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[PMID]:29187488
[Au] Autor:Rades D; Bajrovic A; Bartscht T
[Ad] Endereço:Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
[Ti] Título:Predictive Factors and a Survival Score for Patients Irradiated for Metastatic Spinal Cord Compression from Carcinoma of the Salivary Glands.
[So] Source:Anticancer Res;37(12):7011-7015, 2017 12.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:AIM: To our knowledge, this is the first study focusing on metastatic spinal cord compression (MSCC) from carcinoma of the salivary glands. PATIENTS AND METHODS: Nine patients receiving radiation alone were evaluated for improvement of motor deficits, post-radiation gait function and survival. RESULTS: Of nine characteristics (radiation program, age, sex, additional metastases to bone or to other organs, dynamic of motor deficits, pre-radiation gait function, number of vertebrae affected by MSCC, general condition), strong trends were found for associations between improved motor deficits and their dynamic (p=0.05), post-radiation gait function and pre-treatment ambulatory status (p=0.08) and between survival and additional metastases to other organs (p=0.07), dynamic of motor deficits (p=0.07) and general condition (p=0.07). In addition, a survival score was created. Patients with 2-3 points had a significantly better 6-month survival than those with 0-1 points (100% vs. 0%, p=0.027). CONCLUSION: Characteristics predicting outcomes identified in this study and the new survival score can guide physicians when making treatment decisions.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Salivares/complicações
Compressão da Medula Espinal/radioterapia
[Mh] Termos MeSH secundário: Feminino
Marcha/fisiologia
Seres Humanos
Masculino
Meia-Idade
Transtornos Motores/etiologia
Transtornos Motores/fisiopatologia
Prognóstico
Estudos Retrospectivos
Compressão da Medula Espinal/etiologia
Compressão da Medula Espinal/fisiopatologia
Análise de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:28953991
[Au] Autor:Murad HA; Gazzaz ZJ; Ali SS; Ibraheem MS
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
[Ti] Título:Candesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats.
[So] Source:Braz J Med Biol Res;50(11):e6665, 2017 Sep 21.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Minimal hepatic encephalopathy is more common than the acute syndrome. Losartan, the first angiotensin-II receptor blocker (ARB), and candesartan, another widely-used ARB, have protected against developing fibrogenesis, but there is no clear data about their curative antifibrotic effects. The current study was designed to examine their effects in an already-established model of hepatic fibrosis and also their effects on the associated motor dysfunction. Low-grade chronic liver failure (CLF) was induced in 3-month old Sprague-Dawley male rats using thioacetamide (TAA, 50 mg·kg-1·day-1) intraperitoneally for 2 weeks. The TAA-CLF rats were randomly divided into five groups (n=8) treated orally for 14 days (mg·kg-1·day-1) as follows: TAA (distilled water), losartan (5 and 10 mg/kg), and candesartan (0.1 and 0.3 mg/kg). Rats were tested for rotarod and open-field tests. Serum and hepatic biochemical markers, and hepatic histopathological changes were evaluated by H&E and Masson's staining. The TAA-CLF rats showed significant increases of hepatic malondialdehyde, hepatic expression of tumor necrosis factor-α (TNF-α), and serum ammonia, alanine aminotransferase, γ-glutamyl transferase, TNF-α, and malondialdehyde levels as well as significant decreases of hepatic and serum glutathione levels. All treatments significantly reversed these changes. The histopathological changes were moderate in losartan-5 and candesartan-0.1 groups and mild in losartan-10 and candesartan-0.3 groups. Only candesartan significantly improved TAA-induced motor dysfunction. In conclusion, therapeutic antifibrotic effects of losartan and candesartan in thioacetamide-induced hepatic fibrosis in rats are possibly through angiotensin-II receptor blocking, antioxidant, and anti-inflammatory activities. Improved motor dysfunction by candesartan could be attributed to better brain penetration and slower "off-rate" from angiotensin-II receptors. Clinical trials are recommended.
