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[PMID]:28449599
[Au] Autor:Weikum D; Shrestha R; Ferro EG; Vagenas P; Copenhaver M; Spudich S; Alpert MD; Cabello R; Lama JR; Sanchez J; Altice FL
[Ad] Endereço:a Section of Infectious Diseases, AIDS Program , Yale School of Medicine , New Haven , CT , USA.
[Ti] Título:An explanatory factor analysis of a brief self-report scale to detect neurocognitive impairment among HIV-positive men who have sex with men and transgender women in Peru.
[So] Source:AIDS Care;29(10):1297-1301, 2017 Oct.
[Is] ISSN:1360-0451
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurocognitive impairment (NCI) has been associated with poor clinical outcomes in various patient populations. This study used exploratory factor analysis (EFA) to examine the factor structure of the existing 95-item Neuropsychological Impairment Scale (NIS) to create a suitable NCI screening instrument for people living with HIV (PLH). In Lima, Peru, 313 HIV-positive men who have sex with men (MSM) and transgender women (TGW) prescribed antiretroviral therapy (ART) completed the NIS using computer-assisted self-interviews (CASI). The EFA used principal axis factoring and orthogonal varimax rotation, which resulted in 42 items with an 8-factor solution that explained 51.8% of the overall variance. The revised, 8-factor, Brief Inventory of Neurocognitive Impairment for Peru (BINI-P) showed a diverse set of factors with excellent to good reliability (i.e., F α = 0.92 to F α = 0.78). This EFA supports the use of the BINI-P to screen for NCI among Spanish-speaking, HIV-positive MSM and TGW. Future research should examine the effectiveness of the BINI-P in detecting NCI in clinical care settings and the impact of NCI on HIV health-related outcomes, including linkage and retention in care, ART adherence and HIV risk behaviors.
[Mh] Termos MeSH primário: Infecções por HIV/psicologia
Homossexualidade Masculina/psicologia
Transtornos Neurocognitivos/diagnóstico
Testes Neuropsicológicos
Pessoas Transgênero/psicologia
[Mh] Termos MeSH secundário: Adulto
Análise Fatorial
Feminino
Infecções por HIV/tratamento farmacológico
Seres Humanos
Masculino
Transtornos Neurocognitivos/psicologia
Peru
Reprodutibilidade dos Testes
Autorrelato
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/09540121.2017.1322681


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[PMID]:28461154
[Au] Autor:Roy AL
[Ad] Endereço:Laboratory of Molecular Biology and Immunology, Biomedical Research Center, National Institutes of Health/National Institute on Aging, 251 Bayview Blvd, Baltimore, MD 21224, USA. Electronic address: ananda.roy@nih.gov.
[Ti] Título:Pathophysiology of TFII-I: Old Guard Wearing New Hats.
[So] Source:Trends Mol Med;23(6):501-511, 2017 06.
[Is] ISSN:1471-499X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The biochemical properties of the signal-induced multifunctional transcription factor II-I (TFII-I) indicate that it is involved in a variety of gene regulatory processes. Although gene ablation in murine models and cell-based assays show that it is encoded by an essential gene, GTF2I/Gtf2i, its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythematosus (SLE), and cancer. Here I bring together these diverse observations to illustrate its multiple pathophysiologic functions and further conjecture on how these could be related to its known biochemical properties. I expect that a better understanding of these 'structure-function' relationships would lead to future diagnostic and/or therapeutic potential.
[Mh] Termos MeSH primário: Lúpus Eritematoso Sistêmico
Proteínas de Neoplasias
Neoplasias
Transtornos Neurocognitivos
Fatores de Transcrição TFII
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Lúpus Eritematoso Sistêmico/genética
Lúpus Eritematoso Sistêmico/metabolismo
Camundongos
Proteínas de Neoplasias/genética
Proteínas de Neoplasias/metabolismo
Neoplasias/genética
Neoplasias/metabolismo
Transtornos Neurocognitivos/genética
Transtornos Neurocognitivos/metabolismo
Relação Estrutura-Atividade
Fatores de Transcrição TFII/química
Fatores de Transcrição TFII/genética
Fatores de Transcrição TFII/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Nm] Nome de substância:
0 (GTF2I protein, human); 0 (Gtf2i protein, mouse); 0 (Neoplasm Proteins); 0 (Transcription Factors, TFII)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28458492
[Au] Autor:Belete T; Medfu G; Yemiyamrew E
[Ad] Endereço:Psychiatry Unit, School of Nursing, College of Health Sciences, Mekelle University, Ethiopia.
