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  1 / 907 MEDLINE  
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[PMID]:28741115
[Au] Autor:Woo J; Jung S; Gauvin M; Lachapelle P
[Ad] Endereço:Departments of Ophthalmology and Neurology and Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, Montreal, QC, Canada.
[Ti] Título:The DTL ERG electrode comes in different shapes and sizes: Are they all good?
[So] Source:Doc Ophthalmol;135(2):155-164, 2017 10.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Although the DTL fiber electrode has been in use in the ERG field for more than four decades, its composition was never clearly defined. We compared five different types of conductive (DTL type) yarn (differing in terms of mass, number of filaments, and crimping degree) in order to determine whether we could identify one that would be better suited for the recording of ERGs. METHODS: Photopic flash ERGs were recorded from five subjects using the following DTL electrodes: 27/7, 22/1, 11/1, 11/1*2, and 22/1*2. Data analysis included amplitude and peak time measurements of the a- and b-waves in the time domain (TD) as well as measurements of specific frequency descriptors of the ERG waveform in the time-frequency domain using the discrete wavelet transform (DWT) approach. The degree of comfortableness was also assessed in 12 subjects with two surveys (Likert 5-point and the ranking scale). RESULTS: Comparisons of TD and DWT parameters did not permit to identify the best DTL electrode, all yielding comparable measures. There was a slight trend for the largest electrode (22/1*2) to yield the largest response, but this was at the expense of comfort, the 22/1*2 electrode being rated as the least comfortable. CONCLUSIONS: Given the minimal impact the different electrodes had on the amplitude of the signal, we believe that comfort should dictate our choice. It would appear from our results that use of a multifilament electrode is the best choice since one can get an electrode whose size is optimized for the recording of large responses while minimizing the foreign-body sensation due to the small size of each of the filaments that compose this multifilament electrode.
[Mh] Termos MeSH primário: Eletrodos
Eletrorretinografia/instrumentação
Retina/fisiologia
[Mh] Termos MeSH secundário: Visão de Cores/fisiologia
Eletrorretinografia/métodos
Feminino
Seres Humanos
Masculino
Conforto do Paciente
Satisfação do Paciente
Estimulação Luminosa
Inquéritos e Questionários
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9600-3


  2 / 907 MEDLINE  
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[PMID]:29328638
[Au] Autor:Nikolic L; Jovanovic V
[Ti] Título:Cataract, ocular surgery, aphakia, and the chromatic expression of the painter Jovan Bijelic.
[So] Source:Vojnosanit Pregl;73(11):1003-9, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Approaching art from the standpoint of optics and the artist's eye pathology can sometimes explain the shift of the spectral colors in the work of some artists with cataract and aphakia. This may not be obvious in the paintings of other artists with the same eye pathology. The aim of this study was to create a timeline from the recently obtained details of the cataract surgery, his best corrected aphakic visual acuity, and the last paintings of the artist Jovan Bijelic. Methods: The research included primary and secondary source material: Bijelic's paintings from all stages of his career, interviews with Bijelic and his eye surgeon, art criticism, sources with the description of Bijelic's symptoms, hospital archives, discussion with art historians, comparison of his palette from different periods. Results: Jovan Bijelic was nearly blind from cataract in 1957. He underwent an unsuccessful cataract surgery in 1956, followed by enucleation of the operated eye. In 1958, 20/25­20/20 vision was regained, after the extracapsular cataract extraction and sector iridectomy in his right eye, with the posterior lens capsule discision afterwards. Xanthopsia and cyanopsia are not present in his art, which is not a representation of visualized objects. Conclusion: The response of Jovan Bijelic to cataract and aphakia was predominantly a change of his style.
[Mh] Termos MeSH primário: Afacia Pós-Catarata/história
Extração de Catarata/história
Catarata/história
Visão de Cores
Pinturas/história
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Afacia Pós-Catarata/fisiopatologia
Catarata/fisiopatologia
Catarata/terapia
História do Século XX
Seres Humanos
Acuidade Visual
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Bijelic J
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150313126N


  3 / 907 MEDLINE  
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[PMID]:29208227
[Au] Autor:Lebhardt F; Desplan C
[Ad] Endereço:Department of Biology, New York University, NY 10003, USA.
