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[PMID]:29242902
[Au] Autor:Harrar V; Elkrief L; Bouskila J; Kucera R; Fink-Jensen A; Bouchard JF; Palmour R; Ptito M
[Ad] Endereço:School of Optometry, University of Montreal, Montreal, Quebec, Canada.
[Ti] Título:Effects of Prenatal Alcohol Exposure on the Visual System of Monkeys Measured at Different Stages of Development.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6282-6291, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Fetal alcohol spectrum disorder (FASD) is a developmental disease characterized by behavioral problems and physical defects including malformations of the eye and associated optical defects. How these malformations affect retinal functioning is not well known, although animal models have suggested that scotopic vision is particularly deficient. Age is also known to affect scotopic vision. Here, we determined the combined effects of age and fetal alcohol exposure (FAE) on retinal function using full-field electroretinograms (ERGs) in monkeys (Chlorocebus sabaeus). Methods: ERGs were recorded in monkeys aged 3- to 12-years old, at multiple flash intensities under scotopic and photopic conditions, and functions were fit to the amplitudes of the a- and b-waves. Results: We found that both age and alcohol exposure affected ERGs. In photopic ERGs, amplitudes increased with age, and were higher in FAEs than controls, for data related to the OFF- and ON-pathways. In scotopic ERGs, amplitudes were decreased in young FAE compared with age-matched controls but only for the rod-dominated responses, while at brighter flashes, alcohol exposure led to an increase in the amplitude of the a- and b-waves. Conclusions: The ERGs from the FAE animals closely resembled the data from the older sucrose-control monkeys. This suggests that the FAE monkey retina ages more quickly than the control monkeys. This large sample of nonhuman primates, with carefully monitored ethanol exposure, demonstrates the critical interplay between age and alcohol when assessing the integrity of the retina. We suggest that ERGs might be an important adjunct to diagnosing human FASD.
[Mh] Termos MeSH primário: Cercopithecus aethiops/embriologia
Etanol/toxicidade
Exposição Materna/efeitos adversos
Visão Noturna/efeitos dos fármacos
Prenhez
Efeitos Tardios da Exposição Pré-Natal/diagnóstico
Retina/embriologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Eletrorretinografia/efeitos dos fármacos
Feminino
Gravidez
Retina/efeitos dos fármacos
Retina/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22181


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[PMID]:28602520
[Au] Autor:Yazdanie M; Alvarez J; Agrón E; Wong WT; Wiley HE; Ferris FL; Chew EY; Cukras C
[Ad] Endereço:National Eye Institute, National Institutes of Health, Bethesda, Maryland.
[Ti] Título:Decreased Visual Function Scores on a Low Luminance Questionnaire Is Associated with Impaired Dark Adaptation.
[So] Source:Ophthalmology;124(9):1332-1339, 2017 Sep.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We investigate whether responses on a Low Luminance Questionnaire (LLQ) in patients with a range of age-related macular degeneration (AMD) severity are associated with their performance on focal dark adaptation (DA) testing and with choroidal thickness. DESIGN: Cross-sectional, single-center, observational study. PARTICIPANTS: A total of 113 participants older than 50 years of age with a range of AMD severity. METHODS: Participants answered the LLQ on the same day they underwent DA testing using a focal dark adaptometer measuring rod intercept time (RIT). We performed univariable and multivariable analyses of the LLQ scores and age, RIT, AMD severity, subfoveal choroidal thickness [SFCT], phakic status, and best-corrected visual acuity. MAIN OUTCOME MEASURES: The primary outcome of this study was the score on the 32-question LLQ. Each item in the LLQ is designated to 1 of 6 subscales describing functional problems in low luminance: driving, emotional distress, mobility, extreme lighting, peripheral vision, and general dim lighting. Scores were computed for each subscale, in addition to a weighted total mean score. RESULTS: Responses from 113 participants (mean age, 76.2±9.3 years; 58.4% were female) and 113 study eyes were analyzed. Univariable analysis demonstrated that lower scores on all LLQ subscales were correlated with prolonged DA testing (longer RIT) and decreased choroidal thickness. All associations were statistically significant except for the association of choroidal thickness and "peripheral vision." The strongest association was the LLQ subscale of driving with RIT (r =-0.97, P < 0.001). Multivariable analysis for each of the LLQ subscale outcomes, adjusted for age, included RIT, with total LLQ score, "driving," "extreme lighting," and "mobility" also including choroidal thickness. In all multivariable analyses, RIT had a stronger association than choroidal thickness. CONCLUSIONS: This cross-sectional analysis demonstrates associations of patient-reported functional deficits, as assessed on the LLQ, with both reduced DA and reduced choroidal thickness, in a population of older adults with varying degrees of AMD severity and good visual acuity in at least 1 eye. These analyses suggest that local functional measurements of DA testing (RIT) and choroidal thickness are associated with patient-reported functional deficits.
