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  1 / 12010 MEDLINE  
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[PMID]:29173737
[Au] Autor:Peris TS; Rozenman MS; Sugar CA; McCracken JT; Piacentini J
[Ad] Endereço:UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles. Electronic address: tperis@mednet.ucla.edu.
[Ti] Título:Targeted Family Intervention for Complex Cases of Pediatric Obsessive-Compulsive Disorder: A Randomized Controlled Trial.
[So] Source:J Am Acad Child Adolesc Psychiatry;56(12):1034-1042.e1, 2017 Dec.
[Is] ISSN:1527-5418
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Although evidence-based treatments for pediatric obsessive-compulsive disorder (OCD) exist, many youth fail to respond, and interventions tailored to the needs of specific subsets of patients are lacking. This study examines the efficacy of a family intervention module designed for cases of OCD complicated by poor family functioning. METHOD: Participants were 62 youngsters aged 8 to 17 years (mean age = 12.71 years; 57% male; 65% white) with a primary diagnosis of OCD and at least 2 indicators of poor family functioning. They were randomized to receive 12 sessions of individual child cognitive-behavioral therapy (CBT) plus weekly parent psychoeducation and session review (standard treatment [ST]) or the same 12 child sessions plus 6 sessions of family therapy aimed at improving OCD-related emotion regulation and problem solving (positive family interaction therapy [PFIT]). Blinded raters evaluated outcomes and tracked responders to 3-month follow-up. RESULTS: Compared to ST, PFIT demonstrated better overall response rates on the Clinician Global Impression-Improvement scale (CGI-I; 68% versus 40%, p = .03, φ = 0.28) and rates of remission (58% PFIT versus 27% ST, p = .01, φ = 0.32). PFIT also produced significantly greater reductions in functional impairment, symptom accommodation, and family conflict, and improvements in family cohesion. As expected, these shifts in family functioning constitute an important treatment mechanism, with changes in accommodation mediating treatment response. CONCLUSION: PFIT is efficacious for reducing OCD symptom severity and impairment and for improving family functioning. Findings are discussed in terms of personalized medicine and mechanisms of change in pediatric OCD treatment. Clinical trial registration information-Family Focused Treatment of Pediatric Obsessive Compulsive Disorder; http://clinicaltrials.gov/; NCT01409642.
[Mh] Termos MeSH primário: Terapia Cognitiva/métodos
Terapia Familiar/métodos
Transtorno Obsessivo-Compulsivo/terapia
Pais/educação
[Mh] Termos MeSH secundário: Adolescente
Criança
Terapia Combinada
Relações Familiares
Feminino
Seguimentos
Seres Humanos
Masculino
Transtorno Obsessivo-Compulsivo/diagnóstico
Escalas de Graduação Psiquiátrica
Método Simples-Cego
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


  2 / 12010 MEDLINE  
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[PMID]:28463420
[Au] Autor:Chang YC; Cole TB; Costa LG
[Ad] Endereço:Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
[Ti] Título:Behavioral Phenotyping for Autism Spectrum Disorders in Mice.
[So] Source:Curr Protoc Toxicol;72:11.22.1-11.22.21, 2017 May 02.
[Is] ISSN:1934-9262
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorder (ASD) represents a heterogeneous group of disorders characterized by alterations in three behavioral symptom domains: Social interactions, verbal and nonverbal communication, and repetitive behaviors. Increasing prevalence of ASD in recent years suggests that exposure to environmental toxicants may be critical in modulating etiology of this disease. As clinical diagnosis of autism still relies on behavioral evaluation, it is important to be able to assess similar behavioral traits in animal models, to provide biological plausibility of associations between environmental exposures and ASD. Rodents naturally exhibit a large number of behaviors that can be linked to similar behaviors in human. In this unit, behavioral tests are described that are relevant to the domains affected in ASD. For the repetitive domain, the T-maze spontaneous alternation test and marble burying test are described. For the communication domain, neonatal ultrasonic vocalization and olfactory habituation test toward social and non-social odor are described. Finally, for the sociability domain, the three-chambered social preference test and the reciprocal interaction test are presented. © 2017 by John Wiley & Sons, Inc.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Comportamento Animal
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Modelos Animais de Doenças
Habituação Psicofisiológica
Camundongos
Transtorno Obsessivo-Compulsivo/psicologia
Odorantes
Fenótipo
Olfato
Comportamento Social
Urina/química
Vocalização Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cptx.19


  3 / 12010 MEDLINE  
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[PMID]:28458998
[Au] Autor:Fan J; Zhong M; Zhu X; Gan J; Liu W; Niu C; Liao H; Zhang H; Yi J; Tan C
[Ad] Endereço:Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
[Ti] Título:Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder.
