Base de dados : MEDLINE
Pesquisa : F02.830.816.964 [Categoria DeCS]
Referências encontradas : 18428 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1843 ir para página                         

  1 / 18428 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29278024
[Au] Autor:Bardak H; Uguz AC; Bardak Y
[Ad] Endereço:1 Department of Ophthalmology, Haydarpasa Numune Research and Training Hospital , Istanbul, Turkey.
[Ti] Título:Curcumin regulates intracellular calcium release and inhibits oxidative stress parameters, VEGF, and caspase-3/-9 levels in human retinal pigment epithelium cells.
[So] Source:Physiol Int;104(4):301-315, 2017 Dec 01.
[Is] ISSN:2498-602X
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:In this study, we aimed to observe whether curcumin (cur), a polyphenolic compound derived from the dietary spice turmeric, a yellow substance obtained from the root of the plant Curcuma longa Linn, has any protective effect against blue light irradiation in human retinal pigment epithelium (ARPE-19) cells. For this purpose, we evaluated the intracellular calcium release mechanism, poly ADP ribose polymerase (PARP), procaspase-3/-9 protein expression levels, caspase activation, and reactive oxygen species levels. ARPE-19 cells were divided into four main groups, such as control, cur, blue light, and cur + blue light. Results were evaluated by Kruskal-Wallis and Mann-Whitney U tests as post hoc tests. The cells in cur and cur + blue light samples were incubated with 20 µM cur. Blue light exposure was performed for 24 h in an incubator. Lipid peroxidation and cytosolic-free Ca [Ca ] concentrations were higher in the blue light exposure samples than in the control samples; however, their levels were determined as significantly lower in the cur and cur + blue light exposure samples than in the blue light samples alone. PARP and procaspase-3 levels were significantly higher in blue light samples. Cur administration significantly decreased PARP and procaspase-3 expression levels. Reduced glutathione and glutathione peroxidase values were lower in the blue light exposure samples, although they were higher in the cur and cur + blue light exposure samples. Caspase-3 and -9 activities were lower in the cur samples than in the blue light samples. Moreover, vascular endothelial growth factor (VEGF) levels were significantly higher in the blue light exposure samples. In conclusion, cur strongly induced regulatory effects on oxidative stress, intracellular Ca levels, VEGF levels, PARP expression levels, and caspase-3 and -9 values in an experimental oxidative stress model in ARPE-19 cells.
[Mh] Termos MeSH primário: Sinalização do Cálcio/fisiologia
Caspase 3/metabolismo
Caspase 9/metabolismo
Curcumina/administração & dosagem
Epitélio Pigmentado da Retina/fisiologia
Fator A de Crescimento do Endotélio Vascular/metabolismo
Visão Ocular/fisiologia
[Mh] Termos MeSH secundário: Sinalização do Cálcio/efeitos dos fármacos
Sinalização do Cálcio/efeitos da radiação
Linhagem Celular
Relação Dose-Resposta a Droga
Seres Humanos
Luz
Estresse Oxidativo/fisiologia
Estresse Oxidativo/efeitos da radiação
Espécies Reativas de Oxigênio/metabolismo
Epitélio Pigmentado da Retina/efeitos dos fármacos
Epitélio Pigmentado da Retina/efeitos da radiação
Visão Ocular/efeitos dos fármacos
Visão Ocular/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE
[do] DOI:10.1556/2060.104.2017.4.3


