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[PMID]: 29049717 [Au] Autor: Tsai TI; Joachimsthaler A; Kremers J [Ad] Endereço: Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany. [Ti] Título: Mesopic and Photopic Rod and Cone Photoreceptor-Driven Visual Processes in Mice With Long-Wavelength-Shifted Cone Pigments. [So] Source: Invest Ophthalmol Vis Sci;58(12):5177-5187, 2017 Oct 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: The clearer divergence in spectral sensitivity between native rod and human L-cone (L*-cone) opsins in the transgenic Opn1lwLIAIS mouse (LIAIS) allows normal visual processes mediated by these photoreceptor subtypes to be isolated effectively using the silent substitution technique. The objective of this study was to further characterize the influence of mean luminance and temporal frequency on the functional properties of signals originating in each photoreceptor separately and independently of adaptation state in LIAIS mice. Methods: Electroretinographic (ERG) recordings to sine-wave rod and L*-cone modulation at different mean luminances (0.1-130.0 cd/m2) and temporal frequencies (6-26 Hz) were examined in anesthetized LIAIS (N = 17) and C57Bl/6 mice (N = 8). Results: We report maximum rod-driven response with 8-Hz modulation at 0.1 to 0.5 cd/m2, which was almost four times larger than maximum cone-driven response at 8 Hz, 21.5 to 130 cd/m2. Over these optimal luminances, both rod- and cone-driven response amplitudes exhibited low-pass functions with similar frequency resolution limits, albeit their distinct luminance sensitivities. There were, however, two distinguishing features: (1) the frequency-dependent amplitude decrease of rod-driven responses was more profound, and (2) linear relationships describing rod-driven response phases as a function of stimulus frequency were steeper. Conclusions: Employing the silent substitution method with stimuli of appropriate luminance on the LIAIS mouse (as on human observers) increases the specificity, robustness, and scope to which photoreceptor-driven responses can be reliably assayed compared to the standard photoreceptor isolation methods. [Mh] Termos MeSH primário: Visão de Cores/fisiologia Opsinas dos Cones/metabolismo Visão Mesópica/fisiologia Células Fotorreceptoras de Vertebrados/fisiologia [Mh] Termos MeSH secundário: Animais Eletrorretinografia Feminino Masculino Camundongos Camundongos Endogâmicos C57BL Camundongos Transgênicos Estimulação Luminosa Visão Ocular [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cone Opsins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171027 [Lr] Data última revisão: 171027 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171020 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.17-22553

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[PMID]: 28692722 [Au] Autor: Pfau M; Lindner M; Müller PL; Birtel J; Finger RP; Harmening WM; Fleckenstein M; Holz FG; Schmitz-Valckenberg S [Ad] Endereço: Department of Ophthalmology, University of Bonn, Bonn, Germany. [Ti] Título: Effective Dynamic Range and Retest Reliability of Dark-Adapted Two-Color Fundus-Controlled Perimetry in Patients With Macular Diseases. [So] Source: Invest Ophthalmol Vis Sci;58(6):BIO158-BIO167, 2017 May 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: To determine the effective dynamic range (EDR), retest reliability, and number of discriminable steps (DS) for mesopic and dark-adapted two-color fundus-controlled perimetry (FCP) using the S-MAIA (Scotopic-Macular Integrity Assessment) "micro-perimeter." Methods: In this prospective cross-sectional study, each of the 52 eyes of 52 subjects with various macular diseases (mean age 62.0 ± 16.9 years; range, 19.1-90.1 years) underwent duplicate mesopic (achromatic stimuli, 400-800 nm), dark-adapted cyan (505 nm), and dark-adapted red (627 nm) FCP using a grid of 61 stimuli covering 18° of the central retina. The EDR, the number of DS, and the retest reliability for point-wise sensitivity (PWS) were analyzed. The effects of fixation stability, sensitivity, and age on retest reliability were examined using mixed-effects models. Results: The EDR was 10 to 30 dB with five DS for mesopic and 4 to 17 dB with four DS for dark-adapted cyan and red testing. PWS retest reliability was good among all three types of retinal sensitivity assessments (coefficient of repeatability ±5.79, ±4.72, and ±4.77 dB, respectively) and did not