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  1 / 11922 MEDLINE  
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[PMID]:27779563
[Au] Autor:Liebau A; Pogorzelski O; Salt AN; Plontke SK
[Ad] Endereço:*Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany †Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri, U.S.A.
[Ti] Título:Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols.
[So] Source:Otol Neurotol;38(1):19-30, 2017 01.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Controlled and uncontrolled studies with primary intratympanic or combined intratympanic and systemic application of glucocorticosteroids for idiopathic sudden hearing loss were analyzed by means of a meta-analysis in an attempt to establish optimal local drug delivery protocols. STUDY DESIGN: A total of 25 studies with 28 treatment groups between January 2000 and June 2014 were selected that adequately described drug delivery protocols. Cochlear drug levels were calculated by a validated computer model of drug dispersion in the inner ear fluids based on the concentration and volume of glucocorticoids applied, the time the drug remained in the middle ear, and the specific timing of injections. Various factors were compared with hearing outcome, including baseline data, individual parameters of the application protocols, calculated peak concentration (Cmax), and total dose (area under the curve). RESULTS: There was no dependence of hearing outcome on individual parameters of the application protocol, Cmax, or area under the curve. Final hearing threshold was notably independent of delay of treatment. CONCLUSION: During primary intratympanic or combined steroid therapy of idiopathic sudden hearing loss, the tendency toward early treatment having a positive effect on hearing improvement is thought to be a "sham effect," likely related to spontaneous recovery. Change in pure-tone average may not be an adequate outcome parameter to assess effectiveness of the intervention, as it depends on the degree of initial hearing loss. Final pure-tone average provides a better alternative.
[Mh] Termos MeSH primário: Glucocorticoides/administração & dosagem
Perda Auditiva Súbita/tratamento farmacológico
[Mh] Termos MeSH secundário: Simulação por Computador
Audição/efeitos dos fármacos
Seres Humanos
Injeção Intratimpânica
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  2 / 11922 MEDLINE  
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[PMID]:29365387
[Au] Autor:Huang YY; Chen JY; Shen M; Yang J
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
[Ti] Título:[Strategy for minimally invasive cochlear implantation and residual hearing preservation].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):66-69, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:In the past few decades, considerable development was achieved in the cochlear implantation following the emergence of innovative electrode array and advances in minimally invasive surgery. Minimally invasive technique led to a better preservation of residual low-frequency hearing. The loss of residual hearing was caused by complicated factors. According to previous studies, a slower and stable speed of electrode insertion and the use of perioperative steroids were demonstrated to have a positive impact on hearing preservation. The selection of electrode array or its insertion approaches didn't show any distinctive benefits in hearing preservation.
[Mh] Termos MeSH primário: Implante Coclear/métodos
Implantes Cocleares
Perda Auditiva/prevenção & controle
Perda Auditiva/cirurgia
[Mh] Termos MeSH secundário: Eletrodos Implantados
Audição
Seres Humanos
Procedimentos Cirúrgicos Minimamente Invasivos
Esteroides/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Steroids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.017


  3 / 11922 MEDLINE  
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[PMID]:29317624
[Au] Autor:Clemens J; Ozeri-Engelhard N; Murthy M
[Ad] Endereço:Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08540, USA.
[Ti] Título:Fast intensity adaptation enhances the encoding of sound in Drosophila.
[So] Source:Nat Commun;9(1):134, 2018 01 09.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To faithfully encode complex stimuli, sensory neurons should correct, via adaptation, for stimulus properties that corrupt pattern recognition. Here we investigate sound intensity adaptation in the Drosophila auditory system, which is largely devoted to processing courtship song. Mechanosensory neurons (JONs) in the antenna are sensitive not only to sound-induced antennal vibrations, but also to wind or gravity, which affect the antenna's mean position. Song pattern recognition, therefore, requires adaptation to antennal position (stimulus mean) in addition to sound intensity (stimulus variance). We discover fast variance adaptation in Drosophila JONs, which corrects for background noise over the behaviorally relevant intensity range. We determine where mean and variance adaptation arises and how they interact. A computational model explains our results using a sequence of subtractive and divisive adaptation modules, interleaved by rectification. These results lay the foundation for identifying the molecular and biophysical implementation of adaptation to the statistics of natural sensory stimuli.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Antenas de Artrópodes/fisiologia
Drosophila/fisiologia
Mecanorreceptores/fisiologia
Vocalização Animal
[Mh] Termos MeSH secundário: Animais
Feminino
Audição/fisiologia
Mecanotransdução Celular
Comportamento Sexual Animal
Som
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02453-9


