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  1 / 19007 MEDLINE  
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[PMID]:28464288
[Au] Autor:Giuliano L; Uccello D; Fatuzzo D; Mainieri G; Zappia M; Sofia V
[Ad] Endereço:Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy.
[Ti] Título:Electroclinical findings of minor motor events during sleep in temporal lobe epilepsy.
[So] Source:Epilepsia;58(7):1261-1267, 2017 07.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: It is well known that sleep-related motor seizures can originate from the temporal lobe. However, little is known about the clinical features of minor motor manifestations during sleep in patients with temporal lobe epilepsy. The main objective of our study was to verify the existence of minor motor events during sleep in patients with mesial temporal lobe epilepsy (MTLE) and to define their clinical features and electroencephalography (EEG) correlations. METHODS: We enrolled in the study patients with diagnosis of symptomatic MTLE and a group of healthy controls. All patients and controls underwent long-term video -EEG monitoring, including at least one night of nocturnal sleep. We analyzed all the movements recorded during nocturnal sleep of patients and controls and their electroencephalographic correlations. RESULTS: We analyzed the nocturnal sleep of 15 patients with symptomatic MTLE (8 males and 7 females; mean age ± standard deviation [SD]31.8 ± 14.9 years) and of 15 healthy controls (6 males and 9 females; mean age ± SD 32.8 ± 11.2 years). The analysis of movements during sleep revealed significant differences between groups, with the patients presenting significantly more movements in sleep than healthy controls (56.7 ± 39.2 vs. 15 ± 6.1; p < 0.001) with significant differences regarding oroalimentary automatisms, limb dystonia, straightening movements and gestural automatisms. EEG analysis showed that the proportion of movements preceded by EEG abnormalities was significantly higher in patients than in controls (57.8 ± 35.9 movements vs. 16.6 ± 13.4 movements; p < 0.001). SIGNIFICANCE: The results of our study demonstrated the presence of minor motor events during sleep in patients with MTLE, suggesting an epileptic origin of these episodes. The study of nocturnal sleep in MTLE patients is useful in helping the clinicians in the diagnostic and therapeutic workup of these patients.
[Mh] Termos MeSH primário: Eletroencefalografia
Epilepsia do Lobo Temporal/diagnóstico
Epilepsia do Lobo Temporal/fisiopatologia
Polissonografia
Processamento de Sinais Assistido por Computador
Gravação em Vídeo
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Potenciais de Ação/fisiologia
Adolescente
Adulto
Anticonvulsivantes/uso terapêutico
Automatismo/diagnóstico
Automatismo/tratamento farmacológico
Automatismo/fisiopatologia
Mapeamento Encefálico
Dominância Cerebral/efeitos dos fármacos
Dominância Cerebral/fisiologia
Epilepsia do Lobo Temporal/tratamento farmacológico
Feminino
Seres Humanos
Masculino
Meia-Idade
Atividade Motora/efeitos dos fármacos
Atividade Motora/fisiologia
Lobo Temporal/efeitos dos fármacos
Lobo Temporal/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180107
[Lr] Data última revisão:
180107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13770


  2 / 19007 MEDLINE  
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[PMID]:28448683
[Au] Autor:Morgan VL; Englot DJ; Rogers BP; Landman BA; Cakir A; Abou-Khalil BW; Anderson AW
[Ad] Endereço:Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.
[Ti] Título:Magnetic resonance imaging connectivity for the prediction of seizure outcome in temporal lobe epilepsy.