  2 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29231003
[Au] Autor:Wang M; Yu XY; Chen JM; Liu RJ; Xia WT
[Ad] Endereço:Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, PRC, Shanghai 200063, China.
[Ti] Título:[Contrast Visual Evoked Potentials under Pattern Stimulus in Ocular Trauma].
[So] Source:Fa Yi Xue Za Zhi;33(1):21-24, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To study the characteristic of contrast visual evoked potentials (CVEP) in patients with ocular trauma. METHODS: Sixty patients defined as ocular trauma by forensic clinical examination in our center were selected, and split into 0.2-0.3 (Group A), 0.3-0.5 (Group B) and ≥0.5 (Group C) according to the best corrected visual acuity. The variation characteristics of wave amplitude and latency of CVEP under 100%, 25% and 10% contrast were observed and analyzed statistically. RESULTS: (1) Under the same contrast, the wave amplitude of P100 decreased with the decrease of stimulus perspective. (2) Under the same stimulus perspective, the wave amplitude of P100 decreased with the decrease of contrast ( <0.05). (3) Under the contrast of 100% and 25% with the same stimulus perspective (except 100% 7' perspective stimulus), the difference between group A and group B had no statistical significance ( >0.05). Between group A and group C, group B and group C, the wave amplitude of P100 gradually increased with the increase of vision ( <0.05). Under the contrast of 10% with 15' stimulus perspective, the wave amplitude of P100 increased with the increase of vision ( <0.05). (4) Under the same contrast with the same stimulation perspective, the latency of P100 wave shortened with the increase of vision, while the difference had no statistical significance ( >0.05). Under the same stimulus perspective, the latency of P100 wave was prolonged with the decrease of contrast ( >0.05). CONCLUSIONS: CVEP may become one of the possible methods for the evaluation of contrast visual acuity.
[Mh] Termos MeSH primário: Potenciais Evocados Visuais/fisiologia
Traumatismos Oculares/fisiopatologia
Reconhecimento Visual de Modelos/fisiologia
Acuidade Visual
[Mh] Termos MeSH secundário: Seres Humanos
Estimulação Luminosa
Visão Ocular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.005


  3 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29311648
[Au] Autor:Thiagavel J; Cechetto C; Santana SE; Jakobsen L; Warrant EJ; Ratcliffe JM
[Ad] Endereço:Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, ON, M5S 3B2, Canada.
[Ti] Título:Auditory opportunity and visual constraint enabled the evolution of echolocation in bats.
[So] Source:Nat Commun;9(1):98, 2018 01 08.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Substantial evidence now supports the hypothesis that the common ancestor of bats was nocturnal and capable of both powered flight and laryngeal echolocation. This scenario entails a parallel sensory and biomechanical transition from a nonvolant, vision-reliant mammal to one capable of sonar and flight. Here we consider anatomical constraints and opportunities that led to a sonar rather than vision-based solution. We show that bats' common ancestor had eyes too small to allow for successful aerial hawking of flying insects at night, but an auditory brain design sufficient to afford echolocation. Further, we find that among extant predatory bats (all of which use laryngeal echolocation), those with putatively less sophisticated biosonar have relatively larger eyes than do more sophisticated echolocators. We contend that signs of ancient trade-offs between vision and echolocation persist today, and that non-echolocating, phytophagous pteropodid bats may retain some of the necessary foundations for biosonar.
[Mh] Termos MeSH primário: Percepção Auditiva/fisiologia
Quirópteros/fisiologia
Ecolocação/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Encéfalo/anatomia & histologia
Encéfalo/fisiologia
Quirópteros/anatomia & histologia
Quirópteros/classificação
Olho/anatomia & histologia
Voo Animal/fisiologia
Fenômenos Fisiológicos Oculares
Visão Ocular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02532-x


  4 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28453427
[Au] Autor:Lamson KS; Hinton EG
[Ad] Endereço:a MCPHS University , Worcester , Massachusetts , USA.
[Ti] Título:VisionCite: A Vision Science-Related Database.
[So] Source:Med Ref Serv Q;36(2):165-170, 2017 Apr-Jun.
[Is] ISSN:1540-9597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:VisionCite is a database dedicated to the visual sciences. This paid subscription database provides bibliographic information for optometry and ophthalmology-related resources and is maintained by the Illinois College of Optometry (ICO) Library. A sample search is provided, highlighting different features of the newly redesigned database.
[Mh] Termos MeSH primário: Bases de Dados Factuais
Oftalmologia
Optometria
[Mh] Termos MeSH secundário: Seres Humanos
Illinois
Bibliotecas Médicas
Visão Ocular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/02763869.2017.1293984


