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[PMID]:28251921
[Au] Autor:Ksendzovsky A; Pomeraniec IJ; Zaghloul KA; Provencio JJ; Provencio I
[Ad] Endereço:From the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departme
[Ti] Título:Clinical implications of the melanopsin-based non-image-forming visual system.
[So] Source:Neurology;88(13):1282-1290, 2017 Mar 28.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since the discovery of the non-image-forming visual system, tremendous research efforts have been dedicated to understanding its mechanisms and functional roles. Original functions associated with the melanopsin system include the photoentrainment of circadian sleep-wake cycles and the pupillary light reflex. Recent findings, however, suggest a much broader involvement of this system in an array of physiologic responses to light. This newfound insight into the underlying function of the non-image-forming system has revealed the many connections to human pathology and attendant disease states, including seasonal affective disorder, migraine, glaucoma, inherited mitochondrial optic neuropathy, and sleep dysregulation of aging. In this review, the authors discuss in detail the clinical implications of the melanopsin system.
[Mh] Termos MeSH primário: Ritmo Circadiano/fisiologia
Oftalmopatias
Opsinas de Bastonetes/metabolismo
Vias Visuais/metabolismo
[Mh] Termos MeSH secundário: Animais
Oftalmopatias/complicações
Oftalmopatias/metabolismo
Oftalmopatias/patologia
Seres Humanos
Luz
Fotofobia/metabolismo
Transtorno Afetivo Sazonal
Transtornos do Sono-Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Rod Opsins); 0 (melanopsin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000003761


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[PMID]:28135573
[Au] Autor:Oren DA; Duda M; Koziol K; Romerowicz-Misielak M; Koziorowska A; Solek P; Nowak S; Kulpa M; Koziorowski M
[Ad] Endereço:Department of Psychiatry, Yale University, 300 George Street, Suite 901, New Haven, CT 06511, USA; Department of Physiology and Reproduction of Animals, Institute of Applied Biotechnology and Basic Sciences, University of Rzeszów, Rejtana 16C, 35-959 Rzeszów, Poland. Electronic address: doren@aya.ya
[Ti] Título:Retinal venous blood carbon monoxide response to bright light in male pigs: A preliminary study.
[So] Source:J Photochem Photobiol B;168:12-15, 2017 Mar.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The physical mechanism by which light is absorbed in the eye and has antidepressant and energizing effects in Seasonal Affective Disorder and other forms of psychiatric major depression is of scientific interest. This study was designed to explore one specific aspect of a proposed humoral phototransduction mechanism, namely that carbon monoxide (CO) levels increase in retinal venous blood in response to bright light. Eleven mature male pigs approximately six months of age were kept for 7days in darkness and fasted for 12h prior to surgery. Following mild sedation, anesthesia was induced. Silastic catheters were inserted into the dorsal nasal vein through the angular vein of the eye to reach the ophthalmic sinus, from which venous blood outflowing from the eye area was collected. The animals were exposed to 5000lx of fluorescent-generated white light. CO levels in the blood were analyzed by gas chromatography before and after 80min of light exposure. At baseline, mean CO levels in the retinal venous blood were 0.43±0.05(SE)nmol/ml. After bright light, mean CO levels increased to 0.54±0.06nmol/ml (two-tailed t-test p<0.05). This study provides preliminary mammalian evidence that acute bright light exposure raises carbon monoxide levels in ophthalmic venous blood.
[Mh] Termos MeSH primário: Monóxido de Carbono/sangue
Monóxido de Carbono/efeitos da radiação
Olho/irrigação sanguínea
Transdução de Sinal Luminoso
Luz
[Mh] Termos MeSH secundário: Animais
Monóxido de Carbono/fisiologia
Transdução de Sinal Luminoso/efeitos da radiação
Masculino
Fenômenos Fisiológicos Oculares
Retina
Transtorno Afetivo Sazonal/prevenção & controle
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7U1EE4V452 (Carbon Monoxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE


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[PMID]:28075103
[Au] Autor:Magovern MK; Crawford-Faucher A
[Ad] Endereço:Forbes Family Medicine Residency Program, Pittsburgh, PA, USA.
[Ti] Título:Extended-Release Bupropion for Preventing Seasonal Affective Disorder in Adults.
[So] Source:Am Fam Physician;95(1):10-11, 2017 Jan 01.
[Is] ISSN:1532-0650
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antidepressivos de Segunda Geração/uso terapêutico
Bupropiona/uso terapêutico
Transtorno Afetivo Sazonal/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Canadá
Preparações de Ação Retardada/uso terapêutico
Feminino
Seres Humanos
Masculino
Ensaios Clínicos Controlados Aleatórios como Assunto
Transtorno Afetivo Sazonal/epidemiologia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents, Second-Generation); 0 (Delayed-Action Preparations); 01ZG3TPX31 (Bupropion)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE


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[PMID]:28012610
[Au] Autor:Pereira JC; Pradella Hallinan M; Alves RC
[Ad] Endereço:Departamento de Pediatria, Faculdade de Medicina de Jundiaí, Jundiaí, São Paulo, Brazil. Electronic address: jcpereirajr@uol.com.br.
[Ti] Título:Secondary to excessive melatonin synthesis, the consumption of tryptophan from outside the blood-brain barrier and melatonin over-signaling in the pars tuberalis may be central to the pathophysiology of winter depression.
[So] Source:Med Hypotheses;98:69-75, 2017 Jan.
[Is] ISSN:1532-2777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seasonal affective disorder is defined as recurrent episodes of major depression, mania, or hypomania with seasonal onset and remission. In this class of mood disturbances, a unipolar major depressive disorder known as winter depression is common in populations living in northern latitudes far from the equator. Winter depression repeatedly occurs in the autumn or winter and remits in the spring or summer, and its etiopathogenesis is currently unknown. However, one can surmise that excessive melatonin production during the reduced duration of daily sunlight in the autumn and winter plays a role in its pathophysiology. Melatonin is synthesized from tryptophan within the pineal gland, which is located outside the blood-brain barrier, and overproduction of melatonin may lead to augmented consumption of tryptophan, from which serotonin is synthesized. As tryptophan is captured from the blood and excessively utilized by the pineal gland, tryptophan blood levels may decline; as such, it is more difficult for tryptophan to pass through the blood-brain barrier and reach the serotonergic neurons as the ratio of tryptophan to the other amino acids that compete for the same transporter to enter the brain is diminished. As such, less tryptophan is available for serotonin synthesis. Moreover, melatonin is known to modulate thyrotropin expression in the thyrotrophic cells of the pars tuberalis of the pituitary gland, and overproduction of melatonin in the autumn or winter months may cause excessive signaling in the pars tuberalis, diminishing its release of thyrotropin and resulting in central hypothyroidism. Both conditions reduced serotonin production and central hypothyroidism may cause depression. Furthermore, the excessive synthesis of melatonin during the autumn and winter may negatively affect the expression of neuromedin U in the pars tuberalis, causing an increased appetite, which is common in winter depression patients. The hypersomnia common in winter depressive patients can be ascribed to excessive circulating melatonin, a hormone that increases the propensity for sleep. Furthermore, central hypothyroidism may also increase sleepiness, as it is known that hypothyroid patients usually experience excessive somnolence. In this theoretical article, we also propose studies to evaluate winter depression patients with regard to the necessity, or not, of offering them an increased amount of tryptophan in their diets during the autumn and winter. We also suggest that the administration of triiodothyronine to winter depressive patients may mitigate their central hypothyroidism.
[Mh] Termos MeSH primário: Barreira Hematoencefálica
Transtorno Depressivo Maior/metabolismo
Melatonina/metabolismo
Hipófise/fisiopatologia
Transtorno Afetivo Sazonal/metabolismo
Triptofano/metabolismo
[Mh] Termos MeSH secundário: Animais
Sistema Nervoso Central/metabolismo
Transtorno Depressivo Maior/fisiopatologia
Dieta
Seres Humanos
Luz
Transtorno Afetivo Sazonal/fisiopatologia
Estações do Ano
Serotonina/metabolismo
Transdução de Sinais
Hormônios Tireóideos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thyroid Hormones); 333DO1RDJY (Serotonin); 8DUH1N11BX (Tryptophan); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161226
[St] Status:MEDLINE


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[PMID]:27821410
[Au] Autor:Murray G
[Ad] Endereço:Faculty of Health, Arts and Design, Swinburne University of Technology, Hawthorn, VIC, Australia.
[Ti] Título:SAD schmad: Is seasonal affective disorder a valid construct?
[So] Source:Aust N Z J Psychiatry;51(1):18-19, 2017 Jan.
[Is] ISSN:1440-1614
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtorno Afetivo Sazonal/classificação
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE
[do] DOI:10.1177/0004867416676897


