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[PMID]:27771175
[Au] Autor:Chang C; Gau SS; Huang WS; Shiue CY; Yeh CB
[Ad] Endereço:Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
[Ti] Título:Abnormal serotonin transporter availability in the brains of adults with conduct disorder.
[So] Source:J Formos Med Assoc;116(6):469-475, 2017 Jun.
[Is] ISSN:0929-6646
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/PURPOSE: The aims of the current study were to determine whether patients with conduct disorder (CD) showed an abnormal availability of serotonin reuptake transporter (SERT), and if their hyperkinetic symptoms, impulsivity, and quality of life were correlated with the availability of SERT. METHODS: We recruited 14 drug-naïve patients with CD and eight age-matched healthy controls (HCs). The adult attention-deficit/hyperactivity disorder (ADHD) self-report scale (ASRS), Barrett impulsivity scale (BIS), and the World Health Organization quality of life-brief version (WHOQOL-BREF) scale were administered. Positron emission tomography (PET) of the brain with 4-[ F]-ADAM was arranged for SERT imaging. RESULTS: SERT availability was significantly reduced in the striatum and midbrain of patients with CD. Quality of life and inattention symptoms were also significantly correlated with the availability of SERT in the prefrontal cortex. CONCLUSION: The study suggested that a reduction in the availability of SERT might be associated with CD and could potentially predict poor quality of life or symptoms of inattention for these patients. The implications of our results might be limited to individuals with CD; a future study with a larger sample to validate our preliminary results is warranted.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Transtorno da Conduta/metabolismo
Proteínas da Membrana Plasmática de Transporte de Serotonina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Transtorno do Deficit de Atenção com Hiperatividade/metabolismo
Encéfalo/diagnóstico por imagem
Estudos de Casos e Controles
Seres Humanos
Masculino
Tomografia por Emissão de Pósitrons
Qualidade de Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (SLC6A4 protein, human); 0 (Serotonin Plasma Membrane Transport Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29179827
[Au] Autor:Oruche UM; Robb SL; Aalsma M; Pescosolido B; Brown-Podgorski B; Draucker CB
[Ad] Endereço:School of Nursing, Indiana University-Purdue University Indianapolis, United States. Electronic address: uoruche@iu.edu.
[Ti] Título:Developing a Multiple Caregiver Group for Caregivers of Adolescents With Disruptive Behaviors.
[So] Source:Arch Psychiatr Nurs;31(6):596-601, 2017 12.
[Is] ISSN:1532-8228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article describes the development of a 6-week multiple caregiver group intervention for primary caregivers of adolescents diagnosed with Oppositional Defiant Disorder or Conduct Disorder in low-income African American families. The intervention is aimed at increasing the primary caregivers' self-efficacy in managing interactions within the family and especially with child serving educational, mental health, juvenile justice, and child welfare systems. Development of the intervention involved seven iterative activities performed in a collaborative effort between an interdisciplinary academic team, community engagement specialists, members of the targeted population, and clinical partners from a large public mental health system. The intervention development process described in this article can provide guidance for teams that aim to develop new mental health interventions that target specific outcomes in populations with unique needs.
[Mh] Termos MeSH primário: Cuidadores/educação
Cuidadores/psicologia
Comportamento Problema/psicologia
Autoeficácia
[Mh] Termos MeSH secundário: Adolescente
Grupo com Ancestrais do Continente Africano
Transtorno da Conduta/terapia
Feminino
Seres Humanos
Transtornos Mentais/psicologia
Pais/psicologia
Pobreza
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29173742
[Au] Autor:Wei C; Eisenberg RE; Ramos-Olazagasti MA; Wall M; Chen C; Bird HR; Canino G; Duarte CS
[Ad] Endereço:Division of Child and Adolescent Psychiatry, Columbia University Medical Center/New York State Psychiatric Institute (CUMC/NYSPI), New York.
[Ti] Título:Developmental Psychopathology in a Racial/Ethnic Minority Group: Are Cultural Risks Relevant?
[So] Source:J Am Acad Child Adolesc Psychiatry;56(12):1081-1088.e1, 2017 Dec.
