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[PMID]:28460124
[Au] Autor:Mantua J; Henry OS; Garskovas NF; Spencer RMC
[Ad] Endereço:Department of Psychological and Brain Sciences, Neuroscienceand Behavior Program, Amherst, MA.
[Ti] Título:Mild Traumatic Brain Injury Chronically Impairs Sleep- and Wake-Dependent Emotional Processing.
[So] Source:Sleep;40(6), 2017 Jun 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives : A single traumatic brain injury (TBI), even when mild (ie, concussion), can cause lasting consequences. Individuals with a history of chronic (>1-year prior) mild TBI have an increased risk of mood disturbances (eg, depression, suicide). This population also has lingering sleep alterations, including poor sleep quality and changes in sleep stage proportions. Given these sleep deficits, we aimed to test whether sleep-dependent emotional memory consolidation is reduced in this population. We utilized a mild TBI group (3.7 ± 2.9 years post injury) and an uninjured (non-TBI) population. Methods : Participants viewed negative and neutral images both before and after a 12-hour period containing sleep ("Sleep" group) or an equivalent period of time spent awake ("Wake" group). Participants rated images for valence/arousal at both sessions, and memory recognition was tested at session two. Results : The TBI group had less rapid eye movement (REM), longer REM latency, and more sleep complaints. Sleep-dependent memory consolidation of nonemotional images was present in all participants. However, consolidation of negative images was only present in the non-TBI group. A lack of differentiation between the TBI Sleep and Wake groups was due to poor performance in the sleep group and, unexpectedly, enhanced performance in the wake group. Additionally, although the non-TBI participants habituated to negative images over a waking period, the TBI participants did not. Conclusions : We propose disrupted sleep- and wake-dependent emotional processing contributes to poor emotional outcomes following chronic, mild TBI. This work has broad implications, as roughly one-third of the US population will sustain a mild TBI during their lifetime.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/fisiopatologia
Lesões Encefálicas Traumáticas/psicologia
Emoções
Sono
Vigília
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos de Casos e Controles
Doença Crônica/psicologia
Feminino
Seres Humanos
Masculino
Consolidação da Memória
Distúrbios do Início e da Manutenção do Sono
Sono REM
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx062


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[PMID]:29386443
[Au] Autor:Nakano N; Kinoshita F; Takada H; Nakayama M
[Ad] Endereço:Good Sleep Center Nagoya City University Hospital.
[Ti] Título:[Electromyography Analysis of Rapid Eye Movement Sleep Behavior Disorder].
[So] Source:Nihon Eiseigaku Zasshi;73(1):27-33, 2018.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Polysomnography (PSG), which records physiological phenomena including brain waves, breathing status, and muscle tonus, is useful for the diagnosis of sleep disorders as a gold standard. However, measurement and analysis are complex for several specific sleep disorders, such as rapid eye movement (REM) sleep behavior disorder (RBD). Usually, brain waves during REM sleep indicate an awakening pattern under relaxed conditions of skeletal and antigravity muscles. However, these muscles are activated during REM sleep when patients suffer from RBD. These activated muscle movements during REM, so-called REM without atonia (RWA) recorded by PSG, may be related to a neurodegenerative disease such as Parkinson's disease. Thus, careful analysis of RWA is significant not only physically, but also clinically. Commonly, manual viewing measurement analysis of RWA is time-consuming. Therefore, quantitative studies on RWA are rarely reported. A software program, developed from Microsoft Office Excel , was used to semiautomatically analyze the RWA ratio extracted from PSG to compare with manual viewing measurement analysis. In addition, a quantitative muscle tonus study was carried out to evaluate the effect of medication on RBD patients. Using this new software program, we were able to analyze RWA on the same cases in approximately 15 min as compared with 60 min in the manual viewing measurement analysis. This software program can not only quantify RWA easily but also identify RWA waves for either phasic or tonic bursts. We consider that this software program will support physicians and scientists in their future research on RBD. We are planning to offer this software program for free to physicians and scientists.
[Mh] Termos MeSH primário: Eletromiografia/métodos
Músculo Esquelético/fisiopatologia
Transtorno do Comportamento do Sono REM/diagnóstico
Transtorno do Comportamento do Sono REM/fisiopatologia
Sono REM/fisiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Tono Muscular
Polissonografia
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.73.27


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[PMID]:28449905
[Au] Autor:Xu X; Wu H; Zhuang J; Chen K; Huang B; Zhao Z; Zhao Z
[Ad] Endereço:Department of Neurology, Changzheng Hospital, Second Military Medical University of PLA, Shanghai, PR China.
[Ti] Título:Sleep-wake patterns, non-rapid eye movement, and rapid eye movement sleep cycles in teenage narcolepsy.
[So] Source:Sleep Med;33:47-56, 2017 May.
[Is] ISSN:1878-5506
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To further characterize sleep disorders associated with narcolepsy, we assessed the sleep-wake patterns, rapid eye movement (REM), and non-REM (NREM) sleep cycles in Chinese teenagers with narcolepsy. METHODS: A total of 14 Chinese type 1 narcoleptic patients (13.4 ± 2.6 years of age) and 14 healthy age- and sex-matched control subjects (13.6 ± 1.8 years of age) were recruited. Ambulatory 24-h polysomnography was recorded for two days, with test subjects adapting to the instruments on day one and the study data collection performed on day two. RESULTS: Compared with the controls, the narcoleptic patients showed a 1.5-fold increase in total sleep time over 24 h, characterized by enhanced slow-wave sleep and REM sleep. Frequent sleep-wake transitions were identified in nocturnal sleep with all sleep stages switching to wakefulness, with more awakenings and time spent in wakefulness after sleep onset. Despite eight cases of narcolepsy with sleep onset REM periods at night, the mean duration of NREM-REM sleep cycle episode and the ratio of REM/NREM sleep between patients and controls were not significantly different. CONCLUSION: Our study identified hypersomnia in teenage narcolepsy despite excessive daytime sleepiness. Sleep fragmentation extended to all sleep stages, indicating impaired sleep-wake cycles and instability of sleep stages. The limited effects on NREM-REM sleep cycles suggest the relative conservation of ultradian regulation of sleep.
[Mh] Termos MeSH primário: Narcolepsia/diagnóstico
Narcolepsia/fisiopatologia
Fases do Sono/fisiologia
Sono REM/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Criança
China/epidemiologia
Ritmo Circadiano/fisiologia
Distúrbios do Sono por Sonolência Excessiva/complicações
Distúrbios do Sono por Sonolência Excessiva/epidemiologia
Distúrbios do Sono por Sonolência Excessiva/etiologia
Feminino
Seres Humanos
Masculino
Narcolepsia/epidemiologia
Polissonografia/métodos
Privação do Sono/diagnóstico
Privação do Sono/fisiopatologia
Ritmo Ultradiano/fisiologia
Vigília/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28449901
[Au] Autor:McCarter SJ; St Louis EK; Sandness DJ; Duwell EJ; Timm PC; Boeve BF; Silber MH
[Ad] Endereço:Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, Rochester, MN, USA.
[Ti] Título:Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea.
[So] Source:Sleep Med;33:23-29, 2017 May.
[Is] ISSN:1878-5506
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We aimed to determine whether visual and automated rapid eye movement (REM) sleep without atonia (RSWA) methods could accurately diagnose patients with idiopathic REM sleep behavior disorder (iRBD) and comorbid obstructive sleep apnea (OSA). METHODS: In iRBD patients (n = 15) and matched controls (n = 30) with and without OSA, we visually analyzed RSWA phasic burst durations, phasic, tonic, and "any" muscle activity by 3-s mini-epochs, phasic activity by 30-s (AASM rules) epochs, and automated REM atonia index (RAI). Group RSWA metrics were analyzed with regression models. Receiver operating characteristic (ROC) curves were used to determine the best diagnostic cutoff thresholds for REM sleep behavior disorder (RBD). Both split-night and full-night polysomnographic studies were analyzed. RESULTS: All mean RSWA phasic burst durations and muscle activities were higher in iRBD patients than in controls (p <0.01). Muscle activity (phasic, "any") cutoffs for 3-s mini-epoch scorings were as follows: submentalis (SM) (15.8%, 19.5%), anterior tibialis (AT) (29.7%, 29.7%), and combined SM/AT (39.5%, 39.5%). The tonic muscle activity cutoff was 0.70% and RAI (SM) cutoff 0.86. The phasic muscle burst duration cutoffs were 0.66 s for SM and 0.71 s for AT. Combining phasic burst durations with RSWA muscle activity improved the sensitivity and specificity of iRBD diagnosis. CONCLUSIONS: This study provides evidence for quantitative RSWA diagnostic thresholds applicable in iRBD patients with OSA. Our findings in this study were very similar to those seen in patients with Parkinson's disease-REM sleep behavior disorder (PD-RBD), consistent with a common mechanism and presumed underlying etiology of synucleinopathy in both groups.
[Mh] Termos MeSH primário: Tono Muscular/fisiologia
Músculo Esquelético/fisiopatologia
Transtorno do Comportamento do Sono REM/diagnóstico
Apneia Obstrutiva do Sono/fisiopatologia
Sono REM/fisiologia
[Mh] Termos MeSH secundário: Idoso
Comorbidade
Eletromiografia/métodos
Feminino
Seres Humanos
Masculino
Meia-Idade
Hipotonia Muscular/fisiopatologia
Polissonografia/métodos
Transtorno do Comportamento do Sono REM/complicações
Transtorno do Comportamento do Sono REM/fisiopatologia
Apneia Obstrutiva do Sono/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28931469
[Au] Autor:Noorafshan A; Karimi F; Kamali AM; Karbalay-Doust S; Nami M
[Ad] Endereço:Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Restorative effects of curcumin on sleep-deprivation induced memory impairments and structural changes of the hippocampus in a rat model.
[So] Source:Life Sci;189:63-70, 2017 Nov 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study examined the consequences of rapid eye-movement sleep-deprivation (REM-SD) with or without curcumin treatment. The outcome measures comprised quantitative features in the three-dimensional reconstruction (3DR) CA1 and dentate gyrus in experimental and control animals using stereological procedures. Male rats were arbitrarily assigned to nine groups based on the intervention and treatment administered including: 1-cage control+distilled water, 2-cage control+curcumin (100mg/kg/day), 3-cage control+olive oil, 4-REM-SD+distilled water, 5-REM-SD+curcumin, 6-REM-SD+olive oil, 7-grid-floor control+distilled water, 8-grid-floor control+curcumin, and 9-grid-floor control+olive oil. Animals in the latter three groups were placed on wire-mesh grids in the sleep-deprivation box. REM-SD was induced by an apparatus comprising a water tank and multiple platforms. After a period of 21days, rats were submitted to the novel object-recognition task. Later, their brains were excised and evaluated using stereological methods. Our results indicated a respective 29% and 31% reduction in the total volume of CA1, and dentate gyrus in REM-SD+distilled water group as compared to the grid-floor control+distilled water group (p<0.05). Other than the above, the overall number of the pyramidal cells of CA1 and granular cells of dentate gyrus in the sleep-deprived group were found to be reduced by 48% and 25%, respectively. The REM-SD+distilled water group also exhibited impaired object recognition memory and deformed three-dimensional reconstructions of these regions. The volume, cell number, reconstruction, object recognition time, and body weight were however recovered in the REM-SD+curcumin compared to the REM-SD+distilled water group. This suggests the potential neuro-restorative effects of curcumin in our model.
[Mh] Termos MeSH primário: Curcumina/farmacologia
Hipocampo/patologia
Transtornos da Memória/tratamento farmacológico
Privação do Sono/complicações
Sono REM/fisiologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Tamanho Celular/efeitos dos fármacos
Giro Denteado/patologia
Imagem Tridimensional
Masculino
Transtornos da Memória/etiologia
Ratos
Ratos Sprague-Dawley
Recognição (Psicologia)/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE


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[PMID]:28847002
[Au] Autor:Liu K; Kim J; Kim DW; Zhang YS; Bao H; Denaxa M; Lim SA; Kim E; Liu C; Wickersham IR; Pachinis V; Hattar S; Song J; Brown SP; Blackshaw S
[Ad] Endereço:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
[Ti] Título:Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.
[So] Source:Nature;548(7669):582-587, 2017 08 31.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Multiple populations of wake-promoting neurons have been characterized in mammals, but few sleep-promoting neurons have been identified. Wake-promoting cell types include hypocretin and GABA (γ-aminobutyric-acid)-releasing neurons of the lateral hypothalamus, which promote the transition to wakefulness from non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Here we show that a subset of GABAergic neurons in the mouse ventral zona incerta, which express the LIM homeodomain factor Lhx6 and are activated by sleep pressure, both directly inhibit wake-active hypocretin and GABAergic cells in the lateral hypothalamus and receive inputs from multiple sleep-wake-regulating neurons. Conditional deletion of Lhx6 from the developing diencephalon leads to decreases in both NREM and REM sleep. Furthermore, selective activation and inhibition of Lhx6-positive neurons in the ventral zona incerta bidirectionally regulate sleep time in adult mice, in part through hypocretin-dependent mechanisms. These studies identify a GABAergic subpopulation of neurons in the ventral zona incerta that promote sleep.
[Mh] Termos MeSH primário: Neurônios GABAérgicos/metabolismo
Proteínas com Homeodomínio LIM/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Sono/fisiologia
Fatores de Transcrição/metabolismo
Zona Incerta/citologia
Ácido gama-Aminobutírico/secreção
[Mh] Termos MeSH secundário: Animais
Linhagem da Célula
Neurônios GABAérgicos/efeitos dos fármacos
Neurônios GABAérgicos/secreção
Deleção de Genes
Hipocampo/citologia
Hipocampo/fisiologia
Proteínas com Homeodomínio LIM/deficiência
Proteínas com Homeodomínio LIM/efeitos dos fármacos
Proteínas com Homeodomínio LIM/genética
Masculino
Camundongos
Proteínas do Tecido Nervoso/deficiência
Proteínas do Tecido Nervoso/efeitos dos fármacos
Proteínas do Tecido Nervoso/genética
Orexinas/metabolismo
Terminações Pré-Sinápticas/metabolismo
Sono/efeitos dos fármacos
Sono/genética
Sono REM/efeitos dos fármacos
Sono REM/genética
Sono REM/fisiologia
Fatores de Tempo
Fatores de Transcrição/deficiência
Fatores de Transcrição/efeitos dos fármacos
Fatores de Transcrição/genética
Vigília/efeitos dos fármacos
Vigília/genética
Vigília/fisiologia
Zona Incerta/efeitos dos fármacos
Zona Incerta/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (LHX6 protein, mouse); 0 (LIM-Homeodomain Proteins); 0 (Nerve Tissue Proteins); 0 (Orexins); 0 (Transcription Factors); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1038/nature23663


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[PMID]:28835407
[Au] Autor:Pase MP; Himali JJ; Grima NA; Beiser AS; Satizabal CL; Aparicio HJ; Thomas RJ; Gottlieb DJ; Auerbach SH; Seshadri S
[Ad] Endereço:From the Department of Neurology (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology, Australi
[Ti] Título:Sleep architecture and the risk of incident dementia in the community.
[So] Source:Neurology;89(12):1244-1250, 2017 Sep 19.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). METHODS: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male). Stages of sleep were quantified using home-based polysomnography. Participants were followed for a maximum of 19 years for incident dementia (mean follow-up 12 ± 5 years). RESULTS: We observed 32 cases of incident dementia; 24 were consistent with Alzheimer disease dementia. After adjustments for age and sex, lower REM sleep percentage and longer REM sleep latency were both associated with a higher risk of incident dementia. Each percentage reduction in REM sleep was associated with approximately a 9% increase in the risk of incident dementia (hazard ratio 0.91; 95% confidence interval 0.86, 0.97). The magnitude of association between REM sleep percentage and dementia was similar following adjustments for multiple covariates including vascular risk factors, depressive symptoms, and medication use, following exclusions for persons with mild cognitive impairment at baseline and following exclusions for early converters to dementia. Stages of non-REM sleep were not associated with dementia risk. CONCLUSIONS: Despite contemporary interest in slow-wave sleep and dementia pathology, our findings implicate REM sleep mechanisms as predictors of clinical dementia.
[Mh] Termos MeSH primário: Demência/epidemiologia
Transtornos do Sono-Vigília/fisiopatologia
Sono REM/fisiologia
[Mh] Termos MeSH secundário: Idoso
Demência/etiologia
Feminino
Seguimentos
Seres Humanos
Masculino
Massachusetts/epidemiologia
Meia-Idade
Polissonografia
Risco
Transtornos do Sono-Vigília/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004373


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[PMID]:28821651
[Au] Autor:Funk CM; Peelman K; Bellesi M; Marshall W; Cirelli C; Tononi G
[Ad] Endereço:Department of Psychiatry.
[Ti] Título:Role of Somatostatin-Positive Cortical Interneurons in the Generation of Sleep Slow Waves.
[So] Source:J Neurosci;37(38):9132-9148, 2017 Sep 20.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During non-rapid eye-movement (NREM) sleep, cortical and thalamic neurons oscillate every second or so between ON periods, characterized by membrane depolarization and wake-like tonic firing, and OFF periods, characterized by membrane hyperpolarization and neuronal silence. Cortical slow waves, the hallmark of NREM sleep, reflect near-synchronous OFF periods in cortical neurons. However, the mechanisms triggering such OFF periods are unclear, as there is little evidence for somatic inhibition. We studied cortical inhibitory interneurons that express somatostatin (SOM), because ∼70% of them are Martinotti cells that target diffusely layer I and can block excitatory transmission presynaptically, at glutamatergic terminals, and postsynaptically, at apical dendrites, without inhibiting the soma. In freely moving male mice, we show that SOM+ cells can fire immediately before slow waves and their optogenetic stimulation during ON periods of NREM sleep triggers long OFF periods. Next, we show that chemogenetic activation of SOM+ cells increases slow-wave activity (SWA), slope of individual slow waves, and NREM sleep duration; whereas their chemogenetic inhibition decreases SWA and slow-wave incidence without changing time spent in NREM sleep. By contrast, activation of parvalbumin+ (PV+) cells, the most numerous population of cortical inhibitory neurons, greatly decreases SWA and cortical firing, triggers short OFF periods in NREM sleep, and increases NREM sleep duration. Thus SOM+ cells, but not PV+ cells, are involved in the generation of sleep slow waves. Whether Martinotti cells are solely responsible for this effect, or are complemented by other classes of inhibitory neurons, remains to be investigated. Cortical slow waves are a defining feature of non-rapid eye-movement (NREM) sleep and are thought to be important for many of its restorative benefits. Yet, the mechanism by which cortical neurons abruptly and synchronously cease firing, the neuronal basis of the slow wave, remains unknown. Using chemogenetic and optogenetic approaches, we provide the first evidence that links a specific class of inhibitory interneurons-somatostatin-positive cells-to the generation of slow waves during NREM sleep in freely moving mice.
