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[PMID]:28467924
[Au] Autor:Søberg S; Sandholt CH; Jespersen NZ; Toft U; Madsen AL; von Holstein-Rathlou S; Grevengoed TJ; Christensen KB; Bredie WLP; Potthoff MJ; Solomon TPJ; Scheele C; Linneberg A; Jørgensen T; Pedersen O; Hansen T; Gillum MP; Grarup N
[Ad] Endereço:Section for Metabolic Imaging and Liver Metabolism, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Centre o
[Ti] Título:FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans.
[So] Source:Cell Metab;25(5):1045-1053.e6, 2017 May 02.
[Is] ISSN:1932-7420
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.
[Mh] Termos MeSH primário: Doces
Fatores de Crescimento de Fibroblastos/genética
Preferências Alimentares
Polimorfismo Genético
Açúcares/metabolismo
[Mh] Termos MeSH secundário: Adulto
Apetite
Regulação do Apetite
Estudos de Coortes
Feminino
Fatores de Crescimento de Fibroblastos/sangue
Fatores de Crescimento de Fibroblastos/metabolismo
Genótipo
Seres Humanos
Masculino
Obesidade/genética
Obesidade/metabolismo
Paladar
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sugars); 0 (fibroblast growth factor 21); 62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:27773938
[Au] Autor:Dalvi PS; Chalmers JA; Luo V; Han DY; Wellhauser L; Liu Y; Tran DQ; Castel J; Luquet S; Wheeler MB; Belsham DD
[Ad] Endereço:Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons.
[So] Source:Int J Obes (Lond);41(1):149-158, 2017 Jan.
[Is] ISSN:1476-5497
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Consumption of dietary fat is one of the key factors leading to obesity. High-fat diet (HFD)-induced obesity is characterized by induction of inflammation in the hypothalamus; however, the temporal regulation of proinflammatory markers and their impact on hypothalamic appetite-regulating neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons remains undefined. METHODS: Mice were injected with an acute lipid infusion for 24 h or fed a HFD over 8-20 weeks. Characterized mouse NPY/AgRP hypothalamic cell lines were used for in vitro experimentation. Immunohistochemistry in brain slices or quantitative real-time PCR in cell lines, was performed to determine changes in the expression of key inflammatory markers and neuropeptides. RESULTS: Hypothalamic inflammation, indicated by tumor necrosis factor (TNF)-α expression and astrocytosis in the arcuate nucleus, was evident following acute lipid infusion. HFD for 8 weeks suppressed TNF-α, while significantly increasing heat-shock protein 70 and ciliary neurotrophic factor, both neuroprotective components. HFD for 20 weeks induced TNF-α expression in NPY/AgRP neurons, suggesting a detrimental temporal regulatory mechanism. Using NPY/AgRP hypothalamic cell lines, we found that palmitate provoked a mixed inflammatory response on a panel of inflammatory and endoplasmic reticulum (ER) stress genes, whereas TNF-α significantly upregulated IκBα, nuclear factor (NF)-κB and interleukin-6 mRNA levels. Palmitate and TNF-α exposure predominantly induced NPY mRNA levels. Utilizing an I kappa B kinase ß (IKKß) inhibitor, we demonstrated that these effects potentially occur via the inflammatory IKKß/NF-κB pathway. CONCLUSIONS: These findings indicate that acute lipid and chronic HFD feeding in vivo, as well as acute palmitate and TNF-α exposure in vitro, induce markers of inflammation or ER stress in the hypothalamic appetite-stimulating NPY/AgRP neurons over time, which may contribute to a dramatic alteration in NPY/AgRP content or expression. Acute and chronic HFD feeding in vivo temporally regulates arcuate TNF-α expression with reactive astrocytosis, which suggests a time-dependent neurotrophic or neurotoxic role of lipids.
[Mh] Termos MeSH primário: Apetite/efeitos dos fármacos
Dieta Hiperlipídica/efeitos adversos
Hipotálamo/patologia
Inflamação/induzido quimicamente
Neurônios/efeitos dos fármacos
Neuropeptídeo Y/metabolismo
Palmitatos/farmacologia
Fator de Necrose Tumoral alfa/farmacologia
[Mh] Termos MeSH secundário: Animais
Núcleo Arqueado do Hipotálamo/patologia
Modelos Animais de Doenças
Regulação da Expressão Gênica
Hipotálamo/efeitos dos fármacos
Inflamação/patologia
Interleucina-6/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Neurônios/metabolismo
Obesidade/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 0 (Neuropeptide Y); 0 (Palmitates); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1038/ijo.2016.183


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[PMID]:28294700
[Au] Autor:Morris A; Cramb R; Dodd-Reynolds CJ
[Ad] Endereço:a School of Applied Social Sciences , Durham University , Durham , UK.