  4 / 11922 MEDLINE  
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[PMID]:28457158
[Au] Autor:Blacker CJ
[Ad] Endereço:From the Department of Psychiatry and Psychology, Child and Adolescent Psychiatry, Mayo Clinic, Rochester, Minn.
[Ti] Título:"I Hear You".
[So] Source:Am J Psychiatry;174(5):419-420, 2017 May 01.
[Is] ISSN:1535-7228
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Comunicação
Perda Auditiva Neurossensorial/diagnóstico
Audição/fisiologia
[Mh] Termos MeSH secundário: Perda Auditiva Neurossensorial/fisiopatologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1176/appi.ajp.2017.17020153


  5 / 11922 MEDLINE  
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[PMID]:25815688
[Au] Autor:Molis MR; Kampel SD; McMillan GP; Gallun FJ; Dann SM; Konrad-Martin D
[Ti] Título:Effects of hearing and aging on sentence-level time-gated word recognition.
[So] Source:J Speech Lang Hear Res;58(2):481-96, 2015 Apr.
[Is] ISSN:1558-9102
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Aging is known to influence temporal processing, but its relationship to speech perception has not been clearly defined. To examine listeners' use of contextual and phonetic information, the Revised Speech Perception in Noise test (R-SPIN) was used to develop a time-gated word (TGW) task. METHOD: In Experiment 1, R-SPIN sentence lists were matched on context, target-word length, and median word segment length necessary for target recognition. In Experiment 2, TGW recognition was assessed in quiet and in noise among adults of various ages with normal hearing to moderate hearing loss. Linear regression models of the minimum word duration necessary for correct identification and identification failure rates were developed. Age and hearing thresholds were modeled as continuous predictors with corrections for correlations among multiple measurements of the same participants. RESULTS: While aging and hearing loss both had significant impacts on task performance in the most adverse listening condition (low context, in noise), for most conditions, performance was limited primarily by hearing loss. CONCLUSION: Whereas hearing loss was strongly related to target-word recognition, the effect of aging was only weakly related to task performance. These results have implications for the design and evaluation of studies of hearing and aging.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Audição/fisiologia
Linguagem
Recognição (Psicologia)
Percepção da Fala/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica/métodos
Adulto
Idoso
Limiar Auditivo
Feminino
Perda Auditiva/psicologia
Testes Auditivos
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Ruído
Fonética
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1612
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150328
[St] Status:MEDLINE
[do] DOI:10.1044/2015_JSLHR-H-14-0098