  5 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29324819
[Au] Autor:Imaizumi S; Koyama S; Tanno Y
[Ad] Endereço:Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
[Ti] Título:Development of the Japanese version of the Visual Discomfort Scale.
[So] Source:PLoS One;13(1):e0191094, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Visual stimuli, such as stripes and texts, can induce "visual discomfort" including perceptual and somatic symptoms. Individuals reporting high levels of visual discomfort might experience migraine headache and may have reduced reading efficiency due to visual perceptual difficulties. This study aimed to develop and validate the Japanese version of the Visual Discomfort Scale, which measures proneness to visual discomfort. METHODS AND RESULTS: In Survey 1, 428 adults completed the Japanese version and a questionnaire assessing migraine morbidity. Rasch analysis revealed that the Japanese version is a unidimensional scale with a high amount of unexplained variance due to random noise rather than another dimension, and has high person and item reliabilities. Participants with migraine exhibited high scores in the Japanese version, indicating the construct validity of the scale. Survey 2 with 118 adults revealed a strong test-retest correlation for the Japanese version, indicating the stability of the scale. CONCLUSION: The Japanese version of the Visual Discomfort Scale is a sufficiently reliable and valid scale for assessing visual discomfort, although its unidimensionality leaves room for further improvements.
[Mh] Termos MeSH primário: Estimulação Luminosa
Visão Ocular
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Japão
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191094


  6 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29227508
[Au] Autor:Tandogan T; Son HS; Choi CY; Knorz MC; Auffarth GU; Khoramnia R
[Ti] Título:Laboratory Evaluation of the Influence of Decentration and Pupil Size on the Optical Performance of a Monofocal, Bifocal, and Trifocal Intraocular Lens.
[So] Source:J Refract Surg;33(12):808-812, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the influence of decentration and aperture size on the optical quality of different intraocular lenses (IOLs) of the same material, body design, and refractive power using standardized optical bench testing. METHODS: Using an optical bench set-up, an aspheric monofocal (CT ASPHINA 409M; Carl Zeiss Meditec, Jena, Germany), an aspheric diffractive bifocal (AT LISA 809M; Carl Zeiss Meditec), and an aspheric diffractive trifocal (AT LISA 839M; Carl Zeiss Meditec) intraocular lens (IOL) were evaluated, each with the same distance power, body design, and material. Modulation transfer function (MTF) values were measured at spatial frequencies of 50 lp/mm and aperture sizes of 3 and 4.5 mm. Each IOL was measured while centered, then decentered by 0.25, 0.5, 0.75, and 1 mm. RESULTS: MTF values for the monofocal IOL at far focus with 3- and 4.5-mm aperture size were 0.80/0.80 with maximum reduction to 0.77/0.73 for 1-mm decentration, respectively. Centered IOL MTFs of the bifocal and trifocal IOLs were lower for the far focus at 0.46/0.41 and 0.39/0.26, with reduction at 1-mm decentration to 0.35/0.25 and 0.25/0.18, respectively. Values for near focus of the bifocal and trifocal IOLs reduced from 0.27/0.31 and 0.19/0.18 to 0.2/0.21 and 0.12/0.13, respectively. The trifocal intermediate focus MTF reduced from 0.15/0.10 to 0.12/0.08. MTF values of all three lenses decreased significantly under all conditions with decentration of 0.5 to 0.75 mm. CONCLUSIONS: Monofocal lenses were least negatively affected by decentration, with mean optical quality reduction of less than 10% for 1-mm decentration at physiological pupil sizes. For diffractive bifocal and trifocal lenses, optical quality at all distances was significantly reduced if decentration exceeded 0.75 mm, with intermediate focus showing the least reduction. [J Refract Surg. 2017;33(12):808-812.].
[Mh] Termos MeSH primário: Migração do Implante de Lente Intraocular/fisiopatologia
Iris/anatomia & histologia
Lentes Intraoculares
Óptica e Fotônica
Pseudofacia/fisiopatologia
Pupila/fisiologia
Refração Ocular/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Teóricos
Desenho de Prótese
Visão Ocular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20171004-02