[Is] ISSN:1527-5418
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The current study examined (a) the mediating role of parenting behaviors in the relationship between parental risks and youth antisocial behaviors (YASB), and (b) the role of youth cultural stress in a racial/ethnic minority group (i.e., Puerto Rican [PR] youth). METHOD: This longitudinal study consisted of 3 annual interviews of PR youth (N = 1,150; aged 10-14 years at wave 1) and their caretakers from the South Bronx (SB) in New York City and from San Juan, Puerto Rico. Parents reported on parental risks, parenting behaviors, and YASB. Youth also self-reported on YASB and youth cultural stress. A lagged structural equation model examined the relationship between these variables across 3 yearly waves, with youth cultural stress as a moderator of the association between effective parenting behaviors and YASB. RESULTS: Findings supported the positive influence of effective parenting on YASB, independently of past parental risks and past YASB: higher effective parenting significantly predicted lower YASB at the following wave. Parenting also accounted for (mediated) the association between the composite of parental risks and YASB. Youth cultural stress at wave 1 was cross-sectionally associated with higher YASB and moderated the prospective associations between effective parenting and YASB, such that for youth who perceived higher cultural stress, the positive effect of effective parenting on YASB was weakened compared to those with lower/average cultural stress. CONCLUSION: Among PR families, both parental and cultural risk factors influence YASB. Such findings should be considered when treating racial/ethnic minority youth for whom cultural factors may be a relevant influence on determining behaviors.
[Mh] Termos MeSH primário: Transtorno da Conduta/etnologia
Cultura
Hispano-Americanos/psicologia
Grupos Minoritários/psicologia
Poder Familiar/psicologia
Assunção de Riscos
Estresse Psicológico/etnologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Transtorno da Conduta/psicologia
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Modelos Psicológicos
Modelos Estatísticos
Cidade de Nova Iorque
Estudos Prospectivos
Porto Rico/etnologia
Estresse Psicológico/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29308863
[Au] Autor:Dukanac V; Dzamonja-Ignjatovic T; Milanovic M; Popovic-Citic B
[Ti] Título:Differences in temperament and character dimensions in adolescents with various conduct disorders.
[So] Source:Vojnosanit Pregl;73(4):353-9, 2016 Apr.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Adolescence is characterized both by a large developmental potential and by an increased risk for emergence of different forms of psychopathology. International classifications of mental disorders recognize the psychopathology of adolescence at the age of 15−18 through the categories of conduct disorders and some forms of addiction: chemical and non-chemical. The aim of this research was to analyse the personality structure among four groups of adolescents manifesting different types of conduct disorder based on Cloninger's Psychobiological theory of personality. Methods: The research sample consisted of 140 respondents at the age of 16−18, divided into five groups: 30 respondents manifesting socialized conduct disorder, 20 adolescents in conflict with the law, 30 respondents manifesting abuse of psychoactive substances, 30 respondents with the problem of the Internet addiction and 30 from general population. The Belgrade Adolescent Personality Inventory (BAPI) questionnaire was used for the purpose of assessment of personality. Multivariate analysis of variance (MANOVA), followed by univariate analysis of variance (ANOVA) was used to examine differences between the given groups of adolescents. Results: The results of MANOVA show differences in the personality structure among the groups, both in the dimensions of temperament, F (20,418.84) = 2.71, p < 0.001, Wilks's lambda 0.67, and in the dimensions of character, F (12,344.24) = 3.27, p < 0.001, Wilks's lambda is 0.75. Socialized conduct disorder is characterized by low selfdirectedness and average cooperativeness. Adolescents in conflict with the law have the lowest persistence, together with low self-directedness and cooperativeness. Adolescents abusing psychoactive substances have low harm avoidance and self-transcendence. Adolescents with Internet addiction are characterized by high novelty seeking (impulsivity and curiosity), low self-directedness and the lowest cooperativeness. Conclusion: The results show that the dimensions of personality can play an important role in etiopathogenesis of various disorders in adolescents.
[Mh] Termos MeSH primário: Caráter
Transtorno da Conduta/psicologia
Temperamento
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Masculino
Inventário de Personalidade
Transtornos Relacionados ao Uso de Substâncias/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141007022D


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[PMID]:28468644
[Au] Autor:Meszaros G; Horvath LO; Balazs J
[Ad] Endereço:Semmelweis University, Mental Health Sciences School Of Ph.D., Ülloi út 26, Budapest, 1085, Hungary. meszaros.gergely.83@gmail.com.
[Ti] Título:Self-injury and externalizing pathology: a systematic literature review.