[Mh] Termos MeSH primário: Adaptação à Escuridão/fisiologia
Luz
Degeneração Macular/fisiopatologia
Visão Noturna/fisiologia
Transtornos da Visão/fisiopatologia
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Corioide/patologia
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Inquéritos e Questionários
Visão Ocular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28434717
[Au] Autor:Bhatti T; Tariq A; Shen T; Williams KM; Hammond CJ; Mahroo OA
[Ad] Endereço:Department of Ophthalmology, King's College London, St. Thomas' Hospital Campus, London, United Kingdom; Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital Campus, London, United Kingdom.
[Ti] Título:Relative Genetic and Environmental Contributions to Variations in Human Retinal Electrical Responses Quantified in a Twin Study.
[So] Source:Ophthalmology;124(8):1175-1185, 2017 Aug.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To estimate heritability of parameters of human retinal electrophysiology and to explore which parameters change with age. DESIGN: Prospective, classic twin study. PARTICIPANTS: Adult monozygotic and dizygotic twin pairs recruited from the TwinsUK cohort. METHODS: Electroretinogram responses were recorded using conductive fiber electrodes in response to stimuli incorporating standards set by the International Society for the Clinical Electrophysiology of Vision. These parameters were extracted; in addition, photopic negative-response (PhNR; originating from retinal ganglion cells) and i-wave components were extracted from responses to the photopic single flash. Parameter values were averaged from both eyes. MAIN OUTCOME MEASURES: Mean values were calculated for the cohort. Correlation coefficients with age were calculated (averaging parameters from both twins from each pair). Coefficients of intrapair correlation were calculated for monozygotic and dizygotic twins. Age-adjusted heritability estimates were derived using standard maximum likelihood structural equation twin modeling. RESULTS: Responses were recorded from 210 participants in total (59 monozygotic and 46 dizygotic twin pairs). Ninety-three percent were women. Mean age for the cohort was 62.4 years (standard deviation, 11.4 years). In general, response amplitudes correlated negatively, and implicit times positively, with age. Correlations were statistically significant (P < 0.05) and moderate or strong (coefficient, >0.35) for the following parameters: scotopic standard and bright-flash a-wave implicit times, photopic 30-Hz flicker and single-flash b-wave implicit times, and PhNR and i-wave implicit times. Intrapair correlations were higher for monozygotic than dizygotic twins, suggesting important genetic influences. Age-adjusted estimates of heritability were significant for all parameters (except scotopic dim-flash b-wave implicit time), ranging from 0.34 to 0.85. Highest estimates were for photopic single-flash a-wave and b-wave amplitudes (0.84 and 0.85, respectively). CONCLUSIONS: This study explored heritability of retinal electrophysiologic parameters and included measurements reflecting ganglion cell function. Most parameters showed significant heritability, indicating that genetic factors are important, determining up to 85% of the variance in some cone system response parameters. Scotopic responses tended to show lower heritability (possibly relating to greater rod system susceptibility to environmental factors). Future studies can explore the identity of these genetic factors, improving our understanding of how they shape retinal function.
[Mh] Termos MeSH primário: Interação Gene-Ambiente
Característica Quantitativa Herdável
Retina/fisiologia
Células Ganglionares da Retina/fisiologia
Gêmeos Dizigóticos/genética
Gêmeos Monozigóticos/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Visão de Cores/fisiologia
Eletrorretinografia
Feminino
Seres Humanos
Masculino
Meia-Idade
Visão Noturna/fisiologia
Estimulação Luminosa
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; TWIN STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


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[PMID]:28417832
[Au] Autor:Liggins EP; Serle WP
[Ti] Título:Color Vision in Color Display Night Vision Goggles.