  7 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29358689
[Au] Autor:Gueye M; Manathunga M; Agathangelou D; Orozco Y; Paolino M; Fusi S; Haacke S; Olivucci M; Léonard J
[Ad] Endereço:Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504, F-67034, Strasbourg, France.
[Ti] Título:Engineering the vibrational coherence of vision into a synthetic molecular device.
[So] Source:Nat Commun;9(1):313, 2018 01 22.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The light-induced double-bond isomerization of the visual pigment rhodopsin operates a molecular-level optomechanical energy transduction, which triggers a crucial protein structure change. In fact, rhodopsin isomerization occurs according to a unique, ultrafast mechanism that preserves mode-specific vibrational coherence all the way from the reactant excited state to the primary photoproduct ground state. The engineering of such an energy-funnelling function in synthetic compounds would pave the way towards biomimetic molecular machines capable of achieving optimum light-to-mechanical energy conversion. Here we use resonance and off-resonance vibrational coherence spectroscopy to demonstrate that a rhodopsin-like isomerization operates in a biomimetic molecular switch in solution. Furthermore, by using quantum chemical simulations, we show why the observed coherent nuclear motion critically depends on minor chemical modifications capable to induce specific geometric and electronic effects. This finding provides a strategy for engineering vibrationally coherent motions in other synthetic systems.
[Mh] Termos MeSH primário: Materiais Biomiméticos/química
Indanos/química
Dispositivos Ópticos
Pirróis/química
Retinaldeído/química
Rodopsina/química
[Mh] Termos MeSH secundário: Alquilação
Animais
Materiais Biomiméticos/síntese química
Engenharia Química
Seres Humanos
Indanos/síntese química
Luz
Processos Fotoquímicos
Pirróis/síntese química
Teoria Quântica
Análise Espectral/instrumentação
Análise Espectral/métodos
Vibração
Visão Ocular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Indans); 0 (Pyrroles); 9009-81-8 (Rhodopsin); RR725D715M (Retinaldehyde)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02668-w


  8 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29364947
[Au] Autor:Graham AD; Lundgrin EL; Lin MC
[Ad] Endereço:Clinical Research Center, School of Optometry, University of California, Berkeley, California, United States of America.
[Ti] Título:The Berkeley Dry Eye Flow Chart: A fast, functional screening instrument for contact lens-induced dryness.
[So] Source:PLoS One;13(1):e0190752, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In this article, we introduce a novel flow chart-based screening tool for the categorization of contact lens-induced dryness (CLIDE) and its impact on daily visual activities: the Berkeley Dry Eye Flow Chart (DEFC). METHODS: One hundred thirty (130) experienced soft contact lens wearers discontinued lens wear for 24 hrs, passed a baseline screening and eye health examination, completed the Ocular Surface Disease Index (OSDI) then were dispensed fresh pairs of their habitual lenses. After 6 hrs of wear, subjects were administered a battery of symptom questionnaires, and underwent non-invasive tear breakup time (NITBUT) measurement, grading of distortion in reflected topographer mires, grading of lens surface wettability, and a fluorescein examination of the ocular surface. Subjects returned after at least 48 hrs and repeated all assessments after 6 hrs of wear of a second fresh pair of habitual lenses. RESULTS: The repeatability of the DEFC between visits was within 1%, and Limits of Agreement and Coefficient of Repeatability were comparable to those of the other CLIDE assessments. Higher DEFC score was significantly related to shorter pre-lens NITBUT, higher OSDI score, and higher Visual Analog Scale (VAS) ratings of average and end-of-day severity and frequency of dryness (all p < 0.001). For CLIDE as diagnosed based on DEFC score, the highest sensitivities and specificities were achieved by the OSDI and VAS ratings; pre-lens NITBUT exhibited good sensitivity but poor specificity. The optimum pre-lens NITBUT diagnostic threshold was found to be ≤ 2.0 sec for debilitating CLIDE, and the OSDI threshold was ≥ 11.4. CONCLUSIONS: The DEFC provides a means of quickly categorizing CLIDE patients based on severity and frequency of symptoms, and on the degree to which symptoms impact daily life. The DEFC has several potential advantages as a CLIDE screening and monitoring tool, has good repeatability, and is significantly related to commonly employed clinical assessments for CLIDE.
[Mh] Termos MeSH primário: Lentes de Contato Hidrofílicas/efeitos adversos
Xeroftalmia/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Grupos Populacionais
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Visão Ocular
Molhabilidade
Xeroftalmia/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190752


