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[PMID]:28934093
[Au] Autor:Schmidt RJ; Kogan V; Shelton JF; Delwiche L; Hansen RL; Ozonoff S; Ma CC; McCanlies EC; Bennett DH; Hertz-Picciotto I; Tancredi DJ; Volk HE
[Ad] Endereço:Department of Public Health Sciences, University of California Davis School of Medicine , Davis, California, USA.
[Ti] Título:Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder.
[So] Source:Environ Health Perspect;125(9):097007, 2017 Sep 08.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals. OBJECTIVE: We examined combined exposures to maternal FA and pesticides in relation to autism spectrum disorder (ASD). METHODS: Participants were California children born from 2000-2007 who were enrolled in the Childhood Autism Risks from Genetics and the Environment (CHARGE) case-control study at age 2-5 y, were clinically confirmed to have ASD (n=296) or typical development (n=220), and had information on maternal supplemental FA and pesticide exposures. Maternal supplemental FA and household pesticide product use were retrospectively collected in telephone interviews from 2003-2011. High vs. low daily FA intake was dichotomized at 800µg (median). Mothers' addresses were linked to a statewide database of commercial applications to estimate agricultural pesticide exposure. RESULTS: High FA intake (≥800µg) during the first pregnancy month and no known pesticide exposure was the reference group for all analyses. Compared with this group, ASD was increased in association with <800µg FA and any indoor pesticide exposure {adjusted odds ratio [OR]=2.5 [95% confidence interval (CI): 1.3, 4.7]} compared with low FA [OR=1.2 (95% CI: 0.7, 2.2)] or indoor pesticides [OR=1.7 (95% CI: 1.1, 2.8)] alone. ORs for the combination of low FA and regular pregnancy exposure (≥6 mo) to pet pesticides or to outdoor sprays and foggers were 3.9 (95% CI: 1.4, 11.5) and 4.1 (95% CI: 1.7, 10.1), respectively. ORs for low maternal FA and agricultural pesticide exposure 3 mo before or after conception were 2.2 (95% CI: 0.7, 6.5) for chlorpyrifos, 2.3 (95% CI: 0.98, 5.3) for organophosphates, 2.1 (95% CI: 0.9, 4.8) for pyrethroids, and 1.5 (95% CI: 0.5, 4.8) for carbamates. Except for carbamates, these ORs were approximately two times greater than those for either exposure alone or for the expected ORs for combined exposures under multiplicative or additive models. CONCLUSIONS: In this study population, associations between pesticide exposures and ASD were attenuated among those with high versus low FA intake during the first month of pregnancy. Confirmatory and mechanistic studies are needed. https://doi.org/10.1289/EHP604.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/epidemiologia
Suplementos Nutricionais
Poluentes Ambientais/metabolismo
Ácido Fólico/uso terapêutico
Exposição Materna/estatística & dados numéricos
Praguicidas/metabolismo
Efeitos Tardios da Exposição Pré-Natal/epidemiologia
[Mh] Termos MeSH secundário: Adulto
California/epidemiologia
Estudos de Casos e Controles
Criança
Transtornos Globais do Desenvolvimento Infantil/epidemiologia
Feminino
Seres Humanos
Masculino
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Pesticides); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1289/EHP604


  2 / 6431 MEDLINE  
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[PMID]:28810018
[Au] Autor:Vigod SN; Gomes T; Ray JG
[Ad] Endereço:Women's College Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Prenatal Antidepressant Use and Autism Spectrum Disorder-Reply.
[So] Source:JAMA;318(7):665, 2017 08 15.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antidepressivos
Transtorno do Espectro Autista
[Mh] Termos MeSH secundário: Transtorno Autístico
Transtornos Globais do Desenvolvimento Infantil
Seres Humanos
Efeitos Tardios da Exposição Pré-Natal
Inibidores da Captação de Serotonina
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Serotonin Uptake Inhibitors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.8643


  3 / 6431 MEDLINE  
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[PMID]:28810014
[Au] Autor:Singal D; Chateau D; Brownell M
[Ad] Endereço:Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, Canada.
[Ti] Título:Prenatal Antidepressant Use and Autism Spectrum Disorder.
[So] Source:JAMA;318(7):664-665, 2017 08 15.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antidepressivos
Transtorno do Espectro Autista
[Mh] Termos MeSH secundário: Transtorno Autístico
Transtornos Globais do Desenvolvimento Infantil
Seres Humanos
Efeitos Tardios da Exposição Pré-Natal
Inibidores da Captação de Serotonina
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Serotonin Uptake Inhibitors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.8640


  4 / 6431 MEDLINE  
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[PMID]:28787492
[Au] Autor:Broder-Fingert S; Feinberg E; Silverstein M
[Ad] Endereço:Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts.
[Ti] Título:Music Therapy for Children With Autism Spectrum Disorder.
[So] Source:JAMA;318(6):523-524, 2017 08 08.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtorno do Espectro Autista
Musicoterapia
[Mh] Termos MeSH secundário: Transtorno Autístico
Criança
Transtornos Globais do Desenvolvimento Infantil
Seres Humanos
Música
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.9477


