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[PMID]:29324888
[Au] Autor:Fukui H; Rünker A; Fabel K; Buchholz F; Kempermann G
[Ad] Endereço:German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany.
[Ti] Título:Transcription factor Runx1 is pro-neurogenic in adult hippocampal precursor cells.
[So] Source:PLoS One;13(1):e0190789, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transcription factor Runx1 (Runt Related Transcription Factor 1), plays an important role in the differentiation of hematopoetic stem cells, angiogenesis and the development of nociceptive neurons. These known functions have in common that they relate to lineage decisions. We thus asked whether such role might also be found for Runx1 in adult hippocampal neurogenesis as a process, in which such decisions have to be regulated lifelong. Runx1 shows a widespread low expression in the adult mouse brain, not particularly prominent in the hippocampus and the resident neural precursor cells. Isoforms 1 and 2 of Runx1 (but not 3 to 5) driven by the proximal promoter were expressed in hippocampal precursor cells ex vivo, albeit again at very low levels, and were markedly increased after stimulation with TGF-ß1. Under differentiation conditions (withdrawal of growth factors) Runx1 became down-regulated. Overexpression of Runx1 in vitro reduced proliferation, increased survival of precursor cells by reducing apoptosis, and increased neuronal differentiation, while slightly reducing dendritic morphology and complexity. Transfection with dominant-negative Runx1 in hippocampal precursor cells in vitro did not result in differences in neurogenesis. Hippocampal expression of Runx1 correlated with adult neurogenesis (precursor cell proliferation) across BXD recombinant strains of mice and covarying transcripts enriched in the GO categories "neural precursor cell proliferation" and "neuron differentiation". Runx1 is thus a plausible candidate gene to be involved in regulating initial differentiation-related steps of adult neurogenesis. It seems, however, that the relative contribution of Runx1 to such effect is complementary and will explain only small parts of the cell-autonomous pro-differentiation effect.
[Mh] Termos MeSH primário: Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo
Hipocampo/metabolismo
Células-Tronco Neurais/metabolismo
Neurogênese/fisiologia
[Mh] Termos MeSH secundário: Processamento Alternativo
Animais
Apoptose/fisiologia
Sobrevivência Celular/fisiologia
Células Cultivadas
Subunidade alfa 2 de Fator de Ligação ao Core/genética
Dendritos/metabolismo
Hipocampo/citologia
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos DBA
Células-Tronco Neurais/citologia
Isoformas de Proteínas
RNA Mensageiro/metabolismo
Corrida/fisiologia
Especificidade da Espécie
Biologia de Sistemas
Transcriptoma
Transfecção
Fator de Crescimento Transformador beta1/administração & dosagem
Fator de Crescimento Transformador beta1/metabolismo
Volição
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Core Binding Factor Alpha 2 Subunit); 0 (Protein Isoforms); 0 (RNA, Messenger); 0 (Runx1 protein, mouse); 0 (Transforming Growth Factor beta1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190789


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[PMID]:29183725
[Au] Autor:Jang Y; Lee B; Kim EK; Shim WS; Yang YD; Kim SM
[Ad] Endereço:Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, 02478, USA.
[Ti] Título:Involuntary swimming exercise in pregnant rats disturbs ERK1/2 signaling in embryonic neurons through increased cortisol in the amniotic fluid.