depend on fixation stability or age. PWS had no effect on retest variability in dark-adapted cyan and dark-adapted red testing but had a minor effect in mesopic testing. Conclusions: Combined mesopic and dark-adapted two-color FCP allows for reliable topographic testing of cone and rod function in patients with various macular diseases with and without foveal fixation. Retest reliability is homogeneous across eccentricities and various degrees of scotoma depth, including zones at risk for disease progression. These reliability estimates can serve for the design of future clinical trials. [Mh] Termos MeSH primário: Macula Lutea/fisiopatologia Doenças Retinianas/diagnóstico Testes de Campo Visual/métodos Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Estudos Transversais Adaptação à Escuridão/fisiologia Feminino Seres Humanos Masculino Visão Mesópica/fisiologia Meia-Idade Estudos Prospectivos Reprodutibilidade dos Testes Doenças Retinianas/fisiopatologia Testes de Campo Visual/normas Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170718 [Lr] Data última revisão: 170718 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170711 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.17-21454

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[PMID]: 28564700 [Au] Autor: Kimlin JA; Black AA; Wood JM [Ad] Endereço: School of Optometry and Vision Science, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. [Ti] Título: Nighttime Driving in Older Adults: Effects of Glare and Association With Mesopic Visual Function. [So] Source: Invest Ophthalmol Vis Sci;58(5):2796-2803, 2017 May 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: To examine the associations between nighttime driving performance of older drivers and photopic, mesopic, and glare-based tests of visual function. Methods: Participants included 26 older drivers (71.8 ± 6.3 years), with minimal or no eye disease, but who reported vision-related nighttime driving difficulties. Nighttime driving performance was assessed on a closed-road circuit, which included intermittent glare. An overall driving performance score was calculated based on detection of signs, pedestrians, wooden animals and road markings, lane-keeping, and avoidance of low contrast hazards. Visual function tests included photopic and mesopic visual acuity (VA) and contrast sensitivity (CS). Tests of glare (Berkeley Glare and Aston Halometer) and mesopic motion sensitivity were also assessed. Regression analyses were used to explore the associations between these vision measures and nighttime driving performance. Results: The overall driving performance score was significantly reduced by intermittent glare (P = 0.002); notably, pedestrian detection decreased by 38% in the presence of intermittent glare (P < 0.001). Overall driving scores were most strongly associated with motion sensitivity (P = 0.001) and mesopic high contrast VA (P = 0.002), rather than photopic or glare-based tests. Motion sensitivity accounted for more than twice the variation in driving performance compared to photopic high contrast VA (29% vs. 14%). Conclusions: Glare reduced several aspects of nighttime driving performance. Mesopic tests of visual function, including motion sensitivity and mesopic high contrast VA, were more strongly associated with nighttime driving performance than photopic high-contrast VA. These results highlight the potential importance of nonstandard vision tests for assessing older drivers' visual capacity to drive at night. [Mh] Termos MeSH primário: Condução de Veículo Ofuscação Visão Mesópica/fisiologia Desempenho Psicomotor/fisiologia [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Condução de Veículo/normas Visão de Cores/fisiologia Sensibilidades de Contraste/fisiologia Feminino Seres Humanos Masculino Meia-Idade Transtornos da Visão/fisiopatologia Testes Visuais Acuidade Visual/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170717 [Lr] Data última revisão: 170717 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170601 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.16-21219