[So] Source:Epilepsia;58(7):1251-1260, 2017 07.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Currently, approximately 60-70% of patients with unilateral temporal lobe epilepsy (TLE) remain seizure-free 3 years after surgery. The goal of this work was to develop a presurgical connectivity-based biomarker to identify those patients who will have an unfavorable seizure outcome 1-year postsurgery. METHODS: Resting-state functional and diffusion-weighted 3T magnetic resonance imaging (MRI) was acquired from 22 unilateral (15 right, 7 left) patients with TLE and 35 healthy controls. A seizure propagation network was identified including ipsilateral (to seizure focus) and contralateral hippocampus, thalamus, and insula, with bilateral midcingulate and precuneus. Between each pair of regions, functional connectivity based on correlations of low frequency functional MRI signals, and structural connectivity based on streamline density of diffusion MRI data were computed and transformed to metrics related to healthy controls of the same age. RESULTS: A consistent connectivity pattern representing the network expected in patients with seizure-free outcome was identified using eight patients who were seizure-free at 1-year postsurgery. The hypothesis that increased similarity to the model would be associated with better seizure outcome was tested in 14 other patients (Engel class IA, seizure-free: n = 5; Engel class IB-II, favorable: n = 4; Engel class III-IV, unfavorable: n = 5) using two similarity metrics: Pearson correlation and Euclidean distance. The seizure-free connectivity model successfully separated all the patients with unfavorable outcome from the seizure-free and favorable outcome patients (p = 0.0005, two-tailed Fisher's exact test) through the combination of the two similarity metrics with 100% accuracy. No other clinical and demographic predictors were successful in this regard. SIGNIFICANCE: This work introduces a methodologic framework to assess individual patients, and demonstrates the ability to use network connectivity as a potential clinical tool for epilepsy surgery outcome prediction after more comprehensive validation.
[Mh] Termos MeSH primário: Biomarcadores
Encéfalo/fisiopatologia
Imagem de Difusão por Ressonância Magnética
Epilepsia do Lobo Temporal/fisiopatologia
Epilepsia do Lobo Temporal/cirurgia
Interpretação de Imagem Assistida por Computador
Imagem por Ressonância Magnética
Rede Nervosa/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico
Dominância Cerebral/fisiologia
Eletroencefalografia
Epilepsia do Lobo Temporal/classificação
Epilepsia do Lobo Temporal/diagnóstico
Feminino
Seres Humanos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Recidiva
Valores de Referência
Processamento de Sinais Assistido por Computador
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180107
[Lr] Data última revisão:
180107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13762


  3 / 19007 MEDLINE  
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[PMID]:28768555
[Au] Autor:Price A; Eccles R
[Ad] Endereço:Common Cold Centre,Cardiff School of Biosciences,Cardiff University,Wales,UK.
[Ti] Título:Is there any relationship between right and left hand dominance and right and left nasal airflow dominance?
[So] Source:J Laryngol Otol;131(10):846-852, 2017 Oct.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Left- or right-handedness is a common human trait, and it has been previously reported that human nasal airflow dominance correlates with hand dominance. Any relationship between hand dominance and nasal airflow dominance would be unusual. This study aimed to measure nasal airflow and look for any relationship to handedness. METHODS: The modified Glatzel mirror was used to record the dominant nasal passage at 15-minute intervals over a 6-hour period in 29 healthy participants consisting of 15 left-handers and 14 right-handers. RESULTS: In left-handers, the percentage of time that the left nasal passage was dominant ranged from 0 to 100 per cent. In right-handers, the percentage of time that the right nasal passage was dominant ranged from 4.2 to 95.8 per cent. No correlation between nasal airflow dominance and hand dominance was identified. CONCLUSION: The results do not support the hypothesis that nasal airflow and handedness are related.
[Mh] Termos MeSH primário: Lateralidade Funcional
Mãos/fisiologia
Cavidade Nasal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Dominância Cerebral
Feminino
Seres Humanos
Masculino
Projetos Piloto
Estudos Prospectivos
Fenômenos Fisiológicos Respiratórios
Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001475


  4 / 19007 MEDLINE  
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[PMID]:28710246
[Au] Autor:Cooper AN; Anderson V; Hearps S; Greenham M; Ditchfield M; Coleman L; Hunt RW; Mackay MT; Monagle P; Gordon AL
[Ad] Endereço:Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
[Ti] Título:Trajectories of Motor Recovery in the First Year After Pediatric Arterial Ischemic Stroke.
