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[PMID]: 28466068 [Au] Autor: McMurray MS; Conway SM; Roitman JD [Ad] Endereço: Department of Psychology, Miami University, Oxford, OH 45056. [Ti] Título: Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward. [So] Source: eNeuro;4(2), 2017 Mar-Apr. [Is] ISSN: 2373-2822 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Animal models of decision-making rely on an animal's motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially satiety. Here, we examined the use of brain stimulation reward (BSR) as an alternative reinforcer in rodent models of decision-making and compared it with the effectiveness of sugar pellets. The discriminability of various BSR frequencies was compared to differing numbers of sugar pellets in separate free-choice tasks. We found that BSR was more discriminable and motivated greater task engagement and more consistent preference for the larger reward. We then investigated whether rats prefer BSR of varying frequencies over sugar pellets. We found that animals showed either a clear preference for sugar reward or no preference between reward modalities, depending on the frequency of the BSR alternative and the size of the sugar reward. Overall, these results suggest that BSR is an effective reinforcer in rodent decision-making tasks, removing food-related confounds and resulting in more accurate, consistent, and reliable metrics of choice. [Mh] Termos MeSH primário: Encéfalo/fisiologia Comportamento de Escolha/fisiologia Tomada de Decisões/fisiologia Reforço (Psicologia) Recompensa [Mh] Termos MeSH secundário: Animais Comportamento Animal/fisiologia Condicionamento Operante/fisiologia Estimulação Elétrica Alimentos Masculino Motivação/fisiologia Ratos Long-Evans [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE

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[PMID]: 29240474 [Au] Autor: Glasper A [Ad] Endereço: University of Southampton. [Ti] Título: The Government's progress in promoting choice in end-of-life care. [So] Source: Br J Nurs;26(22):1256-1257, 2017 Dec 14. [Is] ISSN: 0966-0461 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Emeritus Professor Alan Glasper, University of Southampton, discusses the effectiveness of measures to deliver personalisation and choice in care for people nearing the end of life. [Mh] Termos MeSH primário: Comportamento de Escolha Governo Assistência Terminal [Mh] Termos MeSH secundário: Seres Humanos Reino Unido [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: N [Da] Data de entrada para processamento: 171215 [St] Status: MEDLINE [do] DOI: 10.12968/bjon.2017.26.22.1256

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[PMID]: 29362449 [Au] Autor: Korn CW; Bach DR [Ad] Endereço: Division of Clinical Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics; Psychiatric Hospital, University of Zurich, Lengstrasse 31, 8032, Zurich, Switzerland. c.korn@uke.de. [Ti] Título: Heuristic and optimal policy computations in the human brain during sequential decision-making. [So] Source: Nat Commun;9(1):325, 2018 01 23. [Is] ISSN: 2041-1723 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Optimal decisions across extended time horizons require value calculations over multiple probabilistic future states. Humans may circumvent such complex computations by resorting to easy-to-compute heuristics that approximate optimal solutions. To probe the potential interplay between heuristic and optimal computations, we develop a novel sequential decision-making task, framed as virtual foraging in which participants have to avoid virtual starvation. Rewards depend only on final outcomes over five-trial blocks, necessitating planning over five sequential decisions and probabilistic outcomes. Here, we report model comparisons demonstrating that participants primarily rely on the best available heuristic but also use the normatively optimal policy. FMRI signals in medial prefrontal cortex (MPFC) relate to heuristic and optimal policies and associated choice uncertainties. Crucially, reaction times and dorsal MPFC activity scale with discrepancies between heuristic and optimal policies. Thus, sequential decision-making in humans may emerge from integration between heuristic and optimal policies, implemented by controllers in MPFC. [Mh] Termos MeSH primário: Encéfalo/fisiologia Comportamento de Escolha/fisiologia Tomada de Decisões/fisiologia Heurística/fisiologia [Mh] Termos MeSH secundário: Adulto Mapeamento Encefálico Comportamento Alimentar/fisiologia Feminino Seres Humanos Imagem por Ressonância Magnética Masculino Estimulação Luminosa Córtex Pré-Frontal/fisiologia Tempo de Reação/fisiologia Recompensa Incerteza Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180125 [St] Status: MEDLINE [do] DOI: 10.1038/s41467-017-02750-3

