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[PMID]:28463898
[Au] Autor:Gastaldelli A; Gaggini M; DeFronzo R
[Ad] Endereço:aCardiometabolic Risk Laboratory, Institute of Clinical Physiology, National Research Council, Pisa, Italy bUniversity of Texas Health Science Center at San Antonio, TX, USA.
[Ti] Título:Glucose kinetics: an update and novel insights into its regulation by glucagon and GLP-1.
[So] Source:Curr Opin Clin Nutr Metab Care;20(4):300-309, 2017 Jul.
[Is] ISSN:1473-6519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Glucagon and GLP-1 share the same origin (i.e., proglucagon); primarily GLP-1 is generated from intestinal L-cells and glucagon from pancreatic α-cell, but intestinal glucagon and pancreatic GLP-1 secretion is likely. Glucose kinetics are tightly regulated by pancreatic hormones insulin and glucagon, but other hormones, including glucagon-like peptide-1 (GLP-1), also play an important role. The purpose of this review is to describe the recent findings on the mechanisms by which these two hormones regulate glucose kinetics. RECENT FINDINGS: Recent findings showed new important mechanisms of action of glucagon and GLP-1 in the regulation of glucose metabolism. Knock out of glucagon receptors protects against hyperglycemia without causing hypoglycemia. GLP-1 not only stimulates insulin secretion, but it has also an independent effect on the liver and inhibits glucose production. Moreover, when coinfused with glucagon, GLP-1 limits the hyperglycemic effects. Both hormones have also central effects on gastric emptying (delayed), intestinal motility (reduced), and satiety (increased). SUMMARY: The implications of these findings are very important for the management of type 2 diabetes given that GLP-1 receptor agonist are currently approved for the treatment of hyperglycemia and glucagon receptor antagonists and GLP-1/glucagon dual agonists are under development.
[Mh] Termos MeSH primário: Peptídeo 1 Semelhante ao Glucagon/fisiologia
Glucagon/fisiologia
Glucose/metabolismo
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Tipo 2/tratamento farmacológico
Jejum
Esvaziamento Gástrico/fisiologia
Motilidade Gastrointestinal/fisiologia
Glucagon/sangue
Glucagon/farmacologia
Peptídeo 1 Semelhante ao Glucagon/farmacologia
Receptor do Peptídeo Semelhante ao Glucagon 1/agonistas
Receptor do Peptídeo Semelhante ao Glucagon 1/fisiologia
Gluconeogênese/efeitos dos fármacos
Glucose/biossíntese
Homeostase
Seres Humanos
Hiperglicemia/tratamento farmacológico
Cinética
Fígado/efeitos dos fármacos
Fígado/metabolismo
Receptores de Glucagon/antagonistas & inibidores
Receptores de Glucagon/fisiologia
Saciação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucagon-Like Peptide-1 Receptor); 0 (Receptors, Glucagon); 89750-14-1 (Glucagon-Like Peptide 1); 9007-92-5 (Glucagon); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1097/MCO.0000000000000384


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[PMID]:29237125
[Au] Autor:Suh JH; Wang Y; Ho CT
[Ad] Endereço:Food Science and Human Nutrition, Citrus Research and Education Center, University of Florida , 700 Experiment Station Rd, Lake Alfred, Florida 33850, United States.
[Ti] Título:Natural Dietary Products and Their Effects on Appetite Control.
[So] Source:J Agric Food Chem;66(1):36-39, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural dietary products have been thoroughly studied for their effects of antiadipogenesis to prevent and treat obesity for decades. Nevertheless, in the past few years appetite control for the treatment of obesity has attracted much attention as a new target. Homeostatic control of energy intake involves a complex system that conveys peripheral signals to the central nervous system where multiple signals are integrated and then provide feedback to regulate satiation. This perspective aims at elucidating the neuronal mechanisms of food intake and energy balance as well as providing an alternative pathway of controlling weight using natural dietary products.
[Mh] Termos MeSH primário: Adiposidade/fisiologia
Regulação do Apetite/efeitos dos fármacos
Produtos Biológicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais
Hormônios/metabolismo
Seres Humanos
Saciação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05104


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[PMID]:28452130
[Au] Autor:Morley JE
[Ad] Endereço:Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 S. Grand Blvd., M238, St. Louis, MO, 63104, USA.
