol;18(1):39, 2018 Feb 13.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To investigate the relationship between clinical risk factors, including visual field (VF) defects and visual acuity, and a fear of falling, among patients with primary open-angle glaucoma (POAG). METHODS: All participants answered the following question at a baseline ophthalmic examination: Are you afraid of falling? The same question was then answered every 12 months for 3 years. A binocular integrated visual field was calculated by merging a patient's monocular Humphrey field analyzer VFs, using the 'best sensitivity' method. The means of total deviation values in the whole, superior peripheral, superior central, inferior central, and inferior peripheral VFs were calculated. The relationship between these mean VF measurements, and various clinical factors, against patients' baseline fear of falling and future fear of falling was analyzed using multiple logistic regression. RESULTS: Among 392 POAG subjects, 342 patients (87.2%) responded to the fear of falling question at least twice in the 3 years study period. The optimal regression model for patients' baseline fear of falling included age, gender, mean of total deviation values in the inferior peripheral VF and number of previous falls. The optimal regression equation for future fear of falling included age, gender, mean of total deviation values in the inferior peripheral VF and number of previous falls. CONCLUSION: Defects in the inferior peripheral VF area are significantly related to the development of a fear of falling.
[Mh] Termos MeSH primário: Acidentes por Quedas
Medo/psicologia
Glaucoma de Ângulo Aberto/psicologia
Transtornos da Visão/psicologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Glaucoma de Ângulo Aberto/diagnóstico
Glaucoma de Ângulo Aberto/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Qualidade de Vida
Fatores de Risco
Inquéritos e Questionários
Transtornos da Visão/diagnóstico
Transtornos da Visão/fisiopatologia
Acuidade Visual/fisiologia
Campos Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0706-5


  10 / 27720 MEDLINE  
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[PMID]:29394920
[Au] Autor:Vanikieti K; Poonyathalang A; Jindahra P; Cheecharoen P; Chokthaweesak W
[Ad] Endereço:Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.
[Ti] Título:Occipital lobe infarction: a rare presentation of bilateral giant cavernous carotid aneurysms: a case report.
[So] Source:BMC Ophthalmol;18(1):25, 2018 Feb 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cavernous carotid aneurysm (CCA) represents 2-9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bilateral CCAs account for 11-29% of patients and are commonly associated with structural weaknesses in the ICA wall, secondary to systemic hypertension. CCAs are considered benign lesions, given the low risk for developing major neurologic morbidities (i.e., subarachnoid hemorrhage, cerebral infarction, or carotid cavernous fistula). Moreover, concurrent presentation with posterior circulation cerebral infarction is even rarer, given different circulation territory from CCA. Here, we report on a patient with bilateral giant CCAs who presented with both typical and atypical symptoms. CASE PRESENTATION: An 88-year-old hypertensive woman presented with acute vertical oblique binocular diplopia, followed by complete ptosis of the right eye. Ophthalmic examination showed dysfunction of the right third, fourth, and sixth cranial nerves. Further examination revealed hypesthesia of the areas supplied by the ophthalmic (V1) and maxillary (V2) branches of the right trigeminal nerve. Bilateral giant cavernous carotid aneurysms, with a concurrent subacute right occipital lobe infarction, were discovered on brain imaging and angiogram. Additionally, a prominent right posterior communicating artery (PCOM) was revealed. Seven months later, clinical improvement with stable radiographic findings was documented without any intervention. CONCLUSIONS: Dysfunction of the third, fourth, and sixth cranial nerves, and the ophthalmic (V ) and maxillary (V ) branches of the trigeminal nerves, should necessitate brain imaging, with special attention given to the cavernous sinus. Despite unilateral symptomatic presentation, bilateral lesions cannot be excluded solely on the basis of clinical findings. CCA should be included in the differential diagnosis of cavernous sinus lesions. Although rare, ipsilateral posterior circulation cerebral infarction (i.e., occipital lobe infarction) can occur in CCA patients, presumably as a result of distal embolization through an ipsilateral, prominent PCOM. Spontaneous clinical improvement with stable radiographic support may occur.
[Mh] Termos MeSH primário: Infarto Encefálico/diagnóstico por imagem
Doenças das Artérias Carótidas/diagnóstico por imagem
Artéria Carótida Interna/diagnóstico por imagem
Trombose do Corpo Cavernoso/diagnóstico por imagem
Aneurisma Intracraniano/diagnóstico por imagem
Lobo Occipital/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Blefaroptose/diagnóstico
Artéria Carótida Interna/patologia
Diplopia/diagnóstico
Feminino
Seres Humanos
Angiografia por Ressonância Magnética
Imagem por Ressonância Magnética
Lobo Occipital/patologia
Campos Visuais
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0687-4



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