[So] Source:Aerosp Med Hum Perform;88(5):448-456, 2017 May 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Aircrew viewing eyepiece-injected symbology on color display night vision goggles (CDNVGs) are performing a visual task involving color under highly unnatural viewing conditions. Their performance in discriminating different colors and responding to color cues is unknown. METHODS: Experimental laboratory measurements of 1) color discrimination and 2) visual search performance are reported under adaptation conditions representative of a CDNVG. Color discrimination was measured using a two-alternative forced choice (2AFC) paradigm that probes color space uniformly around a white point. Search times in the presence of different degrees of clutter (distractors in the scene) are measured for different potential symbology colors. RESULTS: The discrimination data support previous data suggesting that discrimination is best for colors close to the adapting point in color space (P43 phosphor in this case). There were highly significant effects of background adaptation (white or green) and test color. The search time data show that saturated colors with the greatest chromatic contrast with respect to the background lead to the shortest search times, associated with the greatest saliency. Search times for the green background were around 150 ms longer than for the white. Desaturated colors, along with those close to a typical CDNVG display phosphor in color space, should be avoided by CDNVG designers if the greatest conspicuity of symbology is desired. DISCUSSION: The results can be used by CDNVG symbology designers to optimize aircrew performance subject to wider constraints arising from the way color is used in the existing conventional cockpit instruments and displays.Liggins EP, Serle WP. Color vision in color display night vision goggles. Aerosp Med Hum Perform. 2017; 88(5):448-456.
[Mh] Termos MeSH primário: Visão de Cores
Desenho de Equipamento
Visão Noturna
Percepção Visual
[Mh] Termos MeSH secundário: Adolescente
Adulto
Medicina Aeroespacial
Dispositivos de Proteção dos Olhos
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4605.2017


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[PMID]:28211184
[Au] Autor:Wood JM; Tyrrell RA; Lacherez P; Black AA
[Ad] Endereço:School of Optometry and Vision Science and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
[Ti] Título:Night-time pedestrian conspicuity: effects of clothing on drivers' eye movements.
[So] Source:Ophthalmic Physiol Opt;37(2):184-190, 2017 Mar.
[Is] ISSN:1475-1313
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Drivers' responses and eye movements were assessed as they approached pedestrians at night in order to explore the relative conspicuity benefits of different configurations of retroreflective markings. METHODS: Eye movements were recorded using an ASL Mobile Eye (Applied Science Technologies, www.asleyetracking.com) from 14 young licensed drivers (M = 24.1 ± 6.4 years) as they drove along a closed-road circuit at night. At two locations, pedestrians walked in place facing either towards or away from the road. Pedestrians wore black clothing with a standard retroreflective vest either alone or with additional retroreflective markers positioned in a configuration conveying biological motion (biomotion). Drivers responded when they recognised that a pedestrian was present and again when they identified the direction the pedestrian was facing. RESULTS: Drivers recognised pedestrians from a significantly greater distance (p < 0.05) when the pedestrian's clothing included the biomotion configuration (319.1 m) than when the biomotion markings were absent (184.5 m). Further, the drivers recognised the direction that the pedestrian faced from a longer distance when biomotion markings were present (215.4 m vs 95.6 m). Eye movement data suggested that the biomotion configuration attracted drivers' attention significantly sooner than the vest (time to first fixation: 1.1 vs 3.5 s), that drivers fixated on pedestrians wearing biomotion for significantly less time prior to responding (3.4 s vs 6.1 s), and the time to first recognise a pedestrian was approximately half that for biomotion compared to vest (6.4 vs 13.9 s). CONCLUSION: Adding biomotion reflectors to the vest facilitated earlier recognition of pedestrians and faster identification of the direction that the pedestrian faced. These findings confirm that the conspicuity advantages of biomotion configurations on pedestrians at night result in part from drivers fixating pedestrians earlier and more efficiently.