[Mh] Termos MeSH primário: Ondas Encefálicas/fisiologia
Córtex Cerebral/fisiologia
Sincronização Cortical/fisiologia
Interneurônios/fisiologia
Inibição Neural/fisiologia
Sono REM/fisiologia
Somatostatina/metabolismo
[Mh] Termos MeSH secundário: Animais
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Rede Nervosa/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
51110-01-1 (Somatostatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.1303-17.2017


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[PMID]:28810072
[Au] Autor:Naiman R
[Ad] Endereço:The University of Arizona Center for Integrative Medicine, Tucson, Arizona.
[Ti] Título:Dreamless: the silent epidemic of REM sleep loss.
[So] Source:Ann N Y Acad Sci;1406(1):77-85, 2017 Oct.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We are at least as dream deprived as we are sleep deprived. Many of the health concerns attributed to sleep loss result from a silent epidemic of REM sleep deprivation. REM/dream loss is an unrecognized public health hazard that silently wreaks havoc with our lives, contributing to illness, depression, and an erosion of consciousness. This paper compiles data about the causes and extent of REM/dream loss associated with commonly used medications, endemic substance use disorders, rampant sleep disorders, and behavioral and lifestyle factors. It examines the consequences of REM/dream loss and concludes with recommendations for restoring healthy REM/dreaming.
[Mh] Termos MeSH primário: Sonhos/fisiologia
Sonhos/psicologia
Estilo de Vida
Privação do Sono/diagnóstico
Privação do Sono/epidemiologia
Sono REM/fisiologia
[Mh] Termos MeSH secundário: Consumo de Bebidas Alcoólicas/efeitos adversos
Sonhos/efeitos dos fármacos
Seres Humanos
Fumar Maconha/efeitos adversos
Rememoração Mental/efeitos dos fármacos
Rememoração Mental/fisiologia
Psicotrópicos/efeitos adversos
Privação do Sono/induzido quimicamente
Sono REM/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Psychotropic Drugs)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13447


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[PMID]:28759231
[Au] Autor:Kling A; Jantos K; Mack H; Hornberger W; Drescher K; Nimmrich V; Relo A; Wicke K; Hutchins CW; Lao Y; Marsh K; Moeller A
[Ad] Endereço:Neuroscience Research, AbbVie Deutschland GmbH & Co. KG , Knollstrasse, 67061 Ludwigshafen, Germany.
[Ti] Título:Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.
[So] Source:J Med Chem;60(16):7123-7138, 2017 Aug 24.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to the identification of ketoamide-based 2-(3-phenyl-1H-pyrazol-1-yl)nicotinamides as potent and reversible inhibitors of calpain with high selectivity versus related cysteine protease cathepsins, other proteases, and receptors. Broad efficacy in a set of preclinical models relevant to AD suggests that inhibition of calpain represents an attractive approach with potential benefit for the treatment of AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Aminobutiratos/farmacologia
Calpaína/antagonistas & inibidores
Inibidores de Cisteína Proteinase/farmacologia
Niacinamida/análogos & derivados
Niacinamida/farmacologia
Pirazóis/farmacologia
[Mh] Termos MeSH secundário: Aminobutiratos/síntese química
Aminobutiratos/farmacocinética
Animais
Catepsinas
Inibidores de Cisteína Proteinase/síntese química
Inibidores de Cisteína Proteinase/farmacocinética
Cães
Hipocampo/metabolismo
Seres Humanos
Concentração Inibidora 50
Macaca fascicularis
Masculino
Microssomos Hepáticos/metabolismo
Niacinamida/síntese química
Niacinamida/farmacocinética
Pirazóis/síntese química
Pirazóis/farmacocinética
Ratos Endogâmicos F344
Ratos Sprague-Dawley
Ratos Wistar
Sono REM/efeitos dos fármacos
Espectrina/metabolismo
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (A-933548); 0 (Aminobutyrates); 0 (Cysteine Proteinase Inhibitors); 0 (Pyrazoles); 12634-43-4 (Spectrin); 25X51I8RD4 (Niacinamide); EC 3.4.- (Cathepsins); EC 3.4.22.- (Calpain); EC 3.4.22.52 (CAPN1 protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.7b00731



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