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[PMID]: 27997924 [Au] Autor: Pfau M; Lindner M; Fleckenstein M; Finger RP; Rubin GS; Harmening WM; Morales MU; Holz FG; Schmitz-Valckenberg S [Ad] Endereço: Department of Ophthalmology, University of Bonn, Bonn, Germany. [Ti] Título: Test-Retest Reliability of Scotopic and Mesopic Fundus-Controlled Perimetry Using a Modified MAIA (Macular Integrity Assessment) in Normal Eyes. [So] Source: Ophthalmologica;237(1):42-54, 2017. [Is] ISSN: 1423-0267 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: PURPOSE: To assess the intrasession test-retest reliability of scotopic cyan and scotopic red fundus-controlled perimetry (FCP) in normal subjects using a modified MAIA "microperimeter" (macular integrity assessment) device. METHODS: Forty-seven normal eyes of 30 subjects (aged 33.8 years) underwent duplicate mesopic (achromatic stimuli, 400-800 nm), scotopic cyan (505 nm), and scotopic red (627 nm) FCP, using a grid of 49 stimuli over 14° of the central retina. Test-retest reliability for pointwise sensitivity (PWS), stability of fixation, reaction time and test duration were analyzed using mixed-effects models. RESULTS: PWS test-retest reliability was good among all 3 types of retinal sensitivity assessments (coefficient of repeatability of 4.75 dB for mesopic, 5.26 dB for scotopic cyan, and 4.06 dB for scotopic red testing). While the mean sensitivity decreased with eccentricity for both mesopic and scotopic red testing, it was highest at 7° eccentricity for the scotopic cyan assessment (p < 0.001). CONCLUSIONS: The modified MAIA device allows for reliable scotopic FCP in normal subjects. Our findings suggest that testing of scotopic cyan sensitivity largely reflects rod function. [Mh] Termos MeSH primário: Adaptação à Escuridão/fisiologia Macula Lutea/diagnóstico por imagem Visão Mesópica/fisiologia Escotoma/fisiopatologia Testes de Campo Visual/métodos Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Adulto Feminino Fundo de Olho Seres Humanos Masculino Valores de Referência Reprodutibilidade dos Testes Escotoma/diagnóstico Acuidade Visual [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170314 [Lr] Data última revisão: 170314 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161221 [St] Status: MEDLINE [do] DOI: 10.1159/000453079

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[PMID]: 27743262 [Au] Autor: Hunter M; Godde B; Olk B [Ad] Endereço: Psychology & Methods, Jacobs University Bremen, Campus Ring 1, 28759, Bremen, Germany. m.hunter@jacobs-university.de. [Ti] Título: Effects of absolute luminance and luminance contrast on visual discrimination in low mesopic environments. [So] Source: Atten Percept Psychophys;79(1):243-252, 2017 Jan. [Is] ISSN: 1943-393X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Recent research revealed considerable decline in visual perception under low luminance conditions. However, systematic studies on how visual performance is affected by absolute luminance and luminance contrast under low mesopic conditions (<0.5 cd/m ) is lacking. We examined performance in a simple visual discrimination task under low mesopic luminance conditions in three experiments in which we systematically varied base luminance and luminance contrast between stimulus and background. We further manipulated eccentricity of the stimuli because of known rods and cones gradients along the retina. We identified a "deficiency window" for performance as measured by d' when luminance was < 0.06 cd/m and luminance contrast as measured by the luminance ratio between stimulus and background was below < 1.7. We further calculated performance-based luminance as well as contrast efficiency functions for reaction times (RTs). These power functions demonstrate the contrast asymptote needed to decrease RTs and how such a decrease can be achieved given various combinations of absolute luminance and luminance contrast manipulations. Increased eccentricity resulted in slower RTs indicative of longer scan distances. Our data provide initial insights to performance-based efficiency functions in low mesopic environments that are currently lacking and to the physical mechanisms being utilized for visual perception in these extreme environments. [Mh] Termos MeSH primário: Sensibilidades de Contraste/fisiologia Discriminação (Psicologia)/fisiologia Visão Mesópica/fisiologia Percepção Visual/fisiologia [Mh] Termos MeSH secundário: Adolescente Adulto Feminino Seres Humanos Masculino Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161016 [St] Status: MEDLINE [do] DOI: 10.3758/s13414-016-1219-z