[Mh] Termos MeSH primário: Condução de Veículo
Escuridão
Movimentos Oculares/fisiologia
Percepção de Forma/fisiologia
Percepção de Movimento/fisiologia
Visão Noturna/fisiologia
Roupa de Proteção
[Mh] Termos MeSH secundário: Adolescente
Adulto
Sensibilidades de Contraste/fisiologia
Feminino
Seres Humanos
Masculino
Tempo de Reação
Acuidade Visual/fisiologia
Campos Visuais/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1111/opo.12351


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[PMID]:28087150
[Au] Autor:Ishimaru Y; Sumino A; Kajioka D; Shibagaki F; Yamamuro A; Yoshioka Y; Maeda S
[Ad] Endereço:Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address: ishimaru@pharm.setsunan.ac.jp.
[Ti] Título:Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice.
[So] Source:J Pharmacol Sci;133(1):34-41, 2017 Jan.
[Is] ISSN:1347-8648
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intravitreal injection of NMDA in the retinas of mice. An intravitreal injection of NMDA induced neuronal cell death in both the retinal ganglion cell layer and inner nuclear layer, and reduced the amplitudes of scotopic threshold response (STR) in electroretinography studies. Both cell death and STR amplitudes decrease induced by NMDA were prevented by a co-injection of [Pyr ]-apelin-13, and were facilitated by apelin deficiency. The neuroprotective effects of [Pyr ]-apelin-13 were blocked by an apelin receptor APJ antagonist, and by inhibitors of Akt and extracellular signal-regulated kinase 1/2 signaling pathways. Additionally, an intravitreal injection of tumor necrosis factor-α (TNF-α) neutralizing antibody prevented NMDA-induced retinal neuronal cell death, and exogenous and endogenous apelin suppressed NMDA-induced upregulation of TNF-α in the retina. These results suggest that apelin protects neuronal cells against NMDA-induced death via an APJ receptor in the retina, and that apelin may have beneficial effects in the treatment of glaucoma.
[Mh] Termos MeSH primário: Morte Celular/efeitos dos fármacos
Peptídeos e Proteínas de Sinalização Intercelular/farmacologia
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
N-Metilaspartato/toxicidade
Proteínas Proto-Oncogênicas c-akt/metabolismo
Receptores Acoplados a Proteínas-G/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Mh] Termos MeSH secundário: Animais
Receptores de Apelina
Injeções Intravítreas
Masculino
Camundongos
N-Metilaspartato/administração & dosagem
N-Metilaspartato/antagonistas & inibidores
Neurônios/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Visão Noturna/efeitos dos fármacos
Retina/efeitos dos fármacos
Fator de Necrose Tumoral alfa/biossíntese
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apelin Receptors); 0 (Aplnr protein, mouse); 0 (Intercellular Signaling Peptides and Proteins); 0 (Neuroprotective Agents); 0 (Receptors, G-Protein-Coupled); 0 (Tumor Necrosis Factor-alpha); 0 (apelin-13 peptide); 6384-92-5 (N-Methylaspartate); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


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[PMID]:27216715
[Au] Autor:Dellaa A; Polosa A; Mbarek S; Hammoum I; Messaoud R; Amara S; Azaiz R; Charfeddine R; Dogui M; Khairallah M; Lachapelle P; Ben Chaouacha-Chekir R
[Ad] Endereço:a UR Ecophysiologie et Procédés Agroalimentaires , Institut Supérieur de Biotechnologie, Université de la Manouba , Ariana , Tunisie.
[Ti] Título:Characterizing the Retinal Function of Psammomys obesus: A Diurnal Rodent Model to Study Human Retinal Function.
[So] Source:Curr Eye Res;42(1):79-87, 2017 Jan.
[Is] ISSN:1460-2202
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the retinal function of a diurnal murid rodent, Psammomys obesus, with that of Wistar albino rat and human subjects. MATERIALS AND METHODS: Adult Psammomys obesus were captured and transferred to the animal facilities where they were maintained at 25°C with standard light/dark cycles and natural halophilic plants, rich in water and mineral salts. Standard full-field photopic and scotopic electroretinograms were obtained. RESULTS: The right eye of all animals displayed well detectable and reproducible scotopic and photopic electroretinogram (ERG) responses. Results were compared with those obtained from human subjects and Wistar rats. ERG measurement showed that the amplitudes of scotopic responses in Psammomys obesus are quite similar to those of human subjects. The amplitude of the photopic a-wave was comparable to that of humans and six times higher than that of the albino rat. The amplitudes of photopic b-wave, photopic oscillatory potentials (OPs), and 30 Hz flicker were all markedly larger in Psammomys obesus compared to those obtained from human subjects and Wistar rats. Furthermore, like the human photopic ERG, the photopic ERG of Psammomys obesus also includes prominent post b-wave components (i.e. i- and d-waves) while the ERG of Wistar rats does not. CONCLUSIONS: Our results suggest that the retinal function of Psammomys obesus, especially the cone-mediated function, shares several features with that of human subjects. We believe that Psammomys obesus represents an interesting alternative to study the structure and function of the normal and diseased retina in a human-like rodent model of retinal function.