[Ti] Título:Food intake and appetite following school-based high-intensity interval training in 9-11-year-old children.
[So] Source:J Sports Sci;36(3):286-292, 2018 Feb.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Using a randomised cross-over design, free-living lunch intake and subjective appetite were examined in 10 children (9.8 ± 0.6 years) following high-intensity interval training (HIIT) versus a control sedentary (SED) period, within a school setting. The 22-min HIIT took place during a regular PE lesson and consisted of two rounds of 4 × 30 s sprints. Foods were offered at a regular school lunch immediately following HIIT and SED and were matched between conditions. All food was covertly weighed before and after the meal. Hunger, fullness and prospective consumption were reported immediately before and after HIIT/SED, using visual analogue scales. Heart rate was higher during HIIT than SED (159.3 ± 23.1 vs. 76.9 ± 2.2 bpm, P < 0.05). Lunch energy intake was not different (P = 0.52) following HIIT, compared to SED (2.06 ± 0.35 vs. 2.09 ± 0.29 MJ, respectively). There were no significant differences in macronutrient intake or subjective appetite (P > 0.05). Results suggest that HIIT can be implemented in a PE lesson immediately before lunch, without causing a compensatory increase in food consumption.
[Mh] Termos MeSH primário: Apetite/fisiologia
Ingestão de Alimentos/fisiologia
Treinamento Intervalado de Alta Intensidade
Educação Física e Treinamento/métodos
[Mh] Termos MeSH secundário: Criança
Estudos Cross-Over
Currículo
Ingestão de Energia
Inglaterra
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Masculino
Instituições Acadêmicas
Estilo de Vida Sedentário
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1302599


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[PMID]:29320575
[Au] Autor:Allas S; Caixàs A; Poitou C; Coupaye M; Thuilleaux D; Lorenzini F; Diene G; Crinò A; Illouz F; Grugni G; Potvin D; Bocchini S; Delale T; Abribat T; Tauber M
[Ad] Endereço:Alizé Pharma, Ecully, France.
[Ti] Título:AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial.
[So] Source:PLoS One;13(1):e0190849, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT AND OBJECTIVE: Prader-Willi syndrome (PWS) is characterized by early-onset hyperphagia and increased circulating levels of the orexigenic Acylated Ghrelin (AG) hormone with a relative deficit of Unacylated Ghrelin (UAG). AZP-531, a first-in-class UAG analog, was shown to inhibit the orexigenic effect of AG in animals, to improve glycemic control and decrease body weight in humans. We aimed to investigate the safety and efficacy of AZP-531 in patients with PWS for whom no approved treatment for hyperphagia is currently available. METHODS AND DESIGN: Multi-center, randomized, double-blind, placebo-controlled trial. Forty-seven patients with genetically confirmed PWS and evidence of hyperphagia received daily subcutaneous injections of AZP-531 (3 and 4 mg for 50-70 kg and >70 kg body weight, respectively) or matching placebo for 14 days. Assessments included adverse events, vital signs, safety laboratory tests, the Hyperphagia Questionnaire (HQ), patient-reported appetite, body composition and glycemic measures. RESULTS: AZP-531 was well tolerated. There was a significant improvement with AZP-531 versus placebo in the mean total score, the 9-item score and the severity domain score of the HQ (p < .05). The highest reduction in the total and 9-item scores was observed in AZP-531 subjects with the highest hyperphagia score at baseline. Findings were supported by a reduction in appetite scores observed with AZP-531 only. Body weight did not change in both groups while a significant reduction in waist circumference and fat mass was observed only with AZP-531. AZP-531 significantly decreased post-prandial glucose levels in a baseline glucose dependent fashion. CONCLUSIONS: AZP-531 may constitute a new treatment strategy to improve hyperphagia and metabolic issues in patients with PWS. These findings support further investigation in longer-term clinical trials.