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[PMID]: 27598731 [Au] Autor: Jiménez JR; Alarcón A; Anera RG; Jiménez Del Barco L [Ti] Título: Q-optimized Algorithms: Theoretical Analysis of Factors Influencing Visual Quality After Myopic Corneal Refractive Surgery. [So] Source: J Refract Surg;32(9):612-7, 2016 Aug 01. [Is] ISSN: 1081-597X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To model the effect of pupil size, optical zone, and initial myopic level on the retinal image quality after Q-optimized myopic corneal refractive surgery. METHODS: Different Q-optimized and paraxial Munnerlyn algorithms were tested using a schematic myopic eye model to analyze the optical quality of the final retinal image for initial myopic errors from -1.00 to -7.00 diopters (D). Different optical zones (5.5, 6, and 6.5 mm in diameter) and two pupil diameters (5 and 7 mm, mesopic-scotopic conditions) were included in the comparison. Modulation transfer function (MTF) and area under the MTF from 0 to 60 cycles per degree (MTFa) were calculated by ray tracing to evaluate this retinal image quality. RESULTS: The Q-optimized algorithm with Q = -0.45 provided the highest MTF and MTFa results for myopic corrections less than -5.00 D. For refractive errors greater than -5.00 D, Q = -0.26 provided the highest MTF and MTFa results. CONCLUSIONS: Q-optimized algorithms improve the visual outcomes with respect to the paraxial Munnerlyn algorithm for myopic corneal surgery. The results show that the Q value that optimizes the results of the Q-optimized algorithm depends on the degree of myopia to correct and the size of the pupil. [J Refract Surg. 2016;32(9):612-617.]. [Mh] Termos MeSH primário: Visão de Cores/fisiologia Córnea/cirurgia Visão Mesópica/fisiologia Modelos Teóricos Miopia/cirurgia Pupila/fisiologia Procedimentos Cirúrgicos Refrativos [Mh] Termos MeSH secundário: Algoritmos Córnea/fisiopatologia Seres Humanos Miopia/fisiopatologia Retina/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170825 [Lr] Data última revisão: 170825 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160907 [St] Status: MEDLINE [do] DOI: 10.3928/1081597X-20160531-01

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[PMID]: 27560851 [Au] Autor: Xu R; Thibos L; Bradley A [Ad] Endereço: *MD, PhD †PhD, FAAO ‡PhD Indiana University, School of Optometry, Bloomington, Indiana (all authors). [Ti] Título: Effect of Target Luminance on Optimum Pupil Diameter for Presbyopic Eyes. [So] Source: Optom Vis Sci;93(11):1409-1419, 2016 Nov. [Is] ISSN: 1538-9235 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To quantify the optimum pupil diameters for presbyopic eyes when environmental light levels vary from high photopic to low mesopic. METHODS: We computed the white light visual Strehl ratio from the polychromatic optical transfer function (VSOTF). The impact on image quality of retinal illuminance and the accompanying changes in photon noise were reflected in changing neural contrast sensitivity. VSOTF was calculated for focused and -2D defocused images, over a wide range of photopic and mesopic target luminances, and for pupil diameters ranging from 1 to 7 mm. We compare these modeling data to logMAR visual acuity measured under the same conditions. RESULTS: Optimum pupil depends on the relative gain of optical factors (diffraction and aberrations) and neural thresholds (photon noise effect). When light levels are reduced from 1000 to 2 cd/m, the pupil size that optimizes VSOTF for a well-focused presbyopic eye model also maximizes visual acuity and it increases from 2.5 to 4 mm. A 1-mm-diameter pupil maximizes VSOTF at all light levels when -2D of defocus are included, but at 2 cd/m the optimum pupil diameter for acuity increases slightly to 1.4 mm. At 0.2 cd/m, the pupil size that optimizes VSOTF remains 4 and 1 mm for a focused and -2D defocused eye, respectively, but significantly larger pupils are needed for maximal visual acuity. Reducing pupils to 30% of their natural size is beneficial for distance and near image quality and visual acuity at all light levels, producing more gains for near than for distance. CONCLUSIONS: A fixed 2- to 3-mm small pupil or a 30% pupil miosis can both produce near visual acuity gains without significant losses to distance acuity or image quality, and therefore can be considered as optimal for a presbyope experiencing a wide range of light levels. [Mh] Termos MeSH primário: Luz Presbiopia/fisiopatologia Pupila/efeitos da radiação Reflexo Pupilar/fisiologia [Mh] Termos MeSH secundário: Visão de Cores/fisiologia Simulação por Computador Sensibilidades de Contraste/fisiologia Feminino Seres Humanos Iris/anatomia & histologia Masculino Visão Mesópica/fisiologia Acuidade Visual/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170825 [Lr] Data última revisão: 170825 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160826 [St] Status: MEDLINE