  6 / 11922 MEDLINE  
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[PMID]:27779518
[Au] Autor:Stam M; Smit JH; Twisk JW; Lemke U; Smits C; Festen JM; Kramer SE
[Ad] Endereço:1Section Ear & Hearing, Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands; 2Department of Psychiatry, VU University Medical Center/GGZ inGeest and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands; 3Department of Epidemiology and Biostatistics, VU University Medical Center and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands; and 4Phonak AG, Science and Technology, Stäfa, Switzerland.
[Ti] Título:Change in Psychosocial Health Status Over 5 Years in Relation to Adults' Hearing Ability in Noise.
[So] Source:Ear Hear;37(6):680-689, 2016 Nov/Dec.
[Is] ISSN:1538-4667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to establish the longitudinal relationship between hearing ability in noise and psychosocial health outcomes (i.e., loneliness, anxiety, depression, distress, and somatization) in adults aged 18 to 70 years. An additional objective was to determine whether a change in hearing ability in noise over a period of 5 years was associated with a change in psychosocial functioning. Subgroup effects for a range of factors were investigated. DESIGN: Longitudinal data of the web-based Netherlands Longitudinal Study on Hearing (NL-SH) (N = 508) were analyzed. The ability to recognize speech in noise (i.e., the speech-reception-threshold [SRTn]) was measured with an online digit triplet test at baseline and at 5-year follow-up. Psychosocial health status was assessed by online questionnaires. Multiple linear regression analyses and longitudinal statistical analyses (i.e., generalized estimating equations) were performed. RESULTS: Poorer SRTn was associated longitudinally with more feelings of emotional and social loneliness. For participants with a high educational level, the longitudinal association between SRTn and social loneliness was significant. Changes in hearing ability and loneliness appeared significantly associated only for specific subgroups: those with stable pattern of hearing aid nonuse (increased emotional and social loneliness), who entered matrimony (increased social loneliness), and low educational level (less emotional loneliness). No significant longitudinal associations were found between hearing ability and anxiety, depression, distress, or somatization. CONCLUSIONS: Hearing ability in noise was longitudinally associated with loneliness. Decline in hearing ability in noise was related to increase in loneliness for specific subgroups of participants. One of these subgroups included participants whose hearing deteriorated over 5 years, but who continued to report nonuse of hearing aids. This is an important and alarming finding that needs further investigation.
[Mh] Termos MeSH primário: Ansiedade/psicologia
Depressão/psicologia
Nível de Saúde
Perda Auditiva/psicologia
Audição
Solidão/psicologia
Transtornos Somatoformes/psicologia
Estresse Psicológico/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Escolaridade
Feminino
Auxiliares de Audição
Perda Auditiva/fisiopatologia
Perda Auditiva/reabilitação
Seres Humanos
Estudos Longitudinais
Masculino
Saúde Mental
Meia-Idade
Ruído
Percepção da Fala
Teste do Limiar de Recepção da Fala
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  7 / 11922 MEDLINE  
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[PMID]:29261683
[Au] Autor:Bright T; Mulwafu W; Thindwa R; Zuurmond M; Polack S
[Ad] Endereço:London School of Hygiene & Tropical Medicine, London, United Kingdom.
[Ti] Título:Reasons for low uptake of referrals to ear and hearing services for children in Malawi.
[So] Source:PLoS One;12(12):e0188703, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Early detection and appropriate intervention for children with hearing impairment is important for maximizing functioning and quality of life. The lack of ear and hearing services in low income countries is a significant challenge, however, evidence suggests that even where such services are available, and children are referred to them, uptake is low. The aim of this study was to assess uptake of and barriers to referrals to ear and hearing services for children in Thyolo District, Malawi. METHODS: This was a mixed methods study. A survey was conducted with 170 caregivers of children who were referred for ear and hearing services during community-based screening camps to assess whether they had attended their referral and reasons for non-attendance. Semi-structured interviews were conducted with 23 caregivers of children who did not take up their referral to explore in-depth the reasons for non-uptake. In addition, 15 stakeholders were interviewed. Thematic analysis of the interview data was conducted and emerging trends were analysed. RESULTS: Referral uptake was very low with only 5 out of 150 (3%) children attending. Seven main interacting themes for non-uptake of referral were identified in the semi-structured interviews: location of the hospital, lack of transport, other indirect costs of seeking care, fear and uncertainty about the referral hospital, procedural problems within the camps, awareness and understanding of hearing loss, and lack of visibility and availability of services. CONCLUSION: This study has highlighted a range of interacting challenges faced by families in accessing ear and hearing services in this setting. Understanding these context specific barriers to non-uptake of ear and hearing services is important for designing appropriate interventions to increase uptake.
[Mh] Termos MeSH primário: Orelha/fisiologia
Audição/fisiologia
Encaminhamento e Consulta
[Mh] Termos MeSH secundário: Criança
Custos e Análise de Custo
Feminino
Seguimentos
Conhecimentos, Atitudes e Prática em Saúde
Acesso aos Serviços de Saúde
Perda Auditiva/economia
Perda Auditiva/epidemiologia
Perda Auditiva/fisiopatologia
Seres Humanos
Recém-Nascido
Malaui/epidemiologia
Masculino
Inquéritos e Questionários
Transportes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188703


  8 / 11922 MEDLINE  
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[PMID]:29179790
[Au] Autor:Sagiv D; Migirov L; Madgar O; Nakache G; Wolf M; Shapira Y
[Ad] Endereço:Department of Otolaryngology - Head and Neck Surgery,Sheba Medical Center,Tel Hashomer,Israel.
[Ti] Título:Mobile phone usage does not affect sudden sensorineural hearing loss.
[So] Source:J Laryngol Otol;132(1):29-32, 2018 Jan.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Recent studies found that mobile phone users had a significantly greater risk of having elevated thresholds in speech frequencies. This study investigated the correlation between the laterality of sudden sensorineural hearing loss, handedness and the preferred ear for mobile phone use. METHODS: The study included all patients who presented with sudden sensorineural hearing loss to the Department of Otolaryngology - Head and Neck Surgery in our tertiary referral medical centre between 2014 and 2016. Patients were asked to indicate their dominant hand and preferred ear for mobile phone use. RESULTS: The study comprised 160 patients. No correlation was found between the dominant hand or preferred ear for mobile phone use and the side of sudden sensorineural hearing loss. There was no correlation between the side of the sudden sensorineural hearing loss (preferable or non-preferable for mobile phone use) and audiometric characteristics. CONCLUSION: No correlation was found between the laterality of ears used for mobile phone and sudden sensorineural hearing loss.
[Mh] Termos MeSH primário: Telefone Celular
Perda Auditiva Neurossensorial/etiologia
Perda Auditiva Súbita/etiologia
Audição/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Audiometria de Tons Puros
Feminino
Perda Auditiva Neurossensorial/fisiopatologia
Perda Auditiva Súbita/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117002365