[Mh] Termos MeSH primário: Comportamento Alimentar/efeitos dos fármacos
Grelina/uso terapêutico
Hiperfagia/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Fragmentos de Peptídeos/uso terapêutico
Peptídeos Cíclicos/uso terapêutico
Síndrome de Prader-Willi/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fármacos Antiobesidade/efeitos adversos
Fármacos Antiobesidade/uso terapêutico
Apetite/efeitos dos fármacos
Apetite/fisiologia
Glicemia/efeitos dos fármacos
Composição Corporal/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Método Duplo-Cego
Comportamento Alimentar/fisiologia
Feminino
Seguimentos
Grelina/efeitos adversos
Seres Humanos
Hiperfagia/sangue
Hiperfagia/genética
Hipoglicemiantes/efeitos adversos
Masculino
Meia-Idade
Fragmentos de Peptídeos/efeitos adversos
Peptídeos Cíclicos/efeitos adversos
Síndrome de Prader-Willi/sangue
Síndrome de Prader-Willi/genética
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Blood Glucose); 0 (Ghrelin); 0 (Hypoglycemic Agents); 0 (Peptide Fragments); 0 (Peptides, Cyclic); 0 (cyclic des-acyl ghrelin (6-13))
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190849


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[PMID]:29287061
[Au] Autor:Ajibewa TA; O'Sullivan MP; Nagy MR; Block SS; Robinson LE; Colabianchi N; Hasson RE
[Ad] Endereço:University of Michigan School of Kinesiology, Ann Arbor, Michigan, United States of America.
[Ti] Título:The effects of interrupting prolonged sitting with intermittent activity on appetite sensations and subsequent food intake in preadolescent children.
[So] Source:PLoS One;12(12):e0188986, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Short-term and long-term exposure to prolonged sitting is associated with excess food intake and weight gain in children. Interrupting prolonged sitting with low-intensity activity has been shown to not alter hunger, satiety, or food consumption in children, however it is unclear whether interrupting sitting with high-intensity activity will alter appetite regulation in children. PURPOSE: The purpose of this study was to examine the acute effects of interrupting prolonged sitting with intermittent activity performed at varying intensities on hunger, satiety, prospective food consumption (PFC), and food intake in preadolescent children. METHODS: Thirty-nine children (ages 7-11 years, 54% female, 33% overweight/obese) completed four experimental conditions in random order: 8 hours of sitting interrupted with 20, 2-minute low-, moderate-, or high-intensity activity breaks or 20, 2-minute sedentary screen time breaks. Exercise intensity corresponded with 25%, 50% and 75% of heart rate reserve, respectively. Hunger, satiety, and PFC were assessed using the Visual Analog Scale, at five time points (pre- and post-breakfast, pre- and post-lunch, and pre-dinner) during each experimental condition. Dietary compensation was assessed as total caloric intake during a post-condition dinner standardized to provide 70% of estimated daily energy requirements. RESULTS: There was a significant effect of time on hunger, satiety, and PFC throughout each condition day (p< 0.001). There were no differences across conditions for hunger (sedentary: 4.9±0.3 cm, low: 5.0±0.3 cm, moderate: 5.1±0.3 cm, high: 5.1±0.3 cm, p>0.05), satiety (sedentary: 4.7±0.3 cm, low: 4.4±0.3 cm, moderate: 4.6±0.3 cm, high: 4.2±0.3 cm, p>0.05), and PFC (sedentary: 4.9±0.3 cm, low: 4.7±0.3 cm, moderate: 4.9±0.3 cm, high: 5.0±0.3 cm, p>0.05). There were no significant differences in post-activity food intake across conditions (sedentary: 1071.9±53.6 kcals; low: 1092.6±43.4kcals; moderate: 996.2±54.6kcals; high: 1138.7±62.8kcals, p>0.05). However, there was a significant effect of condition on energy balance (sedentary: +61.4±65.9 kcals, low: +74.9±57.6 kcals, moderate: -58.3±62.8 kcals, high: -391.2±77.9 kcals; p<0.001). There were no significant effects of weight status on hunger, satiety, PFC, post-activity food intake, and mean energy balance across conditions (all p's>0.05). CONCLUSIONS: Interrupting prolonged sitting with physical activity of any intensity does not alter appetite sensations and subsequent food consumption in children. These data suggest that interventions targeting prolonged sitting with high-intensity intermittent activity may be an effective strategy to increase physical activity energy expenditure without increasing food intake, allowing for a short-term energy deficit in both healthy weight and overweight/obese children. Future studies should examine the long-term effects of interrupting prolonged sitting with activity on food consumption and weight status in preadolescent children.