[So] Source:Biochem Biophys Res Commun;495(1):1208-1213, 2018 01 01.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Harmful maternal behaviors, such as drinking and smoking, negatively affect embryonic development. In contrast, regular maternal exercise is believed to be beneficial to the fetus. Although it is not surprising that voluntary physical activities are advantageous to fetal development, it remains unclear whether involuntary maternal exercise has similar effects. The constituents of the amniotic fluid (AF) inevitably reflect the maternal plasma. Therefore, it is speculated that exercise-induced changes in maternal plasma can influence fetal development through changes in AF composition. Therefore, we investigated the effect of AF on fetal neurodevelopment and changes in AF composition after involuntary swimming exercise (SE) in an animal model. We found that there was a severe reduction in the number of embryos implanted in the uterus of SE rats. Surprisingly, cortisol level (an inducible stress hormone) was significantly increased in AF from SE rats. In contrast, the growth factors NGF and VEGF were reduced in the AF from SE rats. In the cultured embryonic cortical neurons, the treatment of control (CTL) rat-derived AF significantly increased the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated signaling that is essential for fetal neurodevelopment. However, the AF extracted from SE rats reversely suppressed the phosphorylation of ERK1/2-mediated signaling in cortical neurons compared to that in CTL rats. Indeed, the co-treatment with control AF and dexamethasone, a synthetic glucocorticoid, inhibited the phosphorylation of ERK1/2 in a dose-dependent manner. This finding suggests that the inhibition of ERK1/2 can be attributed to increased cortisol level in AF resulting from involuntary exercise. Therefore, involuntary maternal swimming increases cortisol level in AF, which ultimately hinders the ERK1/2 signaling pathway in embryonic neurons. These findings also suggest that involuntary maternal exercise can have undesirable effects on fetal neurodevelopment, which is potentially mediated by elevated AF cortisol level.
[Mh] Termos MeSH primário: Líquido Amniótico/metabolismo
Desenvolvimento Embrionário/fisiologia
Hidrocortisona/metabolismo
Sistema de Sinalização das MAP Quinases/fisiologia
Neurônios/metabolismo
Prenhez/metabolismo
Estresse Fisiológico/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Condicionamento Físico Animal/métodos
Gravidez
Ratos
Ratos Sprague-Dawley
Natação
Volição/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  3 / 2781 MEDLINE  
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[PMID]:27773570
[Au] Autor:Jha A; Diehl B; Scott C; McEvoy AW; Nachev P
[Ad] Endereço:Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK; National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
[Ti] Título:Reversed Procrastination by Focal Disruption of Medial Frontal Cortex.
[So] Source:Curr Biol;26(21):2893-2898, 2016 Nov 07.
[Is] ISSN:1879-0445
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An enduring puzzle in the neuroscience of voluntary action is the origin of the remarkably wide dispersion of the reaction time distribution, an interval far greater than is explained by synaptic or signal transductive noise [1, 2]. That we are able to change our planned actions-a key criterion of volition [3]-so close to the time of their onset implies decision-making must reach deep into the execution of action itself [4-6]. It has been influentially suggested the reaction time distribution therefore reflects deliberate neural procrastination [7], giving alternative response tendencies sufficient time for fair competition in pursuing a decision threshold that determines which one is behaviorally manifest: a race model, where action selection and execution are closely interrelated [8-11]. Although the medial frontal cortex exhibits a sensitivity to reaction time on functional imaging that is consistent with such a mechanism [12-14], direct evidence from disruptive studies has hitherto been lacking. If movement-generating and movement-delaying neural substrates are closely co-localized here, a large-scale lesion will inevitably mask any acceleration, for the movement itself could be disrupted. Circumventing this problem, here we observed focal intracranial electrical disruption of the medial frontal wall in the context of the pre-surgical evaluation of two patients with epilepsy temporarily reversing such hypothesized procrastination. Effector-specific behavioral acceleration, time-locked to the period of electrical disruption, occurred exclusively at a specific locus at the ventral border of the pre-supplementary motor area. A cardinal prediction of race models of voluntary action is thereby substantiated in the human brain.
[Mh] Termos MeSH primário: Córtex Pré-Frontal/fisiologia
Procrastinação
Tempo de Reação
Volição
[Mh] Termos MeSH secundário: Adulto
Epilepsia/fisiopatologia
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 2781 MEDLINE  
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[PMID]:29036208
[Au] Autor:Inambao M; Kilembe W; Canary LA; Czaicki NL; Kakungu-Simpungwe M; Chavuma R; Wall KM; Tichacek A; Pulerwitz J; Thior I; Chomba E; Allen SA
[Ad] Endereço:Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States of America.
[Ti] Título:Transitioning couple's voluntary HIV counseling and testing (CVCT) from stand-alone weekend services into routine antenatal and VCT services in government clinics in Zambia's two largest cities.
