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[PMID]: 29362376 [Au] Autor: Ullman JC; Yang J; Sullivan M; Bendor J; Levy J; Pham E; Silm K; Seifikar H; Sohal VS; Nicoll RA; Edwards RH [Ad] Endereço: Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA. [Ti] Título: A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. [So] Source: Nat Commun;9(1):330, 2018 01 23. [Is] ISSN: 2041-1723 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood. Interestingly, recent human genetic studies have implicated the endosomal Na /H exchanger NHE9 in both autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). Plasma membrane NHEs regulate cytosolic pH, but the role of intracellular isoforms has remained unclear. We now find that inactivation of NHE9 in mice reproduces behavioral features of ASD including impaired social interaction, repetitive behaviors, and altered sensory processing. Physiological characterization reveals hyperacidic endosomes, a cell-autonomous defect in glutamate receptor expression and impaired neurotransmitter release due to a defect in presynaptic Ca entry. Acute inhibition of synaptic vesicle acidification rescues release but without affecting the primary defect due to loss of NHE9. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/metabolismo Transtorno do Espectro Autista/metabolismo Cálcio/metabolismo Endossomos/metabolismo Neurônios/metabolismo Trocadores de Sódio-Hidrogênio/genética [Mh] Termos MeSH secundário: Animais Transtorno do Deficit de Atenção com Hiperatividade/genética Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia Transtorno do Espectro Autista/genética Transtorno do Espectro Autista/fisiopatologia Comportamento Animal Modelos Animais de Doenças Eletroencefalografia Endossomos/patologia Feminino Expressão Gênica Ácido Glutâmico/metabolismo Hipocampo/metabolismo Hipocampo/fisiopatologia Seres Humanos Concentração de Íons de Hidrogênio Masculino Camundongos Camundongos Knockout Neurônios/patologia Terminações Pré-Sinápticas/metabolismo Terminações Pré-Sinápticas/patologia Cultura Primária de Células Trocadores de Sódio-Hidrogênio/deficiência Transmissão Sináptica/fisiologia Vesículas Sinápticas/metabolismo Vesículas Sinápticas/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (NHE9 protein, mouse); 0 (Sodium-Hydrogen Exchangers); 3KX376GY7L (Glutamic Acid); SY7Q814VUP (Calcium) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180125 [St] Status: MEDLINE [do] DOI: 10.1038/s41467-017-02716-5

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[PMID]: 27771175 [Au] Autor: Chang C; Gau SS; Huang WS; Shiue CY; Yeh CB [Ad] Endereço: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. [Ti] Título: Abnormal serotonin transporter availability in the brains of adults with conduct disorder. [So] Source: J Formos Med Assoc;116(6):469-475, 2017 Jun. [Is] ISSN: 0929-6646 [Cp] País de publicação: Singapore [La] Idioma: eng [Ab] Resumo: BACKGROUND/PURPOSE: The aims of the current study were to determine whether patients with conduct disorder (CD) showed an abnormal availability of serotonin reuptake transporter (SERT), and if their hyperkinetic symptoms, impulsivity, and quality of life were correlated with the availability of SERT. METHODS: We recruited 14 drug-naïve patients with CD and eight age-matched healthy controls (HCs). The adult attention-deficit/hyperactivity disorder (ADHD) self-report scale (ASRS), Barrett impulsivity scale (BIS), and the World Health Organization quality of life-brief version (WHOQOL-BREF) scale were administered. Positron emission tomography (PET) of the brain with 4-[ F]-ADAM was arranged for SERT imaging. RESULTS: SERT availability was significantly reduced in the striatum and midbrain of patients with CD. Quality of life and inattention symptoms were also significantly correlated with the availability of SERT in the prefrontal cortex. CONCLUSION: The study suggested that a reduction in the availability of SERT might be associated with CD and could potentially predict poor quality of life or symptoms of inattention for these patients. The implications of our results might be limited to individuals with CD; a future study with a larger sample to validate our preliminary results is warranted. [Mh] Termos MeSH primário: Encéfalo/metabolismo Transtorno da Conduta/metabolismo Proteínas da Membrana Plasmática de Transporte de Serotonina/metabolismo [Mh] Termos MeSH secundário: Adulto Transtorno do Deficit de Atenção com Hiperatividade/metabolismo Encéfalo/diagnóstico por imagem Estudos de Casos e Controles Seres Humanos Masculino Tomografia por Emissão de Pósitrons Qualidade de Vida [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (SLC6A4 protein, human); 0 (Serotonin Plasma Membrane Transport Proteins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 29292940 [Au] Autor: Johansson E [Ad] Endereço: Karolinska Institutet - Enheten för dermatologi och venereologi, Institutionen för medicin Solna Stockholm, Sweden Karolinska Institutet - Enheten för dermatologi och venereologi, Institutionen för medicin Solna Stockholm, Sweden. [Ti] Título: Atopiskt eksem vanligt i alla åldrar - Nya rön om samsjuklighet till atopiskt eksem.. [So] Source: Lakartidningen;114, 2017 Nov 21. [Is] ISSN: 1652-7518 [Cp] País de publicação: Sweden [La] Idioma: swe [Ab] Resumo: Atopic eczema common at all ages Eczema (atopic dermatitis) is an inflammatory skin disorder with dry skin and recurrent episodes of inflammation and itch. Onset is most common the first two years of life, but also occurs among older children, adolescents and adults. The prevalence of eczema has increased in Sweden and other industrialized countries the last decades; 15-30% of children and 2-10% of adults are affected. Approximately half of children with eczema early in life are in remission in adolescence. However, many of these will relapse later in life, often as hand eczema. Children with eczema are at increased risk to develop IgE sensitization to common food- and airborne allergens, food allergy, asthma and rhinitis. In addition, recent studies have reported that having eczema is associated with non-allergic disorders such as ADHD, depression and anxiety, epilepsy, overweight and obesity, cardiovascular disease, and different kinds of malignancies. There are also studies that have not found an association between eczema and the above mentioned non-allergic comorbidities. Thus, the association between eczema and non-allergic comorbidities are still largely unknown. [Mh] Termos MeSH primário: Dermatite Atópica [Mh] Termos MeSH secundário: Adolescente Adulto Fatores Etários Idoso Asma/epidemiologia Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia Criança Pré-Escolar Comorbidade Dermatite Atópica/diagnóstico Dermatite Atópica/epidemiologia Dermatite Atópica/etiologia Dermatite Atópica/patologia Seres Humanos Imunoglobulina E/imunologia Lactente Meia-Idade Rinite/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 37341-29-0 (Immunoglobulin E) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180103 [St] Status: MEDLINE

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[PMID]: 28458999 [Au] Autor: Sethi A; Evelyn-Rahr E; Dowell N; Jain S; Voon V; Critchley HD; Harrison NA; Cercignani M [Ad] Endereço: Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, Brighton, UK. [Ti] Título: Magnetization transfer imaging identifies basal ganglia abnormalities in adult ADHD that are invisible to conventional T1 weighted voxel-based morphometry. [So] Source: Neuroimage Clin;15:8-14, 2017. [Is] ISSN: 2213-1582 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: In childhood, Attention Deficit Hyperactivity Disorder (ADHD) is reliably associated with reduced volume of the striatum. In contrast, striatal abnormalities are infrequently detected in voxel-based morphometry (VBM) neuroimaging studies of adults with ADHD. This discrepancy has been suggested to reflect normalisation of striatal morphology with age and prolonged treatment of symptoms. If so, this would indicate that while striatal abnormalities are linked to symptom expression in childhood, they cannot explain the persistence of these symptoms in adulthood. However, this may not be case. Instead, we hypothesized that the lack of evidence for striatal abnormalities in adult ADHD may reflect poor sensitivity of typical (T1-weighted) neuroimaging to detect subcortical differences. To address this, we acquired both magnetisation transfer (MT) saturation maps optimised for subcortical contrast, and conventional T1-weighted images in 30 adults with ADHD and 30 age, IQ, gender and handedness-matched controls. Using VBM of both datasets, we demonstrate volumetric reductions within the left ventral striatum on MT that are not observed on identically pre-processed T1-weighted images from the same participants. Nevertheless, both techniques reported similar sensitivity to cortical abnormalities in the right inferior parietal lobe. Additionally, we show that differences in striatal iron may potentially explain this reduced sensitivity of T1-weighted images in adults. Together, these findings indicate that prior VBM studies reporting no abnormalities in striatal volume in adult ADHD might have been compromised by the methodological insensitivity of T1-weighted VBM to subcortical differences, and that structural abnormalities of the striatum in ADHD do indeed persist into adulthood. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico por imagem Gânglios da Base/diagnóstico por imagem Mapeamento Encefálico/métodos Imagem por Ressonância Magnética/métodos [Mh] Termos MeSH secundário: Adulto Transtorno do Deficit de Atenção com Hiperatividade/metabolismo Gânglios da Base/metabolismo Feminino Seres Humanos Ferro/metabolismo Masculino Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: E1UOL152H7 (Iron) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE [do] DOI: 10.1016/j.nicl.2017.03.012