[Ti] Título:Retinal perception and ecological significance of color vision in insects.
[So] Source:Curr Opin Insect Sci;24:75-83, 2017 Dec.
[Is] ISSN:2214-5753
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Color vision relies on the ability to discriminate different wavelengths and is often improved in insects that inhabit well-lit, spectrally rich environments. Although the Opsin proteins themselves are sensitive to specific wavelength ranges, other factors can alter and further restrict the sensitivity of photoreceptors to allow for finer color discrimination and thereby more informed decisions while interacting with the environment. The ability to discriminate colors differs between insects that exhibit different life styles, between female and male eyes of the same species, and between regions of the same eye, depending on the requirements of intraspecific communication and ecological demands.
[Mh] Termos MeSH primário: Percepção de Cores
Visão de Cores
Insetos/fisiologia
[Mh] Termos MeSH secundário: Animais
Retina/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  4 / 907 MEDLINE  
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[PMID]:25815856
[Au] Autor:de Haan GA; Heutink J; Melis-Dankers BJ; Brouwer WH; Tucha O
[Ad] Endereço:Department of Clinical and Developmental Neuropsychology (GAdH, JH, WHB, OT), University of Groningen, Groningen, the Netherlands; Department of Rehabilitation & Advice (GAdH, JH, BJMM-D), Royal Dutch Visio, Centre of Expertise for Blind and Partially Sighted People, Haren, the Netherlands; and Department of Neurology (WHB), University Medical Center Groningen, Groningen, the Netherlands.
[Ti] Título:Difficulties in Daily Life Reported by Patients With Homonymous Visual Field Defects.
[So] Source:J Neuroophthalmol;35(3):259-64, 2015 Sep.
[Is] ISSN:1536-5166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Homonymous visual field defects (HVFD) are common after postchiasmatic acquired brain injury and may have a significant impact on independent living and participation in society. Vision-related difficulties experienced in daily life are usually assessed using questionnaires. The current study 1) links the content of 3 of these questionnaires to the International Classification of Functioning, Disability and Health (ICF) and 2) provides analyses of vision-related difficulties reported by patients with HVFD and minimal comorbidities. METHODS: Fifty-four patients with homonymous hemianopia or quadrantanopia were asked about difficulties experienced in daily life because of their HVFD. This was performed during a structured interview including 3 standardized questionnaires: National Eye Institute Visual Functioning Questionnaire, Independent Mobility Questionnaire, and Cerebral Visual Disorders Questionnaire. The reported difficulties were linked to the ICF according to the ICF linking rules. Main outcome measures were presence or absence of experienced difficulties. RESULTS: The ICF linking procedure resulted in a classification table that can be used in future studies of vision-related difficulties. Besides well-known difficulties related to reading, orientation, and mobility, a high proportion of patients with HVFD reported problems that previously have not been documented in the literature, such as impaired light sensitivity, color vision, and perception of depth. CONCLUSIONS: A systematic inventory of difficulties experienced in daily life by patients with HVFD was performed using the ICF. These findings have implications for future study, assessment and rehabilitation of patients with HVFD.
[Mh] Termos MeSH primário: Atividades Cotidianas/psicologia
Avaliação da Deficiência
Hemianopsia/fisiopatologia
Hemianopsia/psicologia
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Visão de Cores
Percepção de Profundidade
Feminino
Seres Humanos
Masculino
Inquéritos e Questionários
Testes de Campo Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1606
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150328
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000244


  5 / 907 MEDLINE  
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Berezovsky, Adriana
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[PMID]:29049835
[Au] Autor:Karanjia R; Berezovsky A; Sacai PY; Cavascan NN; Liu HY; Nazarali S; Moraes-Filho MN; Anderson K; Tran JS; Watanabe SE; Moraes MN; Sadun F; DeNegri AM; Barboni P; do Val Ferreira Ramos C; La Morgia C; Carelli V; Belfort R; Coupland SG; Salomao SR; Sadun AA
[Ad] Endereço:Doheny Eye Institute, Los Angeles, California, United States.