[So] Source:BMC Psychiatry;17(1):160, 2017 05 03.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: During the last decade there is a growing scientific interest in nonsuicidal self-injury (NSSI). The aim of the current paper was to review systematically the literature with a special focus on the associations between self-injurious behaviours and externalizing psychopathology. An additional aim was to review terminology and measurements of self-injurious behaviour and the connection between self-injurious behaviours and suicide in the included publications. METHODS: A systematic literature search was conducted on 31st December 2016 in five databases (PubMed, OVID Medline, OVID PsycINFO, Scopus, Web of Science) with two categories of search terms (1. nonsuicidal self-injury, non-suicidal self-injury, NSSI, self-injurious behaviour, SIB, deliberate self-harm, DSH, self-injury; 2. externalizing disorder, attention deficit hyperactivity disorder, ADHD, conduct disorder, CD, oppositional defiant disorder, OD, ODD). RESULTS: Finally 35 papers were included. Eleven different terms were found for describing self-injurious behaviours and 20 methods for measuring it. NSSI has the clearest definition. All the examined externalizing psychopathologies had strong associations with self-injurious behaviours according to: higher prevalence rates in externalizing groups than in control groups, higher externalizing scores on the externalizing scales of questionnaires, higher symptom severity in self-injurious groups. Eight studies investigated the relationship between suicide and self-injurious behaviours and found high overlap between the two phenomena and similar risk factors. CONCLUSIONS: Based on the current findings the association between externalizing psychopathology and self-injurious behaviours has been proven by the scientific literature. Similarly to other reviews on self-injurious behaviours the confusion in terminology and methodology was noticed. NSSI is suggested for use as a distinct term. Further studies should investigate the role of comorbid conditions in NSSI, especially when internalizing and externalizing pathologies are both presented.
[Mh] Termos MeSH primário: Transtorno da Conduta/fisiopatologia
Comportamento Autodestrutivo/fisiopatologia
[Mh] Termos MeSH secundário: Seres Humanos
Fatores de Risco
Tentativa de Suicídio
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-017-1326-y


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[PMID]:28979965
[Au] Autor:Singham T; Viding E; Schoeler T; Arseneault L; Ronald A; Cecil CM; McCrory E; Rijsdijk F; Pingault JB
[Ad] Endereço:Division of Psychology and Language Sciences, University College London, London, England.
[Ti] Título:Concurrent and Longitudinal Contribution of Exposure to Bullying in Childhood to Mental Health: The Role of Vulnerability and Resilience.
[So] Source:JAMA Psychiatry;74(11):1112-1119, 2017 Nov 01.
[Is] ISSN:2168-6238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Exposure to bullying is associated with poor mental health. However, the degree to which observed associations reflect direct detrimental contributions of exposure to bullying to mental health remains uncertain, as noncausal relationships may arise from genetic and environmental confounding (eg, preexisting vulnerabilities). Determining to what extent exposure to bullying contributes to mental health is an important concern, with implications for primary and secondary interventions. Objective: To characterize the concurrent and longitudinal contribution of exposure to bullying to mental health in childhood and adolescence using a twin differences design to strengthen causal inference. Design, Setting, and Participants: Participants were drawn from the Twins Early Development Study, a population-based cohort recruited from population records of births in England and Wales between January 1, 1994, and December 31, 1996. Data collection took place when the participants were between 11 and 16 years of age from December 1, 2005, to January 31, 2013. Data analysis was conducted from January 1, 2016, to June 20, 2017. Exposures: Participants completed the Multidimensional Peer-Victimization Scale at 11 and 14 years of age. Main Outcomes and Measures: Mental health assessments at 11 and 16 years of age included anxiety, depression, hyperactivity and impulsivity, inattention, conduct problems, and psychotic-like experiences (eg, paranoid thoughts or cognitive disorganization). Results: The 11 108 twins included in the final sample (5894 girls and 5214 boys) were a mean age of 11.3 years at the first assessment and 16.3 years at the last assessment. The most stringent twin differences estimates (monozygotic) were consistent with causal contribution of exposure to bullying at 11 years to concurrent anxiety, depression, hyperactivity and impulsivity, inattention, and conduct problems. Effects decreased over time; that is, substantial concurrent contributions to anxiety (ß = 0.27; 95% CI, 0.22-0.33) persisted for 2 years (ß = 0.12; 95% CI, 0.04-0.20) but not 5 years. Direct contributions to paranoid thoughts and cognitive disorganization persisted for 5 years. Conclusions and Relevance: This study is the largest to date to characterize the contribution of exposure to bullying in childhood to mental health using a twin differences design and multi-informant, multiscale data. Stringent evidence of the direct detrimental contribution of exposure to bullying in childhood to mental health is provided. Findings also suggest that childhood exposure to bullying may partly be viewed as a symptom of preexisting vulnerabilities. Finally, the dissipation of effects over time for many outcomes highlights the potential for resilience in children who were bullied. In addition to programs that aim to reduce exposure to bullying, interventions may benefit from addressing preexisting vulnerabilities and focus on resilience.