[Mh] Termos MeSH primário: Bloqueadores do Receptor Tipo 1 de Angiotensina II/uso terapêutico
Benzimidazóis/uso terapêutico
Doença Hepática Terminal/complicações
Losartan/uso terapêutico
Transtornos Motores/tratamento farmacológico
Tetrazóis/uso terapêutico
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Amônia/sangue
Bloqueadores do Receptor Tipo 1 de Angiotensina II/farmacologia
Animais
Benzimidazóis/farmacologia
Modelos Animais de Doenças
Doença Hepática Terminal/patologia
Doença Hepática Terminal/fisiopatologia
Ensaio de Imunoadsorção Enzimática
Glutationa/análise
Fígado/efeitos dos fármacos
Fígado/patologia
Cirrose Hepática/complicações
Cirrose Hepática/patologia
Cirrose Hepática/fisiopatologia
Locomoção/fisiologia
Losartan/farmacologia
Masculino
Malondialdeído/análise
Transtornos Motores/etiologia
Transtornos Motores/fisiopatologia
Distribuição Aleatória
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Tetrazóis/farmacologia
Tioacetamida
Resultado do Tratamento
Fator de Necrose Tumoral alfa/sangue
gama-Glutamiltransferase/sangue
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin II Type 1 Receptor Blockers); 0 (Benzimidazoles); 0 (Tetrazoles); 0 (Tumor Necrosis Factor-alpha); 075T165X8M (Thioacetamide); 4Y8F71G49Q (Malondialdehyde); 7664-41-7 (Ammonia); EC 2.3.2.2 (gamma-Glutamyltransferase); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione); JMS50MPO89 (Losartan); S8Q36MD2XX (candesartan)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:28920888
[Au] Autor:Stinear CM
[Ad] Endereço:University of Auckland, Auckland, New Zealand. Electronic address: c.stinear@auckland.ac.nz.
[Ti] Título:Prediction of motor recovery after stroke: advances in biomarkers.
[So] Source:Lancet Neurol;16(10):826-836, 2017 Oct.
[Is] ISSN:1474-4465
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Stroke remains a leading cause of adult disability, and the recovery of motor function after stroke is crucial for the patient to regain independence. However, making accurate predictions of a patient's motor recovery and outcome is difficult when based on clinical assessment alone. Clinical assessment of motor impairment within a few days of stroke can help to predict subsequent recovery, while neurophysiological and neuroimaging biomarkers of corticomotor structure and function can help to predict both motor recovery and motor outcome after stroke. The combination of biomarkers can provide clinically useful information when planning the personalised rehabilitation of a patient. These biomarkers can also be used for patient selection and stratification in trials investigating rehabilitation interventions that are initiated early after stroke. Ongoing multicentre trials that incorporate motor biomarkers could help to bring their use into routine clinical practice.
[Mh] Termos MeSH primário: Biomarcadores
Eletroencefalografia
Potenciais Evocados/fisiologia
Transtornos Motores/fisiopatologia
Neuroimagem
Recuperação de Função Fisiológica/fisiologia
Reabilitação do Acidente Vascular Cerebral
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Seres Humanos
Transtornos Motores/etiologia
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28719076
[Au] Autor:Ball G; Aljabar P; Nongena P; Kennea N; Gonzalez-Cinca N; Falconer S; Chew ATM; Harper N; Wurie J; Rutherford MA; Counsell SJ; Edwards AD
[Ad] Endereço:Centre for the Developing Brain, King's College London, St Thomas' Hospital, London, United Kingdom.
[Ti] Título:Multimodal image analysis of clinical influences on preterm brain development.
[So] Source:Ann Neurol;82(2):233-246, 2017 Aug.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Premature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents. METHODS: In a prospective cohort of 449 infants (226 male), we performed a multivariate and data-driven analysis combining multiple imaging modalities. Using canonical correlation analysis, we sought separable multimodal imaging markers associated with specific clinical and environmental factors and correlated to neurodevelopmental outcome at 2 years. RESULTS: We found five independent patterns of neuroanatomical variation that related to clinical factors including age, prematurity, sex, intrauterine complications, and postnatal adversity. We also confirmed the association between imaging markers of neuroanatomical abnormality and poor cognitive and motor outcomes at 2 years. INTERPRETATION: This data-driven approach defined novel and clinically relevant imaging markers of cerebral maldevelopment, which offer new insights into the nature of preterm brain injury. Ann Neurol 2017;82:233-246.
[Mh] Termos MeSH primário: Encéfalo/anormalidades
Encéfalo/crescimento & desenvolvimento
Processamento de Imagem Assistida por Computador
Recém-Nascido Prematuro/fisiologia
Recém-Nascido Prematuro/psicologia
[Mh] Termos MeSH secundário: Anisotropia
Pré-Escolar
Disfunção Cognitiva/patologia
Feminino
Seres Humanos
Recém-Nascido
Imagem por Ressonância Magnética
Masculino
Modelos Estatísticos
Transtornos Motores/patologia
Estudos Prospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24995


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[PMID]:28710246
[Au] Autor:Cooper AN; Anderson V; Hearps S; Greenham M; Ditchfield M; Coleman L; Hunt RW; Mackay MT; Monagle P; Gordon AL
[Ad] Endereço:Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
[Ti] Título:Trajectories of Motor Recovery in the First Year After Pediatric Arterial Ischemic Stroke.