[Ti] Título:The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy.
[So] Source:Invest Ophthalmol Vis Sci;58(6):BIO300-BIO306, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The photopic negative response (PhNR) is a slow negative component of a flash photopic full-field ERG that has been shown to be specific for retinal ganglion cell (RGC) activity. Direct evaluation of RGC function is desirable in patients with Leber's hereditary optic neuropathy (LHON) in which the loss of central acuity can make it difficult to monitor patients with standard metrics. The purpose of this study was to evaluate the use of PhNR as an objective noninvasive clinical metric in LHON. Methods: Full-field photopic ERG recordings were collected in subjects with the mt.11778G>A/ND4 LHON mutation using a red on blue stimulus. The PhNR was identified using a computer-based automated detection system, and data were manually examined to remove movement artifacts. Results: The PhNR amplitude was compared between controls (n = 13), carriers (n = 17), and affected (n = 6). Mean PhNR amplitude decreased significantly across groups (P < 0.0001). Post hoc Tukey's test revealed a significant decrease in PhNR amplitude between carriers and controls (P < 0.05) and between carriers and affected (P < 0.01). Conclusions: We are able to demonstrate that the PhNR amplitude is significantly decreased in patients affected by LHON compared to carriers in a well-described pedigree. Surprisingly, there was also a decrease in PhNR in carriers, suggesting potential subclinical RGC dysfunction in some carriers. This is important in patients affected with LHON who typically have a dense central scotoma. The PhNR may be a useful objective outcome measure for future clinical trials.
[Mh] Termos MeSH primário: Visão de Cores/fisiologia
Atrofia Óptica Hereditária de Leber/fisiopatologia
Células Ganglionares da Retina/fisiologia
[Mh] Termos MeSH secundário: Adulto
Análise Mutacional de DNA
DNA Mitocondrial/genética
Eletrorretinografia
Feminino
Heterozigoto
Seres Humanos
Masculino
Meia-Idade
Fibras Nervosas/patologia
Atrofia Óptica Hereditária de Leber/genética
Estimulação Luminosa
Acuidade Visual/fisiologia
Campos Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21773


  6 / 907 MEDLINE  
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[PMID]:29049717
[Au] Autor:Tsai TI; Joachimsthaler A; Kremers J
[Ad] Endereço:Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany.
[Ti] Título:Mesopic and Photopic Rod and Cone Photoreceptor-Driven Visual Processes in Mice With Long-Wavelength-Shifted Cone Pigments.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5177-5187, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The clearer divergence in spectral sensitivity between native rod and human L-cone (L*-cone) opsins in the transgenic Opn1lwLIAIS mouse (LIAIS) allows normal visual processes mediated by these photoreceptor subtypes to be isolated effectively using the silent substitution technique. The objective of this study was to further characterize the influence of mean luminance and temporal frequency on the functional properties of signals originating in each photoreceptor separately and independently of adaptation state in LIAIS mice. Methods: Electroretinographic (ERG) recordings to sine-wave rod and L*-cone modulation at different mean luminances (0.1-130.0 cd/m2) and temporal frequencies (6-26 Hz) were examined in anesthetized LIAIS (N = 17) and C57Bl/6 mice (N = 8). Results: We report maximum rod-driven response with 8-Hz modulation at 0.1 to 0.5 cd/m2, which was almost four times larger than maximum cone-driven response at 8 Hz, 21.5 to 130 cd/m2. Over these optimal luminances, both rod- and cone-driven response amplitudes exhibited low-pass functions with similar frequency resolution limits, albeit their distinct luminance sensitivities. There were, however, two distinguishing features: (1) the frequency-dependent amplitude decrease of rod-driven responses was more profound, and (2) linear relationships describing rod-driven response phases as a function of stimulus frequency were steeper. Conclusions: Employing the silent substitution method with stimuli of appropriate luminance on the LIAIS mouse (as on human observers) increases the specificity, robustness, and scope to which photoreceptor-driven responses can be reliably assayed compared to the standard photoreceptor isolation methods.