[Ti] Título:Prevalence of HIV Associated Neurocognitive Deficit among HIV Positive People in Ethiopia: A Cross Sectional Study at Ayder Referral Hospital.
[So] Source:Ethiop J Health Sci;27(1):67-76, 2017 Jan.
[Is] ISSN:2413-7170
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: HIV associated neurocognitive deficit impairs motor activity, neuropsychiatric functioning, daily activity and work activity usually due to the immune suppression effect of the virus. Sub-Saharan region including Ethiopia is the region with the highest burden of HIV. However, a few studies are found on this aspect nationally. This study was aimed at determining the prevalence and the factors associated with cognitive impairment among HIV positive people in Ethiopia who attended Ayder Comprehensive Specialized Hospital. METHOD: A hospital based cross sectional study was employed on 234 participants selected using systematic random sampling technique. Data was collected thrpugh face-to-face interview, observation and document review. International HIV dementia scale, activity of daily living scale and Hospital Anxiety and Depression scale were used to assess neuro cognitive deficit, activity of daily living, anxiety and depression respectively. The data was analyzed by using SPSS window 20. RESULTS: About 88% of the subjects were receiving highly active antiretroviral therapy. The magnitude of Neuro cognitive deficit was 33.3% (95% CI; 27.7% - 40.6%). Impairment in the activity of daily living was observed on 9.8% of the participants. Besides, 55.6% and 67.1% had anxiety and depressive disorders respectively. Late clinical stage of the illness (AOR= 4.2 (95% CI; 1.19, 14.44)) and impairment in the activity of daily living were significantly associated with neurocognitive deficit (AOR= 7.19 (95% CI; 1.73, 21.83). CONCLUSION: A higher prevalence of neurocognitive deficit was observed that was related to impaired activity of daily living and being in late stages of the illness. Hence, this should be a strong alarm for early detection of the problem and consistent review of the treatment regimen.
[Mh] Termos MeSH primário: Infecções por HIV/epidemiologia
Transtornos Neurocognitivos/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Comorbidade
Estudos Transversais
Etiópia/epidemiologia
Feminino
Hospitais Urbanos
Seres Humanos
Masculino
Meia-Idade
Prevalência
Encaminhamento e Consulta
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29266286
[Au] Autor:Vance DE; Fazeli PL; Azuero A; Wadley VG; Jensen M; Raper JL
[Ad] Endereço:School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama.
[Ti] Título:Can computerized cognitive training reverse the diagnosis of HIV-associated neurocognitive disorder? A research protocol.
[So] Source:Res Nurs Health;41(1):11-18, 2018 02.
[Is] ISSN:1098-240X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nearly 50% of adults with HIV have some form of HIV-associated neurocognitive disorder (HAND), ranging from subtle to symptoms that interfere with everyday functioning and quality of life. HAND is diagnosed when a person performs more than 1 standard deviation below his or her normative mean on standardized measures in two or more cognitive domains (e.g., attention, speed of processing, verbal memory, executive functioning). As adults age with HIV, they are more likely to develop comorbidities such as cardiovascular disease, hypertension, and insulin resistance that may further contribute to poorer cognitive functioning and HAND. Certain computerized cognitive training programs may be able to improve specific cognitive domains in those with HIV. Such programs may be effective in changing the diagnosis of HAND in cognitively vulnerable adults. In this article, we describe the design and methods of TOPS-the Training On Purpose Study. In this on-going experimental study, 146 older adults (50+) with HAND are randomized to either: (i) an Individualized-Targeted Cognitive Training group, or (ii) a no-contact control group. This study targets those cognitive domains in which participants experience a deficit and trains participants with the corresponding computerized cognitive training program for that domain. An Individualized Targeted Cognitive Training approach using cognitive-domain-specific cognitive training programs may offer symptom relief to those individuals diagnosed with HAND, which may actually reverse this diagnosis. Given that these cognitive training programs are commercially available, this approach represents a potential paradigm shift in how HAND is considered and treated.