[So] Source:Pediatrics;140(2), 2017 Aug.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neuromotor impairments are common after pediatric stroke, but little is known about functional motor outcomes. We evaluated motor function and how it changed over the first 12 months after diagnosis. We also examined differences in outcome according to age at diagnosis and whether fine motor (FM) or gross motor (GM) function at 12 months was associated with adaptive behavior. METHODS: This prospective, longitudinal study recruited children ( = 64) from The Royal Children's Hospital, Melbourne who were diagnosed with acute arterial ischemic stroke (AIS) between December 2007 and November 2013. Motor assessments were completed at 3 time points after the diagnosis of AIS (1, 6, and 12 months). Children were grouped as follows: neonates ( = 27), preschool-aged ( = 19), and school-aged ( = 18). RESULTS: A larger lesion size was associated with poorer GM outcomes at 12 months ( = .016). Neonatal AIS was associated with better FM and GM function initially but with a reduction in scores over time. For the preschool- and school-aged groups, FM remained relatively stable over time. For GM outcomes, the preschool- and the school-aged age groups displayed similar profiles, with gradual recovery over time. Overall, poor FM and GM outcomes at 12 months were associated with poorer adaptive behavior scores. CONCLUSIONS: Motor outcomes and the trajectory of recovery post-AIS differed according to a child's age at stroke onset. These findings indicate that an individualized approach to surveillance and intervention may be needed that is informed in part by age at diagnosis.
[Mh] Termos MeSH primário: Infarto Cerebral/diagnóstico
Hipóxia-Isquemia Encefálica/diagnóstico
Transtornos Motores/diagnóstico
[Mh] Termos MeSH secundário: Doença Aguda
Adaptação Psicológica
Adolescente
Criança
Pré-Escolar
Avaliação da Deficiência
Dominância Cerebral
Feminino
Hemiplegia/diagnóstico
Seres Humanos
Lactente
Recém-Nascido
Estudos Longitudinais
Masculino
Limitação da Mobilidade
Exame Neurológico
Estudos Prospectivos
Recuperação de Função Fisiológica
Inquéritos e Questionários
Vitória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28437520
[Au] Autor:Schmidt B; Roberts RS; Anderson PJ; Asztalos EV; Costantini L; Davis PG; Dewey D; D'Ilario J; Doyle LW; Grunau RE; Moddemann D; Nelson H; Ohlsson A; Solimano A; Tin W; Caffeine for Apnea of Prematurity (CAP) Trial Group
[Ad] Endereço:Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada2Division of Neonatology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia.
[Ti] Título:Academic Performance, Motor Function, and Behavior 11 Years After Neonatal Caffeine Citrate Therapy for Apnea of Prematurity: An 11-Year Follow-up of the CAP Randomized Clinical Trial.
[So] Source:JAMA Pediatr;171(6):564-572, 2017 Jun 01.