[Mh] Termos MeSH primário: Apetite
Ingestão de Alimentos
Postura
[Mh] Termos MeSH secundário: Antropometria
Criança
Exercício
Seres Humanos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188986


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[PMID]:29185930
[Au] Autor:Zamaratskaia G; Johansson DP; Junqueira MA; Deissler L; Langton M; Hellström PM; Landberg R
[Ad] Endereço:1Department of Molecular Sciences,BioCenter,Swedish University of Agricultural Sciences (SLU),750 07 Uppsala,Sweden.
[Ti] Título:Impact of sourdough fermentation on appetite and postprandial metabolic responses - a randomised cross-over trial with whole grain rye crispbread.
[So] Source:Br J Nutr;118(9):686-697, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sourdough fermentation is considered to have beneficial effects on postprandial satiety and metabolic responses, but studies demonstrating effects at physiological conditions are lacking. The aim of this acute breakfast intervention study was to determine the effect of consumption of sourdough-fermented and unfermented rye crispbread on self-rated appetite, postprandial glucose and insulin response in healthy subjects. In all, twenty-four Swedish adults were included in a single-blinded, randomised cross-over trial. Three crispbreads (sourdough-fermented and unfermented whole grain rye and yeast-fermented refined wheat as control) were consumed as part of a standardised breakfast. Subjective appetite score, assessed using visual analogue scale, and plasma glucose and insulin concentrations were measured at baseline and postprandially until 360 and 240 min, respectively. Structural changes and viscosity during mastication and gastric digestion were investigated using in vitro methods. Hunger and desire to eat were lower (P<0·05) based on AUC measurements after intake of sourdough-fermented rye crispbread compared with after intake of yeast-fermented refined wheat crispbread. On the basis of AUC (0-230 min), insulin response was lowest after intake of unfermented rye crispbread compared with sourdough-fermented rye and yeast-fermented refined wheat crispbread. Degradation of viscous fibres and faster bolus disintegration for the sourdough-fermented bread may partly explain the less favourable metabolic responses compared with unfermented bread. Our results showed that food processing affects the composition and structural characteristics of rye bread, which has implications for appetite and metabolic responses.
[Mh] Termos MeSH primário: Apetite
Glicemia/metabolismo
Pão
Alimentos Fermentados
Período Pós-Prandial
Secale/química
[Mh] Termos MeSH secundário: Adulto
Desjejum
Estudos Cross-Over
Fibras na Dieta/administração & dosagem
Digestão
Feminino
Peptídeo 1 Semelhante ao Glucagon/sangue
Seres Humanos
Insulina/sangue
Masculino
Meia-Idade
Saciação
Método Simples-Cego
Suécia
Triticum/química
Grãos Integrais/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fiber); 0 (Insulin); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1017/S000711451700263X


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[PMID]:29185929
[Au] Autor:Arguin H; Tremblay A; Blundell JE; Després JP; Richard D; Lamarche B; Drapeau V
[Ad] Endereço:1Department of Kinesiology, Faculty of Medicine,Laval University,Quebec,QC,Canada, G1V 0A6.
[Ti] Título:Impact of a non-restrictive satiating diet on anthropometrics, satiety responsiveness and eating behaviour traits in obese men displaying a high or a low satiety phenotype.
[So] Source:Br J Nutr;118(9):750-760, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the impact of a non-restrictive satiating diet in men displaying various degrees of satiety efficiency. In all, sixty-nine obese men aged 41·5 (sd 5·7) years were randomly assigned to a control (10-15, 55-60 and 30 % energy as protein, carbohydrate and lipid, respectively; n 34) or satiating (20-25, 45-50 and 30-35 % energy as protein, carbohydrate and lipid, respectively; n 35) diet for 16 weeks, and were classified as having a low (LSP) or high (HSP) satiety phenotype. Both diets were consumed ad libitum. Changes in body weight, BMI, percent fat mass, waist circumference, satiety responsiveness and eating behaviour traits were assessed following the intervention. Dropout rates were higher in the control diet (44·1 %) compared with the satiating diet (8·6 %). Decreases in body weight, BMI and waist circumference were significant in both groups, yet HSP individuals lost more body weight than LSP individuals (P=0·048). Decreases in % fat mass were greater in the satiating diet (LSP: -2·1 (sd 2·1) %; P<0·01 and HSP: -3·0 (sd 2·5) %; P<0·001) compared with the control diet (LSP: -1·1 (sd 2·5) % and HSP: -1·3 (sd 2·6) %) (P=0·034). Satiety responsiveness was markedly improved in the satiating diet, whereas no significant changes were observed in the control group. Changes in dietary restraint (+3·3 (sd 2·9) to +7·2 (sd 5·5)), flexible control (+0·9 (sd 1·4) to +2·3 (sd 2·7)), rigid control (+2·2 (sd 1·5) to +2·5 (sd 2·8)), disinhibition (-2·8 (sd 3·7) to -3·2 (sd 2·6)) and susceptibility to hunger (-2·7 (sd 4·1) to -4·6 (sd 3·9)) were similar between the diets. Compared with the control diet, the satiating diet favoured adherence, decreased % fat mass and improved satiety responsiveness in both HSP and LSP individuals.