[Mh] Termos MeSH primário: Terapia Cognitiva/métodos
Instrução por Computador/métodos
Infecções por HIV/complicações
Infecções por HIV/psicologia
Transtornos Neurocognitivos/etiologia
Transtornos Neurocognitivos/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1002/nur.21841


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[PMID]:29198722
[Au] Autor:Palmer EE; Kumar R; Gordon CT; Shaw M; Hubert L; Carroll R; Rio M; Murray L; Leffler M; Dudding-Byth T; Oufadem M; Lalani SR; Lewis AM; Xia F; Tam A; Webster R; Brammah S; Filippini F; Pollard J; Spies J; Minoche AE; Cowley MJ; Risen S; Powell-Hamilton NN; Tusi JE; Immken L; Nagakura H; Bole-Feysot C; Nitschké P; Garrigue A; de Saint Basile G; Kivuva E; Scott RH; Rendon A; Munnich A; Newman W; Kerr B; Besmond C; Rosenfeld JA; Amiel J; Field M; Gecz J; DDD Study
[Ad] Endereço:Genetics of Learning Disability Service, Hunter Genetics, Waratah, NSW 2298, Australia; School of Women and Children's Health, University of New South Wales, Randwick, NSW 2031, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
[Ti] Título:A Recurrent De Novo Nonsense Variant in ZSWIM6 Results in Severe Intellectual Disability without Frontonasal or Limb Malformations.
[So] Source:Am J Hum Genet;101(6):995-1005, 2017 Dec 07.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A recurrent de novo missense variant within the C-terminal Sin3-like domain of ZSWIM6 was previously reported to cause acromelic frontonasal dysostosis (AFND), an autosomal-dominant severe frontonasal and limb malformation syndrome, associated with neurocognitive and motor delay, via a proposed gain-of-function effect. We present detailed phenotypic information on seven unrelated individuals with a recurrent de novo nonsense variant (c.2737C>T [p.Arg913Ter]) in the penultimate exon of ZSWIM6 who have severe-profound intellectual disability and additional central and peripheral nervous system symptoms but an absence of frontonasal or limb malformations. We show that the c.2737C>T variant does not trigger nonsense-mediated decay of the ZSWIM6 mRNA in affected individual-derived cells. This finding supports the existence of a truncated ZSWIM6 protein lacking the Sin3-like domain, which could have a dominant-negative effect. This study builds support for a key role for ZSWIM6 in neuronal development and function, in addition to its putative roles in limb and craniofacial development, and provides a striking example of different variants in the same gene leading to distinct phenotypes.
[Mh] Termos MeSH primário: Proteínas de Ligação a DNA/genética
Deficiência Intelectual/genética
Transtornos Neurocognitivos/genética
[Mh] Termos MeSH secundário: Sistema Nervoso Central/anormalidades
Sistema Nervoso Central/embriologia
Códon sem Sentido/genética
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Deformidades Congênitas dos Membros/genética
Disostose Mandibulofacial/genética
Sistema Nervoso Periférico/anormalidades
Sistema Nervoso Periférico/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon, Nonsense); 0 (DNA-Binding Proteins); 0 (ZSWIM6 protein, human)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:27771876
[Au] Autor:Stoff DM; Colosi D; Rubtsova A; Wingood G
[Ad] Endereço:National Institute of Mental Health, Bethesda, MD, USA. dstoff@mail.nih.gov.
[Ti] Título:HIV and Aging Research in Women: An Overview.