[So] Source:PLoS One;12(10):e0185142, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Most HIV infections in Africa are acquired by married/cohabiting adults and WHO recommends couple's voluntary HIV counseling and testing (CVCT) for prevention. The handover from NGO-sponsored weekend CVCT to government-sponsored services in routine weekday antenatal care (ANC) and individual voluntary testing and counseling (VCT) services in Zambia's two largest cities from 2009-2015 is described. METHODS: Government clinic counselors were trained to provide CVCT, and along with community health workers they promoted CVCT services in their clinic and surrounding areas. When client volume exceeded the capacity of on-duty staff in ANC and VCT, non-governmental organization (NGO) subsidies were offered for overtime pay. RESULTS: Implementation of routine CVCT services varied greatly by clinic and city. The 12 highest volume clinics were examined further, while 13 clinics had CVCT numbers that were too low to warrant further investigation. In Lusaka, the proportion of pregnant women whose partners were tested rose from 2.6% in 2009 to a peak of 26.2% in 2012 and 24.8% in 2015. Corresponding reports in Ndola were 2.0% in 2009, 17.0% in 2012 and 14.5% in 2015. Obstacles to CVCT included: limited space and staffing, competing priorities, record keeping not adapted for couples, and few resources for promotion and increasing male involvement. Conflicting training models for 'partner testing' with men and women separately vs. CVCT with joint post-test counseling led to confusion in reporting to district health authorities. DISCUSSION: A focused and sustained effort will be required to reach a meaningful number of couples with CVCT to prevent heterosexual and perinatal HIV transmission. Establishing targets and timelines, funding for dedicated and appropriately trained staff, adoption of standardized data recording instruments with couple-level indicators, and expansion of community and clinic-based promotions using proven models are recommended.
[Mh] Termos MeSH primário: Infecções por HIV/prevenção & controle
Cuidado Pré-Natal
Parceiros Sexuais
[Mh] Termos MeSH secundário: Cidades
Feminino
Governo
Promoção da Saúde
Seres Humanos
Transmissão Vertical de Doença Infecciosa/prevenção & controle
Masculino
Guias de Prática Clínica como Assunto
Gravidez
Fatores de Tempo
Volição
Zâmbia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185142


  5 / 2781 MEDLINE  
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[PMID]:28902857
[Au] Autor:Lim SH; Mburu G; Bourne A; Pang J; Wickersham JA; Wei CKT; Yee IA; Wang B; Cassolato M; Azwa I
[Ad] Endereço:Center of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Willingness to use pre-exposure prophylaxis for HIV prevention among men who have sex with men in Malaysia: Findings from an online survey.
[So] Source:PLoS One;12(9):e0182838, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We examined willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM) in Malaysia. METHODS: An online survey of 990 MSM was conducted between March and April 2016. Eligibility criteria included being biological male, Malaysian citizen, 18 years of age or above, identifying as MSM, and being HIV negative or unknown status. Participants' demographics, sexual and drug use behaviors, attitudes towards PrEP, and preferences regarding future access to PrEP were collected. Bivariate analysis and logistic regression were performed to determine factors associated with willingness to use PrEP. RESULTS: Fewer than half of participants (44%) knew about PrEP before completing the survey. Overall, 39% of the sample were willing to take PrEP. Multivariate logistic regression indicated that Malay men (AOR: 1.73, 95% CI:1.12, 2.70), having 2 or more male anal sex partners in the past 6 months (AOR: 1.98, 95% CI: 1.29, 3.05), previous knowledge of PrEP (AOR: 1.40, 95%CI: 1.06, 1.86), lack of confidence in practising safer sex (AOR: 1.36, 95% CI: 1.02, 1.81), and having ever paid for sex with a male partner (AOR: 1.39, 95% CI: 1.01, 1.91) were independently associated with greater willingness to use PrEP, while men who identified as heterosexual were less willing to use PrEP (AOR, 0.36, 95% CI: 0.13, 0.97). Majority of participants preferred to access PrEP at affordable cost below 100 Malaysian Ringgit (USD25) per month from community based organisations followed by private or government hospitals. CONCLUSIONS: Overall, MSM in Malaysia reported a relatively low level of willingness to use PrEP, although willingness was higher among those previously aware of PrEP. There is a need to provide PrEP at affordable cost, increase demand and awareness of PrEP, and to provide access to this preventative medication via diverse, integrated and tailored sexual health services.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Infecções por HIV/prevenção & controle
Homossexualidade Masculina/estatística & dados numéricos
Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos
Profilaxia Pré-Exposição/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
HIV-1
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Malásia/epidemiologia
Masculino
Meia-Idade
Motivação
Sistemas On-Line
Parceiros Sexuais
Inquéritos e Questionários
Volição
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182838


  6 / 2781 MEDLINE  
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[PMID]:28692658
[Au] Autor:Joiner WM; Sing GC; Smith MA
[Ad] Endereço:John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.
