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[PMID]:27770622
[Au] Autor:Mitchell TV
[Ad] Endereço:Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Worcester, MA, USA; Brandeis University, Waltham, MA, USA. Electronic address: teresa.mitchell@umassmed.edu.
[Ti] Título:Category selectivity of the N170 and the role of expertise in deaf signers.
[So] Source:Hear Res;343:150-161, 2017 Jan.
[Is] ISSN:1878-5891
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Deafness is known to affect processing of visual motion and information in the visual periphery, as well as the neural substrates for these domains. This study was designed to characterize the effects of early deafness and lifelong sign language use on visual category sensitivity of the N170 event-related potential. Images from nine categories of visual forms including upright faces, inverted faces, and hands were presented to twelve typically hearing adults and twelve adult congenitally deaf signers. Classic N170 category sensitivity was observed in both participant groups, whereby faces elicited larger amplitudes than all other visual categories, and inverted faces elicited larger amplitudes and slower latencies than upright faces. In hearing adults, hands elicited a right hemispheric asymmetry while in deaf signers this category elicited a left hemispheric asymmetry. Pilot data from five hearing native signers suggests that this effect is due to lifelong use of American Sign Language rather than auditory deprivation itself.
[Mh] Termos MeSH primário: Surdez/reabilitação
Potenciais Evocados Visuais
Percepção de Movimento
Pessoas com Deficiência Auditiva/reabilitação
Linguagem de Sinais
Percepção Visual
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Surdez/fisiopatologia
Surdez/psicologia
Eletroencefalografia
Face
Feminino
Lateralidade Funcional
Mãos
Seres Humanos
Masculino
Pessoas com Deficiência Auditiva/psicologia
Estimulação Luminosa
Projetos Piloto
Tempo de Reação
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  2 / 53250 MEDLINE  
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[PMID]:28463345
[Au] Autor:Upadhyaya MA; Nasrallah HA
[Ad] Endereço:The Everest Foundation, Los Angeles, CA USA E-mail: mupadhya@bronxleb.org
[Ti] Título:The intense desire for healthy limb amputation: A dis-proprioceptive neuropsychiatric disorder.
[So] Source:Ann Clin Psychiatry;29(2):125-132, 2017 05.
[Is] ISSN:1547-3325
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The first mention of a condition in which apparently nonpsychotic individuals have a strong, unrelenting desire to amputate ≥1 of their healthy limbs was published nearly 4 decades ago. Once dismissed as a paraphilia, the condition in recent years has been re-investigated with neurologic testing and imaging, yielding evidence suggesting it may be attributable to a neuroanatomical anomaly. METHODS: A literature review of data was conducted of recently published studies with pinprick testing, magnetic resonance imaging (MRI)/functional MRI imaging, magnetoencephalography, and interviews of individuals with a desire for limb amputation. RESULTS: Published literature on this condition features studies with a limited number of participants. However, the results indicate that affected individuals predominantly desire amputation of the left lower limb, and correspondingly, usually have changes in cortical thickness in the right parietal lobe. CONCLUSIONS: Further investigation of this condition is warranted, particularly, more research into the precise nature of the anomalous neuroanatomy, biopsychosocial background of those with the condition, and longitudinal perspective of the childhood onset and evolution of symptoms. Large sample studies involving a collaborative effort across multiple sites are required.
[Mh] Termos MeSH primário: Amputação/psicologia
Transtornos Dismórficos Corporais
Técnicas de Rastreamento Neuroanatômico/métodos
Distúrbios Somatossensoriais
[Mh] Termos MeSH secundário: Transtornos Dismórficos Corporais/patologia
Transtornos Dismórficos Corporais/psicologia
Lateralidade Funcional
Seres Humanos
Imagem por Ressonância Magnética/métodos
Testes Neuropsicológicos
Distúrbios Somatossensoriais/patologia
Distúrbios Somatossensoriais/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  3 / 53250 MEDLINE  
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[PMID]:29342176
[Au] Autor:Ashraf MI; Sinha S
[Ad] Endereço:The Institute of Mathematical Sciences, Chennai, Tamil Nadu, India.
[Ti] Título:The "handedness" of language: Directional symmetry breaking of sign usage in words.