[So] Source:Curr HIV/AIDS Rep;13(6):383-391, 2016 Dec.
[Is] ISSN:1548-3576
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper reviews some background issues as a foundation to place the ensuing supplement papers of this special issue section in context. The articles in this special supplement issue deepen and expand our understanding of biomedical, neurocognitive, and psychosocial aspects involved in human immunodeficiency virus (HIV) of older women, primarily through the use of the Women's Interagency HIV Study (WIHS) prospective cohort study. As it relates to research on the intersection between HIV and aging in women, we discuss (i) epidemiology as introduction, (ii) the cohort study design featuring the WIHS, (iii) definitions, (iv) models, and (v) section articles.
[Mh] Termos MeSH primário: Envelhecimento
Infecções por HIV
Saúde da Mulher
[Mh] Termos MeSH secundário: Idoso
Pesquisa Biomédica
Feminino
Seres Humanos
Meia-Idade
Transtornos Neurocognitivos
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28453871
[Au] Autor:Shabani E; Ouma BJ; Idro R; Bangirana P; Opoka RO; Park GS; Conroy AL; John CC
[Ad] Endereço:Department of Pediatrics, Division of Global Pediatrics, University of Minnesota, Minneapolis, MN, USA.
[Ti] Título:Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.
[So] Source:Parasite Immunol;39(7), 2017 Jul.
[Is] ISSN:1365-3024
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Systemic tumour necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration. However, less is known about the role of central nervous system (CNS) TNF-α in CM. We assessed plasma (n=249) and cerebrospinal fluid (CSF) (n=167) TNF-α levels in Ugandan children with CM, plasma TNF-α in Ugandan community control children (n=198) and CSF TNF-α in North American control children who had recovered from leukaemia (n=13). Plasma and CSF TNF-α were measured by magnetic bead assay. We compared plasma and CSF TNF-α levels in children with CM to mortality, acute and chronic neurologic deficits and long-term neurocognitive impairment. Plasma and CSF TNF-α levels were higher in CM than control children (P<.0001 for both). CSF TNF-α levels were higher in children who had neurologic deficits at discharge or 6-month follow-up (P≤.05 for both). Elevated CSF but not plasma TNF-α was associated with longer coma duration (Spearman's rho .18, P=.02) and deficits in overall cognition in children 5 years and older (ß coefficient -.74, 95% CI -1.35 to -0.13, P=.02). The study findings suggest that CNS TNF-α may be involved in the development of acute and chronic neurologic and cognitive sequelae in children with CM.
[Mh] Termos MeSH primário: Transtornos Cognitivos/etiologia
Malária Cerebral/complicações
Transtornos Neurocognitivos/etiologia
Plasmodium falciparum/imunologia
Fator de Necrose Tumoral alfa/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Transtornos Cognitivos/líquido cefalorraquidiano
Transtornos Cognitivos/epidemiologia
Transtornos Cognitivos/parasitologia
Estudos de Coortes
Feminino
Seres Humanos
Lactente
Malária Cerebral/líquido cefalorraquidiano
Malária Cerebral/epidemiologia
Malária Cerebral/imunologia
Masculino
Transtornos Neurocognitivos/líquido cefalorraquidiano
Transtornos Neurocognitivos/epidemiologia
Transtornos Neurocognitivos/parasitologia
Estudos Prospectivos
Fator de Necrose Tumoral alfa/sangue
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/pim.12438


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[PMID]:29195572
[Au] Autor:Benedetto U; Caputo M; Guida G; Bucciarelli-Ducci C; Thai J; Bryan A; Angelini GD
[Ad] Endereço:Bristol Heart Institute, University of Bristol, School of Clinical Sciences, Bristol, UK. Electronic address: umberto.benedetto@bristol.ac.uk.
[Ti] Título:Carbon Dioxide Insufflation During Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials.
[So] Source:Semin Thorac Cardiovasc Surg;29(3):301-310, 2017 Autumn.