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[PMID]: 29294192 [Au] Autor: Balamurali GS; Nicholls E; Somanathan H; Hempel de Ibarra N [Ad] Endereço: School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, India. [Ti] Título: A comparative analysis of colour preferences in temperate and tropical social bees. [So] Source: Naturwissenschaften;105(1-2):8, 2018 Jan 02. [Is] ISSN: 1432-1904 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The spontaneous occurrence of colour preferences without learning has been demonstrated in several insect species; however, the underlying mechanisms are still not understood. Here, we use a comparative approach to investigate spontaneous and learned colour preferences in foraging bees of two tropical and one temperate species. We hypothesised that tropical bees utilise different sets of plants and therefore might differ in their spontaneous colour preferences. We tested colour-naive bees and foragers from colonies that had been enclosed in large flight cages for a long time. Bees were shortly trained with triplets of neutral, UV-grey stimuli placed randomly at eight locations on a black training disk to induce foraging motivation. During unrewarded tests, the bees' responses to eight colours were video-recorded. Bees explored all colours and displayed an overall preference for colours dominated by long or short wavelengths, rather than a single colour stimulus. Naive Apis cerana and Bombus terrestris showed similar choices. Both inspected long-wavelength stimuli more than short-wavelength stimuli, whilst responses of the tropical stingless bee Tetragonula iridipennis differed, suggesting that resource partitioning could be a determinant of spontaneous colour preferences. Reward on an unsaturated yellow colour shifted the bees' preference curves as predicted, which is in line with previous findings that brief colour experience overrides the expression of spontaneous preferences. We conclude that rather than determining foraging behaviour in inflexible ways, spontaneous colour preferences vary depending on experimental settings and reflect potential biases in mechanisms of learning and decision-making in pollinating insects. [Mh] Termos MeSH primário: Abelhas/fisiologia Comportamento de Escolha/fisiologia Cor Flores/fisiologia [Mh] Termos MeSH secundário: Animais Aprendizagem Especificidade da Espécie Clima Tropical Raios Ultravioleta [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180103 [St] Status: MEDLINE [do] DOI: 10.1007/s00114-017-1531-z

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[PMID]: 28455259 [Au] Autor: Wengreen HJ; Nix E; Madden GJ [Ad] Endereço: Utah State University, 8700 Old Main Hill, Logan, UT 84321, United States. Electronic address: heidi.wengreen@usu.edu. [Ti] Título: The effect of social norms messaging regarding skin carotenoid concentrations among college students. [So] Source: Appetite;116:39-44, 2017 09 01. [Is] ISSN: 1095-8304 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Descriptive social-normative messaging positively influences short-term dietary choices and healthy food intake. The purpose of this study was to evaluate the effects of descriptive normative messages on college students' skin carotenoid concentrations (a biomarker of carotenoid-containing fruit and vegetable [FV] intake) over an 8-week period. 251 college students consented to participate and 74% completed the study. Students were randomly assigned to groups who, following a baseline evaluation of skin-carotenoid levels, were told how their score ranked within a peer group of college students attending the same university (Individualized Normative group), that their score was in the lower 20th percentile of the peer group (Manipulated Normative group), or were given no information about their score or the peer group (Control group). Skin carotenoid concentrations were reassessed 8 weeks after the normative messages were presented or withheld. Skin carotenoid levels of those in the Manipulated Normative group increased significantly more than did scores of those in the Control group (t (126) = 3.74, p < 0.001; d = 0.67), but these students' self-reported FV intake did not increase. This finding suggests normative messaging can influence behavior for up to 8 weeks, but future research must better evaluate if the increase in skin carotenoids reflects increased FV consumption, increased consumption of carotenoid-containing FV (with decreased consumption of other FV), or is accounted for by some other behavior change (e.g., increased use of supplements). These findings support further exploration of normative messaging as a technique for producing the long-term behavior change needed to impact public health. [Mh] Termos MeSH primário: Carotenoides/metabolismo Frutas Dieta Saudável Cooperação do Paciente Pele/metabolismo Normas Sociais Verduras [Mh] Termos MeSH secundário: Adulto Biomarcadores/metabolismo Comportamento de Escolha Feminino Preferências Alimentares Dieta Saudável/psicologia Seres Humanos Internet Masculino Inquéritos Nutricionais Ciências da Nutrição/educação Cooperação do Paciente/psicologia Estudo de Prova de Conceito Estudantes Universidades Utah Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Biomarkers); 36-88-4 (Carotenoids) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170430 [St] Status: MEDLINE