[So] Source:Pediatrics;140(2), 2017 Aug.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neuromotor impairments are common after pediatric stroke, but little is known about functional motor outcomes. We evaluated motor function and how it changed over the first 12 months after diagnosis. We also examined differences in outcome according to age at diagnosis and whether fine motor (FM) or gross motor (GM) function at 12 months was associated with adaptive behavior. METHODS: This prospective, longitudinal study recruited children ( = 64) from The Royal Children's Hospital, Melbourne who were diagnosed with acute arterial ischemic stroke (AIS) between December 2007 and November 2013. Motor assessments were completed at 3 time points after the diagnosis of AIS (1, 6, and 12 months). Children were grouped as follows: neonates ( = 27), preschool-aged ( = 19), and school-aged ( = 18). RESULTS: A larger lesion size was associated with poorer GM outcomes at 12 months ( = .016). Neonatal AIS was associated with better FM and GM function initially but with a reduction in scores over time. For the preschool- and school-aged groups, FM remained relatively stable over time. For GM outcomes, the preschool- and the school-aged age groups displayed similar profiles, with gradual recovery over time. Overall, poor FM and GM outcomes at 12 months were associated with poorer adaptive behavior scores. CONCLUSIONS: Motor outcomes and the trajectory of recovery post-AIS differed according to a child's age at stroke onset. These findings indicate that an individualized approach to surveillance and intervention may be needed that is informed in part by age at diagnosis.
[Mh] Termos MeSH primário: Infarto Cerebral/diagnóstico
Hipóxia-Isquemia Encefálica/diagnóstico
Transtornos Motores/diagnóstico
[Mh] Termos MeSH secundário: Doença Aguda
Adaptação Psicológica
Adolescente
Criança
Pré-Escolar
Avaliação da Deficiência
Dominância Cerebral
Feminino
Hemiplegia/diagnóstico
Seres Humanos
Lactente
Recém-Nascido
Estudos Longitudinais
Masculino
Limitação da Mobilidade
Exame Neurológico
Estudos Prospectivos
Recuperação de Função Fisiológica
Inquéritos e Questionários
Vitória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


  5 / 19007 MEDLINE  
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[PMID]:28591482
[Au] Autor:Scholly J; Staack AM; Kahane P; Scavarda D; Régis J; Hirsch E; Bartolomei F
[Ad] Endereço:Medical and Surgical Epilepsy Unit, Hautepierre Hospital, University of Strasbourg, Strasbourg, France.
[Ti] Título:Hypothalamic hamartoma: Epileptogenesis beyond the lesion?
[So] Source:Epilepsia;58 Suppl 2:32-40, 2017 Jun.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The discovery of intrinsic epileptogenicity of the hypothalamic hamartoma (HH) marked a new area in understanding the associated clinical syndrome, often manifesting as progressive epileptic encephalopathy. However, therapeutic procedures targeting the HH proved to be inefficient to cure seizures in up to 50% of cases, whereas in cases with partial improvement, the electroclinical patterns of persisting seizures suggest an involvement of distant cortical regions. The concept of kindling-like secondary epileptogenesis has been suggested as a possible underlying mechanism. Yet the role of the hypothalamic lesion in the pathophysiology of the syndrome remains debatable. In the Strasbourg-Kork series, the best outcomes were obtained when the duration of epilepsy before endoscopic HH surgery did not exceed 10 years. In two patients with HH ablation followed at a later time by a temporal lobectomy, only this second surgical step allowed complete seizure freedom. These findings suggest the existence of an independent, third stage of secondary epileptogenesis in human. In the Grenoble series, stereotactic intracerebral recordings (stereo electroencephalography [SEEG]) of five HH cases demonstrated that gelastic/dacrystic seizures were correlated with discharges within the HH, whereas other seizure types were related to discharges affecting cortical regions, which sometimes seemed to be triggered by HH. In the Marseille series, two cases explored by SEEG provided evidence of extended epileptogenicity outside the limits of the HH, forming complex epileptogenic networks, with HH still triggering clusters of neocortical seizures in the first, but not obligatory involved in spontaneous seizures in the second case. Taken together, our data argue for the existence of dynamic ictal network organization, with possible "kindling-like" relationships between the HH and the neocortex or widespread epileptogenesis. Despite the existence of secondary epileptogenesis, the epileptogenic zone could still be limited to the hamartoma, for which early surgical treatment should be pragmatically considered as a first surgical step.