[Mh] Termos MeSH primário: Antropometria
Dieta
Comportamento Alimentar
Obesidade/dietoterapia
Saciação
[Mh] Termos MeSH secundário: Adulto
Apetite
Composição Corporal
Carboidratos da Dieta/administração & dosagem
Gorduras na Dieta/administração & dosagem
Proteínas na Dieta/administração & dosagem
Seres Humanos
Masculino
Meia-Idade
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002549


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[PMID]:28870887
[Au] Autor:Holliday A; Blannin A
[Ad] Endereço:School of SportExercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK a.j.holliday@leedsbeckett.ac.uk.
[Ti] Título:Appetite, food intake and gut hormone responses to intense aerobic exercise of different duration.
[So] Source:J Endocrinol;235(3):193-205, 2017 Dec.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of the study is to investigate the effect of acute bouts of high-intensity aerobic exercise of differing durations on subjective appetite, food intake and appetite-associated hormones in endurance-trained males. Twelve endurance-trained males (age = 21 ± 2 years; BMI = 21.0 ± 1.6 kg/m ; VO = 61.6 ± 6.0 mL/kg/min) completed four trials, within a maximum 28 day period, in a counterbalanced order: resting (REST); 15 min exercise bout (15-min); 30 min exercise bout (30-min) and 45 min exercise bout (45-min). All exercise was completed on a cycle ergometer at an intensity of ~76% VO Sixty minutes post exercise, participants consumed an meal. Measures of subjective appetite and blood samples were obtained throughout the morning, with plasma analyzed for acylated ghrelin, total polypeptide tyrosine-tyrosine (PYY) and total glucagon-like peptide 1 (GLP-1) concentrations. The following results were obtained: Neither subjective appetite nor absolute food intake differed between trials. Relative energy intake (intake - expenditure) was significantly greater after REST (2641 ± 1616 kJ) compared with both 30-min (1039 ± 1520 kJ) and 45-min (260 ± 1731 kJ), and significantly greater after 15-min (2699 ± 1239 kJ) compared with 45-min (condition main effect, < 0.001). GLP-1 concentration increased immediately post exercise in 30-min and 45-min, respectively (condition × time interaction, < 0.001). Acylated ghrelin was transiently suppressed in all exercise trials (condition × time interaction, = 0.011); the greatest, most enduring suppression, was observed in 45-min. PYY concentration was unchanged with exercise. In conclusion, high-intensity aerobic cycling lasting up to 45 min did not suppress subjective appetite or affect absolute food intake, but did reduce relative energy intake, in well-trained endurance athletes. Findings question the role of appetite hormones in regulating subjective appetite in the acute post-exercise period.
[Mh] Termos MeSH primário: Apetite/fisiologia
Ingestão de Alimentos/fisiologia
Exercício/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos Cross-Over
Ingestão de Energia/fisiologia
Metabolismo Energético/fisiologia
Hormônios Gastrointestinais/metabolismo
Grelina/metabolismo
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Seres Humanos
Masculino
Peptídeo YY/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gastrointestinal Hormones); 0 (Ghrelin); 106388-42-5 (Peptide YY); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-16-0570


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[PMID]:28817798
[Au] Autor:Andermann ML; Lowell BB
[Ad] Endereço:Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address: manderma@bidmc.harvard.edu.
[Ti] Título:Toward a Wiring Diagram Understanding of Appetite Control.