[Mh] Termos MeSH primário: Visão de Cores/fisiologia
Opsinas dos Cones/metabolismo
Visão Mesópica/fisiologia
Células Fotorreceptoras de Vertebrados/fisiologia
[Mh] Termos MeSH secundário: Animais
Eletrorretinografia
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Estimulação Luminosa
Visão Ocular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cone Opsins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22553


  7 / 907 MEDLINE  
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[PMID]:28871030
[Au] Autor:Tuten WS; Harmening WM; Sabesan R; Roorda A; Sincich LC
[Ad] Endereço:School of Optometry and Vision Science Graduate Group, University of California, Berkeley, California 94720, tutenws@sas.upenn.edu.
[Ti] Título:Spatiochromatic Interactions between Individual Cone Photoreceptors in the Human Retina.
[So] Source:J Neurosci;37(39):9498-9509, 2017 Sep 27.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A remarkable feature of human vision is that the retina and brain have evolved circuitry to extract useful spatial and spectral information from signals originating in a photoreceptor mosaic with trichromatic constituents that vary widely in their relative numbers and local spatial configurations. A critical early transformation applied to cone signals is horizontal-cell-mediated lateral inhibition, which imparts a spatially antagonistic surround to individual cone receptive fields, a signature inherited by downstream neurons and implicated in color signaling. In the peripheral retina, the functional connectivity of cone inputs to the circuitry that mediates lateral inhibition is not cone-type specific, but whether these wiring schemes are maintained closer to the fovea remains unsettled, in part because central retinal anatomy is not easily amenable to direct physiological assessment. Here, we demonstrate how the precise topography of the long (L)-, middle (M)-, and short (S)-wavelength-sensitive cones in the human parafovea (1.5° eccentricity) shapes perceptual sensitivity. We used adaptive optics microstimulation to measure psychophysical detection thresholds from individual cones with spectral types that had been classified independently by absorptance imaging. Measured against chromatic adapting backgrounds, the sensitivities of L and M cones were, on average, receptor-type specific, but individual cone thresholds varied systematically with the number of preferentially activated cones in the immediate neighborhood. The spatial and spectral patterns of these interactions suggest that interneurons mediating lateral inhibition in the central retina, likely horizontal cells, establish functional connections with L and M cones indiscriminately, implying that the cone-selective circuitry supporting red-green color vision emerges after the first retinal synapse. We present evidence for spatially antagonistic interactions between individual, spectrally typed cones in the central retina of human observers using adaptive optics. Using chromatic adapting fields to modulate the relative steady-state activity of long (L)- and middle (M)-wavelength-sensitive cones, we found that single-cone detection thresholds varied predictably with the spectral demographics of the surrounding cones. The spatial scale and spectral pattern of these photoreceptor interactions were consistent with lateral inhibition mediated by retinal horizontal cells that receive nonselective input from L and M cones. These results demonstrate a clear link between the neural architecture of the visual system inputs-cone photoreceptors-and visual perception and have implications for the neural locus of the cone-specific circuitry supporting color vision.