[Is] ISSN:2168-6211
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Caffeine citrate therapy for apnea of prematurity reduces the rates of bronchopulmonary dysplasia, severe retinopathy, and neurodevelopmental disability at 18 months and may improve motor function at 5 years. Objective: To evaluate whether neonatal caffeine therapy is associated with improved functional outcomes 11 years later. Design, Setting, and Participants: A follow-up study was conducted at 14 academic hospitals in Canada, Australia, and the United Kingdom from May 7, 2011, to May 27, 2016, of English- or French-speaking children who had been enrolled in the randomized, placebo-controlled Caffeine for Apnea of Prematurity trial between October 11, 1999, and October 22, 2004. A total of 1202 children with birth weights of 500 to 1250 g were eligible for this study; 920 (76.5%) had adequate data for the main outcome. Interventions: Caffeine citrate or placebo until drug therapy for apnea of prematurity was no longer needed. Main Outcomes and Measures: Functional impairment was a composite of poor academic performance (defined as at least 1 standard score greater than 2 SD below the mean on the Wide Range Achievement Test-4), motor impairment (defined as a percentile rank of ≤5 on the Movement Assessment Battery for Children-Second Edition), and behavior problems (defined as a Total Problem T score ≥2 SD above the mean on the Child Behavior Checklist). Results: Among the 920 children (444 females and 476 males; median age, 11.4 years [interquartile range, 11.1-11.8 years]), the combined rates of functional impairment were not significantly different between the 457 children assigned to receive caffeine compared with the 463 children assigned to receive placebo (145 [31.7%] vs 174 [37.6%]; adjusted odds ratio, 0.78; 95% CI, 0.59-1.02; P = .07). With all available data, including those from up to 24 Swedish trial participants, the rates of poor academic performance on 1 or more of 4 subtests (66 of 458 [14.4%] vs 61 of 462 [13.2%]; adjusted odds ratio, 1.11; 95% CI, 0.77-1.61; P = .58) and behavior problems (52 of 476 [10.9%] vs 40 of 481 [8.3%]; adjusted odds ratio, 1.32; 95% CI, 0.85-2.07; P = .22) were broadly similar between the group that received caffeine and the group that received placebo. However, caffeine therapy was associated with a reduced risk of motor impairment compared with placebo (90 of 457 [19.7%] vs 130 of 473 [27.5%]; adjusted odds ratio, 0.66; 95% CI, 0.48-0.90; P = .009). Conclusions and Relevance: Caffeine therapy for apnea of prematurity did not significantly reduce the combined rate of academic, motor, and behavioral impairments but was associated with a reduced risk of motor impairment in 11-year-old children with very low birth weight. At the doses used in this trial, neonatal caffeine therapy is effective and safe into middle school age. Trial Registration: clinicaltrials.gov Identifier: NCT00182312; isrctn.org Identifier: ISRCTN44364365.
[Mh] Termos MeSH primário: Apneia/tratamento farmacológico
Cafeína/uso terapêutico
Estimulantes do Sistema Nervoso Central/uso terapêutico
Transtornos do Comportamento Infantil/prevenção & controle
Citratos/uso terapêutico
Doenças do Prematuro/tratamento farmacológico
Transtornos Motores/prevenção & controle
[Mh] Termos MeSH secundário: Apneia/complicações
Peso ao Nascer
Transtornos do Comportamento Infantil/etiologia
Desenvolvimento Infantil
Deficiências do Desenvolvimento/etiologia
Deficiências do Desenvolvimento/prevenção & controle
Método Duplo-Cego
Escolaridade
Feminino
Seguimentos
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Recém-Nascido de muito Baixo Peso
Masculino
Transtornos Motores/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 0 (Citrates); 3G6A5W338E (Caffeine); U26EO4675Q (caffeine citrate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1001/jamapediatrics.2017.0238


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[PMID]:28393013
[Au] Autor:Olivito G; Cercignani M; Lupo M; Iacobacci C; Clausi S; Romano S; Masciullo M; Molinari M; Bozzali M; Leggio M
[Ad] Endereço:Ataxia Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
[Ti] Título:Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis.
[So] Source:Neuroimage Clin;14:719-725, 2017.
[Is] ISSN:2213-1582
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affected by SCA2 present also cognitive impairments and psychiatric symptoms. The cerebellum is known to modulate cortical activity and to contribute to distinct functional networks related to higher-level functions beyond motor control. It is therefore conceivable that one or more networks, rather than isolated regions, may be dysfunctional in cerebellar degenerative diseases and that an abnormal connectivity within specific cerebello-cortical regions might explain the widespread deficits typically observed in patients. In the present study, the network-based statistics (NBS) approach was used to assess differences in functional connectivity between specific cerebellar and cerebral "nodes" in SCA2 patients. Altered inter-nodal connectivity was found between more posterior regions in the cerebellum and regions in the cerebral cortex clearly related to cognition and emotion. Furthermore, more anterior cerebellar lobules showed altered inter-nodal connectivity with motor and somatosensory cerebral regions. The present data suggest that in SCA2 a cerebellar dysfunction affects long-distance cerebral regions and that the clinical symptoms may be specifically related with connectivity changes between motor and non-motor cerebello-cortical nodes.
[Mh] Termos MeSH primário: Mapeamento Encefálico
Transtornos Cognitivos/etiologia
Transtornos Motores/etiologia
Rede Nervosa/diagnóstico por imagem
Ataxias Espinocerebelares/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Cerebelo/diagnóstico por imagem
Transtornos Cognitivos/diagnóstico por imagem
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Transtornos Motores/diagnóstico por imagem
Oxigênio/sangue
Descanso
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1016/j.nicl.2017.03.009


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[PMID]:28291212
[Au] Autor:Zuev AA; Korotchenko EN; Ivanova DS; Pedyash NV; Teplykh BA
[Ad] Endereço:Pirogov National Medical and Surgical Center, Moscow, Russia.