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[PMID]: 28459929 [Au] Autor: Sikkens JJ; van Agtmael MA; Peters EJG; Lettinga KD; van der Kuip M; Vandenbroucke-Grauls CMJE; Wagner C; Kramer MHH [Ad] Endereço: Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands. [Ti] Título: Behavioral Approach to Appropriate Antimicrobial Prescribing in Hospitals: The Dutch Unique Method for Antimicrobial Stewardship (DUMAS) Participatory Intervention Study. [So] Source: JAMA Intern Med;177(8):1130-1138, 2017 Aug 01. [Is] ISSN: 2168-6114 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Importance: Inappropriate antimicrobial prescribing leads to antimicrobial resistance and suboptimal clinical outcomes. Changing antimicrobial prescribing is a complex behavioral process that is not often taken into account in antimicrobial stewardship programs. Objective: To examine whether an antimicrobial stewardship approach grounded in behavioral theory and focusing on preserving prescriber autonomy and participation is effective in improving appropriateness of antimicrobial prescribing in hospitals. Design, Setting, and Participants: The Dutch Unique Method for Antimicrobial Stewardship (DUMAS) study was a prospective, stepped-wedge, participatory intervention study performed from October 1, 2011, through December 31, 2015. Outcomes were measured during a baseline period of 16 months and an intervention period of 12 months. The study was performed at 7 clinical departments (2 medical, 3 surgical, and 2 pediatric) in a tertiary care medical center and a general teaching hospital in the Netherlands. Physicians prescribing systemic antimicrobial drugs for any indication for patients admitted to the participating departments during the study period were included in the study. Interventions: We offered prescribers a free choice of how to improve their antimicrobial prescribing. Prescribers were stimulated to choose interventions with higher potential for success based on a root cause analysis of inappropriate prescribing. Main Outcomes and Measures: Appropriateness of antimicrobial prescriptions was determined using a validated approach based on guideline adherence and motivated guideline deviation and measured with repeated point prevalence surveys (6 per year). Appropriateness judgment was masked for the study period. Antimicrobial consumption was extracted from pharmacy records and measured as days of therapy per admission. We used linear and logistic mixed-model regression analysis to model outcomes over time. Results: A total of 1121 patient cases with 700 antimicrobial prescriptions were assessed during the baseline period and 882 patient cases with 531 antimicrobial prescriptions during the intervention period. The mean antimicrobial appropriateness increased from 64.1% at intervention start to 77.4% at 12-month follow-up (+13.3%; relative risk, 1.17; 95% CI, 1.04-1.27), without a change in slope. No decrease in antimicrobial consumption was found. Conclusions and Relevance: Use of a behavioral approach preserving prescriber autonomy resulted in an increase in antimicrobial appropriateness sustained for at least 12 months. The approach is inexpensive and could be easily transferable to various health care environments. [Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico Atitude do Pessoal de Saúde Infecções Bacterianas Resistência Microbiana a Medicamentos/efeitos dos fármacos Prescrição Inadequada Melhoria de Qualidade/organização & administração [Mh] Termos MeSH secundário: Infecções Bacterianas/tratamento farmacológico Infecções Bacterianas/epidemiologia Comportamento de Escolha Fidelidade a Diretrizes Hospitais/estatística & dados numéricos Seres Humanos Prescrição Inadequada/efeitos adversos Prescrição Inadequada/prevenção & controle Prescrição Inadequada/psicologia Prescrição Inadequada/estatística & dados numéricos Conduta do Tratamento Medicamentoso/organização & administração Países Baixos/epidemiologia Padrões de Prática Médica/estatística & dados numéricos Estudos Prospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180228 [Lr] Data última revisão: 180228 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE [do] DOI: 10.1001/jamainternmed.2017.0946