[So] Source:PLoS One;13(1):e0190735, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Language, which allows complex ideas to be communicated through symbolic sequences, is a characteristic feature of our species and manifested in a multitude of forms. Using large written corpora for many different languages and scripts, we show that the occurrence probability distributions of signs at the left and right ends of words have a distinct heterogeneous nature. Characterizing this asymmetry using quantitative inequality measures, viz. information entropy and the Gini index, we show that the beginning of a word is less restrictive in sign usage than the end. This property is not simply attributable to the use of common affixes as it is seen even when only word roots are considered. We use the existence of this asymmetry to infer the direction of writing in undeciphered inscriptions that agrees with the archaeological evidence. Unlike traditional investigations of phonotactic constraints which focus on language-specific patterns, our study reveals a property valid across languages and writing systems. As both language and writing are unique aspects of our species, this universal signature may reflect an innate feature of the human cognitive phenomenon.
[Mh] Termos MeSH primário: Lateralidade Funcional
Linguagem
[Mh] Termos MeSH secundário: Seres Humanos
Redação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190735


  4 / 53250 MEDLINE  
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[PMID]:28464421
[Au] Autor:Sebastianelli L; Versace V; Martignago S; Brigo F; Trinka E; Saltuari L; Nardone R
[Ad] Endereço:Department of Neurorehabilitation, Hospital of Vipiteno, Vipiteno, Italy.
[Ti] Título:Low-frequency rTMS of the unaffected hemisphere in stroke patients: A systematic review.
[So] Source:Acta Neurol Scand;136(6):585-605, 2017 Dec.
[Is] ISSN:1600-0404
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:The aim of this review was to summarize the evidence for the effectiveness of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) over the unaffected hemisphere in promoting functional recovery after stroke. We performed a systematic search of the studies using LF-rTMS over the contralesional hemisphere in stroke patients and reviewed the 67 identified articles. The studies have been gathered together according to the time interval that had elapsed between the stroke onset and the beginning of the rTMS treatment. Inhibitory rTMS of the contralesional hemisphere can induce beneficial effects on stroke patients with motor impairment, spasticity, aphasia, hemispatial neglect and dysphagia, but the therapeutic clinical significance is unclear. We observed considerable heterogeneity across studies in the stimulation protocols. The use of different patient populations, regardless of lesion site and stroke aetiology, different stimulation parameters and outcome measures means that the studies are not readily comparable, and estimating real effectiveness or reproducibility is very difficult. It seems that careful experimental design is needed and it should consider patient selection aspects, rTMS parameters and clinical assessment tools. Consecutive sessions of rTMS, as well as the combination with conventional rehabilitation therapy, may increase the magnitude and duration of the beneficial effects. In an increasing number of studies, the patients have been enrolled early after stroke. The prolonged follow-up in these patients suggests that the effects of contralesional LF-rTMS can be long-lasting. However, physiological evidence indicating increased synaptic plasticity, and thus, a more favourable outcome, in the early enrolled patients, is still lacking. Carefully designed clinical trials designed are required to address this question. LF rTMS over unaffected hemisphere may have therapeutic utility, but the evidence is still preliminary and the findings need to be confirmed in further randomized controlled trials.
[Mh] Termos MeSH primário: Reabilitação do Acidente Vascular Cerebral/métodos
Estimulação Magnética Transcraniana/métodos
[Mh] Termos MeSH secundário: Idoso
Feminino
Lateralidade Funcional
Seres Humanos
Masculino
Meia-Idade
Recuperação de Função Fisiológica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/ane.12773


  5 / 53250 MEDLINE  
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[PMID]:28125330
[Au] Autor:Iglesias-Soler E; Mayo X; Dopico X; Fernández-Del-Olmo M; Carballeira E; Fariñas J; Fernández-Uribe S
[Ad] Endereço:a University of A Coruna, Performance and Health Group , Department of Physical Education and Sport, Faculty of Sports Sciences and Physical Education , A Coruña , Spain.
[Ti] Título:Effects of bilateral and non-dominant practices on the lateral preference in judo matches.
[So] Source:J Sports Sci;36(1):111-115, 2018 Jan.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study analysed the effects of bilateral and non-dominant practice on novice practitioners' lateral preference for judo skills in a combat context (i.e., randori). Thirty sports sciences students (22 men and 8 women; mean age 19 ± 1 years) with right hand, foot, and counterclockwise rotation preferences were divided into 3 groups: bilateral (BG; n = 8), non-dominant (NDG; n = 11), and control (CG; n = 11). Participants received 8 weeks of training at a rate of 3 days per week. The NDG was trained to perform judo skills exclusive with their non-dominant side, while the BG performed every task symmetrically. Before and after training, participants were recorded during two 3-min randoris to obtain the percentage of their engagement in dominant side actions. Pretest percentages were 73.1 ± 19.9%, 77.8 ± 18.8%, and 68.9 ± 27.2% for BG, NDG, and CG, respectively. Post-test values were 75.0 ± 15.6%, 23.3 ± 27.9%, and 72.2.9 ± 20.4%, respectively. Significant differences were observed between NDG and each of the other groups after the training. Changes from pretest were only significant for NDG (P = 0.003). These results suggest that lateral preference among novice judo practitioners during randori can be modulated by the type of practice.