  5 / 6431 MEDLINE  
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[PMID]:28523973
[Au] Autor:Kamp-Becker I; Poustka L
[Ad] Endereço:1 Klinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Philipps-Universität Marburg.
[Ti] Título:[Between Hype and Hope ­ considerations for research in autism spectrum disorders].
[Ti] Título:Zwischen Hype und Hope ­ Wo steht die Forschung der Autismus-Spektrum-Störungen?.
[So] Source:Z Kinder Jugendpsychiatr Psychother;45(3):175-179, 2017.
[Is] ISSN:1422-4917
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Transtorno do Espectro Autista
Transtornos Globais do Desenvolvimento Infantil
[Mh] Termos MeSH secundário: Seres Humanos
Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1024/1422-4917/a000527


  6 / 6431 MEDLINE  
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[PMID]:28418468
[Au] Autor:King BH
[Ad] Endereço:Department of Psychiatry, Weill Institute for Neurosciences, Benioff Children's Hospitals, University of California, San Francisco.
[Ti] Título:Association Between Maternal Use of SSRI Medications and Autism in Their Children.
[So] Source:JAMA;317(15):1568-1569, 2017 04 18.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtorno Autístico
Transtornos Globais do Desenvolvimento Infantil
[Mh] Termos MeSH secundário: Criança
Família
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.20614


  7 / 6431 MEDLINE  
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[PMID]:28353224
[Au] Autor:Guest PC; Martins-de-Souza D
[Ad] Endereço:Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255 F/01, Cidade Universitária Zeferino Vaz, 13083-862, Campinas, Brazil. paulcguest@yahoo.com.
[Ti] Título:What Have Proteomic Studies Taught Us About Novel Drug Targets in Autism?
[So] Source:Adv Exp Med Biol;974:49-67, 2017.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorders (ASDs) are a heterogeneous group of conditions with complex behavioural phenotypes. Although ASDs show a high rate of heritability, genetic research alone has not provided a complete understanding of the underlying causes. Recent developments using imaging techniques and proteomic-based molecular profiling approaches have now begun to generate new insights into the underlying pathways affected in both the brain and the periphery in individuals with these conditions. Of potential high importance is the constant finding of gender-specific biomarker profiles in ASD patients. This suggests that there are either distinct adaptive mechanisms or different aetiological causes in male and female ASD patients. This chapter addresses the findings using these approaches with a view to identification of novel drug targets or new treatment strategies based on personalized medicine objectives. Eventually, this will lead to a better disease understanding of ASD at the physiological and molecular levels, which may facilitate novel drug discovery efforts in this challenging area of medicine.
[Mh] Termos MeSH primário: Transtorno Autístico/tratamento farmacológico
Biomarcadores/sangue
Proteômica/métodos
[Mh] Termos MeSH secundário: Transtorno Autístico/sangue
Transtorno Autístico/diagnóstico por imagem
Química Encefálica
Fármacos do Sistema Nervoso Central/uso terapêutico
Transtornos Globais do Desenvolvimento Infantil/tratamento farmacológico
Descoberta de Drogas
Drogas em Investigação/uso terapêutico
Feminino
Seres Humanos
Masculino
Neuroimagem
Medicina de Precisão
Terapias em Estudo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Central Nervous System Agents); 0 (Drugs, Investigational)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-52479-5_3


  8 / 6431 MEDLINE  
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[PMID]:28346760
[Au] Autor:Chakrabarti B
[Ad] Endereço:Centre for Autism, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
[Ti] Título:Commentary: Critical considerations for studying low-functioning autism.
[So] Source:J Child Psychol Psychiatry;58(4):436-438, 2017 Apr.
[Is] ISSN:1469-7610
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Jack and Pelphrey provide a systematic review of neuroimaging studies in understudied populations within the autistic spectrum, focussing specifically on those with minimal verbal ability, intellectual disability and developmental regression. Despite accounting for nearly a third of the autistic spectrum, the number of studies focussing on these populations is extremely low. This review highlights a critical need for further neuroimaging research on these populations, and provides practical suggestions for overcoming the challenges posed by it. In this commentary, I discuss some of the theoretical questions that arise from the review, on the conceptualisation of the autistic spectrum as well as on optimising experimental design and analysis.
[Mh] Termos MeSH primário: Transtorno Autístico
Transtornos Globais do Desenvolvimento Infantil
[Mh] Termos MeSH secundário: Seres Humanos
Neuroimagem
Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1111/jcpp.12720