[Ti] Título:Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia.
[So] Source:J Cachexia Sarcopenia Muscle;8(4):523-526, 2017 Aug.
[Is] ISSN:2190-6009
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The anorexia of aging was first recognized as a physiological syndrome 30 years ago. Its major causes are an alteration in fundal compliance with an increase in antral stretch and enhanced cholecystokinin activity leading to increased satiation.This anorexia leads to weight loss in aging persons and is one of the component causes of the aging related sarcopenia. This physiological anorexia also increases the risk of more severe anorexia when an older person has an increase in inflammatory cytokines such as occurs when they have an illness. This results in an increase in the anorexia due to cachexia in older persons.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Anorexia/etiologia
Caquexia/etiologia
Sarcopenia/etiologia
[Mh] Termos MeSH secundário: Idoso
Anorexia/metabolismo
Seres Humanos
Saciação/fisiologia
Perda de Peso/fisiologia
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1002/jcsm.12192


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[PMID]:29184212
[Au] Autor:Ryan PJ; Ross SI; Campos CA; Derkach VA; Palmiter RD
[Ad] Endereço:Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA. philip.ryan@florey.edu.au.
[Ti] Título:Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake.
[So] Source:Nat Neurosci;20(12):1722-1733, 2017 Dec.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brain regions that regulate fluid satiation are not well characterized, yet are essential for understanding fluid homeostasis. We found that oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (Oxtr neurons) are key regulators of fluid satiation. Chemogenetic activation of Oxtr neurons robustly suppressed noncaloric fluid intake, but did not decrease food intake after fasting or salt intake following salt depletion; inactivation increased saline intake after dehydration and hypertonic saline injection. Under physiological conditions, Oxtr neurons were activated by fluid satiation and hypertonic saline injection. Oxtr neurons were directly innervated by oxytocin neurons in the paraventricular hypothalamus (Oxt neurons), which mildly attenuated fluid intake. Activation of neurons in the nucleus of the solitary tract substantially suppressed fluid intake and activated Oxtr neurons. Our results suggest that Oxtr neurons act as a key node in the fluid satiation neurocircuitry, which acts to decrease water and/or saline intake to prevent or attenuate hypervolemia and hypernatremia.
[Mh] Termos MeSH primário: Comportamento de Ingestão de Líquido/fisiologia
Neurônios/metabolismo
Núcleos Parabraquiais/metabolismo
Receptores de Ocitocina/fisiologia
[Mh] Termos MeSH secundário: Animais
Desidratação/psicologia
Ingestão de Alimentos/fisiologia
Hipernatremia/genética
Hipernatremia/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Optogenética
Núcleos Parabraquiais/citologia
Núcleo Hipotalâmico Paraventricular/fisiologia
Receptores de Ocitocina/genética
Solução Salina Hipertônica/farmacologia
Saciação/fisiologia
Sódio na Dieta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (OXTR protein, mouse); 0 (Receptors, Oxytocin); 0 (Saline Solution, Hypertonic); 0 (Sodium, Dietary)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/s41593-017-0014-z


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[PMID]:29185930
[Au] Autor:Zamaratskaia G; Johansson DP; Junqueira MA; Deissler L; Langton M; Hellström PM; Landberg R
[Ad] Endereço:1Department of Molecular Sciences,BioCenter,Swedish University of Agricultural Sciences (SLU),750 07 Uppsala,Sweden.
[Ti] Título:Impact of sourdough fermentation on appetite and postprandial metabolic responses - a randomised cross-over trial with whole grain rye crispbread.
[So] Source:Br J Nutr;118(9):686-697, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sourdough fermentation is considered to have beneficial effects on postprandial satiety and metabolic responses, but studies demonstrating effects at physiological conditions are lacking. The aim of this acute breakfast intervention study was to determine the effect of consumption of sourdough-fermented and unfermented rye crispbread on self-rated appetite, postprandial glucose and insulin response in healthy subjects. In all, twenty-four Swedish adults were included in a single-blinded, randomised cross-over trial. Three crispbreads (sourdough-fermented and unfermented whole grain rye and yeast-fermented refined wheat as control) were consumed as part of a standardised breakfast. Subjective appetite score, assessed using visual analogue scale, and plasma glucose and insulin concentrations were measured at baseline and postprandially until 360 and 240 min, respectively. Structural changes and viscosity during mastication and gastric digestion were investigated using in vitro methods. Hunger and desire to eat were lower (P<0·05) based on AUC measurements after intake of sourdough-fermented rye crispbread compared with after intake of yeast-fermented refined wheat crispbread. On the basis of AUC (0-230 min), insulin response was lowest after intake of unfermented rye crispbread compared with sourdough-fermented rye and yeast-fermented refined wheat crispbread. Degradation of viscous fibres and faster bolus disintegration for the sourdough-fermented bread may partly explain the less favourable metabolic responses compared with unfermented bread. Our results showed that food processing affects the composition and structural characteristics of rye bread, which has implications for appetite and metabolic responses.
[Mh] Termos MeSH primário: Apetite
Glicemia/metabolismo
Pão
Alimentos Fermentados
Período Pós-Prandial
Secale/química
[Mh] Termos MeSH secundário: Adulto
Desjejum
Estudos Cross-Over
Fibras na Dieta/administração & dosagem
Digestão
Feminino
Peptídeo 1 Semelhante ao Glucagon/sangue
Seres Humanos
Insulina/sangue
Masculino
Meia-Idade
Saciação
Método Simples-Cego
Suécia
Triticum/química
Grãos Integrais/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fiber); 0 (Insulin); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1017/S000711451700263X


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[PMID]:29185929
[Au] Autor:Arguin H; Tremblay A; Blundell JE; Després JP; Richard D; Lamarche B; Drapeau V
[Ad] Endereço:1Department of Kinesiology, Faculty of Medicine,Laval University,Quebec,QC,Canada, G1V 0A6.
[Ti] Título:Impact of a non-restrictive satiating diet on anthropometrics, satiety responsiveness and eating behaviour traits in obese men displaying a high or a low satiety phenotype.
[So] Source:Br J Nutr;118(9):750-760, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the impact of a non-restrictive satiating diet in men displaying various degrees of satiety efficiency. In all, sixty-nine obese men aged 41·5 (sd 5·7) years were randomly assigned to a control (10-15, 55-60 and 30 % energy as protein, carbohydrate and lipid, respectively; n 34) or satiating (20-25, 45-50 and 30-35 % energy as protein, carbohydrate and lipid, respectively; n 35) diet for 16 weeks, and were classified as having a low (LSP) or high (HSP) satiety phenotype. Both diets were consumed ad libitum. Changes in body weight, BMI, percent fat mass, waist circumference, satiety responsiveness and eating behaviour traits were assessed following the intervention. Dropout rates were higher in the control diet (44·1 %) compared with the satiating diet (8·6 %). Decreases in body weight, BMI and waist circumference were significant in both groups, yet HSP individuals lost more body weight than LSP individuals (P=0·048). Decreases in % fat mass were greater in the satiating diet (LSP: -2·1 (sd 2·1) %; P<0·01 and HSP: -3·0 (sd 2·5) %; P<0·001) compared with the control diet (LSP: -1·1 (sd 2·5) % and HSP: -1·3 (sd 2·6) %) (P=0·034). Satiety responsiveness was markedly improved in the satiating diet, whereas no significant changes were observed in the control group. Changes in dietary restraint (+3·3 (sd 2·9) to +7·2 (sd 5·5)), flexible control (+0·9 (sd 1·4) to +2·3 (sd 2·7)), rigid control (+2·2 (sd 1·5) to +2·5 (sd 2·8)), disinhibition (-2·8 (sd 3·7) to -3·2 (sd 2·6)) and susceptibility to hunger (-2·7 (sd 4·1) to -4·6 (sd 3·9)) were similar between the diets. Compared with the control diet, the satiating diet favoured adherence, decreased % fat mass and improved satiety responsiveness in both HSP and LSP individuals.
[Mh] Termos MeSH primário: Antropometria
Dieta
Comportamento Alimentar
Obesidade/dietoterapia
Saciação
[Mh] Termos MeSH secundário: Adulto
Apetite
Composição Corporal
Carboidratos da Dieta/administração & dosagem
Gorduras na Dieta/administração & dosagem
Proteínas na Dieta/administração & dosagem
Seres Humanos
Masculino
Meia-Idade
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002549


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[PMID]:29056105
[Au] Autor:Llopart EE; Cian RE; López-Oliva MME; Zuleta Á; Weisstaub A; Drago SR
[Ad] Endereço:1Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ingeniería Química,Instituto de Tecnología de Alimentos,Universidad Nacional del Litoral,Santiago del Estero 2829,Santa Fe,Argentina.
[Ti] Título:Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats.
[So] Source:Br J Nutr;118(8):589-597, 2017 Oct.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Colonic effects of extruded whole-grain sorghum diets were evaluated using a model of growing rats. In all, twenty-four male Wistar rats were fed control (C), extruded white sorghum (EWS) or red sorghum (ERS). Consumption of sorghum diets showed satiety properties, with reduction of caecal pH, and lower activity of ß-glucosidase and ß-glucuronidase enzymes. Decreased copper zinc superoxide dismutase and manganese superoxide dismutase and increased catalase and glutathione peroxidase levels were observed in colonic mucosa. The induction of antioxidant enzymes occurred through the activation of the nuclear factor erythroid 2-related factor 2 protein and its subsequent translocation into the nucleus. ERS was able to decrease the proliferation of proximal mucosa of colon, demonstrating a possible effect against colorectal tumourigenesis. EWS increased proliferation and also apoptosis, ensuring the re-establishment of homoeostasis of the colonic mucosa. No antioxidant systemic effect (serum or hepatic level) was observed. It is likely that despite the extrusion the low bioavailability of the phenolic compounds of sorghum diets caused them to exert mainly acute effects at the colon level. Extruded whole-grain sorghum is a good functional ingredient that might be promising in dietary prevention of intestinal diseases.
[Mh] Termos MeSH primário: Colo/metabolismo
Dieta
Sorghum/química
Grãos Integrais/química
[Mh] Termos MeSH secundário: Animais
Catalase/metabolismo
Modelos Animais de Doenças
Glucuronidase/metabolismo
Glutationa Peroxidase/metabolismo
Concentração de Íons de Hidrogênio
Enteropatias/prevenção & controle
Mucosa Intestinal/metabolismo
Masculino
Fator 2 Relacionado a NF-E2/genética
Fator 2 Relacionado a NF-E2/metabolismo
Ratos
Ratos Wistar
Saciação
Superóxido Dismutase/metabolismo
beta-Glucosidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, rat); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 3.2.1.21 (beta-Glucosidase); EC 3.2.1.31 (Glucuronidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002513


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[PMID]:28917503
[Au] Autor:Surette V; Ward S; Morin P; Vatanparast H; Bélanger M
[Ti] Título:Food Reluctance of Preschool Children Attending Daycare Centers Is Associated with a Lower Body Mass Index.
[So] Source:J Acad Nutr Diet;117(11):1749-1756, 2017 Nov.