[Mh] Termos MeSH primário: Ritmo Circadiano/fisiologia
Visão de Cores/fisiologia
Modelos Animais
Visão Noturna/fisiologia
Retina/fisiologia
[Mh] Termos MeSH secundário: Adulto
Animais
Eletrorretinografia
Gerbillinae
Seres Humanos
Masculino
Oscilometria
Ratos
Ratos Wistar
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE
[do] DOI:10.3109/02713683.2016.1141963


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[PMID]:27779951
[Au] Autor:Pousette MW; Lo Martire R; Linder J; Kristoffersson M; Äng BO
[Ad] Endereço:Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
[Ti] Título:Neck Muscle Strain in Air Force Pilots Wearing Night Vision Goggles.
[So] Source:Aerosp Med Hum Perform;87(11):928-932, 2016.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Flight-induced neck pain is common in high performance jet pilots, with incidents frequently attributed to high G flight maneuvers. The additional load of helmet-mounted night vision goggles (NVG) is believed to increase the risk, possibly from neck muscle strain in counteracting muscles. Hence, the aim was to investigate the effect of NVG on neck muscle strain as well as on the activity level distribution through a simulated flight session in air force pilots. METHODS: In this post hoc randomized crossover trial, four senior air force pilots each completed two identical 1.5-h dynamic flight simulations in a human centrifuge: one with a standard helmet and NVG, and one with a standard helmet only. Simulations included repeated exposure to 3-7 G , during which neck muscle activity was recorded bilaterally from the anterior neck, the upper and lower posterior neck, and the upper shoulders. The number of muscle activities surpassing 50% of maximum voluntary electrical activity (MVE) and total time of activity at each MVE percentile were compared between NVG and control flights. RESULTS: There was no overall effect in number of neck strain activities between NVG and control flights; however, significantly more activities emerged in the anterior neck. In addition, MVE percentile data showed a tendency of higher activity in the lower posterior neck during NVG flights. CONCLUSIONS: The results showed that the additional load of helmet-mounted NVG increases neck muscle strain in anterior stabilizing muscles, indicating that the inertia of head-worn NVG elevates the risk of flight-related neck pain. Pousette MW, Lo Martire R, Linder J, Kristoffersson M, Äng BO. Neck muscle strain in air force pilots wearing night vision goggles. Aerosp Med Hum Perform. 2016; 87(11):928-932.
[Mh] Termos MeSH primário: Dispositivos de Proteção dos Olhos
Dispositivos de Proteção da Cabeça
Militares
Músculos do Pescoço/fisiopatologia
Visão Noturna
Pilotos
Entorses e Distensões/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Medicina Aeroespacial
Estudos Cross-Over
Eletromiografia
Seres Humanos
Cervicalgia
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:27485069
[Au] Autor:Bouskila J; Harrar V; Javadi P; Casanova C; Hirabayashi Y; Matsuo I; Ohyama J; Bouchard JF; Ptito M
[Ad] Endereço:School of Optometry,University of Montreal,Montreal,Quebec,Canada.
[Ti] Título:Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55.
[So] Source:Vis Neurosci;33:E006, 2016 01.