[Mh] Termos MeSH primário: Epilepsias Parciais/fisiopatologia
Hamartoma/fisiopatologia
Doenças Hipotalâmicas/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Lobectomia Temporal Anterior
Criança
Pré-Escolar
Modelos Animais de Doenças
Progressão da Doença
Dominância Cerebral/fisiologia
Eletrodos Implantados
Eletroencefalografia
Epilepsias Parciais/diagnóstico
Epilepsias Parciais/cirurgia
Feminino
Hamartoma/diagnóstico
Hamartoma/cirurgia
Hipocampo/fisiopatologia
Seres Humanos
Doenças Hipotalâmicas/diagnóstico
Doenças Hipotalâmicas/cirurgia
Excitação Neurológica/fisiologia
Masculino
Neocórtex/fisiopatologia
Neocórtex/cirurgia
Rede Nervosa/fisiopatologia
Rede Nervosa/cirurgia
Neurônios/fisiologia
Processamento de Sinais Assistido por Computador
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13755


  6 / 19007 MEDLINE  
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[PMID]:28591477
[Au] Autor:Wagner K; Schulze-Bonhage A; Urbach H; Trippel M; Spehl TS; Buschmann F; Metternich B; Ofer I; Meyer PT; Frings L
[Ad] Endereço:Epilepsy Center, Medical Center - University of Freiburg, Freiburg, Germany.
[Ti] Título:Reduced glucose metabolism in neocortical network nodes remote from hypothalamic hamartomas reflects cognitive impairment.
[So] Source:Epilepsia;58 Suppl 2:41-49, 2017 Jun.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The clinical appearance of patients with hypothalamic hamartomas is very heterogeneous, and interindividual variability of intellectual abilities is not completely understood. We retrospectively investigated cerebral dysfunction as indicated by reduced regional glucose metabolism in 29 patients (age range 7-49 years) with epilepsy due to hypothalamic hamartomas. Brain metabolism assessed by [ F]FDG-PET was compared between patients with and without cognitive impairment controlled for unevenly distributed hamartoma lateralization seen on magnetic resonance imaging (MRI). Due to the broad age range, the variable "age" was included in the imaging analyses as a covariate. Additional voxel-wise analysis with hamartoma volume, disease duration, seizure severity, seizure frequency, and antiepileptic drug (AED) load as well as dosage and gender as further covariates was accomplished. Furthermore, global visual ratings on laterality of hypometabolism patterns were assessed according to clinical standards and related to hamartoma lateralization on MRI as well as lateralization of electroencephalography (EEG) abnormalities. Cognitively impaired patients showed significantly reduced glucose metabolism in bilateral frontal as well as right parietal and posterior midline cortices (p < 0.005), irrespective of hamartoma lateralization seen on MRI. Additional voxel-wise analysis with the above-mentioned further covariates revealed comparable results. FDG uptake values within the main right frontal cluster obtained from group comparison were not associated with hamartoma volume, disease duration, or AED load. Irrespective of cognitive functioning, lateralization of reduced FDG uptake in global visual ratings was associated with lateralization of hypothalamic hamartomas seen on MRI (p < 0.01), but not with EEG abnormalities. We found regions of reduced glucose metabolism in cognitively impaired patients remote from the hypothalamic hamartomas in frontal and parietal regions, which have been identified as important network nodes in the human brain and are linked to higher cognitive functions.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Transtornos Cognitivos/fisiopatologia
Hamartoma/fisiopatologia
Doenças Hipotalâmicas/fisiopatologia
Neocórtex/fisiopatologia
Rede Nervosa/fisiopatologia
Nós Neurofibrosos/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Transtornos Cognitivos/diagnóstico
Dominância Cerebral/fisiologia
Eletroencefalografia
Feminino
Fluordesoxiglucose F18
Hamartoma/diagnóstico
Seres Humanos
Doenças Hipotalâmicas/diagnóstico
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Testes Neuropsicológicos
Tomografia por Emissão de Pósitrons
Estudos Retrospectivos
Processamento de Sinais Assistido por Computador
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13757


  7 / 19007 MEDLINE  
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Valenca, Marcelo Moraes
Texto completo SciELO Brasil
[PMID]:28591389
[Au] Autor:Kitamura MAP; Costa LF; Silva DOA; Batista LL; Holanda MMA; Valença MM
[Ad] Endereço:Universidade Federal de Pernambuco, Departamento de Neuropsiquiatria, Recife PB, Brasil.