  9 / 18428 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29364891
[Au] Autor:Gorbet DJ; Sergio LE
[Ad] Endereço:School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
[Ti] Título:Move faster, think later: Women who play action video games have quicker visually-guided responses with later onset visuomotor-related brain activity.
[So] Source:PLoS One;13(1):e0189110, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A history of action video game (AVG) playing is associated with improvements in several visuospatial and attention-related skills and these improvements may be transferable to unrelated tasks. These facts make video games a potential medium for skill-training and rehabilitation. However, examinations of the neural correlates underlying these observations are almost non-existent in the visuomotor system. Further, the vast majority of studies on the effects of a history of AVG play have been done using almost exclusively male participants. Therefore, to begin to fill these gaps in the literature, we present findings from two experiments. In the first, we use functional MRI to examine brain activity in experienced, female AVG players during visually-guided reaching. In the second, we examine the kinematics of visually-guided reaching in this population. Imaging data demonstrate that relative to women who do not play, AVG players have less motor-related preparatory activity in the cuneus, middle occipital gyrus, and cerebellum. This decrease is correlated with estimates of time spent playing. Further, these correlations are strongest during the performance of a visuomotor mapping that spatially dissociates eye and arm movements. However, further examinations of the full time-course of visuomotor-related activity in the AVG players revealed that the decreased activity during motor preparation likely results from a later onset of activity in AVG players, which occurs closer to beginning motor execution relative to the non-playing group. Further, the data presented here suggest that this later onset of preparatory activity represents greater neural efficiency that is associated with faster visually-guided responses.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Tempo de Reação
Jogos de Vídeo
Visão Ocular
[Mh] Termos MeSH secundário: Adulto
Encéfalo/diagnóstico por imagem
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Desempenho Psicomotor/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189110


  10 / 18428 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29304147
[Au] Autor:Jeong MJ; Kim HG; Jeon CJ
[Ad] Endereço:Department of Biology, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, and Brain Science and Engineering Institute, Kyungpook National University, Daegu, South Korea.
[Ti] Título:The organization of melanopsin-immunoreactive cells in microbat retina.
[So] Source:PLoS One;13(1):e0190435, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intrinsically photosensitive retinal ganglion cells (ipRGCs) respond to light and play roles in non-image forming vision, such as circadian rhythms, pupil responses, and sleep regulation, or image forming vision, such as processing visual information and directing eye movements in response to visual clues. The purpose of the present study was to identify the distribution, types, and proportion of melanopsin-immunoreactive (IR) cells in the retina of a nocturnal animal, i.e., the microbat (Rhinolophus ferrumequinum). Three types of melanopsin-IR cells were observed in the present study. The M1 type had dendritic arbors that extended into the OFF sublayer of the inner plexiform layer (IPL). M1 soma locations were identified either in the ganglion cell layer (GCL, M1c; 21.00%) or in the inner nuclear layer (INL, M1d; 5.15%). The M2 type had monostratified dendrites in the ON sublayer of the IPL and their cell bodies lay in the GCL (M2; 5.79%). The M3 type was bistratified cells with dendrites in both the ON and OFF sublayers of the IPL. M3 soma locations were either in the GCL (M3c; 26.66%) or INL (M3d; 4.69%). Additionally, some M3c cells had curved dendrites leading up towards the OFF sublayer of the IPL and down to the ON sublayer of the IPL (M3c-crv; 7.67%). Melanopsin-IR cells displayed a medium soma size and medium dendritic field diameters. There were 2-5 primary dendrites and sparsely branched dendrites with varicosities. The total number of the neurons in the GCL was 12,254.17 ± 660.39 and that of the optic nerve axons was 5,179.04 ± 208.00 in the R. ferrumequinum retina. The total number of melanopsin-IR cells was 819.74 ± 52.03. The ipRGCs constituted approximately 15.83% of the total RGC population. This study demonstrated that the nocturnal microbat, R. ferrumequinum, has a much higher density of melanopsin-IR cells than documented in diurnal animals.
[Mh] Termos MeSH primário: Quirópteros/metabolismo
Retina/metabolismo
Opsinas de Bastonetes/metabolismo
[Mh] Termos MeSH secundário: Animais
Quirópteros/fisiologia
Sinais (Psicologia)
Retina/citologia
Visão Ocular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Rod Opsins); 0 (melanopsin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190435



página 1 de 1843 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde