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Pesquisa : F03.625.164.113 [Categoria DeCS]
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[PMID]:29297068
[Au] Autor:Xu G; Strathearn L; Liu B; Bao W
[Ad] Endereço:Department of Epidemiology, University of Iowa College of Public Health, Iowa City.
[Ti] Título:Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016.
[So] Source:JAMA;319(1):81-82, 2018 01 02.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Prevalência
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.17812


  2 / 3134 MEDLINE  
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[PMID]:29408620
[Au] Autor:Qiu S; Li Y; Li Y; Zhong W; Shi M; Zhao Q; Zhang K; Wang Y; Lu M; Zhu X; Jiang H; Yu Y; Cheng Y; Liu Y
[Ad] Endereço:Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
[Ti] Título:Association between SHANK3 polymorphisms and susceptibility to autism spectrum disorder.
[So] Source:Gene;651:100-105, 2018 Apr 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorder (ASD), as one of neurodevelopmental disorders, affects about 1/160 of people worldwide. The etiology and pathogenesis of ASD remain elusive. Synapses are essential components of neurons and basic information transmission unit in the nervous system, adjusting behavior to environmental stimuli and controlling body functions, memories, and emotions. SHANK3 is one of the synapse genes which play important roles in maintaining synaptic structure and function. SHANK3 has been researched as a probably susceptibility gene for ASD. We investigated the association between polymorphisms in SHANK3 and ASD in the Northeast Han Chinese population. A total of 470 subjects (229 cases and 241 controls) were enrolled in our case-control study. Five single nucleotide polymorphisms (SNPs) (rs756638, rs4824116, rs76268556, rs9616915, and rs75767639) in SHANK3 were selected and genotyped. Our study did not identify a significant association of SHANK3 SNPs with ASD in the Northeast Han Chinese population. Future studies need to test more SHANK3 SNPs in large sample to demonstrate the association between SNPs in SHANK3 and ASD.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Transtorno do Espectro Autista/genética
Proteínas do Tecido Nervoso/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Pré-Escolar
Feminino
Estudos de Associação Genética
Predisposição Genética para Doença
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nerve Tissue Proteins); 0 (SHANK3 protein, human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  3 / 3134 MEDLINE  
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[PMID]:28463420
[Au] Autor:Chang YC; Cole TB; Costa LG
[Ad] Endereço:Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
[Ti] Título:Behavioral Phenotyping for Autism Spectrum Disorders in Mice.
[So] Source:Curr Protoc Toxicol;72:11.22.1-11.22.21, 2017 May 02.
[Is] ISSN:1934-9262
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorder (ASD) represents a heterogeneous group of disorders characterized by alterations in three behavioral symptom domains: Social interactions, verbal and nonverbal communication, and repetitive behaviors. Increasing prevalence of ASD in recent years suggests that exposure to environmental toxicants may be critical in modulating etiology of this disease. As clinical diagnosis of autism still relies on behavioral evaluation, it is important to be able to assess similar behavioral traits in animal models, to provide biological plausibility of associations between environmental exposures and ASD. Rodents naturally exhibit a large number of behaviors that can be linked to similar behaviors in human. In this unit, behavioral tests are described that are relevant to the domains affected in ASD. For the repetitive domain, the T-maze spontaneous alternation test and marble burying test are described. For the communication domain, neonatal ultrasonic vocalization and olfactory habituation test toward social and non-social odor are described. Finally, for the sociability domain, the three-chambered social preference test and the reciprocal interaction test are presented. © 2017 by John Wiley & Sons, Inc.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Comportamento Animal
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Modelos Animais de Doenças
Habituação Psicofisiológica
Camundongos
Transtorno Obsessivo-Compulsivo/psicologia
Odorantes
Fenótipo
Olfato
Comportamento Social
Urina/química
Vocalização Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cptx.19


  4 / 3134 MEDLINE  
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[PMID]:29362376
[Au] Autor:Ullman JC; Yang J; Sullivan M; Bendor J; Levy J; Pham E; Silm K; Seifikar H; Sohal VS; Nicoll RA; Edwards RH
[Ad] Endereço:Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA.
[Ti] Título:A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.
[So] Source:Nat Commun;9(1):330, 2018 01 23.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood. Interestingly, recent human genetic studies have implicated the endosomal Na /H exchanger NHE9 in both autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). Plasma membrane NHEs regulate cytosolic pH, but the role of intracellular isoforms has remained unclear. We now find that inactivation of NHE9 in mice reproduces behavioral features of ASD including impaired social interaction, repetitive behaviors, and altered sensory processing. Physiological characterization reveals hyperacidic endosomes, a cell-autonomous defect in glutamate receptor expression and impaired neurotransmitter release due to a defect in presynaptic Ca entry. Acute inhibition of synaptic vesicle acidification rescues release but without affecting the primary defect due to loss of NHE9.
[Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/metabolismo
Transtorno do Espectro Autista/metabolismo
Cálcio/metabolismo
Endossomos/metabolismo
Neurônios/metabolismo
Trocadores de Sódio-Hidrogênio/genética
[Mh] Termos MeSH secundário: Animais
Transtorno do Deficit de Atenção com Hiperatividade/genética
Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia
Transtorno do Espectro Autista/genética
Transtorno do Espectro Autista/fisiopatologia
Comportamento Animal
Modelos Animais de Doenças
Eletroencefalografia
Endossomos/patologia
Feminino
Expressão Gênica
Ácido Glutâmico/metabolismo
Hipocampo/metabolismo
Hipocampo/fisiopatologia
Seres Humanos
Concentração de Íons de Hidrogênio
Masculino
Camundongos
Camundongos Knockout
Neurônios/patologia
Terminações Pré-Sinápticas/metabolismo
Terminações Pré-Sinápticas/patologia
Cultura Primária de Células
Trocadores de Sódio-Hidrogênio/deficiência
Transmissão Sináptica/fisiologia
Vesículas Sinápticas/metabolismo
Vesículas Sinápticas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (NHE9 protein, mouse); 0 (Sodium-Hydrogen Exchangers); 3KX376GY7L (Glutamic Acid); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02716-5


  5 / 3134 MEDLINE  
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Roesler, Rafael
Texto completo
[PMID]:28452904
[Au] Autor:Marchezan J; Becker M; Schwartsmann G; Ohlweiler L; Roesler R; Renck LB; Gonçalves MMM; Ranzan J; Riesgo RDS
[Ad] Endereço:*Postgraduate Program in Child and Adolescent Health, School of Medicine, Federal University of Rio Grande do Sul; †Department of Pediatrics, Child Neurology Unit, Hospital de Clínicas de Porto Alegre; ‡Department of Internal Medicine, School of Medicine, Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), §Department of Pharmacology, Institute for Basic Health Sciences, Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), and ∥Department of Pediatrics, Child Neurology Unit, Postgraduate Program in Child and Adolescent Health, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
[Ti] Título:A Placebo-Controlled Crossover Trial of Gastrin-Releasing Peptide in Childhood Autism.
[So] Source:Clin Neuropharmacol;40(3):108-112, 2017 May/Jun.
[Is] ISSN:1537-162X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to evaluate the efficacy, safety, and tolerability of gastrin-releasing peptide (GRP) compared with placebo in autism spectrum disorder symptoms. METHODOLOGY: This is a randomized, double-blind, placebo-controlled crossover trial using GRP 160 pmol/kg for 4 consecutive days in 10 children with autism. Outcomes were measured by the Aberrant Behavior Checklist (ABC) scale. RESULTS: All participants were boys, aged between 4 and 9 years. There was a reduction in the scores of the ABC range and its subscales after use GRP and placebo. The reduction was more prominent with GRP, particularly in the subscale "hyperactivity and noncompliance," but there was no statistical difference between the results (P = 0.334). After a week of infusion, 5 children showed improvement of 25% or greater in the total score of the ABC scale with GRP use and 2 with placebo use; however, there was no statistical difference (P = 0.375). There were no adverse effects, changes in vital signs, or laboratory abnormalities associated with the use of GRP. CONCLUSIONS: The results of this study, despite the small sample size, reinforce previous data on the safety of the GRP in short-term use. There is a need for further research with other designs and a larger sample size to evaluate the efficacy and safety of GRP in children with autism.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/tratamento farmacológico
Comportamento Infantil/efeitos dos fármacos
Peptídeo Liberador de Gastrina/uso terapêutico
Psicotrópicos/uso terapêutico
[Mh] Termos MeSH secundário: Antiulcerosos/uso terapêutico
Anticonvulsivantes/efeitos adversos
Anticonvulsivantes/uso terapêutico
Antipsicóticos/efeitos adversos
Antipsicóticos/uso terapêutico
Transtorno do Espectro Autista/fisiopatologia
Transtorno do Espectro Autista/psicologia
Criança
Pré-Escolar
Terapia Combinada/efeitos adversos
Estudos Cross-Over
Manual Diagnóstico e Estatístico de Transtornos Mentais
Método Duplo-Cego
Quimioterapia Combinada/efeitos adversos
Seguimentos
Peptídeo Liberador de Gastrina/administração & dosagem
Peptídeo Liberador de Gastrina/efeitos adversos
Seres Humanos
Infusões Intravenosas
Masculino
Omeprazol/uso terapêutico
Escalas de Graduação Psiquiátrica
Psicotrópicos/administração & dosagem
Psicotrópicos/efeitos adversos
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Anticonvulsants); 0 (Antipsychotic Agents); 0 (Psychotropic Drugs); 80043-53-4 (Gastrin-Releasing Peptide); KG60484QX9 (Omeprazole)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1097/WNF.0000000000000213


  6 / 3134 MEDLINE  
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[PMID]:29406647
[Au] Autor:Stokes D
[Ti] Título:Empowering Children with Autism Spectrum Disorder and Their Families within the Healthcare Environment.
[So] Source:Pediatr Nurs;42(5):254-5, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patient and family education is a critical element of diabetes management. Many children with new onset type 1 diabetes present with symptoms of diabetic ketoacidosis (DKA) and are hospitalized at diagnosis. These children and their families receive their initial education in the hospital setting. As soon as blood glucose levels are stabilized and the acidosis is corrected. The patient is discharged home, usually within three days (Nettles, 2005). There is little time to provide the skills and education, as well as emotional support, for a smooth transition to home. It is a challenge to achieve these goals if the only resource person for diabetes education is the clinical nurse specialist (CNS). The CNS for a 14-bed pediatric unit sought to expand the role of the bedside nurse to being the primary educator of patients with diabetes through education and support. All nurses attended an eight-hour workshop on diabetes. A DKA protocol was developed through multidisciplinary collaboration, and nurses were educated on this protocol. Additionally, the CNS organized a diabetes resource cart that contains the tools for diabetes education. The protocol and education materials were uploaded in the Pediatric Share Point site to make them accessible to nurses. Most importantly, the CNS developed a structured patient education plan that is outcome-oriented, and based on review of current literature and practices in the unit. This initiative resulted in an increase in nursing confidence and expertise related to diabetes care as demonstrated by competencies met by nurses and anecdotal evidence from nurses and patients' caregivers.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Crianças com Deficiência/psicologia
Família/psicologia
Pessoal de Saúde/psicologia
Relações Interprofissionais
Poder (Psicologia)
[Mh] Termos MeSH secundário: Adolescente
Adulto
Atitude Frente à Saúde
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  7 / 3134 MEDLINE  
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[PMID]:29406641
[Au] Autor:Celia T; Freysteinson WW; Frye RE
[Ti] Título:Concurrent Medical Conditions in Autism Spectrum Disorders.
[So] Source:Pediatr Nurs;42(5):230-4, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Long thought to be purely psychological in origin, current research lends credenceto the idea that autism has a medical basis. Patients with autism can be among themost challenging patients that a healthcare provider may care for. Often the presentingsymptoms of autism make these patients difficult to examine and may alsomask underlying concurrent conditions. This article reviews some of the more commonconditions found concurrently in the autistic population.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/complicações
Transtorno do Espectro Autista/diagnóstico
Gastroenteropatias/etiologia
Doenças do Sistema Imune/etnologia
Doenças do Sistema Nervoso/etiologia
Transtornos do Sono-Vigília/etiologia
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/epidemiologia
Transtorno do Espectro Autista/fisiopatologia
Criança
Pré-Escolar
Comorbidade
Feminino
Gastroenteropatias/epidemiologia
Gastroenteropatias/terapia
Seres Humanos
Doenças do Sistema Imune/epidemiologia
Doenças do Sistema Imune/terapia
Lactente
Masculino
Doenças do Sistema Nervoso/epidemiologia
Doenças do Sistema Nervoso/terapia
Transtornos do Sono-Vigília/epidemiologia
Transtornos do Sono-Vigília/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  8 / 3134 MEDLINE  
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[PMID]:29406628
[Au] Autor:Cavalieri A
[Ti] Título:Sleep Issues in Children with AutismSpectrum Disorder.
[So] Source:Pediatr Nurs;42(4):169-74, 2016 Jul-Aug.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sleep issues are more prevalent in children with autism spectrum disorder (ASD)than in typically developing children. Parents often seek help from providers toimprove their child's ability to fall asleep, stay asleep longer, and decrease awakeningsthrough the night. The pathophysiology of ASD, as well as sleep issuesin children with ASD, are not well understood, which poses certain difficulties inchoosing the most effective and appropriate treatment options. This article discussesprobable causes of sleep problems in children with ASD, existing treatments,and implications for clinical practice and future research.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/complicações
Transtorno do Espectro Autista/terapia
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/terapia
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/fisiopatologia
Criança
Seres Humanos
Prevalência
Transtornos do Sono-Vigília/fisiopatologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  9 / 3134 MEDLINE  
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[PMID]:29480832
[Au] Autor:Wan H; Zhang C; Li H; Luan S; Liu C
[Ad] Endereço:Department of Mental Health.
[Ti] Título:Association of maternal diabetes with autism spectrum disorders in offspring: A systemic review and meta-analysis.
[So] Source:Medicine (Baltimore);97(2):e9438, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies on the association of maternal diabetes with autism spectrum disorders (ASDs) in offspring provide inconsistent findings; therefore an updated and comprehensive literature review and meta-analysis is necessary to perform in order to evaluate the available evidences.After searching databases systematically, we established the inclusion criteria and selected the eligible studies. In both overall and stratified analyses, the estimated effects were synthesized dependent on the presence or absence of heterogeneity.Twelve articles involving 16 studies were included and synthesized, demonstrating a significant association of maternal diabetes with ASDs among children (relative risk [RR] = 1.48). However, high heterogeneity was observed (I = 56.3%) and publication bias was identified. In terms of the analyses on reliable evidences from case-control studies, heterogeneity and publication bias disappeared, and the risk of ASDs was increased by 62% among diabetic mothers compared with non-diabetic mothers.Maternal diabetes, especially gestational diabetes mellitus, is associated with ASDs in offspring based on a limited number of convincing case-control studies. More large-scale population-based prospective studies are still needed to draw firm conclusions.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/epidemiologia
Diabetes Mellitus/epidemiologia
[Mh] Termos MeSH secundário: Diabetes Mellitus/etiologia
Seres Humanos
Mães
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009438


  10 / 3134 MEDLINE  
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[PMID]:29386446
[Au] Autor:Hirasawa K
[Ad] Endereço:Department of Pediatrics, Tokyo Women's Medical University.
[Ti] Título:[Topics on Child Development in Pediatrics].
[So] Source:Nihon Eiseigaku Zasshi;73(1):46-50, 2018.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Over the past few decades, advances in neonatal medicine have increased survival rates among very-low-birth-weight (VLBW) babies. Despite improvements in short-term outcomes, there is increasing concern about the probability of mild cognitive dysfunction in this population. Our analysis of VLBW babies born in our hospital revealed that the incidence of mild developmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactive disorder (ADHD) at the age of 3 years is 7.2%, which is markedly higher than the 2.8% incidence of ASD in the general population. Because problems related to ASD or ADHD tend to become more prominent as children grow up, the ages at diagnosis of developmental disorders are generally 6 years or above. Thus, in our follow up study of VLBW babies at age 6, the incidence of these developmental disorders had risen to 30%. These patients are apparently obstinate and difficult to train, causing parental problems with child care. It is important to support these children and help them establish good relationships with their parents. Given these problems, it is necessary to follow up VLBW children in the longterm, at least until they are elementary school students.
[Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade
Transtorno do Espectro Autista
Disfunção Cognitiva
Deficiências do Desenvolvimento
Recém-Nascido de muito Baixo Peso
[Mh] Termos MeSH secundário: Fatores Etários
Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia
Transtorno do Espectro Autista/epidemiologia
Criança
Pré-Escolar
Disfunção Cognitiva/epidemiologia
Deficiências do Desenvolvimento/epidemiologia
Intervenção Precoce (Educação)
Seguimentos
Seres Humanos
Incidência
Lactente
Recém-Nascido
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.73.46



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