[Mh] Termos MeSH primário: Desempenho Atlético/fisiologia
Lateralidade Funcional/fisiologia
Artes Marciais/fisiologia
Destreza Motora/fisiologia
Condicionamento Físico Humano/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1283431


  6 / 53250 MEDLINE  
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[PMID]:28457906
[Au] Autor:Üçal M; Haindl MT; Adzemovic MZ; Strasser J; Theisl L; Zeitelhofer M; Kraitsy K; Ropele S; Schäfer U; Fazekas F; Hochmeister S
[Ad] Endereço:Research Unit of Experimental Neurotraumatology, Department of Neurosurgery, Medical University Graz, Auenbruggerplatz 2.2, 8036 Graz, Austria.
[Ti] Título:Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats.
[So] Source:Exp Neurol;294:32-44, 2017 08.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cortical demyelination is a common finding in patients with chronic multiple sclerosis (MS) and contributes to disease progression and overall disability. The exact pathomechanism that leads to cortical lesions is not clear. Research is limited by the fact that standard animal models of multiple sclerosis do not commonly affect the cortex, or if they do in some variants, the cortical demyelination is rather sparse and already remyelinated within a few days. In an attempt to overcome these limitations we implanted a tissue-compatible catheter into the cortex of Dark Agouti rats. After 14days the rats were immunized with 5µg myelin oligodendrocyte glycoprotein (MOG) in incomplete Freund's Adjuvant, which did not cause any clinical signs but animals developed a stable anti-MOG antibody titer. Then the animals received an injection of proinflammatory cytokines through the catheter. This led to a demyelination of cortical and subcortical areas starting from day 1 in a cone-like pattern spreading from the catheter area towards the subarachnoid space. On day 3 cortical demyelination already expanded to the contralateral hemisphere and reached its peak between days 9-15 after cytokine injection with a widespread demyelination of cortical and subcortical areas of both hemispheres. Clinically the animals showed only discrete signs of fatigue and recovered completely after day 15. Even on day 30 we still were able to detect demyelination in subpial and intracortical areas along with areas of partial and complete remyelination. Loss of cortical myelin was accompanied with marked microglia activation. A second injection of cytokines through the catheter on day 30 led to a second demyelination phase with the same symptoms, but again no detectable motor dysfunction. Suffering of the animals appeared minor compared to standard Experimental Autoimmune Encephalomyelitis and therefore, even long-term observation and repeated demyelination phases seem ethically acceptable.
[Mh] Termos MeSH primário: Córtex Cerebral/patologia
Citocinas/toxicidade
Doenças Desmielinizantes/induzido quimicamente
Doenças Desmielinizantes/patologia
Encefalomielite Autoimune Experimental/patologia
Lateralidade Funcional/fisiologia
[Mh] Termos MeSH secundário: Animais
Proteínas de Ligação ao Cálcio/metabolismo
Caspase 3/metabolismo
Citocinas/metabolismo
Modelos Animais de Doenças
Encefalomielite Autoimune Experimental/induzido quimicamente
Encefalomielite Autoimune Experimental/diagnóstico por imagem
Encefalomielite Autoimune Experimental/imunologia
Fibrina/metabolismo
Adjuvante de Freund/efeitos adversos
Lateralidade Funcional/efeitos dos fármacos
Imunização/efeitos adversos
Lipídeos/efeitos adversos
Masculino
Proteínas dos Microfilamentos/metabolismo
Microscopia Confocal
Atividade Motora
Proteína Proteolipídica de Mielina/metabolismo
Glicoproteína Associada a Mielina/efeitos adversos
Glicoproteína Associada a Mielina/sangue
Proteínas do Tecido Nervoso/metabolismo
Ratos
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aif1 protein, rat); 0 (Calcium-Binding Proteins); 0 (Cytokines); 0 (Lipids); 0 (Microfilament Proteins); 0 (Myelin Proteolipid Protein); 0 (Myelin-Associated Glycoprotein); 0 (Nerve Tissue Proteins); 0 (incomplete Freund's adjuvant); 9001-31-4 (Fibrin); 9007-81-2 (Freund's Adjuvant); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:27778407
[Au] Autor:Kuhn T; Schonfeld D; Sayegh P; Arentoft A; Jones JD; Hinkin CH; Bookheimer SY; Thames AD
[Ad] Endereço:Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 740 Westwood Plaza, C8-746, Los Angeles, California.