[So] Source:Neuroimage Clin;15:1-7, 2017.
[Is] ISSN:2213-1582
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Few studies have explored the neurobiological basis of insight level in obsessive-compulsive disorder (OCD), though the salience network (SN) has been implicated in insight deficits in schizophrenia. This study was then designed to investigate whether resting-state (rs) functional connectivity (FC) of SN was associated with insight level in OCD patients. We analyzed rs-functional magnetic resonance imaging (fMRI) data from 21 OCD patients with good insight (OCD-GI), 19 OCD patients with poor insight (OCD-PI), and 24 healthy controls (HCs). Seed-based whole-brain FC and ROI (region of interest)-wise connectivity analyses were performed with seeds/ROIs in the bilateral anterior insula (AI) and dorsal anterior cingulate cortex (dACC). The right AI-right medial orbital frontal cortex (mOFC) connectivity was found to be uniquely decreased in the OCD-PI group, and the value of this aberrant connectivity correlated with insight level in OCD patients. In addition, we found that the OCD-GI group had significantly increased right AI-left dACC connectivity within the SN, relative to HCs (overall trend for groups: OCD-GI > OCD-PI > HC). Our findings suggest that abnormal right AI-right mOFC FC may mediate insight deficits in OCD, perhaps due to impaired encoding and integration of self-evaluative information about OCD-related beliefs and behaviors. Our findings indicate a SN connectivity dissociation between OCD-GI and OCD-PI patients and support the notion of considering OCD-GI and OCD-PI as two distinct disorder subtypes.
[Mh] Termos MeSH primário: Lobo Frontal/diagnóstico por imagem
Imagem por Ressonância Magnética
Rede Nervosa/diagnóstico por imagem
Transtorno Obsessivo-Compulsivo/diagnóstico por imagem
Córtex Pré-Frontal/diagnóstico por imagem
Descanso
[Mh] Termos MeSH secundário: Adolescente
Adulto
Córtex Cerebral/diagnóstico por imagem
Córtex Cerebral/fisiopatologia
Feminino
Lobo Frontal/fisiopatologia
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Rede Nervosa/fisiopatologia
Transtorno Obsessivo-Compulsivo/fisiopatologia
Córtex Pré-Frontal/fisiopatologia
Descanso/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1016/j.nicl.2017.04.002


  4 / 12010 MEDLINE  
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[PMID]:29384866
[Au] Autor:Jiang C; Ma X; Qi S; Han G; Li Y; Liu Y; Liu L
[Ad] Endereço:Hebei Center for Disease Control and Prevention.
[Ti] Título:Association between TNF-α-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.
[So] Source:Medicine (Baltimore);97(5):e9769, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tumor necrosis factor-alpha (TNF-α) is an important cytokine and has been reported to be associated with the pathogenesis of many autoimmune and inflammatory diseases. TNF-α gene is located on a region that has been found to be associated with obsessive-compulsive disorder (OCD). We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-α-238G/A gene polymorphism. METHODS: An extensive search of the available literature on the association between the susceptibility to OCD and the TNF gene polymorphism was conducted by searching PubMed, Web of Knowledge, Embase, Chinese Web of Knowledge, Wanfang, and Chongqing VIP database. The database was searched up to December 2016 and includes language of English and/or Chinese with the keywords of "obsessive-compulsive disorder" or "OCD," polymorphism or variant or mutation, "tumor necrosis factor" or "TNF" or "cytokine." The association between TNF-α-238G/A gene polymorphism and the susceptibility of OCD was anticipated by odds ratio (OR) with the corresponding 95% confidence interval (95% CI). RESULTS: Four studies including 435 cases and 1073 controls were incorporated in our meta-analysis. In general, TNF-α-238G/A gene polymorphism might lead to a decreased risk of OCD susceptibility (G vs A genotype model: OR = 1.01, 95% CI = 0.37-2.77, P = .981; GG vs AA+AG model: OR = 0.93, 95% CI = 0.37-2.36, P = .879; GG+AG vs AA model: OR = 0.22, 95% CI = 0.06-0.73, P = .014; GG vs AA model: OR = 0.21, 95% CI = 0.06-0.71, P = .012; AG vs AA model: OR = 0.29, 95% CI = 0.07-1.16, P = .081; GG+AA vs AG model: OR = 1.17, 95% CI = 0.55-2.51, P = .683). CONCLUSION: TNF-α-238G/A gene polymorphism might lead to a decreased risk of OCD susceptibility.