[Ti] Título:Temporal specificity of the initial adaptive response in motor adaptation.
[So] Source:PLoS Comput Biol;13(7):e1005438, 2017 Jul.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Repeated exposure to a novel physical environment eventually leads to a mature adaptive response whereby feedforward changes in motor output mirror both the amplitude and temporal structure of the environmental perturbations. However, adaptive responses at the earliest stages of learning have been found to be not only smaller, but systematically less specific in their temporal structure compared to later stages of learning. This observation has spawned a lively debate as to whether the temporal structure of the initial adaptive response is, in fact, stereotyped and non-specific. To settle this debate, we directly measured the adaptive responses to velocity-dependent and position-dependent force-field perturbations (vFFs and pFFs) at the earliest possible stage of motor learning in humans-after just a single-movement exposure. In line with previous work, we found these earliest stage adaptive responses to be more similar than the perturbations that induced them. However, the single-trial adaptive responses for vFF and pFF perturbations were clearly distinct, and the disparity between them reflected the difference between the temporal structure of the perturbations that drove them. Critically, we observed these differences between single-trial adaptive responses when vFF and pFF perturbations were randomly intermingled from one trial to the next within the same block, indicating perturbation response specificity at the single trial level. These findings demonstrate that the initial adaptive responses to physical perturbations are not stereotyped. Instead, the neural plasticity in sensorimotor areas is sensitive to the temporal structure of a movement perturbation even at the earliest stage in learning. This insight has direct implications for the development of computational models of early-stage motor adaptation and the evolution of this adaptive response with continued training.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Retroalimentação Sensorial/fisiologia
Aprendizagem/fisiologia
Movimento/fisiologia
Desempenho Psicomotor/fisiologia
[Mh] Termos MeSH secundário: Simulação por Computador
Feminino
Seres Humanos
Masculino
Modelos Neurológicos
Comportamento Estereotipado/fisiologia
Fatores de Tempo
Volição
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005438


  7 / 2781 MEDLINE  
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[PMID]:28538993
[Au] Autor:Bakst L; Fleuriet J; Mustari MJ
[Ad] Endereço:Graduate Program in Neuroscience, University of Washington, Seattle, WA, USAWashington National Primate Research Center, University of Washington, Seattle, WA, USA.
[Ti] Título:FEFsem neuronal response during combined volitional and reflexive pursuit.
[So] Source:J Vis;17(5):13, 2017 May 01.
[Is] ISSN:1534-7362
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although much is known about volitional and reflexive smooth eye movements individually, much less is known about how they are coordinated. It is hypothesized that separate cortico-ponto-cerebellar loops subserve these different types of smooth eye movements. Specifically, the MT-MST-DLPN pathway is thought to be critical for ocular following eye movements, whereas the FEF-NRTP pathway is understood to be vital for volitional smooth pursuit. However, the role that these loops play in combined volitional and reflexive behavior is unknown. We used a large, textured background moving in conjunction with a small target spot to investigate the eye movements evoked by a combined volitional and reflexive pursuit task. We also assessed the activity of neurons in the smooth eye movement subregion of the frontal eye field (FEFsem). We hypothesized that the pursuit system would show less contribution from the volitional pathway in this task, owing to the increased involvement of the reflexive pathway. In accordance with this hypothesis, a majority of FEFsem neurons (63%) were less active during pursuit maintenance in a combined volitional and reflexive pursuit task than during purely volitional pursuit. Interestingly and surprisingly, the neuronal response to the addition of the large-field motion was highly correlated with the neuronal response to a target blink. This suggests that FEFsem neuronal responses to these different perturbations-whether the addition or subtraction of retinal input-may be related. We conjecture that these findings are due to changing weights of both the volitional and reflexive pathways, as well as retinal and extraretinal signals.