[Ti] Título:The effects of HIV and aging on subcortical shape alterations: A 3D morphometric study.
[So] Source:Hum Brain Mapp;38(2):1025-1037, 2017 02.
[Is] ISSN:1097-0193
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Standard volumetric neuroimaging studies have demonstrated preferential atrophy of subcortical structures among individuals with HIV. However, to our knowledge, no study has investigated subcortical shape alterations secondary to HIV and whether advancing age impacts that relationship. This study employed 3D morphometry to examine the independent and interactive effects of HIV and age on shape differences in nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus in 81 participants ranging in age from 24 to 76 including 59 HIV+ individuals and 22 HIV-seronegative controls. T1-weighted MRI underwent a preprocessing pipeline followed by automated subcortical segmentation. Parametric statistical analyses were used to determine independent effects of HIV infection and age on volume and shape in each region of interest (ROI) and the interaction between age and HIV serostatus in predicting volume/shape in each ROI. Significant main effects for HIV were found in the shape of right caudate and nucleus accumbens, left pallidum, and hippocampus. Age was associated with differences in shape in left pallidum, right nucleus accumbens and putamen, and bilateral caudate, hippocampus, and thalamus. Of greatest interest, an age × HIV interaction effect was found in the shape of bilateral nucleus accumbens, amygdala, caudate, and thalamus as well as right pallidum and putamen such that increasing age in HIV participants was associated with greater shape alterations. Traditional volumemetric analyses revealed main effects for both HIV and age but no age × HIV interaction. These findings may suggest that age and HIV infection conferred additional deleterious effects on subcortical shape abnormalities beyond the independent effects of these factors. Hum Brain Mapp 38:1025-1037, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Envelhecimento/patologia
Encéfalo/diagnóstico por imagem
Infecções por HIV/patologia
Imagem Tridimensional
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Adulto
Idoso
Encéfalo/virologia
Mapeamento Encefálico
Feminino
Lateralidade Funcional
Seres Humanos
Masculino
Meia-Idade
Escalas de Graduação Psiquiátrica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1002/hbm.23436


  8 / 53250 MEDLINE  
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[PMID]:29390458
[Au] Autor:Jang SH; Ha JW; Kim HY; Seo YS
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University.
[Ti] Título:Recovery of injured Broca's portion of arcuate fasciculus in the dominant hemisphere in a patient with traumatic brain injury.
[So] Source:Medicine (Baltimore);96(51):e9183, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Recovery of injured AF in patients with traumatic brain injury (TBI) has not been reported. In this study, we report on a patient with TBI who recovered from an injury to Broca's portion of AF in the dominant hemisphere, diagnosed by diffusion tensor tractography (DTT). PATIENT CONCERNS: A 28-year-old right-handed male patient suffered head trauma resulting from sliding while riding a motorcycle. DIAGNOSES: He was diagnosed with a traumatic contusional hemorrhage in the left frontal lobe, subarachnoid hemorrhage, and subdural hemorrhage in the left fronto-temporal lobe. INTERVENTIONS: He underwent craniectomy on the left fronto-temporal area, and hematoma removal for the subdural hemorrhage in the neurosurgery department of a university hospital. Two weeks after the injury, he was transferred to the rehabilitation department of another university hospital. He showed severe aphasia and brain MRI showed leukomalactic lesion in the left frontal lobe. OUTCOMES: The result WAB for the patient showed severe aphasia, with an aphasia quotient of 45.3 percentile. However, his aphasia improved rapidly by 9 months with an aphasia quotient at the 100.0 percentile. 2-week DTT detected discontinuity in the subcortical white matter at the branch to Broca's area of left AF. By contrast, on 9-month DTT, the discontinued portion of left AF was elongated to the left Broca's area. LESSONS: Recovery of injured Broca's portion of AF in the dominant hemisphere along with excellent improvement of aphasia was demonstrated in a patient with TBI. This study has important implications in brain rehabilitation because the mechanism of recovery from aphasia following TBI has not been elucidated.