[Mh] Termos MeSH primário: Bullying
Resiliência Psicológica
Gêmeos/psicologia
[Mh] Termos MeSH secundário: Adolescente
Ansiedade/psicologia
Transtorno do Deficit de Atenção com Hiperatividade/psicologia
Criança
Transtorno da Conduta/psicologia
Depressão/psicologia
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Transtornos Psicóticos/psicologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; TWIN STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1001/jamapsychiatry.2017.2678


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[PMID]:28813114
[Au] Autor:Wendt GW; Bartoli AJ; Arteche A
[Ad] Endereço:Department of Psychology, Goldsmiths, University of London, London, United Kingdom.
[Ti] Título:Dimensions of youth psychopathy differentially predict concurrent pro- and antisocial behavior.
[So] Source:Rev Bras Psiquiatr;39(3):267-270, 2017 Jul-Sep.
[Is] ISSN:1809-452X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective:: To investigate the unique contribution of narcissism and impulsivity, in addition to callous-unemotional (CU) traits, in explaining concurrent prosocial and antisocial behavior. Method:: Two hundred and forty-nine schoolchildren (53% female; age 9-12 years) completed the self-report Strengths and Difficulties Questionnaire (SDQ) and the Antisocial Process Screening Device (APSD). Two statistical models were tested, predicting conduct problems (CP) and prosocial behavior (PB). In the first one, CU traits and gender were entered into the equation. The second model added narcissism and impulsivity. Results:: Gender, narcissism and impulsivity, but not CU, were statistically significant predictors of CP in the second model (F3,226 = 45.07, p < 0.001, R2 = 43.7%; betas: gender = -0.20, narcissism = 0.29, impulsivity = 0.36, CU = 0.06). PB was significantly predicted by all domains except gender (F3,226 = 42.57, p < 0.001, R2 = 42.4%; betas: gender = 0.08, narcissism = -0.16, impulsivity = -0.23, CU = -0.41). Conclusion:: Our results confirmed that CU traits refer to a distinct manifestation of psychopathy in youth, but we also found that narcissism and impulsivity are equally important when predicting CP. Previous reports of sex differences on APSD and SDQ domains were also corroborated.
[Mh] Termos MeSH primário: Transtorno da Personalidade Antissocial/psicologia
Transtornos do Comportamento Infantil/psicologia
Transtorno da Conduta/psicologia
Inquéritos Epidemiológicos
[Mh] Termos MeSH secundário: Transtorno da Personalidade Antissocial/epidemiologia
Criança
Feminino
Seres Humanos
Comportamento Impulsivo
Londres/epidemiologia
Masculino
Narcisismo
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


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[PMID]:28791693
[Au] Autor:Loy JH; Merry SN; Hetrick SE; Stasiak K
[Ad] Endereço:Child and Adolescent Mental Health, Waikato DHB, 206 Colllingwood Street, Hamilton, New Zealand.
[Ti] Título:Atypical antipsychotics for disruptive behaviour disorders in children and youths.