[Mh] Termos MeSH primário: Neurônios/fisiologia
Acompanhamento Ocular Uniforme/fisiologia
Percepção Visual/fisiologia
Volição/fisiologia
[Mh] Termos MeSH secundário: Animais
Macaca mulatta
Modelos Animais
Estimulação Luminosa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1167/17.5.13


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[PMID]:28522734
[Au] Autor:Taylor JA; Rodgers KM; Bercum FM; Booth CJ; Dudek FE; Barth DS
[Ad] Endereço:Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309.
[Ti] Título:Voluntary Control of Epileptiform Spike-Wave Discharges in Awake Rats.
[So] Source:J Neurosci;37(24):5861-5869, 2017 Jun 14.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genetically inherited absence epilepsy in humans is typically characterized by brief (seconds) spontaneous seizures, which involve spike-wave discharges (SWDs) in the EEG and interruption of consciousness and ongoing behavior. Genetic (inbred) models of this disorder in rats have been used to examine mechanisms, comorbidities, and antiabsence drugs. SWDs have also been proposed as models of complex partial seizures (CPSs) following traumatic brain injury (post-traumatic epilepsy). However, the ictal characteristics of these rat models, including SWDs and associated immobility, are also prevalent in healthy outbred laboratory rats. We therefore hypothesized that SWDs are not always associated with classically defined absence seizures or CPSs. To test this hypothesis, we used operant conditioning in male rats to determine whether outbred strains, Sprague Dawley and Long-Evans, and/or the inbred strain (a rat model of heritable human absence epilepsy) could exercise voluntary control over these epileptiform events. We discovered that both inbred and outbred rats could shorten the duration of SWDs to obtain a reward. These results indicate that SWD and associated immobility in rats may not reflect the obvious cognitive/behavioral interruption classically associated with absence seizures or CPSs in humans. One interpretation of these results is that human absence seizures and perhaps CPSs could permit a far greater degree of cognitive capacity than often assumed and might be brought under voluntary control in some cases. However, these results also suggest that SWDs and associated immobility may be nonepileptic in healthy outbred rats and reflect instead voluntary rodent behavior unrelated to genetic manipulation or to brain trauma. Our evidence that inbred and outbred rats learn to control the duration of spike-wave discharges (SWDs) suggests a voluntary behavior with maintenance of consciousness. If SWDs model mild absence seizures and/or complex partial seizures in humans, then an opportunity may exist for operant control complementing or in some cases replacing medication. Their equal occurrence in outbred rats also implies a major potential confound for behavioral neuroscience experiments, at least in adult rats where SWDs are prevalent. Alternatively, the presence and voluntary control of SWDs in healthy outbred rats could indicate that these phenomena do not always model heritable absence epilepsy or post-traumatic epilepsy in humans, and may instead reflect typical rodent behavior.
[Mh] Termos MeSH primário: Potenciais de Ação
Biorretroalimentação Psicológica/métodos
Ondas Encefálicas
Encéfalo/fisiopatologia
Epilepsia/fisiopatologia
Volição
[Mh] Termos MeSH secundário: Animais
Masculino
Ratos
Ratos Long-Evans
Ratos Sprague-Dawley
Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.3235-16.2017


  9 / 2781 MEDLINE  
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[PMID]:28443489
[Au] Autor:Dandanell S; Elbe AM; Pfister G; Elsborg P; W Helge J
[Ad] Endereço:1 Center of Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Denmark.
[Ti] Título:Relationship between volition, physical activity and weight loss maintenance: Study rationale, design, methods and baseline characteristics.
[So] Source:Scand J Public Health;45(3):299-304, 2017 May.