[Ti] Título:[Surgical treatment of eloquent brain area tumors using neurophysiological mapping of the speech and motor areas and conduction tracts].
[Ti] Título:Khirurgicheskoe lechenie opukholei funktsional'no znachimykh zon golovnogo mozga s primeneniem metoda neirofiziologicheskogo kartirovaniya rechevykh, motornykh zon i provodyashchikh putei..
[So] Source:Zh Vopr Neirokhir Im N N Burdenko;81(1):39-50, 2017.
[Is] ISSN:0042-8817
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To evaluate the efficacy of intraoperative neurophysiological mapping in removing eloquent brain area tumors (EBATs). MATERIAL AND METHODS: Sixty five EBAT patients underwent surgical treatment using intraoperative neurophysiological mapping at the Pirogov National Medical and Surgical Center in the period from 2014 to 2015. On primary neurological examination, 46 (71%) patients were detected with motor deficits of varying severity. Speech disorders were diagnosed in 17 (26%) patients. Sixteen patients with concomitant or isolated lesions of the speech centers underwent awake surgery using the asleep-awake-asleep protocol. Standard neurophysiological monitoring included transcranial stimulation as well as motor and, if necessary, speech mapping. The motor and speech areas were mapped with allowance for the preoperative planning data (obtained with a navigation station) synchronized with functional MRI. In this case, a broader representation of the motor and speech centers was revealed in 12 (19%) patients. During speech mapping, no speech disorders were detected in 7 patients; in 9 patients, stimulation of the cerebral cortex in the intended surgical area induced motor (3 patients), sensory (4), and amnesic (2) aphasia. In the total group, we identified 11 patients in whom the tumor was located near the internal capsule. Upon mapping of the conduction tracts in the internal capsule area, the stimulus strength during tumor resection was gradually decreased from 10 mA to 5 mA. Tumor resection was stopped when responses retained at a stimulus strength of 5 mA, which, when compared to the navigation data, corresponded to a distance of about 5 mm to the internal capsule. Completeness of tumor resection was evaluated (contrast-enhanced MRI) in all patients on the first postoperative day. RESULTS: According to the control MRI data, the tumor was resected totally in 60% of patients, subtotally in 24% of patients, and partially in 16% of patients. In the early postoperative period, the development or aggravation of a motor neurological deficit was detected in 18 patients: worsening of paresis was observed in 11 patients, and worsening of speech disorders occurred in 7 patients. After 4 months, motor and speech disorders regressed in 10 patients. Therefore, a persistent neurological deficit developed after surgery in 8 (12%) patients (motor deficit in 5 cases; speech deficit in 3 cases). CONCLUSION: Resection of eloquent brain area tumors using intraoperative neurophysiological monitoring enables complete resection of the tumor at a low risk of persistent neurological deficits, which ultimately improves the patient's life prognosis.
[Mh] Termos MeSH primário: Mapeamento Encefálico
Neoplasias Encefálicas
Neuroimagem Funcional/métodos
Córtex Motor
Transtornos Motores
Distúrbios da Fala
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/fisiopatologia
Neoplasias Encefálicas/cirurgia
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Córtex Motor/diagnóstico por imagem
Córtex Motor/fisiopatologia
Córtex Motor/cirurgia
Transtornos Motores/diagnóstico por imagem
Transtornos Motores/fisiopatologia
Transtornos Motores/cirurgia
Distúrbios da Fala/diagnóstico por imagem
Distúrbios da Fala/fisiopatologia
Distúrbios da Fala/cirurgia
Estimulação Transcraniana por Corrente Contínua/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.17116/neiro201780739-50


  9 / 167 MEDLINE  
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[PMID]:28283581
[Au] Autor:Satake T; Yamashita K; Hayashi K; Miyatake S; Tamura-Nakano M; Doi H; Furuta Y; Shioi G; Miura E; Takeo YH; Yoshida K; Yahikozawa H; Matsumoto N; Yuzaki M; Suzuki A
[Ad] Endereço:Molecular Cellular Biology Laboratory, Yokohama City University Graduate School of Medical Life Science, Tsurumi-ku Yokohama, Japan.
[Ti] Título:MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment.
[So] Source:EMBO J;36(9):1227-1242, 2017 May 02.