[Ti] Título:Cranial venous sinus dominance: what to expect? Analysis of 100 cerebral angiographies.
[So] Source:Arq Neuropsiquiatr;75(5):295-300, 2017 May.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Methods: Data of 100 cerebral angiographies were retrospectively analyzed (p = 0.05). Results: Mean age was 56.3 years, 62% female and 38% male. Measurements and dominance are shown in the Tables. There was no association between age or gender and dominance. Right parasagittal division of the superior sagittal sinus was associated with right dominance of the transverse sinus, sigmoid sinus and internal jugular vein; and left parasagittal division of the superior sagittal sinus was associated with left dominance of the transverse sinus, sigmoid sinus and internal jugular vein. Conclusion: A dominance pattern of cranial venous sinuses was found. Age and gender did not influence this pattern. Angiographic findings, such as division of the superior sagittal sinus, were associated with a pattern of cranial venous dominance. We hope this article can add information and assist in preoperative venous analysis for neurosurgeons and neuroradiologists.
[Mh] Termos MeSH primário: Angiografia Cerebral
Veias Cerebrais/anatomia & histologia
Circulação Cerebrovascular
Cavidades Cranianas/anatomia & histologia
Dominância Cerebral
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Veias Cerebrais/diagnóstico por imagem
Cavidades Cranianas/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  8 / 19007 MEDLINE  
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[PMID]:28532914
[Au] Autor:Turco L; Cornell DL; Phillips B
[Ad] Endereço:Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA. Electronic address: LTurco@kumc.edu.
[Ti] Título:Penetrating Bihemispheric Traumatic Brain Injury: A Collective Review of Gunshot Wounds to the Head.
[So] Source:World Neurosurg;104:653-659, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Head injuries that cross midline structures of the brain are bihemispheric. Other terms have been used to describe such injuries, but bihemispheric is the most accurate and should be standard nomenclature. Bihemispheric head injuries are associated with greater mortality and morbidity than other penetrating traumatic brain injuries (TBIs). Currently, there is a tendency to manage severe gunshot wounds (GSWs) to the head nonoperatively, despite reports of improved outcome in military patients treated aggressively. Thus, controversy exists in the management of civilian TBI. METHODS: PubMed was searched for query terms, and PRISMA guidelines were used. Studies were selected by relevance and inclusion of data regarding etiology, diagnosis, and management of bihemispheric TBI. Case reports, studies not in English, and records lacking information on mechanism or bihemispheric injuries were excluded. RESULTS: Thirteen studies were included and most contained level IV evidence. The mean mortality rate of all head GSWs was 62% in adults and 32% in children. Bihemispheric GSWs had greater mortality rates of 82% in adults and 60% in children. There was a larger proportion of self-inflicted injury in studies with greater rates of bihemispheric injuries. CONCLUSIONS: Bihemispheric injuries have greater mortality rates than other penetrating TBI. Violation of midline brain structures such as the diencephalon and mesencephalon, increased rate of self-inflicted wounds, and lack of a standard management algorithm may increase the lethality of these injuries. Although bihemispheric injuries historically have been considered nonsalvageable, an aggressive surgical approach has been shown to improve outcomes, particularly in the military population.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/cirurgia
Ferimentos por Arma de Fogo/cirurgia
[Mh] Termos MeSH secundário: Adulto
Algoritmos
Lesões Encefálicas Traumáticas/mortalidade
Criança
Dominância Cerebral
Feminino
Fidelidade a Diretrizes
Seres Humanos
Masculino
Fatores de Risco
Taxa de Sobrevida
Ferimentos por Arma de Fogo/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


  9 / 19007 MEDLINE  
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[PMID]:28425015
[Au] Autor:Fisher RS
[Ad] Endereço:Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 213 Quarry Road, Palo Alto, CA, 94304-5979, USA. robert.fisher@stanford.edu.