[Mh] Termos MeSH primário: Predisposição Genética para Doença/genética
Transtorno Obsessivo-Compulsivo/genética
Polimorfismo de Nucleotídeo Único/genética
Fator de Necrose Tumoral alfa/genética
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009769


  5 / 12010 MEDLINE  
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[PMID]:27772535
[Au] Autor:Ljungberg M; Nilsson MKL; Melin K; Jönsson L; Carlsson A; Carlsson Å; Forssell-Aronsson E; Ivarsson T; Carlsson M; Starck G
[Ad] Endereço:1Department of Radiation Physics,Institute of Clinical Sciences,Sahlgrenska Academy,University of Gothenburg,Göteborg,Sweden.
[Ti] Título:1H magnetic resonance spectroscopy evidence for occipital involvement in treatment-naive paediatric obsessive-compulsive disorder.
[So] Source:Acta Neuropsychiatr;29(3):179-190, 2017 Jun.
[Is] ISSN:1601-5215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder leading to considerable distress and disability. Therapies are effective in a majority of paediatric patients, however, many only get partial response. It is therefore important to study the underlying pathophysiology of the disorder. METHODS: 1H magnetic resonance spectroscopy (MRS) was used to study the concentration of brain metabolites in four different locations (cingulate gyrus and sulcus, occipital cortex, thalamus and right caudate nucleus). Treatment-naive children and adolescents with OCD (13 subjects) were compared with a group of healthy age- and gender-matched subjects (11 subjects). Multivariate analyses were performed on the concentration values. RESULTS: No separation between controls and patients was found. However, a correlation between metabolite concentrations and symptom severity as measured with the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) was found. Strongest was the correlation with the CY-BOCS obsession subscore and aspartate and choline in the caudate nucleus (positively correlated with obsessions), lipids at 2 and 0.9 ppm in thalamus, and occipital glutamate+glutamine, N-acetylaspartate and myo-inosytol (negatively correlated with obsessions). CONCLUSIONS: The observed correlations between 1H MRS and CY-BOCS in treatment-naive patients further supports an occipital involvement in OCD. The results are consistent with our previous study on adult OCD patients. The 1H MRS data were not supportive of a separation between the patient and control groups.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Transtorno Obsessivo-Compulsivo/diagnóstico por imagem
Transtorno Obsessivo-Compulsivo/metabolismo
Lobo Occipital/diagnóstico por imagem
Espectroscopia de Prótons por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adolescente
Ácido Aspártico/análogos & derivados
Ácido Aspártico/metabolismo
Encéfalo/metabolismo
Criança
Colina/metabolismo
Feminino
Seres Humanos
Inositol/metabolismo
Masculino
Transtorno Obsessivo-Compulsivo/tratamento farmacológico
Transtorno Obsessivo-Compulsivo/fisiopatologia
Lobo Occipital/metabolismo
Índice de Gravidade de Doença
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
30KYC7MIAI (Aspartic Acid); 4L6452S749 (Inositol); 997-55-7 (N-acetylaspartate); N91BDP6H0X (Choline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1017/neu.2016.52


  6 / 12010 MEDLINE  
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[PMID]:29304071
[Au] Autor:Kim HW; Kang JI; Hwang EH; Kim SJ
[Ad] Endereço:Department of Medical Education, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population.
[So] Source:PLoS One;13(1):e0190593, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Accumulating evidence suggests that the glutamatergic system plays a major role in the pathophysiology of obsessive compulsive disorder (OCD) and empathic processing. Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous studies, but several studies did not replicate the result. Therefore, we aimed to replicate the associations between the SLC1A1 and OCD in a Korean population. In addition, we investigated the influence of SLC1A1 on trait empathy, impairments in which are characteristic of OCD. Six single-nucleotide polymorphisms (SNP) of SLC1A1 were genotyped in 615 patients with OCD and 508 healthy controls. The interpersonal reactivity index (IRI)-which consists of four subscales (perspective taking, PT; fantasy seeking, FS; empathic concern, EC; personal distress, PD)-was assessed from 277 patients with OCD and 395 controls. There were no significant associations between OCD and SNPs or haplotypes of SLC1A1. Patients with OCD exhibited significantly lower PT and higher PD scores than controls. The C-T-G haplotype at rs301430-rs301434-rs3087879 of SLC1A1 was significantly associated with higher PD scores after adjusted for age, sex, and OCD status. Our results suggest that six common SNPs of SLC1A1 may not contribute to the development of OCD, but may contribute to certain aspect of trait empathy such as personal distress. However, insufficient sample size and limited number of SLC1A1 SNPs may have reduced the likelihood of detecting significant associations. Therefore, further studies with larger sample size and more tag SNPs of the SLC1A1 gene were warranted.