[Is] ISSN:1460-2075
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The axon initial segment (AIS) is a specialized domain essential for neuronal function, the formation of which begins with localization of an ankyrin-G (AnkG) scaffold. However, the mechanism directing and maintaining AnkG localization is largely unknown. In this study, we demonstrate that knockdown of microtubule cross-linking factor 1 (MTCL1) in cerebellar Purkinje cells causes loss of axonal polarity coupled with AnkG mislocalization. MTCL1 lacking MT-stabilizing activity failed to restore these defects, and stable MT bundles spanning the AIS were disorganized in knockdown cells. Interestingly, during early postnatal development, colocalization of MTCL1 with these stable MT bundles was observed prominently in the axon hillock and proximal axon. These results indicate that MTCL1-mediated formation of stable MT bundles is crucial for maintenance of AnkG localization. We also demonstrate that gene disruption results in abnormal motor coordination with Purkinje cell degeneration, and provide evidence suggesting possible involvement of MTCL1 dysfunction in the pathogenesis of spinocerebellar ataxia.
[Mh] Termos MeSH primário: Segmento Inicial do Axônio/fisiologia
Proteínas Associadas aos Microtúbulos/metabolismo
Células de Purkinje/citologia
Células de Purkinje/fisiologia
[Mh] Termos MeSH secundário: Animais
Técnicas de Silenciamento de Genes
Técnicas de Inativação de Genes
Camundongos
Camundongos Knockout
Transtornos Motores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MTCL1 protein, mouse); 0 (Microtubule-Associated Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.15252/embj.201695630


  10 / 167 MEDLINE  
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[PMID]:28274397
[Au] Autor:Rades D; Veninga T; Conde-Moreno AJ; Cacicedo J; Metz M; Segedin B; Norkus D; Rudat V; Schild SE
[Ad] Endereço:Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. Electronic address: Rades.Dirk@gmx.net.
[Ti] Título:Results of a multicenter study investigating the potential impact of the overall treatment time on outcomes of radiation therapy alone with 5×4 Gy for metastatic epidural spinal cord compression.
[So] Source:Pract Radiat Oncol;7(2):137-144, 2017 Mar - Apr.
[Is] ISSN:1879-8519
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE/OBJECTIVE: A 5×4 Gy program is commonly used for metastatic epidural spinal cord compression (MESCC). It is unclear whether an overall treatment time (OTT) of 5 days (5 consecutive fractions) results in better outcomes than an OTT of 7 days (ie, no irradiation during the weekend). METHODS AND MATERIALS: A total of 111 patients who received 5×4 Gy over 5 consecutive days were retrospectively compared with 277 patients treated with 5×4 Gy over 7 days (no irradiation during the weekend) for effect on motor function, local control of MESCC, and overall survival (OS). Ten further characteristics were evaluated: age, gender, interval tumor diagnosis to MESCC, visceral metastases, other bone metastases, primary tumor type, time developing motor deficits, walking ability, vertebrae involved, and performance status. RESULTS: On multivariate analysis regarding post-radiation therapy motor function, primary tumor type (P = .011) and time developing motor weakness (P < .001) were significant, whereas the OTT did not even achieve significance on univariate analysis (P = .99). On multivariate analysis of local control, visceral metastases (P = .006) were significant. Again, the OTT was not even significant on univariate analysis (P = .81). On multivariate analysis of OS, interval tumor diagnosis to MESCC (P = .015), visceral metastases (P .001), tumor type (P = .003), walking ability (P < .001), and Eastern Cooperative Oncology Group performance score (P < .001) achieved significance. Even on univariate analysis, OTT did not have an effect on OS (P = .79). CONCLUSIONS: Longer OTT did not impair outcomes of irradiation with 5×4 Gy for MESCC; thus, no compensation (for example an additional radiation fraction) is necessary if the radiation treatment is not continued during the weekend.
[Mh] Termos MeSH primário: Fracionamento de Dose
Neoplasias Epidurais/radioterapia
Compressão da Medula Espinal/radioterapia
[Mh] Termos MeSH secundário: Idoso
Neoplasias Epidurais/complicações
Neoplasias Epidurais/secundário
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos Motores/diagnóstico
Transtornos Motores/etiologia
Análise Multivariada
Prognóstico
Lesões por Radiação/diagnóstico
Lesões por Radiação/etiologia
Estudos Retrospectivos
Compressão da Medula Espinal/etiologia
Fatores de Tempo
Resultado do Tratamento
Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE



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