  9 / 6431 MEDLINE  
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[PMID]:28316773
[Au] Autor:Vuillermot S; Luan W; Meyer U; Eyles D
[Ad] Endereço:Swiss Federal Institute of Technology (ETH) Zurich, 8603 Schwerzenbach, Switzerland.
[Ti] Título:Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation.
[So] Source:Mol Autism;8:9, 2017.
[Is] ISSN:2040-2392
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prenatal exposure to infection is a recognized environmental risk factor for neuropsychiatric disorders of developmental origins such as autism or schizophrenia. Experimental work in animals indicates that this link is mediated by maternal immune activation (MIA) involving interactions between cytokine-associated inflammatory events, oxidative stress, and other pathophysiological processes such as hypoferremia and zinc deficiency. Maternal administration of the viral mimic polyriboinosinic-polyribocytidylic acid (poly(I:C)) in mice produces several behavioral phenotypes in adult offspring of relevance to autism spectrum disorder (ASD) and other neurodevelopmental disorders. METHODS: Here, we investigated whether some of these phenotypes might also present in juveniles. In addition, given the known immunomodulatory and neuroprotective effects of vitamin D, we also investigated whether the co-administration of vitamin D could block MIA-induced ASD-related behaviors. We co-administered the hormonally active form of vitamin D, 1α,25 dihydroxy vitamin D3 (1,25OHD), simultaneously with poly(I:C) and examined (i) social interaction, stereotyped behavior, emotional learning and memory, and innate anxiety-like behavior in juveniles and (ii) the levels of the pro-inflammatory cytokines IL-1ß, IL-6 and TNF-α in maternal plasma and fetal brains. RESULTS: We show that like adult offspring that were exposed to MIA, juveniles display similar deficits in social approach behavior. Juvenile MIA offspring also show abnormal stereotyped digging and impaired acquisition and expression of tone-cued fear conditioning. Importantly, our study reveals that prenatal administration of 1,25OHD abolishes all these behavioral deficits in poly(I:C)-treated juveniles. However, prenatal administration of vitamin D had no effect on pro-inflammatory cytokine levels in dams or in fetal brains suggesting the anti-inflammatory actions of vitamin D are not the critical mechanism for its preventive actions in this ASD animal model. CONCLUSIONS: This work raises the possibility that early dietary supplementation with vitamin D may open new avenues for a successful attenuation or even prevention of neurodevelopmental disorders following maternal inflammation during pregnancy.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Transtornos Globais do Desenvolvimento Infantil/prevenção & controle
Citocinas/sangue
Polinucleotídeos/efeitos adversos
Efeitos Tardios da Exposição Pré-Natal/prevenção & controle
Comportamento Estereotipado/efeitos dos fármacos
Vitamina D/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Transtornos Globais do Desenvolvimento Infantil/induzido quimicamente
Modelos Animais de Doenças
Feminino
Seres Humanos
Camundongos
Fenótipo
Poli I-C
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Polynucleotides); 1406-16-2 (Vitamin D); O84C90HH2L (Poly I-C)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1186/s13229-017-0125-0


  10 / 6431 MEDLINE  
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[PMID]:28291301
[Au] Autor:Küçükköse M; Kabukçu Basay B
[Ti] Título:[Acute Dystonia due to Aripiprazole Use in Two Children with Autism Spectrum Disorder in the First Five Years of Life].
[Ti] Título:Otizm Spektrum Bozuklugu Olan Bes Yas Öncesi Iki Çocukta Aripiprazol Kullanimina Bagli Akut Distoni..
[So] Source:Turk Psikiyatri Derg;28(1):71-73, 2017.
[Is] ISSN:1300-2163
[Cp] País de publicação:Turkey
[La] Idioma:tur
[Ab] Resumo:Autism spectrum disorders (ASD) are neuropsychiatric disorders characterized by impairment in social interactions, in verbal and non-verbal communication, and restricted and stereotyped patterns of interest and behavior within the first 3 years of life. Pharmacologic interventions may be needed for the treatment of temper tantrums, aggression, hyperactivity, and stereotypes in children with ASD. The approval of aripiprazole by the United States Food and Drug Administration (USFDA) for the treatment of temper tantrums in children and adolescents with ASD has gained increased interest for the use in these patients. Aripiprazole is a partial agonist for the dopamine D2, serotonin 5-HT1A receptors, and an antagonist for 5HT2A receptors. Because aripiprazole is a partial agonist, it has been is speculated that aripiprazole has a protective effect for extrapyramidal side effects, movement disorders, and metabolic problems. But the increased use in children and adolescents is associated with an increase in the number of case reports related with such problems. Nevertheless, our review of the literature uncovered limited data regarding the association between acute dystonia and aripiprazole use in ASD children under five years of age is. In this paper, we present two cases of autistic spectrum disorder children with ages under 5 years that developed acute dystonia taking aripiprazole.
[Mh] Termos MeSH primário: Antipsicóticos/efeitos adversos
Aripiprazol/efeitos adversos
Transtornos Globais do Desenvolvimento Infantil/tratamento farmacológico
Distonia/diagnóstico
[Mh] Termos MeSH secundário: Pré-Escolar
Diagnóstico Diferencial
Distonia/induzido quimicamente
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); 82VFR53I78 (Aripiprazole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE



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