[Mh] Termos MeSH primário: Empatia
Transtorno Obsessivo-Compulsivo/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
República da Coreia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190593


  7 / 12010 MEDLINE  
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[PMID]:29301426
[Au] Autor:Winkelbeiner S; Suker S; Bachofner H; Eisenhardt S; Steinau S; Walther S; Federspiel A; Dierks T; Strik W; Homan P
[Ad] Endereço:From the Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Psychiatric University Hospital Zurich, Switzerland; and the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Hofstra Northwell School of
[Ti] Título:Targeting Obsessive-Compulsive Symptoms With rTMS and Perfusion Imaging.
[So] Source:Am J Psychiatry;175(1):81-83, 2018 01 01.
[Is] ISSN:1535-7228
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtorno Obsessivo-Compulsivo
Imagem de Perfusão/métodos
Estimulação Magnética Transcraniana/métodos
[Mh] Termos MeSH secundário: Adulto
Córtex Cerebral/irrigação sanguínea
Terapia Cognitiva/métodos
Corpo Estriado/irrigação sanguínea
Resistência a Medicamentos
Seres Humanos
Masculino
Transtorno Obsessivo-Compulsivo/diagnóstico
Transtorno Obsessivo-Compulsivo/psicologia
Transtorno Obsessivo-Compulsivo/terapia
Escalas de Graduação Psiquiátrica
Inibidores da Captação de Serotonina/administração & dosagem
Inibidores da Captação de Serotonina/efeitos adversos
Tálamo/irrigação sanguínea
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Serotonin Uptake Inhibitors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1176/appi.ajp.2017.17060634


  8 / 12010 MEDLINE  
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[PMID]:28457837
[Au] Autor:Ooms P; Blankers M; Figee M; Bergfeld IO; van den Munckhof P; Schuurman PR; Denys D
[Ad] Endereço:Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: p.ooms@amc.nl.
[Ti] Título:Cost-effectiveness of deep brain stimulation versus treatment as usual for obsessive-compulsive disorder.
[So] Source:Brain Stimul;10(4):836-842, 2017 Jul - Aug.
[Is] ISSN:1876-4754
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Deep Brain Stimulation (DBS) is effective for obsessive-compulsive disorder (OCD), but requires expensive medical procedures. To date, no study has examined the cost-effectiveness of DBS for OCD. OBJECTIVE: To perform the first economic evaluation of DBS for therapy refractory OCD. METHODS: We conducted a 2-year prospective, open cost-effectiveness study, comparing DBS (n = 17) with treatment as usual (TAU) (n = 11), with cost per Quality-Adjusted-Life-Year (QALY) as outcome measure. Apart from the base-case, or primary analysis, we conducted two practice-based scenarios: (1) standard care scenario, without research and innovation costs, and (2) rechargeable scenario, in which we assume the use of a rechargeable battery. Base-case and both scenarios were extrapolated to four years to estimate long-term cost-effectiveness. RESULTS: Compared to TAU, DBS provides an additional 0.26 QALY (SD = 0.16). Median cost per QALY gained is estimated at €141,446 for base-case, €115,916 for standard care and €65,394 for the rechargeable scenario. Extending the time-horizon to four years results in a median cost per QALY of €80,313 for base-case, €69,287 for standard care, and turned out to be cost-saving at €4678 per QALY for the rechargeable scenario. Assuming a willingness to pay threshold of €80,000/QALY, DBS, under base-case and standard care had 25% and 35% probability of being more cost-effective than TAU. With the rechargeable scenario and in all scenarios extrapolated to four years, the probability of cost-effectiveness was equal or higher than TAU. CONCLUSIONS: This study indicates DBS for OCD is cost-effective in the long-term, especially when rechargeable batteries are taken into account.