[Mh] Termos MeSH primário: Percepção de Cores
Visão de Cores
Células Fotorreceptoras Retinianas Cones/fisiologia
Vias Visuais/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Interneurônios/fisiologia
Limiar Sensorial
Vias Visuais/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0529-17.2017


  8 / 907 MEDLINE  
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[PMID]:28800648
[Au] Autor:Böni C; Thorne JE; Spaide RF; Ostheimer TA; Sarraf D; Levinson RD; Goldstein DA; Rifkin LM; Vitale AT; Jaffe GJ; Holland GN
[Ad] Endereço:Ocular Inflammatory Disease Center, UCLA Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
[Ti] Título:Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4015-4025, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to describe fundus autofluorescence (FAF) findings in eyes with birdshot chorioretinitis (BSCR) and to compare findings to demographic, medical, and clinical characteristics. Methods: In this multicenter, prospective, cross-sectional study, 172 eyes (86 patients) with BSCR were investigated. Participants underwent a standardized evaluation including collection of demographic data, ophthalmic and treatment history, and ophthalmologic examination. Using a standardized protocol, hypo- and hyperautofluorescence in macular and extramacular regions and specific patterns of abnormal FAF could be scored for 167 eyes. Images were scored by two independent, masked graders. Measures of visual function included best-corrected visual acuity (BCVA), contrast sensitivity (CS), color vision, and Humphrey visual field mean deviation (HVF-MD). Results: Any abnormal FAF finding was observed in 132 eyes (79.0%); macular abnormalities were observed in 84 eyes (49.1%). The most common findings were peripapillary confluent hypoautofluorescence (122 eyes [73.1%]); extramacular granular hypoautofluorescence (100 eyes [59.9%]); and macular granular hypoautofluorescence (67 eyes [40.1%]). Confluent hypoautofluorescence was related to longer median disease duration (8.7 years) than granular hypoautofluorescence (7.9 years) or hyperautofluorescence (5.6 years). Macular confluent hypoautofluorescence was associated with BCVA ≤20/25 (odds ratio [OR] = 7.83, P = 0.007), BCVA ≤20/50 (OR = 4.94, P = 0.002), and abnormal CS (OR = 4.56, P = 0.009). Presence of macular or extramacular hypoautofluorescence was related to HVF-MD ≤-3 dB (OR = 2.43, P = 0.01 and OR = 2.89, P = 0.003, respectively). Conclusions: In this large cohort, various FAF abnormalities were found, indicating that disorders of the retinal pigment epithelium are features of BSCR. Abnormal FAF is a marker of visual dysfunction in the disease.
[Mh] Termos MeSH primário: Coriorretinite/diagnóstico
Imagem Óptica
Epitélio Pigmentado da Retina/patologia
[Mh] Termos MeSH secundário: Coriorretinite/fisiopatologia
Visão de Cores/fisiologia
Estudos Transversais
Feminino
Angiofluoresceinografia
Fundo de Olho
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Epitélio Pigmentado da Retina/fisiopatologia
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
Testes de Campo Visual
Campos Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21897


  9 / 907 MEDLINE  
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[PMID]:28728170
[Au] Autor:Kim YJ; Reynaud A; Hess RF; Mullen KT
[Ad] Endereço:McGill Vision Research, Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
[Ti] Título:A Normative Data Set for the Clinical Assessment of Achromatic and Chromatic Contrast Sensitivity Using a qCSF Approach.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3628-3636, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The measurement of achromatic sensitivity has been an important tool for monitoring subtle changes in vision as the result of disease or response to therapy. In this study, we aimed to provide a normative data set for achromatic and chromatic contrast sensitivity functions within a common cone contrast space using an abbreviated measurement approach suitable for clinical practice. In addition, we aimed to provide comparisons of achromatic and chromatic binocular summation across spatial frequency. Methods: We estimated monocular cone contrast sensitivity functions (CCSFs) using a quick Contrast Sensitivity Function (qCSF) approach for achromatic as well as isoluminant, L/M cone opponent, and S cone opponent stimuli in a healthy population of 51 subjects. We determined the binocular CCSFs for achromatic and chromatic vision to evaluate the degree of binocular summation across spatial frequency for these three different mechanisms in a subset of 20 subjects. Results: Each data set shows consistent contrast sensitivity across the population. They highlight the extremely high cone contrast sensitivity of L/M cone opponency compared with the S-cone and achromatic responses. We also find that the two chromatic sensitivities are correlated across the healthy population. In addition, binocular summation for all mechanisms depends strongly on stimulus spatial frequency. Conclusions: This study, using an approach well suited to the clinic, is the first to provide a comparative normative data set for the chromatic and achromatic contrast sensitivity functions, yielding quantitative comparisons of achromatic, L/M cone opponent, and S cone opponent chromatic sensitivities as a function of spatial frequency.