[Is] ISSN:2212-2672
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Food reluctance can present as fussiness, picky eating, slowness in eating, and high satiety responsiveness. It can be associated with inadequate weight gain during early childhood. Although a majority of preschoolers attend daycare centers, associations between their eating behaviors at daycare and their body composition have not been studied. OBJECTIVE: Our aim was to develop an estimate of food reluctance and to assess the relationship between food reluctance at daycare and body mass index (BMI) and waist circumference of preschoolers. DESIGN: We conducted a cross-sectional secondary analyses. Food reluctance was estimated using weighted digital plate waste analysis. Intra-rater, inter-rater, and test-retest reliability and convergent validity of the food reluctance score were tested. The food reluctance score was then compared to preschool children's BMI and waist circumference. PARTICIPANTS/SETTING: Participants included 309 children aged 3 to 5 years in 24 daycare centers across the Canadian province of New Brunswick. MAIN OUTCOME MEASURES: Preschool children's waist circumference and age-adjusted BMI derived from objectively measured height and weight were analyzed. STATISTICAL ANALYSES PERFORMED: Intraclass correlations were used to determine the reliability of the new estimate. Spearman correlation was used to compare the estimate with parental report of food reluctance. Multivariate linear regressions were used to examine the relationship between food reluctance and waist circumference and age-adjusted BMI. RESULTS: The estimated food reluctance score demonstrated excellent inter- and intra-rater reliability (intraclass correlation>0.97; P<0.0001) and good test-retest reliability (intraclass correlation=0.72; P<0.0001). It also provided evidence of convergent validity through correlation with reluctance-related subscales of the Child Eating Behavior Questionnaire (ρ=.53, P<0.0001). Greater demonstration of food reluctance at the daycare center was associated with a lower age-adjusted BMI (adjusted ß -1.41; 95% CI -.15 to -2.67), but was not associated with children's waist circumference (adjusted ß -.60; 95% CI -2.06 to .86). CONCLUSIONS: Signs of food reluctance can be observed in daycare and relate to lower BMI among preschoolers.
[Mh] Termos MeSH primário: Índice de Massa Corporal
Creches
Comportamento Alimentar/fisiologia
[Mh] Termos MeSH secundário: Composição Corporal
Canadá/epidemiologia
Comportamento Infantil
Pré-Escolar
Estudos Transversais
Feminino
Alimentos
Seres Humanos
Masculino
Desnutrição/epidemiologia
Pais
Reprodutibilidade dos Testes
Saciação
Inquéritos e Questionários
Circunferência da Cintura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE


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[PMID]:28794212
[Au] Autor:Kehlet U; Kofod J; Holst JJ; Ritz C; Aaslyng MD; Raben A
[Ad] Endereço:Danish Meat Research Institute, Danish Technological Institute, Taastrup, Denmark; unk@teknologisk.dk.
[Ti] Título:Addition of Rye Bran and Pea Fiber to Pork Meatballs Enhances Subjective Satiety in Healthy Men, but Does Not Change Glycemic or Hormonal Responses: A Randomized Crossover Meal Test Study.
[So] Source:J Nutr;147(9):1700-1708, 2017 Sep.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The development of high-protein, fiber-rich foods targeting appetite control could be an efficient tool in obesity prevention. We investigated whether ad libitum energy intake (EI), appetite, and metabolic markers in a meal context were affected by ) fiber addition (rye bran and pea fiber) to pork meatballs, ) the food matrix of the fiber (fiber meatballs compared with fiber bread), or ) the protein source (animal compared with vegetable protein patties). In a crossover design, 40 healthy men [mean ± SD: body mass index (BMI; in kg/m ), 22.2 ± 1.9; age, 23.3 ± 2.9 y] consumed 4 test meals: a low-fiber meal consisting of pork meatballs plus wheat bread (LF meal); pork meatballs plus fiber bread; fiber meatballs plus wheat bread, and vegetable patties with a natural fiber content plus wheat bread (∼3000 kJ; protein ∼18% of energy, carbohydrate ∼50% of energy, fat ∼30% of energy; 13 g fiber in the fiber meals). Ad libitum EI after 4 h was the primary endpoint. Moreover, appetite sensations and postprandial responses of glucose, insulin, glucagon-like peptide-1, peptide YY 3-36, and plasma amino acids were measured. Ad libitum EI did not differ significantly between the meals. Satiety and fullness increased 11% and 13%, respectively, and hunger and prospective intake decreased 17% and 15%, respectively, after the meal of fiber meatballs plus wheat bread compared with the LF meal ( < 0.01). Hormonal and metabolic responses did not differ between the meals. In general, plasma amino acid concentrations were higher after the fiber-rich meals than after the LF meal. Meals based on meatballs and bread with differences in the fiber content, food matrix of fiber, and protein source had similar effects on ad libitum EI in healthy men. However, fiber addition to pork meatballs favorably affected appetite sensations but without changes in hormonal and metabolic responses. Moreover, animal- and vegetable-protein-based, fiber-matched meals had similar effects on appetite regulation. This trial was registered at clinicaltrials.gov as NCT02521805.