[Is] ISSN:1532-9488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the widespread use of carbon dioxide insufflation (CDI) in cardiac surgery, there is still paucity of evidence to prove its benefit in terms of neurologic protection. Therefore, we conducted a meta-analysis of available randomized controlled trials comparing CDI vs standard de-airing maneuvers. Electronic searches were performed to identify relevant randomized controlled trials. Primary outcomes investigated were postoperative stroke, neurocognitive deterioration, and in-hospital mortality. Risk difference (RD) was used as summary statistic. Pooled estimates were obtained by means of random-effects model to account for possible clinical diversity and methodological variation between studies. Eight studies were identified with 668 patients randomized to CDI (n = 332) vs standard de-airing maneuvers (n = 336). In-hospital mortality was 2.1% vs 3.0% in the CDI and control group, respectively (RD 0%; 95% confidence interval [CI] -2% to 2%; P = 0.87; I = 0%). Incidence of stroke was similar between the 2 groups (1.0% vs 1.2% in the CDI and control group, respectively; RD 0%; 95% CI -1% to 2%; P = 0.62; I = 0%). Neurocognitive deterioration rate was 12% vs 21% in the CDI and control group, respectively, but this difference was not statistically significant (RD: -7%; 95% CI -0.22% to 8%; P = 0.35; I = 0%). The present meta-analysis did not find any significant protective effect from the use of CDI when compared with manual de-airing maneuvers in terms of clinical outcomes, including postoperative neurocognitive decline.
[Mh] Termos MeSH primário: Dióxido de Carbono/administração & dosagem
Procedimentos Cirúrgicos Cardíacos/efeitos adversos
Sistema Nervoso Central/efeitos dos fármacos
Cognição/efeitos dos fármacos
Insuflação/métodos
Transtornos Neurocognitivos/prevenção & controle
[Mh] Termos MeSH secundário: Dióxido de Carbono/efeitos adversos
Procedimentos Cirúrgicos Cardíacos/mortalidade
Sistema Nervoso Central/fisiopatologia
Distribuição de Qui-Quadrado
Mortalidade Hospitalar
Seres Humanos
Insuflação/efeitos adversos
Insuflação/mortalidade
Transtornos Neurocognitivos/mortalidade
Transtornos Neurocognitivos/fisiopatologia
Transtornos Neurocognitivos/psicologia
Razão de Chances
Ensaios Clínicos Controlados Aleatórios como Assunto
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE


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[PMID]:28953682
[Au] Autor:Han L; Jia Z; Cao C; Liu Z; Liu F; Wang L; Ren W; Sun M; Wang B; Li C; Chen L
[Ad] Endereço:aDepartment of Endocrinology Qilu Hospital of Shandong University, Jinan bGout Laboratory, The Affiliated Hospital of Qingdao University, Qingdao cState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
[Ti] Título:Potential contribution of the neurodegenerative disorders risk loci to cognitive performance in an elderly male gout population.
[So] Source:Medicine (Baltimore);96(39):e8195, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cognitive impairment has been described in elderly subjects with high normal concentrations of serum uric acid. However, it remains unclear if gout confers an increased poorer cognition than those in individuals with asymptomatic hyperuricemia. The present study aimed at evaluating cognitive function in patients suffering from gout in an elderly male population, and further investigating the genetic contributions to the risk of cognitive function.This study examined the cognitive function as assessed by Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) in 205 male gout patients and 204 controls. The genetic basis of these cognitive measures was evaluated by genome-wide association study (GWAS) data in 102 male gout patients. Furthermore, 7 loci associated with cognition in GWAS were studied for correlation with gout in 1179 male gout patients and 1848 healthy male controls.Compared with controls, gout patients had significantly lower MoCA scores [22.78 ±â€Š3.01 vs 23.42 ±â€Š2.95, P = .023, adjusted by age, body mass index (BMI), education, and emotional disorder]. GWAS revealed 7 single-nucleotide polymorphisms (SNPs) associations with MoCA test at a level of conventional genome-wide significance (P < 9.6 × 10). The most significant association was observed between rs12895072 and rs12434554 within the KTN1 gene (Padjusted = 4.2 × 10, Padjusted = 4.7 × 10) at 14q22. The next best signal was in RELN gene (rs155333, Padjusted = 1.3 × 10) at 7q22, while the other variants at rs17458357 (Padjusted = 3.98 × 10), rs2572683 (Padjusted = 8.9 × 10), rs12555895 (Padjusted = 2.6 × 10), and rs3764030 (Padjusted = 9.4 × 10) were also statistically significant. The 7 SNPs were not associated with gout in further analysis (all P > .05).Elderly male subjects with gout exhibit accelerated decline in cognition performance. Several neurodegenerative disorders risk loci were identified for genetic contributors to cognitive performance in our Chinese elderly male gout population. Larger prospective studies of the cognitive performance and genetic analysis in gout subjects are recommended.