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[PMID]:27975357
[Au] Autor:Lemmer B
[Ti] Título:[Light and Medicine].
[Ti] Título:Licht und Medizin..
[So] Source:Dtsch Med Wochenschr;141(25):1840-1844, 2016 Dec.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:There would be no life without light. The rotation of the earth around its axis has introduced the development of biological clocks in all living subjects regulating all functions of the body. The rhythms best described are the 24-hour/circadian and the seasonal rhythms. The rhythmic composition around the body clock has great impact on health and disease, both in diagnostics and treatment. Nowadays, bright light, e.g. in seasonal affective disorder, can be regarded as a drug, being even more effective than selective serotonin reuptake inhibitors.
[Mh] Termos MeSH primário: Ritmo Circadiano/efeitos da radiação
Iluminação/métodos
Fototerapia/métodos
Transtorno Afetivo Sazonal/prevenção & controle
Transtorno Afetivo Sazonal/fisiopatologia
Estações do Ano
[Mh] Termos MeSH secundário: Medicina Baseada em Evidências
Seres Humanos
Luz
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE


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[PMID]:27821114
[Au] Autor:Bais B; Kamperman AM; van der Zwaag MD; Dieleman GC; Harmsen van der Vliet-Torij HW; Bijma HH; Lieverse R; Hoogendijk WJ; Lambregtse-van den Berg MP
[Ad] Endereço:Department of Psychiatry, Erasmus University Medical Centre Rotterdam, 's Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands. b.bais@erasmusmc.nl.
[Ti] Título:Bright light therapy in pregnant women with major depressive disorder: study protocol for a randomized, double-blind, controlled clinical trial.
[So] Source:BMC Psychiatry;16(1):381, 2016 Nov 08.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Depression during pregnancy is a common and high impact disease. Generally, 5-10 % of pregnant women suffer from depression. Children who have been exposed to maternal depression during pregnancy have a higher risk of adverse birth outcomes and more often show cognitive, emotional and behavioural problems. Therefore, early detection and treatment of antepartum depression is necessary. Both psychotherapy and antidepressant medication, first choice treatments in a non-pregnant population, have limitations in treating depression during pregnancy. Therefore, it is urgent and relevant to investigate alternative treatments for antepartum depression. Bright light therapy (BLT) is a promising treatment for pregnant women with depressive disorder, for it combines direct availability, sufficient efficacy, low costs and high safety, taking the safety for the unborn child into account as well. METHODS: In this study, 150 pregnant women (12-18 weeks pregnant) with a DSM-V diagnosis of depressive disorder will be randomly allocated in a 1:1 ratio to one of the two treatment arms: treatment with BLT (9.000 lux) or treatment with dim red light therapy (100 lux). Both groups will be treated for 6 weeks at home on a daily basis for 30 min, within 30 min of habitual wake-up time. Follow-up will take place after 6 weeks of therapy, 3 and 10 weeks after end of therapy, at birth and 2, 6 and 18 months postpartum. Primary outcome will be the average change in depressive symptoms between the two groups, as measured by the Structured Interview Guide for the Hamilton Depression Scale - Seasonal Affective Disorder version and the Edinburg Postnatal Depression Scale. Changes in rating scale scores of these questionnaires over time will be analysed using generalized linear mixed models. Secondary outcomes will be the changes in maternal cortisol and melatonin levels, in maternal sleep quality and gestational age, birth weight, infant behaviour, infant cortisol exposure and infant cortisol stress response. DISCUSSION: If BLT reduces depressive symptoms in pregnant women, it will provide a safe, cheap, non-pharmacological and efficacious alternative treatment for psychotherapy and antidepressant medication in treating antepartum depression, without any expected adverse reactions for the unborn child. TRIAL REGISTRATION: Netherlands Trial Register NTR5476 . Registered 5 November 2015.
[Mh] Termos MeSH primário: Transtorno Depressivo Maior/terapia
Fototerapia/métodos
Complicações na Gravidez/terapia
Gestantes/psicologia
[Mh] Termos MeSH secundário: Adulto
Ritmo Circadiano
Transtorno Depressivo Maior/psicologia
Método Duplo-Cego
Feminino
Seres Humanos
Países Baixos
Gravidez
Complicações na Gravidez/psicologia
Transtorno Afetivo Sazonal/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


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[PMID]:27553523
[Au] Autor:Tyrer AE; Levitan RD; Houle S; Wilson AA; Nobrega JN; Rusjan PM; Meyer JH
[Ad] Endereço:CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Departments of Psychiatry, Pharmacology and Toxicology, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
[Ti] Título:Serotonin transporter binding is reduced in seasonal affective disorder following light therapy.
[So] Source:Acta Psychiatr Scand;134(5):410-419, 2016 Nov.
[Is] ISSN:1600-0447
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effects of light therapy on serotonin transporter binding (5-HTT BP ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC) during winter in seasonal affective disorder (SAD). 5-HTT BP fluctuates seasonally to a greater extent in SAD relative to health. We hypothesized that in SAD, 5-HTT BP would be reduced in the ACC and PFC following light therapy. METHODS: Eleven SAD participants underwent [ C] DASB positron emission tomography (PET) scans to measure 5-HTT BP before and after 2 weeks of daily morning light therapy. RESULTS: The primary finding was a main effect of treatment on 5-HTT BP in the ACC and PFC (repeated-measures manova, F = 6.82, P = 0.016). This effect was significant in the ACC (F = 15.11 and P = 0.003, magnitude of decrease, 11.94%) and PFC (F = 8.33, P = 0.016, magnitude of decrease, 9.13%). 5-HTT BP also decreased in other regions assayed following light therapy (repeated-measures manova, F = 8.54, P = 0.028) including the hippocampus, ventral striatum, dorsal putamen, thalamus and midbrain (F = 8.02-36.94, P < 0.0001-0.018; magnitude -8.83% to -16.74%). CONCLUSIONS: These results demonstrate that light therapy reaches an important therapeutic target in the treatment of SAD and provide a basis for improvement of this treatment via application of [ C]DASB PET.
[Mh] Termos MeSH primário: Fototerapia/métodos
Transtorno Afetivo Sazonal/terapia
Proteínas da Membrana Plasmática de Transporte de Serotonina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Feminino
Giro do Cíngulo/metabolismo
Seres Humanos
Masculino
Tomografia por Emissão de Pósitrons/métodos
Córtex Pré-Frontal/metabolismo
Ligação Proteica
Transtorno Afetivo Sazonal/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (SLC6A4 protein, human); 0 (Serotonin Plasma Membrane Transport Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.1111/acps.12632


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[PMID]:27423070
[Au] Autor:Wynchank DS; Bijlenga D; Lamers F; Bron TI; Winthorst WH; Vogel SW; Penninx BW; Beekman AT; Kooij JS
[Ad] Endereço:PsyQ Expertise Center Adult ADHD, The Hague, The Netherlands. Electronic address: d.wynchank@psyq.nl.
[Ti] Título:ADHD, circadian rhythms and seasonality.
[So] Source:J Psychiatr Res;81:87-94, 2016 Oct.
[Is] ISSN:1879-1379
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We evaluated whether the association between Adult Attention-Deficit/Hyperactivity Disorder (ADHD) and Seasonal Affective Disorder (SAD) was mediated by the circadian rhythm. METHOD: Data of 2239 persons from the Netherlands Study of Depression and Anxiety (NESDA) were used. Two groups were compared: with clinically significant ADHD symptoms (N = 175) and with No ADHD symptoms (N = 2064). Sleep parameters were sleep-onset and offset times, mid sleep and sleep duration from the Munich Chronotype Questionnaire. We identified the prevalence of probable SAD and subsyndromal SAD using the Seasonal Pattern Assessment Questionnaire (SPAQ). Clinically significant ADHD symptoms were identified by using a T score>65 on the Conners Adult ADHD Rating Scale. RESULTS: The prevalence of probable SAD was estimated at 9.9% in the ADHD group (vs. 3.3% in the No ADHD group) and of probable s-SAD at 12.5% in the ADHD group (vs 4.6% in the No ADHD group). Regression analyses showed consistently significant associations between ADHD symptoms and probable SAD, even after adjustment for current depression and anxiety, age, sex, education, use of antidepressants and benzodiazepines (B = 1.81, p < 0.001). Late self-reported sleep onset was an important mediator in the significant relationship between ADHD symptoms and probable SAD, even after correction for confounders (total model effects: B = 0.14, p ≤ 0.001). CONCLUSION: Both seasonal and circadian rhythm disturbances are significantly associated with ADHD symptoms. Delayed sleep onset time in ADHD may explain the increase in SAD symptoms. Treating patients with SAD for possible ADHD and delayed sleep onset time may reduce symptom severity in these complex patients.
[Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia
Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia
Ritmo Circadiano/fisiologia
Transtorno Afetivo Sazonal/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Países Baixos/epidemiologia
Prevalência
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE


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[PMID]:27298382
[Au] Autor:Melrose S
[Ad] Endereço:Athabasca University, Athabasca, Alberta, Canada; sherrim@athabascau.ca.
[Ti] Título:Treating seasonal affective disorder with cognitive behavioural therapy is comparable to light therapy.
[So] Source:Evid Based Ment Health;19(3):e21, 2016 08.
[Is] ISSN:1468-960X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Fototerapia
Transtorno Afetivo Sazonal/psicologia
[Mh] Termos MeSH secundário: Terapia Cognitiva
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.1136/eb-2016-102327



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