[So] Source:Cochrane Database Syst Rev;8:CD008559, 2017 08 09.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This is an update of the original Cochrane Review, last published in 2012 (Loy 2012). Children and youths with disruptive behaviour disorders may present to health services, where they may be treated with atypical antipsychotics. There is increasing usage of atypical antipsychotics in the treatment of disruptive behaviour disorders. OBJECTIVES: To evaluate the effect and safety of atypical antipsychotics, compared to placebo, for treating disruptive behaviour disorders in children and youths. The aim was to evaluate each drug separately rather than the class effect, on the grounds that each atypical antipsychotic has different pharmacologic binding profile (Stahl 2013) and that this is clinically more useful. SEARCH METHODS: In January 2017, we searched CENTRAL, MEDLINE, Embase, five other databases and two trials registers. SELECTION CRITERIA: Randomised controlled trials of atypical antipsychotics versus placebo in children and youths aged up to and including 18 years, with a diagnosis of disruptive behaviour disorders, including comorbid ADHD. The primary outcomes were aggression, conduct problems and adverse events (i.e. weight gain/changes and metabolic parameters). The secondary outcomes were general functioning, noncompliance, other adverse events, social functioning, family functioning, parent satisfaction and school functioning. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures expected by Cochrane. Two review authors (JL and KS) independently collected, evaluated and extracted data. We used the GRADE approach to assess the quality of the evidence. We performed meta-analyses for each of our primary outcomes, except for metabolic parameters, due to inadequate outcome data. MAIN RESULTS: We included 10 trials (spanning 2000 to 2014), involving a total of 896 children and youths aged five to 18 years. Bar two trials, all came from an outpatient setting. Eight trials assessed risperidone, one assessed quetiapine and one assessed ziprasidone. Nine trials assessed acute efficacy (over four to 10 weeks); one of which combined treatment with stimulant medication and parent training. One trial was a six-month maintenance trial assessing symptom recurrence.The quality of the evidence ranged from low to moderate. Nine studies had some degree of pharmaceutical support/funding. Primary outcomesUsing the mean difference (MD), we combined data from three studies (238 participants) in a meta-analysis of aggression, as assessed using the Aberrant Behaviour Checklist (ABC) ‒ Irritability subscale. We found that youths treated with risperidone show reduced aggression compared to youths treated with placebo (MD -6.49, 95% confidence interval (CI) -8.79 to -4.19; low-quality evidence). Using the standardised mean difference (SMD), we pooled data from two risperidone trials (190 participants), which used different scales: the Overt Aggression Scale ‒ Modified (OAS-M) Scale and the Antisocial Behaviour Scale (ABS); as the ABS had two subscales that could not be combined (reactive and proactive aggression), we performed two separate analyses. When we combined the ABS Reactive subscale and the OAS-M, the SMD was -1.30 in favour of risperidone (95% CI -2.21 to -0.40, moderate-quality evidence). When we combined the ABS Proactive subscale and OAS-M, the SMD was -1.12 (95% CI -2.30 to 0.06, moderate-quality evidence), suggesting uncertainty about the estimate of effect, as the confidence intervals overlapped the null value. In summary, there was some evidence that aggression could be reduced by risperidone. Data were lacking on other atypical antipsychotics, like quetiapine and ziprasidone, with regard to their effects on aggression.We pooled data from two risperidone trials (225 participants) in a meta-analysis of conduct problems, as assessed using the Nisonger Child Behaviour Rating Form ‒ Conduct Problem subscale (NCBRF-CP). This yielded a final mean score that was 8.61 points lower in the risperidone group compared to the placebo group (95% CI -11.49 to -5.74; moderate-quality evidence).We investigated the effect on weight by performing two meta-analyses. We wanted to distinguish between the effects of antipsychotic medication only and the combined effect with stimulants, since the latter can have a counteracting effect on weight gain due to appetite suppression. Pooling two trials with risperidone only (138 participants), we found that participants on risperidone gained 2.37 kilograms (kg) more (95% CI 0.26 to 4.49; moderate-quality evidence) than those on placebo. When we added a trial where all participants received a combination of risperidone and stimulants, we found that those on the combined treatment gained 2.14 kg more (95% CI 1.04 to 3.23; 3 studies; 305 participants; low-quality evidence) than those on placebo. Secondary outcomesOut of the 10 included trials, three examined general functioning, social functioning and parent satisfaction. No trials examined family or school functioning. Data on non-compliance/attrition rate and other adverse events were available from all 10 trials. AUTHORS' CONCLUSIONS: There is some evidence that in the short term risperidone may reduce aggression and conduct problems in children and youths with disruptive behaviour disorders There is also evidence that this intervention is associated with significant weight gain.For aggression, the difference in scores of 6.49 points on the ABC ‒ Irritability subscale (range 0 to 45) may be clinically significant. It is challenging to interpret the clinical significance of the differential findings on two different ABS subscales as it may be difficult to distinguish between reactive and proactive aggression in clinical practice. For conduct problems, the difference in scores of 8.61 points on the NCBRF-CP (range 0 to 48) is likely to be clinically significant. Weight gain remains a concern.Caution is required in interpreting the results due to the limitations of current evidence and the small number of high-quality trials. There is a lack of evidence to support the use of quetiapine, ziprasidone or any other atypical antipsychotic for disruptive behaviour disorders in children and youths and no evidence for children under five years of age. It is uncertain to what degree the efficacy found in clinical trials will translate into real-life clinical practice. Given the effectiveness of parent-training interventions in the management of these disorders, and the somewhat equivocal evidence on the efficacy of medication, it is important not to use medication alone. This is consistent with current clinical guidelines.