[Mh] Termos MeSH primário: Visão de Cores/fisiologia
Sensibilidades de Contraste/fisiologia
Células Fotorreceptoras Retinianas Cones/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Distribuição Normal
Estimulação Luminosa
Limiar Sensorial
Testes Visuais/métodos
Visão Binocular/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21645


  10 / 907 MEDLINE  
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[PMID]:28567618
[Au] Autor:Cvenkel B; Sustar M; Perovsek D
[Ad] Endereço:Department of Ophthalmology, University Medical Centre Ljubljana, Grabloviceva 46, 1000, Ljubljana, Slovenia. barbara.cvenkel@gmail.com.
[Ti] Título:Ganglion cell loss in early glaucoma, as assessed by photopic negative response, pattern electroretinogram, and spectral-domain optical coherence tomography.
[So] Source:Doc Ophthalmol;135(1):17-28, 2017 Aug.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate discrimination ability of pattern electroretinography (PERG) and photopic negative response (PhNR) between early glaucoma and healthy controls, and their relationship with structural measurements using spectral-domain optical coherence tomography (SD-OCT). METHODS: Cross-sectional study with 34 patients with ocular hypertension (n = 7), suspect glaucoma (n = 17), and early glaucoma (n = 10), plus 24 age-matched controls. The following parameters were analyzed: P50 and N95 amplitude of the PERG, PhNR amplitude and PhNR/b-wave ratio, peripapillary retinal and macular nerve fiber layer (NFL) thicknesses, and ganglion cell complex (GCC) thickness. Data from only one eye per individual were included in the statistical analysis. Descriptive statistics, ANOVA, receiver operating characteristics (ROC) curves, and correlation tests were used for analysis of the variables. RESULTS: PERG N95 and PhNR amplitudes were significantly reduced in suspect and early glaucoma eyes versus controls. Significant differences across ocular hypertensive, suspect, and early glaucoma eyes were found for macular NFL and GCC thickness, but not for any of the ERG parameters. The mean PhNR amplitude did not differ across these groups and was already reduced on average by 46% in ocular hypertensive and early glaucoma eyes and by 52% in suspect glaucoma eyes. The P50 and N95 amplitudes showed similar reduction in suspect and early glaucoma eyes on average by 15 and 26%, respectively. Of the ERG parameters, PhNR amplitude distinguished best between glaucoma and control groups, with an area under ROC curve of 0.90 for suspect glaucoma, and 0.86 for early glaucoma. PhNR/b-wave ratio showed strongest association in suspect glaucoma eyes with peripapillary retinal (r, 0.61) and macular NFL (r, 0.76) thicknesses. In eyes with early glaucoma, peripapillary retinal NFL thickness correlated best with PhNR amplitude (r, 0.71) and PERG P50 amplitude (r, 0.67). CONCLUSIONS: In eyes with suspect glaucoma, important decrease in PhNR amplitude is associated with small changes in peripapillary retinal and macular NFL thicknesses. These findings suggest that PhNR may be a useful and sensitive test in eyes with diagnostic dilemma, although further follow-up of such eyes is required for definitive confirmation.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/diagnóstico
Fibras Nervosas/patologia
Doenças Retinianas/diagnóstico
Células Ganglionares da Retina/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Visão de Cores/fisiologia
Estudos Transversais
Diagnóstico Precoce
Eletrorretinografia/métodos
Feminino
Glaucoma de Ângulo Aberto/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Hipertensão Ocular/diagnóstico
Curva ROC
Doenças Retinianas/fisiopatologia
Tomografia de Coerência Óptica
Campos Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9595-9



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