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[PMID]: 27391936 [Au] Autor: Yilmaz I; Perente I; Saracoglu B; Yazici AT; Taskapili M [Ad] Endereço: Retina Department, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey. [Ti] Título: Changes in pupil size following panretinal retinal photocoagulation: conventional laser vs pattern scan laser (PASCAL). [So] Source: Eye (Lond);30(10):1359-1364, 2016 Oct. [Is] ISSN: 1476-5454 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: PurposeTo evaluate and compare the possible changes in pupil size subsequent to panretinal laser photocoagulation (PRP) via conventional laser and pattern scan laser (PASCAL).Patients and methodsForty eyes of 40 patients with diabetic retinopathy were included. 20 eyes had a PRP via conventional laser and formed Group 1. 20 eyes had a PRP via PASCAL laser and formed Group 2. The participants underwent standard ophthalmologic examination at baseline. Automated infrared pupillometry were performed at baseline and month 1.ResultsThe mean pupillary measurements (mm) for Group 1 (in the order photopic, mesopic, and scotopic conditions) were 2.88±0.34, 3.38±0.40, and 3.95±0.38, and changed to 3.64±0.42, 4.18±0.42, and 4.58±0.48, respectively. There was significant increase in pupil size at month 1 (P<0.001, P<0.001, and P<0.00, respectively). For Group 2, they were 2.90±0.38, 3.43±0.36, and 3.90±0.40, and changed to 3.18±0.42, 3.74±0.36, and 4.10±0.38, respectively. There was significant increase in pupil size at month 1 (P=0.018, P=0.014, and P=0.014, respectively). The pupil size increased significantly in both groups in all illumination conditions.ConclusionWe have demonstrated via automated infrared pupillary measurements that PRP may significantly increase pupil size whether it is performed with conventional laser or PASCAL laser. [Mh] Termos MeSH primário: Retinopatia Diabética/cirurgia Técnicas de Diagnóstico Oftalmológico/instrumentação Fotocoagulação a Laser/métodos Pupila/fisiologia [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Visão de Cores Paquimetria Corneana Feminino Seres Humanos Pressão Intraocular/fisiologia Lasers Masculino Visão Mesópica Meia-Idade Visão Noturna Lâmpada de Fenda Tonometria Ocular Acuidade Visual/fisiologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 171001 [Lr] Data última revisão: 171001 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160709 [St] Status: MEDLINE [do] DOI: 10.1038/eye.2016.135

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[PMID]: 27304602 [Au] Autor: Lin L; van de Pol C; Vilupuru S; Pepose JS [Ti] Título: Contrast Sensitivity in Patients With Emmetropic Presbyopia Before and After Small-Aperture Inlay Implantation. [So] Source: J Refract Surg;32(6):386-93, 2016 Jun 01. [Is] ISSN: 1081-597X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To develop a normative contrast sensitivity function and examine the postoperative contrast sensitivity outcomes for emmetropic patients with presbyopia implanted with a KAMRA intracorneal inlay (AcuFocus Inc., Irvine, CA) in their non-dominant eyes. METHODS: A prospective, non-randomized, multicenter clinical trial was conducted on 507 patients between 45 and 60 years of age who were monocularly implanted with the KAMRA inlay. A predetermined subgroup of 335 patients in the contrast sensitivity substudy were measured preoperatively and postoperatively with the Functional Acuity Contrast Test (FACT) chart in the Optec 6500 Vision Tester (Stereo Optical Co., Chicago, IL) under monocular and binocular, photopic and mesopic without glare, and binocular mesopic with glare conditions each over four spatial frequencies (3, 6, 12, and 18 cycles per degree for photopic conditions and 1.5, 3, 6, and 12 cycles per degree for mesopic conditions). Normative ranges were developed using 1.96 standard deviations from the preoperative mean logCS (log10 unit of contrast sensitivity). RESULTS: The preoperative contrast sensitivity measurements were used to develop the normative contrast sensitivity curves. Postoperatively, contrast sensitivity was stable both monocularly and binocularly and average contrast sensitivity remained within the normative ranges. Postoperative contrast sensitivity was mildly reduced monocularly but not binocularly, and the ratio of area under logCS function comparing postoperative to preoperative values was above 90% for all but one condition. CONCLUSIONS: Normative contrast sensitivity curves for a presbyopic population are established to provide a referent in the investigation of the impact of other presbyopia-correcting ophthalmic procedures on contrast sensitivity. [J Refract Surg. 2016;32(6):386-393.]