[Mh] Termos MeSH primário: Análise Custo-Benefício
Estimulação Encefálica Profunda/economia
Transtorno Obsessivo-Compulsivo/terapia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Anos de Vida Ajustados por Qualidade de Vida
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  9 / 12010 MEDLINE  
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[PMID]:28457988
[Au] Autor:Medeiros GC; Torres AR; Boisseau CL; Leppink EW; Eisen JL; Fontenelle LF; do Rosário MC; Mancebo MC; Rasmussen SA; Ferrão YA; Grant JE
[Ad] Endereço:Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL, United States of America. Electronic address: gcmedeiros@live.com.
[Ti] Título:A cross-cultural clinical comparison between subjects with obsessive-compulsive disorder from the United States and Brazil.
[So] Source:Psychiatry Res;254:104-111, 2017 Aug.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Although OCD is a global problem, the literature comparing, in a direct and standardized way, the manifestations across countries is scarce. Therefore, questions remain as to whether some important clinical findings are replicable worldwide, especially in the developing world. The objective of this study was to perform a clinical comparison of OCD patients recruited in the United States (U.S.) and Brazil. Our sample consisted of 1187 adult, treatment-seeking OCD outpatients from the U.S. (n=236) and Brazil (n=951). With regards to the demographics, U.S. participants with OCD were older, more likely to identify as Caucasian, had achieved a higher educational level, and were less likely to be partnered when compared to Brazilians. Concerning the clinical variables, after controlling for demographics the two samples presented largely similar profiles. Brazilian participants with OCD, however, endorsed significantly greater rates of generalized anxiety disorder and post-traumatic stress disorder, whereas U.S. subjects were significantly more likely to endorse a lifetime history of addiction (alcohol-use and substance-use disorders). This is the largest direct cross-cultural comparison to date in the OCD field. Our results provide much needed insight regarding the development of culture-sensitive treatments.
[Mh] Termos MeSH primário: Comparação Transcultural
Transtorno Obsessivo-Compulsivo/etnologia
Transtorno Obsessivo-Compulsivo/psicologia
[Mh] Termos MeSH secundário: Adulto
Brasil/etnologia
Comorbidade
Estudos Transversais
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Transtorno Obsessivo-Compulsivo/diagnóstico
Estados Unidos/etnologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  10 / 12010 MEDLINE  
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[PMID]:28448804
[Au] Autor:Schreuder MJ; Schirmbeck F; Meijer C; de Haan L; GROUP Investigators
[Ad] Endereço:Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
[Ti] Título:The associations between childhood trauma, neuroticism and comorbid obsessive-compulsive symptoms in patients with psychotic disorders.
[So] Source:Psychiatry Res;254:48-53, 2017 Aug.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Various studies reported remarkably high prevalence rates of obsessive-compulsive symptoms (OCS) in patients with a psychotic disorder. Little is known about the pathogenesis of this co-occurrence. The current study aimed to investigate the contribution of shared underlying risk factors, such as childhood trauma and neuroticism, to the onset and course of OCS in patients with psychosis. Data were retrieved from 161 patients with psychosis included in the 'Genetic Risk and Outcome in Psychosis' project. Patients completed measures of OCS and psychotic symptoms at study entrance and three years later. Additionally, childhood maltreatment and neuroticism were assessed. Between-group comparisons revealed increased neuroticism and positive symptoms in patients who reported comorbid OCS compared to OCS-free patients. Subsequent mediation analyses suggested a small effect of childhood abuse on comorbid OCS severity at baseline, which was mediated by positive symptom severity. Additionally, results showed a mediating effect of neuroticism as well as a moderating effect of positive symptoms on the course of OCS severity over time. OCS severity in patients with psychosis might thus be associated with common vulnerability factors, such as childhood abuse and neuroticism. Furthermore, the severity of positive symptoms might be associated with more severe or persistent comorbid OCS.
[Mh] Termos MeSH primário: Maus-Tratos Infantis/psicologia
Neuroticismo/fisiologia
Transtorno Obsessivo-Compulsivo/epidemiologia
Transtorno Obsessivo-Compulsivo/psicologia
Transtornos Psicóticos/epidemiologia
Transtornos Psicóticos/psicologia
[Mh] Termos MeSH secundário: Adulto
Criança
Comorbidade
Feminino
Predisposição Genética para Doença/epidemiologia
Predisposição Genética para Doença/psicologia
Seres Humanos
Estudos Longitudinais
Masculino
Transtorno Obsessivo-Compulsivo/genética
Estudos Prospectivos
Transtornos Psicóticos/genética
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE



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