[Mh] Termos MeSH primário: Afasia de Broca/fisiopatologia
Núcleo Arqueado do Hipotálamo/fisiopatologia
Lesões Encefálicas Traumáticas/diagnóstico
Lesões Encefálicas Traumáticas/reabilitação
Vias Neurais/lesões
[Mh] Termos MeSH secundário: Adulto
Afasia de Broca/etiologia
Lesões Encefálicas Traumáticas/cirurgia
Área de Broca/lesões
Craniotomia/métodos
Imagem de Tensor de Difusão/métodos
Seguimentos
Lobo Frontal/lesões
Lobo Frontal/patologia
Lateralidade Funcional
Hematoma Subdural/diagnóstico
Hematoma Subdural/reabilitação
Hematoma Subdural/cirurgia
Seres Humanos
Escala de Gravidade do Ferimento
Imagem por Ressonância Magnética/métodos
Masculino
Recuperação de Função Fisiológica
Medição de Risco
Lobo Temporal/lesões
Lobo Temporal/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009183


  9 / 53250 MEDLINE  
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[PMID]:28454916
[Au] Autor:Platto S; Zhang C; Pine MK; Feng WK; Yang LG; Irwin A; Wang D
[Ad] Endereço:The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People's Republic of China; Department of Preventative Veterinary Medicine, The State Key Laboratory of Agricultural Microbiology, Huazhon
[Ti] Título:Behavioral laterality in Yangtze finless porpoises (Neophocaena asiaeorientalis asiaeorientalis).
[So] Source:Behav Processes;140:104-114, 2017 Jul.
[Is] ISSN:1872-8308
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) is a critically endangered species with less than 1000 individuals expected to be left in the wild. While many studies have been conducted on laterality among several cetacean species, no studies investigating the Yangtze finless porpoise have been conducted. Using event sampling methods, several behaviors such as flipper-body touching, object touching, barrel-rolls, side swimming, and swimming direction were recorded from six captive porpoises (three males and three females). Analyses of 360 observations recorded over two months revealed that, at group level, porpoises showed laterality in swimming behaviors. Porpoises swam preferentially with their right pectoral fin upward and their left pectoral fin downward with a clockwise swimming direction and also displayed a consistent bias for a counterclockwise barrel-roll direction. No significant differences were reported for flipper use either during the interaction with conspecifics or with objects. The results from the current study provide novel insight into the cerebral asymmetry in a species previously ignored within the literature, thus improving our understanding on the extent of laterality in cetaceans and on the evolutionary history of hemispheric laterality for vertebrates in general.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Lateralidade Funcional/fisiologia
Toninhas/fisiologia
[Mh] Termos MeSH secundário: Animais
Espécies em Perigo de Extinção
Feminino
Masculino
Natação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  10 / 53250 MEDLINE  
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[PMID]:28741419
[Au] Autor:Toraldo A; Romaniello C; Sommaruga P
[Ad] Endereço:a Department of Brain and Behavioural Sciences , University of Pavia , Pavia , Italy.
[Ti] Título:Measuring and diagnosing unilateral neglect: a standardized statistical procedure.
[So] Source:Clin Neuropsychol;31(6-7):1248-1267, 2017 Aug - Oct.
[Is] ISSN:1744-4144
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Unilateral neglect is usually investigated by adminstering stimuli (targets) in different positions, with targets being responded to by the patient (Hit) or omitted. In spite of this homogeneity of data type, neglect indices and diagnostic criteria vary considerably, causing inconsistencies in both clinical and experimental settings. We aimed at deriving a standard analysis which would apply to all tasks sharing this data form. METHODS: A-priori theoretical reasoning demonstrated that the mean position of Hits in space (MPH) is an optimal index for correctly diagnosing and quantifying neglect. Crucially MPH eliminates the confounding effects of deficits that are different from neglect (non-lateral) but which decrease Hit rate. We ran a Monte Carlo study to assess MPH's (so far overlooked) statistical behavior as a function of numbers of targets and Hits. RESULTS: While average MPH was indeed insensitive to non-lateral deficits, MPH's variance (like that of all other neglect indices) increased dramatically with increasing non-lateral deficits. This instability would lead to alarmingly high false-positive rates (FPRs) when applying a classical diagnostic procedure that compares one patient with a control sample. We solved the problem by developing an equation that takes into account MPH instability and provides correct cut-offs and close-to-nominal FPRs, even without control subjects. We developed a computerized program which, given the raw data, yields the MPH, a z-score and a p-value. CONCLUSIONS: We provided a standard method that allows clinical and experimental neuropsychologists to diagnose and measure neglect in a consistent way across the vast majority of tasks.
[Mh] Termos MeSH primário: Testes Neuropsicológicos/normas
[Mh] Termos MeSH secundário: Feminino
Lateralidade Funcional
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1080/13854046.2017.1349181



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