[So] Source:Neuron;95(4):757-778, 2017 Aug 16.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prior mouse genetic research has set the stage for a deep understanding of appetite regulation. This goal is now being realized through the use of recent technological advances, such as the ability to map connectivity between neurons, manipulate neural activity in real time, and measure neural activity during behavior. Indeed, major progress has been made with regard to meal-related gut control of appetite, arcuate nucleus-based hypothalamic circuits linking energy state to the motivational drive, hunger, and, finally, limbic and cognitive processes that bring about hunger-mediated increases in reward value and perception of food. Unexpected findings are also being made; for example, the rapid regulation of homeostatic neurons by cues that predict future food consumption. The aim of this review is to cover the major underpinnings of appetite regulation, describe recent advances resulting from new technologies, and synthesize these findings into an updated view of appetite regulation.
[Mh] Termos MeSH primário: Apetite/fisiologia
Núcleo Arqueado do Hipotálamo/citologia
Trato Gastrointestinal/fisiologia
Vias Neurais/fisiologia
Neurônios/fisiologia
[Mh] Termos MeSH secundário: Proteína Relacionada com Agouti/metabolismo
Animais
Regulação do Apetite
Trato Gastrointestinal/inervação
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Agouti-Related Protein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE


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[PMID]:28814400
[Au] Autor:de Lauzon-Guillain B; Clifton EA; Day FR; Clément K; Brage S; Forouhi NG; Griffin SJ; Koudou YA; Pelloux V; Wareham NJ; Charles MA; Heude B; Ong KK
[Ad] Endereço:Early Origin of Child Health and Development (ORCHAD) Team 6, Center of Research in Epidemiology and UMR 1153 Statistics Sorbonne Paris Cité (CRESS), National Institute of Health and Medical Research (INSERM), Paris, France.
[Ti] Título:Mediation and modification of genetic susceptibility to obesity by eating behaviors.
[So] Source:Am J Clin Nutr;106(4):996-1004, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many genetic variants show highly robust associations with body mass index (BMI). However, the mechanisms through which genetic susceptibility to obesity operates are not well understood. Potentially modifiable mechanisms, including eating behaviors, are of particular interest to public health. Here we explore whether eating behaviors mediate or modify genetic susceptibility to obesity. Genetic risk scores for BMI (BMI-GRSs) were calculated for 3515 and 2154 adults in the Fenland and EDEN (Etude des déterminants pré et postnatals de la santé et du développement de l'enfant) population-based cohort studies, respectively. The eating behaviors-emotional eating, uncontrolled eating, and cognitive restraint-were measured through the use of a validated questionnaire. The mediating effect of each eating behavior on the association between the BMI-GRS and measured BMI was assessed by using the Sobel test. In addition, we tested for interactions between each eating behavior and the BMI-GRS on BMI. The association between the BMI-GRS and BMI was mediated by both emotional eating (EDEN: Sobel = 0.01; Fenland: Sobel = 0.02) and uncontrolled eating (EDEN: Sobel = 0.04; Fenland: -Sobel = 0.0006) in both sexes combined. Cognitive restraint did not mediate this association ( -Sobel > 0.10), except among EDEN women ( -Sobel = 0.0009). Cognitive restraint modified the relation between the BMI-GRS and BMI among men (EDEN: -interaction = 0.0001; Fenland: -interaction = 0.04) and Fenland women ( -interaction = 0.0004). By tertiles of cognitive restraint, the association between the BMI-GRS and BMI was strongest in the lowest tertile of cognitive restraint, and weakest in the highest tertile. Genetic susceptibility to obesity was partially mediated by the "appetitive" eating behavior traits (uncontrolled and emotional eating) and, in 3 of the 4 population groups studied, was modified by cognitive restraint. High levels of cognitive control over eating appear to attenuate the genetic susceptibility to obesity. Future research into interventions designed to support restraint may help to protect genetically susceptible individuals from weight gain.
[Mh] Termos MeSH primário: Cognição
Ingestão de Alimentos/psicologia
Emoções
Comportamento Alimentar
Interação Gene-Ambiente
Obesidade/etiologia
Autocontrole
[Mh] Termos MeSH secundário: Adulto
Apetite
Índice de Massa Corporal
Comportamento Alimentar/psicologia
Feminino
Predisposição Genética para Doença
Seres Humanos
Hiperfagia/complicações
Hiperfagia/psicologia
Masculino
Meia-Idade
Obesidade/genética
Obesidade/psicologia
Fatores de Risco
Fatores Sexuais
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.157396



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