[Mh] Termos MeSH primário: Moléculas de Adesão Celular Neuronais/genética
Cognição/fisiologia
Proteínas da Matriz Extracelular/genética
Gota
Proteínas de Membrana/genética
Proteínas do Tecido Nervoso/genética
Transtornos Neurocognitivos
Serina Endopeptidases/genética
[Mh] Termos MeSH secundário: Idoso
China/epidemiologia
Testes Genéticos
Estudo de Associação Genômica Ampla
Gota/sangue
Gota/complicações
Gota/epidemiologia
Gota/psicologia
Seres Humanos
Testes de Inteligência
Masculino
Meia-Idade
Transtornos Neurocognitivos/diagnóstico
Transtornos Neurocognitivos/epidemiologia
Transtornos Neurocognitivos/genética
Transtornos Neurocognitivos/fisiopatologia
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Adhesion Molecules, Neuronal); 0 (Extracellular Matrix Proteins); 0 (KTN1 protein, human); 0 (Membrane Proteins); 0 (Nerve Tissue Proteins); EC 3.4.21.- (Serine Endopeptidases); EC 3.4.21.- (reelin protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008195


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[PMID]:28809653
[Au] Autor:Jensen L; Padilla R
[Ad] Endereço:Lou Jensen, OTD, OTR/L, is Assistant Professor of Occupational Therapy, Creighton University, Omaha, NE; loujensen@creighton.edu.
[Ti] Título:Effectiveness of Environment-Based Interventions That Address Behavior, Perception, and Falls in People With Alzheimer's Disease and Related Major Neurocognitive Disorders: A Systematic Review.
[So] Source:Am J Occup Ther;71(5):7105180030p1-7105180030p10, 2017 Sep/Oct.
[Is] ISSN:0272-9490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This systematic review evaluated the effectiveness of environment-based interventions that address behavior, perception, and falls in the home and other settings for people with Alzheimer's disease (AD) and related major neurocognitive disorders (NCDs). METHOD: Database searches were limited to outcomes studies published in English in peer-reviewed journals between January 2006 and April 2014. RESULTS: A total of 1,854 articles were initially identified, of which 42 met inclusion criteria. CONCLUSION: Strong evidence indicates that person-centered approaches can improve behavior. Moderate evidence supports noise regulation, environmental design, unobtrusive visual barriers, and environmental relocation strategies to reduce problematic behaviors. Evidence is insufficient for the effectiveness of mealtime ambient music, bright light, proprioceptive input, wander gardens, optical strategies, and sensory devices in improving behavior or reducing wandering and falls. Although evidence supports many environment-based interventions used by occupational therapy practitioners to address behavior, perception, and falls in people with AD and related major NCDs, more studies are needed.
[Mh] Termos MeSH primário: Acidentes por Quedas/prevenção & controle
Doença de Alzheimer/reabilitação
Terapia Ocupacional/métodos
Comportamento Problema
Comportamento Errante
[Mh] Termos MeSH secundário: Seres Humanos
Transtornos Neurocognitivos/reabilitação
Terapias Sensoriais através das Artes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.5014/ajot.2017.027409



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