  9 / 11922 MEDLINE  
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[PMID]:29176873
[Au] Autor:Han JH; Won JY; Hong SK; Kim JH; Kim ES; Kim HJ; Lee HJ
[Ad] Endereço:Laboratory of Brain & Cognitive Sciences for Convergence Medicine, Hallym University College of Medicine, Chuncheon, Republic of Korea.
[Ti] Título:Objective measurement of subjective tinnitus using the acoustic change complex.
[So] Source:PLoS One;12(11):e0188268, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:At present, there is no objective method for diagnosing subjective sensorineural tinnitus. Recently, the acoustic change complex (ACC) has been used to evaluate neural detection of sounds. Thus, the present study aimed to examine whether the ACC can reflect cortical detection and discrimination of sounds matched with tinnitus frequencies. We hypothesized that the ACC to change stimuli matched with tinnitus frequencies would be decreased in tinnitus patients because the tinnitus interferes with the perception of acoustic changes. To test the hypothesis, 96 ears of normal-hearing (NH) tinnitus patients and controls were tested. Among the tinnitus patients, 33 ears with a tinnitus frequency of 8 kHz constituted the tinnitus group, and the remaining 63 ears with no experience of tinnitus were allocated to the control group. For the 4 kHz non-tinnitus matched frequency, a subset of tinnitus (n = 17) and NH (n = 47) subjects was tested. The acoustic stimuli were pure tones with a total duration of 500 ms consisting of a 1 kHz tone in the first 250 ms and a second tone of either 8 kHz or 4 kHz in the latter 250 ms. The normalized amplitude of the ACC (naACC) was calculated separately for the amplitude of the N1'-P2' complex evoked by an 8 kHz or 4 kHz change stimulus and for the amplitude of the N1-P2 complex elicited by the initial 1 kHz background stimulus. Our results showed that the naACC to an 8 kHz stimulus in the tinnitus group was significantly smaller than those to 4 kHz and 8 kHz in normal controls. Additionally, in the tinnitus group, the naACC to 4 kHz was greater compared to 8 kHz. The receiver operating characteristic (ROC) curve analysis conducted for naACC to 8 kHz at UCL revealed a fair degree of diagnostic efficacy. Overall, our results indicated that the ACC to a change stimulus matched with the tinnitus frequency can provide an objective measure of frequency-specific tinnitus.
[Mh] Termos MeSH primário: Acústica
Zumbido/diagnóstico
[Mh] Termos MeSH secundário: Estimulação Acústica
Adulto
Limiar Auditivo
Estudos de Casos e Controles
Demografia
Feminino
Audição
Seres Humanos
Masculino
Curva ROC
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188268


  10 / 11922 MEDLINE  
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[PMID]:28982139
[Au] Autor:Hambrook DA; Ilievski M; Mosadeghzad M; Tata M
[Ad] Endereço:Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
[Ti] Título:A Bayesian computational basis for auditory selective attention using head rotation and the interaural time-difference cue.
[So] Source:PLoS One;12(10):e0186104, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The process of resolving mixtures of several sounds into their separate individual streams is known as auditory scene analysis and it remains a challenging task for computational systems. It is well-known that animals use binaural differences in arrival time and intensity at the two ears to find the arrival angle of sounds in the azimuthal plane, and this localization function has sometimes been considered sufficient to enable the un-mixing of complex scenes. However, the ability of such systems to resolve distinct sound sources in both space and frequency remains limited. The neural computations for detecting interaural time difference (ITD) have been well studied and have served as the inspiration for computational auditory scene analysis systems, however a crucial limitation of ITD models is that they produce ambiguous or "phantom" images in the scene. This has been thought to limit their usefulness at frequencies above about 1khz in humans. We present a simple Bayesian model and an implementation on a robot that uses ITD information recursively. The model makes use of head rotations to show that ITD information is sufficient to unambiguously resolve sound sources in both space and frequency. Contrary to commonly held assumptions about sound localization, we show that the ITD cue used with high-frequency sound can provide accurate and unambiguous localization and resolution of competing sounds. Our findings suggest that an "active hearing" approach could be useful in robotic systems that operate in natural, noisy settings. We also suggest that neurophysiological models of sound localization in animals could benefit from revision to include the influence of top-down memory and sensorimotor integration across head rotations.
[Mh] Termos MeSH primário: Atenção
Teorema de Bayes
Cabeça/fisiologia
Audição
Modelos Teóricos
[Mh] Termos MeSH secundário: Algoritmos
Potenciais Pós-Sinápticos Excitadores
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186104



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