[Ti] Título:The New Classification of Seizures by the International League Against Epilepsy 2017.
[So] Source:Curr Neurol Neurosci Rep;17(6):48, 2017 Jun.
[Is] ISSN:1534-6293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: This review presents the newly developed International League Against Epilepsy (ILAE) 2017 classification of seizure types. RECENT FINDINGS: The fundamental distinction is between seizures that begin focally in one hemisphere of the brain, generalized onset seizures that apparently originate in both hemispheres, and seizures of unknown onset. Focal seizures optionally can be subclassified according to whether awareness (a surrogate marker for consciousness) is intact or impaired. The next level of classification for focal seizures is motor (with subgroups automatisms, atonic, clonic, epileptic spasms, hyperkinetic, myoclonic, tonic), non-motor (with subgroups autonomic, behavior arrest, cognitive, emotional, sensory), and focal to bilateral tonic-clonic. Generalized seizures are categorized as motor (tonic-clonic, clonic, tonic, myoclonic, myoclonic-tonic-clonic, myoclonic-atonic, atonic, epileptic spasms) and non-motor/absence (typical, atypical, myoclonic, eyelid myoclonia). The classification allows new types of focal seizures and a few new generalized seizures, and clarifies terms used to name seizures.
[Mh] Termos MeSH primário: Convulsões/classificação
[Mh] Termos MeSH secundário: Estado de Consciência/classificação
Dominância Cerebral
Seres Humanos
Sociedades Médicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1007/s11910-017-0758-6


  10 / 19007 MEDLINE  
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[PMID]:28424103
[Au] Autor:Gros A; Manera V; De March CA; Guevara N; König A; Friedman L; Robert P; Golebiowski J; David R
[Ad] Endereço:Ressource and Research Memory Center,France.
[Ti] Título:Olfactory disturbances in ageing with and without dementia: towards new diagnostic tools.
[So] Source:J Laryngol Otol;131(7):572-579, 2017 Jul.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Olfactory disorders increase with age and often affect elderly people who have pre-dementia or dementia. Despite the frequent occurrence of olfactory changes at the early stages of neurodegenerative disorders such as Alzheimer's disease, olfactory disorders are rarely assessed in daily clinical practice, mainly due to a lack of standardised assessment tools. The aims of this review were to (1) summarise the existing literature on olfactory disorders in ageing populations and patients with neurodegenerative disorders; (2) present the strengths and weaknesses of current olfactory disorder assessment tools; and (3) discuss the benefits of developing specific olfactory tests for neurodegenerative diseases. METHODS: A systematic review was performed of literature published between 2000 and 2015 addressing olfactory disorders in elderly people with or without Alzheimer's disease or other related disorders to identify the main tools currently used for olfactory disorder assessment. RESULTS: Olfactory disorder assessment is a promising method for improving both the early and differential diagnosis of Alzheimer's disease. However, the current lack of consensus on which tests should be used does not permit the consistent integration of olfactory disorder assessment into clinical settings. CONCLUSION: Otolaryngologists are encouraged to use olfactory tests in older adults to help predict the development of neurodegenerative diseases. Olfactory tests should be specifically adapted to assess olfactory disorders in Alzheimer's disease patients.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico
Transtornos do Olfato/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Doença de Alzheimer/epidemiologia
Doença de Alzheimer/fisiopatologia
Comorbidade
Dominância Cerebral/fisiologia
Diagnóstico Precoce
Seres Humanos
Odorantes
Transtornos do Olfato/epidemiologia
Transtornos do Olfato/fisiopatologia
Condutos Olfatórios/fisiopatologia
Distorção da Percepção/fisiologia
Psicofísica
Limiar Sensorial/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117000858



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