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[PMID]: 29386446 [Au] Autor: Hirasawa K [Ad] Endereço: Department of Pediatrics, Tokyo Women's Medical University. [Ti] Título: [Topics on Child Development in Pediatrics]. [So] Source: Nihon Eiseigaku Zasshi;73(1):46-50, 2018. [Is] ISSN: 1882-6482 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: Over the past few decades, advances in neonatal medicine have increased survival rates among very-low-birth-weight (VLBW) babies. Despite improvements in short-term outcomes, there is increasing concern about the probability of mild cognitive dysfunction in this population. Our analysis of VLBW babies born in our hospital revealed that the incidence of mild developmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactive disorder (ADHD) at the age of 3 years is 7.2%, which is markedly higher than the 2.8% incidence of ASD in the general population. Because problems related to ASD or ADHD tend to become more prominent as children grow up, the ages at diagnosis of developmental disorders are generally 6 years or above. Thus, in our follow up study of VLBW babies at age 6, the incidence of these developmental disorders had risen to 30%. These patients are apparently obstinate and difficult to train, causing parental problems with child care. It is important to support these children and help them establish good relationships with their parents. Given these problems, it is necessary to follow up VLBW children in the longterm, at least until they are elementary school students. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade Transtorno do Espectro Autista Disfunção Cognitiva Deficiências do Desenvolvimento Recém-Nascido de muito Baixo Peso [Mh] Termos MeSH secundário: Fatores Etários Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia Transtorno do Espectro Autista/epidemiologia Criança Pré-Escolar Disfunção Cognitiva/epidemiologia Deficiências do Desenvolvimento/epidemiologia Intervenção Precoce (Educação) Seguimentos Seres Humanos Incidência Lactente Recém-Nascido [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180228 [Lr] Data última revisão: 180228 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180202 [St] Status: MEDLINE [do] DOI: 10.1265/jjh.73.46

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[PMID]: 29206949 [Au] Autor: Wan ESF; Ma JLC; Lai KYC; Lo JWK [Ad] Endereço: Department of Psychiatry, and Department of Social Work, The Chinese University of Hong Kong, Shatin. [Ti] Título: The Subjective Experiences of Attention-Deficit/Hyperactivity Disorder of Chinese Families in Hong Kong: Co-Construction of Meanings in Multiple Family Groups. [So] Source: Health Soc Work;41(3):164-172, 2016 Aug 01. [Is] ISSN: 0360-7283 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The subjective experiences of Chinese children in Hong Kong with attention-deficit/hyperactivity disorder (ADHD) are underexplored. This article reports the results of a qualitative study that aims to understand the subjective experiences of children with ADHD in Hong Kong, taken from among a clinical sample of Chinese families with children struggling with ADHD who have participated in cross-disciplinary research of multiple family groups (MFG). The participating children revealed the subjective experiences of their struggle with the disorder in response to their parents' concern at a "press conference," one of the MFG activities, which underscored the importance of developing a new social work model to meet the multiple psychosocial service needs of these families. The article concludes with the discussion of the implications for the new model. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/psicologia Família/psicologia Relações Pais-Filho [Mh] Termos MeSH secundário: Adaptação Psicológica Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico Conscientização Criança Feminino Necessidades e Demandas de Serviços de Saúde Hong Kong Seres Humanos Masculino Pesquisa Qualitativa Estigma Social Inquéritos e Questionários [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171206 [St] Status: MEDLINE [do] DOI: 10.1093/hsw/hlw023

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[PMID]: 29339866 [Au] Autor: Wasserman RM; Stoner AM; Stern A; Holmbeck GN [Ad] Endereço: Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas. [Ti] Título: ADHD and Attention Problems in Children With and Without Spina Bifida. [So] Source: Top Spinal Cord Inj Rehabil;22(4):253-259, 2016. [Is] ISSN: 1945-5763 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: To identify differences in the diagnosis and treatment of attention deficit/hyperactivity disorder (ADHD) between typically developing children and children with spina bifida. Sixty-eight children with spina bifida and 68 demographically matched, typically developing children participated in a larger, longitudinal study. Rates of maternal, paternal, and teacher reports of attention problems, as well as rates of maternal reports of ADHD diagnosis, diagnosing provider, pharmaceutical treatment, mental health treatment, and academic accommodations were obtained at 5 time points over a period of 8 years and were compared across groups. Children with spina bifida were more likely to have an ADHD diagnosis and attention problems. Attention problems and ADHD diagnoses were first reported at earlier time points for children with spina bifida than typically developing children. Among children with ADHD or attention problems, children with spina bifida were more likely to be treated with medication, but they were just as likely to use mental health services and receive resource services at school. Children with spina bifida were diagnosed with ADHD and identified as having attention problems more frequently and at an earlier age. This finding could be due to earlier symptom development, greater parental awareness, or more contact with providers. Among those with ADHD or attention problems, stimulant medication was more likely to be prescribed to children with spina bifida, despite research that suggests it may not be as beneficial for them. Further research on the effectiveness of ADHD pharmacological treatment for children with spina bifida is recommended. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/complicações Disrafismo Espinal/complicações [Mh] Termos MeSH secundário: Atenção Estudos de Casos e Controles Estimulantes do Sistema Nervoso Central Criança Feminino Seres Humanos Estudos Longitudinais Masculino [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Central Nervous System Stimulants) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180118 [St] Status: MEDLINE [do] DOI: 10.1310/sci2204-253

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[PMID]: 28449914 [Au] Autor: Kalil Neto F; Nunes ML [Ad] Endereço: Division of Neurology, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. [Ti] Título: Evaluation of sleep organization in patients with attention deficit hyperactivity disorder (ADHD) and ADHD as a comorbidity of epilepsy. [So] Source: Sleep Med;33:91-96, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE/BACKGROUND: Epilepsy or attention deficit hyperactivity disorder (ADHD) can influence sleep organization in different ways. The aim of this study was to evaluate sleep organization in children and adolescents with ADHD and epilepsy, and to analyze the influence of methylphenidate. METHODS: This was an observational, cross-sectional study of children and adolescents with epilepsy, who were seizure free for at least three months, and were also diagnosed with ADHD. They were selected from the epilepsy and child neurology outpatient clinic of a university hospital in Brazil. After sample size calculation, patients were consecutively included into four different groups, with 21 patients each: epilepsy + ADHD using methylphenidate, epilepsy + ADHD not using methylphenidate, only ADHD, and a healthy control group. All participants were evaluated with the Sleep Disturbance Scale for Children (SDSC) and monitored with actigraphy for five nights/days. RESULTS: Actigraphic analysis showed a higher number of night awakenings in the epilepsy + ADHD groups; they were most prominent in the group without methylphenidate (p = 0.001). Parental reports demonstrated a higher risk for sleep disturbances in the epilepsy + ADHD without methylphenidate and the ADHD groups (p < 0.001). CONCLUSION: Primary ADHD as a comorbidity of epilepsy impairs sleep organization in children, and the use of short-acting methylphenidate seems to improve it. Both objective (actigraphic) and subjective (SDSC) measures showed significant sleep alterations between primary ADHD and ADHD as a comorbidity of epilepsy; this was most prominent in the group without methylphenidate. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/complicações Epilepsia/complicações Metilfenidato/efeitos adversos Transtornos do Sono-Vigília/tratamento farmacológico Sono/efeitos dos fármacos [Mh] Termos MeSH secundário: Actigrafia/métodos Adolescente Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia Brasil/epidemiologia Estimulantes do Sistema Nervoso Central/efeitos adversos Estimulantes do Sistema Nervoso Central/farmacologia Criança Comorbidade Estudos Transversais Epilepsia/diagnóstico Epilepsia/tratamento farmacológico Epilepsia/epidemiologia Feminino Seres Humanos Masculino Metilfenidato/farmacologia Transtornos do Sono-Vigília/epidemiologia Transtornos do Sono-Vigília/fisiopatologia Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 0 (Central Nervous System Stimulants); 207ZZ9QZ49 (Methylphenidate) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 27770673 [Au] Autor: Sari Gokten E; Saday Duman N; Soylu N; Uzun ME [Ad] Endereço: Yuksek Ihtisas Training ve Research Hospital, Bursa, Child and Adolescent Psychiatry, Turkey. Electronic address: esgokten@hotmail.com. [Ti] Título: Effects of attention-deficit/hyperactivity disorder on child abuse and neglect. [So] Source: Child Abuse Negl;62:1-9, 2016 12. [Is] ISSN: 1873-7757 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: It is known that children with mental and developmental problems are at risk of abuse and neglect. Attention-deficit/hyperactivity disorder is one of the most frequent neurodevelopmental disorders in children and adolescents. The purpose of this study is to examine whether children diagnosed with ADHD are under more risk in terms of child abuse and neglect compared to controls. In this case-control study, 104 children, who applied to Child and Adolescent Psychiatry Unit of Bursa Yuksek Ihtisas Training and