[Is] ISSN:1469-8714
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The endogenous cannabinoid system plays important roles in the retina of mice and monkeys via their classic CB1 and CB2 receptors. We have previously reported that the G protein-coupled receptor 55 (GPR55), a putative cannabinoid receptor, is exclusively expressed in rod photoreceptors in the monkey retina, suggesting its possible role in scotopic vision. To test this hypothesis, we recorded full-field electroretinograms (ERGs) after the intravitreal injection of the GPR55 agonist lysophosphatidylglucoside (LPG) or the selective GPR55 antagonist CID16020046 (CID), under light- and dark-adapted conditions. Thirteen vervet monkeys (Chlorocebus sabaeus) were used in this study: four controls (injected with the vehicle dimethyl sulfoxide, DMSO), four injected with LPG and five with CID. We analyzed amplitudes and latencies of the a-wave (photoreceptor responses) and the b-wave (rod and cone system responses) of the ERG. Our results showed that after injection of LPG, the amplitude of the scotopic b-wave was significantly higher, whereas after the injection of CID, it was significantly decreased, compared to the vehicle (DMSO). On the other hand, the a-wave amplitude, and the a-wave and b-wave latencies, of the scotopic ERG responses were not significantly affected by the injection of either compound. Furthermore, the photopic ERG waveforms were not affected by either drug. These results support the hypothesis that GPR55 plays an instrumental role in mediating scotopic vision.
[Mh] Termos MeSH primário: Visão Noturna/fisiologia
Células Fotorreceptoras de Vertebrados/fisiologia
Receptores de Canabinoides/fisiologia
Receptores Acoplados a Proteínas-G/fisiologia
[Mh] Termos MeSH secundário: Animais
Compostos Azabicíclicos/farmacologia
Benzoatos/farmacologia
Agonistas de Receptores de Canabinoides/farmacologia
Antagonistas de Receptores de Canabinoides/farmacologia
Cercopithecus aethiops
Eletrorretinografia
Feminino
Glicerofosfatos/farmacologia
Injeções Intravítreas
Masculino
Estimulação Luminosa
Receptores Acoplados a Proteínas-G/agonistas
Receptores Acoplados a Proteínas-G/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid); 0 (Azabicyclo Compounds); 0 (Benzoates); 0 (Cannabinoid Receptor Agonists); 0 (Cannabinoid Receptor Antagonists); 0 (Glycerophosphates); 0 (Receptors, Cannabinoid); 0 (Receptors, G-Protein-Coupled); 0 (lysophosphoglycerides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE
[do] DOI:10.1017/S095252381600002X


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[PMID]:27391936
[Au] Autor:Yilmaz I; Perente I; Saracoglu B; Yazici AT; Taskapili M
[Ad] Endereço:Retina Department, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
[Ti] Título:Changes in pupil size following panretinal retinal photocoagulation: conventional laser vs pattern scan laser (PASCAL).
[So] Source:Eye (Lond);30(10):1359-1364, 2016 Oct.
[Is] ISSN:1476-5454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PurposeTo evaluate and compare the possible changes in pupil size subsequent to panretinal laser photocoagulation (PRP) via conventional laser and pattern scan laser (PASCAL).Patients and methodsForty eyes of 40 patients with diabetic retinopathy were included. 20 eyes had a PRP via conventional laser and formed Group 1. 20 eyes had a PRP via PASCAL laser and formed Group 2. The participants underwent standard ophthalmologic examination at baseline. Automated infrared pupillometry were performed at baseline and month 1.ResultsThe mean pupillary measurements (mm) for Group 1 (in the order photopic, mesopic, and scotopic conditions) were 2.88±0.34, 3.38±0.40, and 3.95±0.38, and changed to 3.64±0.42, 4.18±0.42, and 4.58±0.48, respectively. There was significant increase in pupil size at month 1 (P<0.001, P<0.001, and P<0.00, respectively). For Group 2, they were 2.90±0.38, 3.43±0.36, and 3.90±0.40, and changed to 3.18±0.42, 3.74±0.36, and 4.10±0.38, respectively. There was significant increase in pupil size at month 1 (P=0.018, P=0.014, and P=0.014, respectively). The pupil size increased significantly in both groups in all illumination conditions.ConclusionWe have demonstrated via automated infrared pupillary measurements that PRP may significantly increase pupil size whether it is performed with conventional laser or PASCAL laser.
[Mh] Termos MeSH primário: Retinopatia Diabética/cirurgia
Técnicas de Diagnóstico Oftalmológico/instrumentação
Fotocoagulação a Laser/métodos
Pupila/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Visão de Cores
Paquimetria Corneana
Feminino
Seres Humanos
Pressão Intraocular/fisiologia
Lasers
Masculino
Visão Mesópica
Meia-Idade
Visão Noturna
Lâmpada de Fenda
Tonometria Ocular
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2016.135



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