[Mh] Termos MeSH primário: Agressão/efeitos dos fármacos
Antipsicóticos/uso terapêutico
Transtornos de Deficit da Atenção e do Comportamento Disruptivo/tratamento farmacológico
Dibenzotiazepinas/uso terapêutico
Piperazinas/uso terapêutico
Fumarato de Quetiapina/uso terapêutico
Risperidona/uso terapêutico
Tiazóis/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Antipsicóticos/efeitos adversos
Transtornos de Ansiedade/tratamento farmacológico
Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico
Criança
Pré-Escolar
Transtorno da Conduta/tratamento farmacológico
Transtorno Depressivo Maior/tratamento farmacológico
Dibenzotiazepinas/efeitos adversos
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Risperidona/efeitos adversos
Ganho de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Dibenzothiazepines); 0 (Piperazines); 0 (Thiazoles); 2S3PL1B6UJ (Quetiapine Fumarate); 6UKA5VEJ6X (ziprasidone); L6UH7ZF8HC (Risperidone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD008559.pub3


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[PMID]:28618856
[Au] Autor:Quinlan EB; Cattrell A; Jia T; Artiges E; Banaschewski T; Barker G; Bokde ALW; Bromberg U; Büchel C; Brühl R; Conrod PJ; Desrivieres S; Flor H; Frouin V; Gallinat J; Garavan H; Gowland P; Heinz A; Martinot JL; Paillère Martinot ML; Nees F; Papadopoulos-Orfanos D; Paus T; Poustka L; Smolka MN; Vetter NC; Walter H; Whelan R; Glennon JC; Buitelaar JK; Happé F; Loth E; Barker ED; Schumann G; IMAGEN Consortium
[Ad] Endereço:From the Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, the Department of Psychology, the Department of Forensic and Neurodevelopmental Sciences, the Addictions Department, and the Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology, and Neuroscience
[Ti] Título:Psychosocial Stress and Brain Function in Adolescent Psychopathology.
[So] Source:Am J Psychiatry;174(8):785-794, 2017 Aug 01.
[Is] ISSN:1535-7228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships. METHOD: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions. RESULTS: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms who had also experienced a greater number of stressful life events showed hyperactivity of the amygdala and several regions across the brain. This effect was not observed with emotional symptoms. A cluster in the midcingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested that amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms. CONCLUSIONS: The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress affects functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms.
[Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia
Encéfalo/fisiopatologia
Transtorno da Conduta/fisiopatologia
Emoções/fisiologia
Expressão Facial
Imagem por Ressonância Magnética
Reconhecimento Visual de Modelos/fisiologia
Meio Social
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Tonsila do Cerebelo/fisiopatologia
Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico
Transtorno do Deficit de Atenção com Hiperatividade/psicologia
Transtorno da Conduta/diagnóstico
Transtorno da Conduta/psicologia
Feminino
Seres Humanos
Masculino
Vias Neurais/fisiopatologia
Lobo Parietal/fisiopatologia
Estresse Psicológico/complicações
Estresse Psicológico/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1176/appi.ajp.2017.16040464


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[PMID]:28564632
[Au] Autor:Rahman SM; Kippler M; Tofail F; Bölte S; Hamadani JD; Vahter M
[Ad] Endereço:Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden.
[Ti] Título:Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study.
[So] Source:Environ Health Perspect;125(5):057003, 2017 05 26.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. OBJECTIVES: We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior. METHODS: We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry. RESULTS: The median W-Mn was 0.20 mg/L (range 0.001­6.6) during pregnancy and 0.34mg/L (<0.001­8.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the children's cognitive abilities. Stratifying by gender (p for interaction in general <0.081) showed that prenatal W-Mn (3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 24­43% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)]. CONCLUSIONS: Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect children's behavior. https://doi.org/10.1289/EHP631.
[Mh] Termos MeSH primário: Cognição/efeitos dos fármacos
Água Potável/química
Manganês/efeitos adversos
[Mh] Termos MeSH secundário: Bangladesh/epidemiologia
Criança
Estudos de Coortes
Transtorno da Conduta/induzido quimicamente
Água Potável/efeitos adversos
Feminino
Seres Humanos
Testes de Inteligência
Masculino
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Estudos Prospectivos
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1289/EHP631



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