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[PMID]: 29373590 [Au] Autor: Lopez-Guzman S; Konova AB; Louie K; Glimcher PW [Ad] Endereço: Center for Neural Science, New York University, New York, United States of America. [Ti] Título: Risk preferences impose a hidden distortion on measures of choice impulsivity. [So] Source: PLoS One;13(1):e0191357, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Measuring temporal discounting through the use of intertemporal choice tasks is now the gold standard method for quantifying human choice impulsivity (impatience) in neuroscience, psychology, behavioral economics, public health and computational psychiatry. A recent area of growing interest is individual differences in discounting levels, as these may predispose to (or protect from) mental health disorders, addictive behaviors, and other diseases. At the same time, more and more studies have been dedicated to the quantification of individual attitudes towards risk, which have been measured in many clinical and non-clinical populations using closely related techniques. Economists have pointed to interactions between measurements of time preferences and risk preferences that may distort estimations of the discount rate. However, although becoming standard practice in economics, discount rates and risk preferences are rarely measured simultaneously in the same subjects in other fields, and the magnitude of the imposed distortion is unknown in the assessment of individual differences. Here, we show that standard models of temporal discounting -such as a hyperbolic discounting model widely present in the literature which fails to account for risk attitudes in the estimation of discount rates- result in a large and systematic pattern of bias in estimated discounting parameters. This can lead to the spurious attribution of differences in impulsivity between individuals when in fact differences in risk attitudes account for observed behavioral differences. We advance a model which, when applied to standard choice tasks typically used in psychology and neuroscience, provides both a better fit to the data and successfully de-correlates risk and impulsivity parameters. This results in measures that are more accurate and thus of greater utility to the many fields interested in individual differences in impulsivity. [Mh] Termos MeSH primário: Comportamento de Escolha Comportamento Impulsivo Assunção de Riscos [Mh] Termos MeSH secundário: Adulto Atitude Feminino Seres Humanos Masculino Meia-Idade Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180127 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191357

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[PMID]: 29251973 [Au] Autor: Hardy L; Hogarth L [Ad] Endereço: School of Psychology, University of Exeter. [Ti] Título: A novel concurrent pictorial choice model of mood-induced relapse in hazardous drinkers. [So] Source: Exp Clin Psychopharmacol;25(6):448-455, 2017 12. [Is] ISSN: 1936-2293 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: This study tested whether a novel concurrent pictorial choice procedure, inspired by animal self-administration models, is sensitive to the motivational effect of negative mood induction on alcohol-seeking in hazardous drinkers. Forty-eight hazardous drinkers (scoring ≥7 on the Alcohol Use Disorders Inventory) recruited from the community completed measures of alcohol dependence, depression, and drinking coping motives. Baseline alcohol-seeking was measured by percent choice to enlarge alcohol- versus food-related thumbnail images in two alternative forced-choice trials. Negative and positive mood was then induced in succession by means of self-referential affective statements and music, and percent alcohol choice was measured after each induction in the same way as baseline. Baseline alcohol choice correlated with alcohol dependence severity, r = .42, p = .003, drinking coping motives (in two questionnaires, r = .33, p = .02 and r = .46, p = .001), and depression symptoms, r = .31, p = .03. Alcohol choice was increased by negative mood over baseline (p < .001, ηp2 = .280), and matched baseline following positive mood (p = .54, ηp2 = .008). The negative mood-induced increase in alcohol choice was not related to gender, alcohol dependence, drinking to cope, or depression symptoms (ps ≥ .37). The concurrent pictorial choice measure is a sensitive index of the relative value of alcohol, and provides an accessible experimental model to study negative mood-induced relapse mechanisms in hazardous drinkers. (PsycINFO Database Record [Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/psicologia Comportamento de Escolha/fisiologia Comportamento Perigoso Motivação [Mh] Termos MeSH secundário: Adulto Análise de Variância Feminino Seres Humanos Masculino Meia-Idade Estimulação Luminosa Distribuição Espacial da População Inquéritos e Questionários Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180224 [Lr] Data última revisão: 180224 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171219 [St] Status: MEDLINE [do] DOI: 10.1037/pha0000155