. [Mh] Termos MeSH primário: Sensibilidades de Contraste/fisiologia Emetropia/fisiologia Polivinil Presbiopia/cirurgia Próteses e Implantes Implante de Prótese [Mh] Termos MeSH secundário: Substância Própria/cirurgia Feminino Seres Humanos Masculino Visão Mesópica/fisiologia Meia-Idade Satisfação do Paciente Presbiopia/fisiopatologia Estudos Prospectivos Refração Ocular/fisiologia Retalhos Cirúrgicos/cirurgia Visão Binocular/fisiologia Acuidade Visual/fisiologia [Pt] Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY [Nm] Nome de substância: 0 (Polyvinyls); 24937-79-9 (polyvinylidene fluoride) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170825 [Lr] Data última revisão: 170825 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160616 [St] Status: MEDLINE [do] DOI: 10.3928/1081597X-20160217-04

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[PMID]: 27225020 [Au] Autor: Maynard ML; Zele AJ; Feigl B [Ad] Endereço: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD, Australia. [Ti] Título: Mesopic Pelli-Robson contrast sensitivity and MP-1 microperimetry in healthy ageing and age-related macular degeneration. [So] Source: Acta Ophthalmol;94(8):e772-e778, 2016 Dec. [Is] ISSN: 1755-3768 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: PURPOSE: To determine whether decreasing illumination of the Pelli-Robson contrast sensitivity (CS) chart and MP-1 microperimeter to low mesopic conditions is more sensitive to vision changes occurring with healthy ageing and in early and intermediate age-related macular degeneration (AMD) and whether these mesopic tests can differentiate visual function between healthy older participants with and without AMD risk genotypes. METHODS: Retinal sensitivity was measured in 98 healthy participants (19-85 years) and 21 AMD (AREDS Grade 2/3) patients (73.9 ± 6.5 years) using the Pelli-Robson CS chart and MP-1 microperimeter under low mesopic and standard illumination. The effect of ageing and AMD on retinal sensitivity was estimated using regression analysis. Healthy older participants (>50 years; n = 24) were genotyped for AMD risk genes CFH and/or ARMS2 and retinal sensitivity was compared between genotypes. RESULTS: With healthy ageing, photopic and mesopic Pelli-Robson CS showed a similar decline (-0.004 log CS/year). In AMD, photopic CS showed a similar decline to healthy ageing (-0.004 log CS/year) while mesopic CS was significantly reduced (-0.007 log CS/year). Both standard and low mesopic microperimetry showed a significant decline (-0.51 and -0.73% contrast/year) with healthy ageing and greater decline (-0.73 and -0.99% contrast/year) with AMD onset. Pelli-Robson CS and microperimetry sensitivity did not differ between AMD risk genotypes in healthy participants. CONCLUSIONS: Mesopic Pelli-Robson CS detects functional deficits before photopic CS in early and intermediate AMD that can be differentiated from ageing. This test can be easily administered in clinical practice and may provide a means for early detection of retinal dysfunction. [Mh] Termos MeSH primário: Envelhecimento/fisiologia Sensibilidades de Contraste/fisiologia Degeneração Macular/fisiopatologia Visão Mesópica/fisiologia Retina/fisiopatologia Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Fator H do Complemento/genética Feminino Genótipo Voluntários Saudáveis Seres Humanos Degeneração Macular/genética Masculino Meia-Idade Proteínas/genética Testes Visuais Testes de Campo Visual Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (ARMS2 protein, human); 0 (Proteins); 0 (complement factor H, human); 80295-65-4 (Complement Factor H) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170126 [Lr] Data última revisão: 170126 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160527 [St] Status: MEDLINE [do] DOI: 10.1111/aos.13112

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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