Research Hospital between January and June 2015, were diagnosed with ADHD, and had no other psychiatric comorbidity except for disruptive behavior disorders, and 104 healthy children were compared. Abuse Assessment Questionnaire was applied to children after approval of the families was received. It was determined that the children diagnosed with ADHD were exposed to more physical (96.2%) and emotional abuse (87.5%) in a statistically significant way compared to controls (46.2%; 34.6%), they were exposed to physical and emotional neglect (5.8%) at a lower rate compared to healthy children (24.0%), and there was no difference between them and healthy children in terms of witnessing family violence (56.7%; 47.1%) and being exposed to sexual abuse (5.8%; 1.9%). The children diagnosed with ADHD were exposed to physical and emotional abuse at a higher rate; further studies should emphasize the role of parents in this topic and how parental education and treatment programs change the results. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia Transtorno do Deficit de Atenção com Hiperatividade/psicologia Maus-Tratos Infantis/estatística & dados numéricos [Mh] Termos MeSH secundário: Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico Transtornos de Deficit da Atenção e do Comportamento Disruptivo Estudos de Casos e Controles Criança Maus-Tratos Infantis/diagnóstico Maus-Tratos Infantis/psicologia Abuso Sexual na Infância/diagnóstico Abuso Sexual na Infância/psicologia Abuso Sexual na Infância/estatística & dados numéricos Comorbidade Estudos Transversais Violência Doméstica Feminino Seres Humanos Masculino Transtornos do Neurodesenvolvimento Pais/psicologia Fatores de Risco Fatores Socioeconômicos Estatística como Assunto Inquéritos e Questionários Turquia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161023 [St] Status: MEDLINE

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[PMID]: 27770470 [Au] Autor: Vanicek T; Kutzelnigg A; Philippe C; Sigurdardottir HL; James GM; Hahn A; Kranz GS; Höflich A; Kautzky A; Traub-Weidinger T; Hacker M; Wadsak W; Mitterhauser M; Kasper S; Lanzenberger R [Ad] Endereço: Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria. [Ti] Título: Altered interregional molecular associations of the serotonin transporter in attention deficit/hyperactivity disorder assessed with PET. [So] Source: Hum Brain Mapp;38(2):792-802, 2017 02. [Is] ISSN: 1097-0193 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well as increased motor activity, all exemplifying key symptoms of ADHD. The main objectives of this positron emission tomography (PET) study were to investigate the serotonin transporter binding potential (SERT BP ) in patients with ADHD and to assess associations of SERT BP between the brain regions. 25 medication-free patients with ADHD (age ± SD; 32.39 ± 10.15; 10 females) without any psychiatric comorbidity and 25 age and sex matched healthy control subjects (33.74 ± 10.20) were measured once with PET and the highly selective and specific radioligand [ C]DASB. SERT BP maps in nine a priori defined ROIs exhibiting high SERT binding were compared between groups by means of a linear mixed model. Finally, adopted from structural and functional connectivity analyses, we performed correlational analyses using regional SERT binding potentials to examine molecular interregional associations between all selected ROIs. We observed significant differences in the interregional correlations between the precuneus and the hippocampus in patients with ADHD compared to healthy controls, using SERT BP of the investigated ROIs (P < 0.05; Bonferroni corrected). When correlating SERT BP and age in the ADHD and the healthy control group, we confirmed an age-related decline in brain SERT binding in the thalamus and insula (R = 0.284, R = 0.167, Ps < 0.05; Bonferroni corrected). The results show significantly different interregional molecular associations of the SERT expression for the precuneus with hippocampus in patients with ADHD, indicating presumably altered functional coupling. Altered interregional coupling between brain regions might be a sensitive approach to demonstrate functional and molecular alterations in psychiatric conditions. Hum Brain Mapp 38:792-802, 2017. © 2016 Wiley Periodicals, Inc. [Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico por imagem Transtorno do Deficit de Atenção com Hiperatividade/metabolismo Encéfalo/diagnóstico por imagem Tomografia por Emissão de Pósitrons Proteínas da Membrana Plasmática de Transporte de Serotonina/metabolismo [Mh] Termos MeSH secundário: Adulto Encéfalo/metabolismo Estudos de Casos e Controles Feminino Seres Humanos Modelos Lineares Masculino Escalas de Graduação Psiquiátrica Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Serotonin Plasma Membrane Transport Proteins) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180217 [Lr] Data última revisão: 180217 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161026 [St] Status: MEDLINE [do] DOI: 10.1002/hbm.23418

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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