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[PMID]: 29280834 [Au] Autor: Valiga TMT; Thornlow D [Ad] Endereço: At the Duke University School of Nursing in Durham, N.C., Theresa M. "Terry" Valiga is a professor emerita, and Deirdre Thornlow is an assistant professor. [Ti] Título: What to consider when choosing a graduate nursing program. [So] Source: Nursing;48(1):11-14, 2018 Jan. [Is] ISSN: 1538-8689 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Comportamento de Escolha Educação de Pós-Graduação em Enfermagem Enfermeiras e Enfermeiros/psicologia [Mh] Termos MeSH secundário: Seres Humanos Motivação Pesquisa em Avaliação de Enfermagem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: N [Da] Data de entrada para processamento: 171228 [St] Status: MEDLINE [do] DOI: 10.1097/01.NURSE.0000527614.67902.8e

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[PMID]: 29293614 [Au] Autor: Kim K; Ahn S; Lee B; Lee K; Yoo S; Lee K; Suh DH; No JH; Kim YB [Ad] Endereço: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-Si, Gyeonggi-Do, Republic of Korea. [Ti] Título: Factors associated with patients' choice of physician in the Korean population: Database analyses of a tertiary hospital. [So] Source: PLoS One;13(1):e0190472, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: This study aimed to determine the factors influencing patients' choice of physician at the first visit through database analysis of a tertiary hospital in South Korea. We collected data on the first treatments performed by physicians who had treated patients for at least 3 consecutive years over 10 years (from 2003 to 2012) from the database of Seoul National University's affiliated tertiary hospital. Ultimately, we obtained data on 524,012 first treatments of 319,004 patients performed by 115 physicians. Variables including physicians' age and medical school and patients' age were evaluated as influencing factors for the number of first treatments performed by each physician in each year using a Poisson regression through generalized estimating equations with a log link. The number of first treatments decreased over the study period. Notably, the relative risk for first treatments was lower among older physicians than among younger physicians (relative risk 0.96; 95% confidence interval 0.95 to 0.98). Physicians graduating from Seoul National University (SNU) also had a higher risk for performing first treatments than did those not from SNU (relative risk 1.58; 95% confidence interval 1.18 to 2.10). Finally, relative risk was also higher among older patients than among younger patients (relative risk 1.03; 95% confidence interval 1.01 to 1.04). This study systematically demonstrated that physicians' age, whether the physician graduated from the highest-quality university, and patients' age all related to patients' choice of physician at the first visit in a tertiary university hospital. These findings might be due to Korean cultural factors. [Mh] Termos MeSH primário: Comportamento de Escolha Sistemas de Informação Hospitalar Centros de Atenção Terciária/organização & administração [Mh] Termos MeSH secundário: Adulto Idoso Feminino Seres Humanos Masculino Meia-Idade Distribuição de Poisson República da Coreia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180103 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0190472

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