[Mh] Termos MeSH primário: Regulação do Apetite/efeitos dos fármacos
Glicemia/metabolismo
Fibras na Dieta/farmacologia
Proteínas na Dieta/administração & dosagem
Carne Vermelha
Resposta de Saciedade/efeitos dos fármacos
Verduras
[Mh] Termos MeSH secundário: Adulto
Dieta
Ingestão de Energia/efeitos dos fármacos
Peptídeo 1 Semelhante ao Glucagon/sangue
Seres Humanos
Insulina/sangue
Masculino
Obesidade/prevenção & controle
Ervilhas/química
Fragmentos de Peptídeos/sangue
Peptídeo YY/sangue
Proteínas de Plantas/administração & dosagem
Estudos Prospectivos
Valores de Referência
Saciação
Secale/química
Sementes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fiber); 0 (Dietary Proteins); 0 (Insulin); 0 (Peptide Fragments); 0 (Plant Proteins); 106388-42-5 (Peptide YY); 123583-37-9 (peptide YY (3-36)); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.250332


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[PMID]:28592602
[Au] Autor:Desai AJ; Dong M; Langlais BT; Dueck AC; Miller LJ
[Ad] Endereço:Department of Molecular Pharmacology and Experimental Therapeutics and.
[Ti] Título:Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype.
[So] Source:Am J Clin Nutr;106(2):447-456, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cholecystokinin (CCK) is an important satiety factor, acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clinical trials for obesity. We postulated that CCK1R function might be defective in such patients due to abnormal membrane composition, such as that observed in cholesterol gallstone disease. Due to the challenges in directly studying CCK1Rs relevant to appetite control, our goal was to develop and apply a method to determine the impact of a patient's own cellular environment on CCK stimulus-activity coupling and to determine whether CCK sensitivity correlated with the metabolic phenotype of a high-risk population. Wild-type CCK1Rs were expressed on leukocytes from 112 Hispanic patients by using adenoviral transduction and 24-h culture, with quantitation of cholesterol composition and intracellular calcium responses to CCK. Results were correlated with clinical, biochemical, and morphometric characteristics. Broad ranges of cellular cholesterol and CCK responsiveness were observed, with elevated cholesterol correlated with reduced CCK sensitivity. This was prominent with increasing degrees of obesity and the presence of diabetes, particularly when poorly controlled. No single standard clinical metric correlated directly with CCK responsiveness. Reduced CCK sensitivity best correlated with elevated serum triglycerides in normal-weight participants and with low HDL concentrations and elevated glycated hemoglobin in obese and diabetic patients. CCK responsiveness varies widely across the population, with reduced signaling in patients with obesity and diabetes. This could explain the failure of CCK agonists in previous clinical trials and supports the rationale to develop corrective modulators to reverse this defective servomechanism for appetite control. This trial was registered at www.clinicaltrials.gov as NCT03121755.
[Mh] Termos MeSH primário: Regulação do Apetite/efeitos dos fármacos
Glicemia/metabolismo
Colecistocinina/metabolismo
Diabetes Mellitus/metabolismo
Lipídeos/sangue
Obesidade/metabolismo
Receptores da Colecistocinina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Fármacos Antiobesidade/farmacologia
Colecistocinina/agonistas
HDL-Colesterol/sangue
Diabetes Mellitus/sangue
Diabetes Mellitus/tratamento farmacológico
Feminino
Hemoglobinas/metabolismo
Seres Humanos
Hipoglicemiantes/farmacologia
Masculino
Meia-Idade
Obesidade/sangue
Obesidade/tratamento farmacológico
Fenótipo
Valores de Referência
Saciação/fisiologia
Transdução de Sinais
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Blood Glucose); 0 (Cholesterol, HDL); 0 (Hemoglobins); 0 (Hypoglycemic Agents); 0 (Lipids); 0 (Receptors, Cholecystokinin); 0 (Triglycerides); 9011-97-6 (Cholecystokinin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.156943



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