[Is] ISSN:1651-1905
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:AIMS: To investigate the relationship between volition, physical activity and weight loss maintenance. METHODS: We recruited 84 sedentary (maximal oxygen uptake: 25 ± 5 ml/min), overweight and obese (Body mass index (BMI) 38 ± 7 m/h , fat 44 ± 7 %) women ( n = 55) and men ( n = 29) for an interdisciplinary prospective study with follow-up. The change in lifestyle and weight loss is promoted via a 3-month intensive lifestyle intervention at a private health school. The intervention consists of supervised training (1-3 hours/day), a healthy hypo-caloric diet (-500 to -700 kCal/day) and education in healthy lifestyle in classes/groups. The participants' body weight and composition (Dual Energy X-ray absorptiometry), volitional skills (questionnaire), physical activity level (heart rate accelerometer/questionnaire) and maximal oxygen uptake (indirect calorimetry) are to be monitored before, after, and 3 and 12 months after the intervention. RESULTS: At the 12-month follow-up, three different groups will be established: Clinical weight loss maintenance (> 10% weight loss from baseline), moderate weight loss maintenance (1-10% weight loss) and no weight loss (or weight regain). A linear mixed model analysis will be used to compare levels of volitional skills, physical activity and maximal oxygen uptake over time, between the three groups. Correlational analyses will be used to investigate possible associations between volition, maximal oxygen uptake, physical activity level and weight loss maintenance. CONCLUSIONS: If specific volitional skills are identified as predictors of adherence to physical activity and success in clinical weight loss maintenance, these can be trained in future intensive lifestyle interventions in order to optimize the success rate.
[Mh] Termos MeSH primário: Exercício/psicologia
Obesidade/terapia
Sobrepeso/terapia
Volição
Perda de Peso
Programas de Redução de Peso/métodos
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Dinamarca
Feminino
Seguimentos
Seres Humanos
Estilo de Vida
Masculino
Meia-Idade
Obesidade/psicologia
Sobrepeso/psicologia
Cooperação do Paciente/psicologia
Cooperação do Paciente/estatística & dados numéricos
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1177/1403494816682378


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[PMID]:28352170
[Au] Autor:Liu Z; Lin L; Liu X
[Ad] Endereço:Geriatrics Department, Peking University First Hospital, Beijing, People's Republic of China.
[Ti] Título:Clinical application value of impulse oscillometry in geriatric patients with COPD.
[So] Source:Int J Chron Obstruct Pulmon Dis;12:897-905, 2017.
[Is] ISSN:1178-2005
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clinical application value of IOS in geriatric patients with COPD remains unclear. AIM: The aim of this study was to investigate the clinical application value of IOS in geriatric patients with COPD. SUBJECTS AND METHODS: A total of 234 subjects were retrospectively enrolled in this study, including 133 patients with COPD and 101 healthy volunteers. All the participants underwent IOS and spirometry examination. The data were collected and analyzed in the overall group, the geriatric group (aged ≥65 years), and the advanced elderly group (aged ≥80 years). RESULTS: 1) In COPD patients, a significant increase in respiratory impedance (Z5), resonant frequency (Fres), and respiratory resistance (R5, R20, R5-R20) and a decrease in respiratory reactance (X5) were observed in the overall group, the geriatric group, and the advanced elderly group compared with the healthy control subjects. 2) The IOS parameters correlated well with spirometry in COPD. In particular, R5-R20 showed the best correlation with forced expiratory volume in 1 second (FEV ) in the different age groups. 3) Fres and R5-R20 had the best diagnostic efficiency for COPD. The area under the curve (AUC) values for Fres, expressed by the receiver operating characteristic (ROC) curve, were 0.905, 0.909, and 0.914, for the different age groups, respectively. 4) The optimal cutoff values for Fres to diagnose airflow obstruction from ROC curves was 17.715 in the COPD patients. Its sensitivity and specificity were 0.789 and 0.931, respectively, and the cutoff values were similar in geriatric and advanced elderly patients. CONCLUSION: IOS demonstrated good relevance compared with spirometry for geriatric patients with COPD. IOS may serve as an alternative method for spirometry in elderly subjects for the evaluation of the state of COPD.
[Mh] Termos MeSH primário: Avaliação Geriátrica/métodos
Pulmão/fisiopatologia
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Testes de Função Respiratória/métodos
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Área Sob a Curva
Comportamento Cooperativo
Feminino
Volume Expiratório Forçado
Seres Humanos
Masculino
Oscilometria
Valor Preditivo dos Testes
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Doença Pulmonar Obstrutiva Crônica/psicologia
Curva ROC
Estudos Retrospectivos
Espirometria
Volição
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.2147/COPD.S129974



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