Base de dados : MEDLINE
Pesquisa : F03.625.374.250 [Categoria DeCS]
Referências encontradas : 44 [refinar]
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[PMID]:28644796
[Au] Autor:Zheng Z; Fu Q; Zhao H; Swanson AR; Weitlauf AS; Warren ZE; Sarkar N
[Ti] Título:Design of an Autonomous Social Orienting Training System (ASOTS) for Young Children With Autism.
[So] Source:IEEE Trans Neural Syst Rehabil Eng;25(6):668-678, 2017 Jun.
[Is] ISSN:1558-0210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Social communication is among the core areas of impairment for children with Autism Spectrum Disorders (ASD). The training of social orientation is important for improving social communication of children with ASD. In recent years, technology-assisted ASD intervention had gained momentum due to its potential advantages in terms of precision, sustainability, flexibility and cost. In this paper, we propose a closed-loop autonomous computer system, named ASOTS, for training social orientation skills to young children with ASD. This system is designed to detect and track a child's attention in response to social orientation bids and help the child towards appropriate social orientation when needed. Response to name, an important social orientation skill, was used to demonstrate the functionality of the proposed system. Ten toddlers with ASD participated in a pilot user study to show whether the system could be used on young children who have been diagnosed with ASD. Another pilot user study with 10 TD infants tested whether this system has a potential to be applied for early detection for infants who were younger than the age when ASD diagnoses can be done. This was done intentionally to separately demonstrate utility and functionality for the clinical population of interest and to demonstrate functionality beyond current clinical identification capacity (i.e., infants). The results showed that the proposed system and the protocol were well tolerated by both groups, successfully captured young children's attention, and elicited the desired behavior.
[Mh] Termos MeSH primário: Transtorno Autístico/reabilitação
Biorretroalimentação Psicológica/métodos
Reabilitação Neurológica/métodos
Autocuidado/métodos
Transtorno de Comunicação Social/reabilitação
Terapia Assistida por Computador/métodos
Interface Usuário-Computador
[Mh] Termos MeSH secundário: Transtorno Autístico/psicologia
Comportamento Infantil/psicologia
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Reabilitação Neurológica/psicologia
Orientação
Projetos Piloto
Autocuidado/psicologia
Comportamento Social
Transtorno de Comunicação Social/etiologia
Transtorno de Comunicação Social/psicologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1109/TNSRE.2016.2598727


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[PMID]:28271437
[Au] Autor:Hulbert SW; Jiang YH
[Ad] Endereço:Department of Neurobiology, School of Medicine, Duke University, Durham, NC, 27710, USA.
[Ti] Título:Cellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain.
[So] Source:Neurosci Bull;33(2):205-218, 2017 Apr.
[Is] ISSN:1995-8218
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Transgenic mice carrying mutations that cause Autism Spectrum Disorders (ASDs) continue to be valuable for determining the molecular underpinnings of the disorders. Recently, researchers have taken advantage of such models combined with Cre-loxP and similar systems to manipulate gene expression over space and time. Thus, a clearer picture is starting to emerge of the cell types, circuits, brain regions, and developmental time periods underlying ASDs. ASD-causing mutations have been restricted to or rescued specifically in excitatory or inhibitory neurons, different neurotransmitter systems, and cells specific to the forebrain or cerebellum. In addition, mutations have been induced or corrected in adult mice, providing some evidence for the plasticity and reversibility of core ASD symptoms. The limited availability of Cre lines that are highly specific to certain cell types or time periods provides a challenge to determining the cellular and circuitry bases of autism, but other technological advances may eventually overcome this obstacle.
[Mh] Termos MeSH primário: Transtorno Autístico
Encéfalo/patologia
Expressão Gênica
Técnicas Genéticas
Transgenes/genética
[Mh] Termos MeSH secundário: Animais
Transtorno Autístico/complicações
Transtorno Autístico/genética
Transtorno Autístico/patologia
Seres Humanos
Camundongos
Camundongos Transgênicos
Mutação
Neurônios/patologia
Transtorno de Comunicação Social/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1007/s12264-017-0112-7


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[PMID]:28161678
[Au] Autor:Bosco FM; Parola A; Sacco K; Zettin M; Angeleri R
[Ad] Endereço:Center for Cognitive Science, Department of Psychology, University of Turin, Italy; Institute of Neurosciences of Turin, Italy.
[Ti] Título:Communicative-pragmatic disorders in traumatic brain injury: The role of theory of mind and executive functions.
[So] Source:Brain Lang;168:73-83, 2017 May.
[Is] ISSN:1090-2155
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Previous research has shown that communicative-pragmatic ability, as well as executive functions (EF) and Theory of Mind (ToM), may be impaired in individuals with traumatic brain injury (TBI). However, the role of such cognitive deficits in explaining communicative-pragmatic difficulty in TBI has still not been fully investigated. The study examined the relationship between EF (working memory, planning and flexibility) and ToM and communicative-pragmatic impairment in patients with TBI. 30 individuals with TBI and 30 healthy controls were assessed using the Assessment Battery of Communication (ABaCo), and a set of cognitive, EF and ToM, tasks. The results showed that TBI participants performed poorly in comprehension and production tasks in the ABaCo, using both linguistic and extralinguistic means of expression, and that they were impaired in EF and ToM abilities. Cognitive difficulties were able to predict the pragmatic performance of TBI individuals, with both executive functions and ToM contributing to explaining patients' scores on the ABaCo.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/psicologia
Função Executiva/fisiologia
Transtorno de Comunicação Social/fisiopatologia
Teoria da Mente/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Lesões Encefálicas Traumáticas/fisiopatologia
Estudos de Casos e Controles
Comunicação
Compreensão/fisiologia
Feminino
Seres Humanos
Linguística
Masculino
Meia-Idade
Testes Neuropsicológicos
Transtorno de Comunicação Social/psicologia
Análise e Desempenho de Tarefas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


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[PMID]:28114071
[Au] Autor:Kuriakose S; Lahiri U
[Ti] Título:Design of a Physiology-Sensitive VR-Based Social Communication Platform for Children With Autism.
[So] Source:IEEE Trans Neural Syst Rehabil Eng;25(8):1180-1191, 2017 Aug.
[Is] ISSN:1558-0210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Individuals with autism are often characterized by impairments in communication, reciprocal social interaction and explicit expression of their affective states. In conventional techniques, a therapist adjusts the intervention paradigm by monitoring the affective state e.g., anxiety of these individuals for effective floor-time-therapy. Conventional techniques, though powerful, are observation-based and face resource limitations. Technology-assisted systems can provide a quantitative, individualized rehabilitation platform. Presently-available systems are designed primarily to chain learning via aspects of one's performance alone restricting individualization. Specifically, these systems are not sensitive to one's anxiety. Our presented work seeks to bridge this gap by developing a novel VR-based interactive system with Anxiety-Sensitive adaptive technology. Specifically, such a system is capable of objectively identifying and quantifying one's anxiety level from real-time biomarkers, along with performance metrics. In turn it can adaptively respond in an individualized manner to foster improved social communication skills. In our present research, we have used Virtual Reality (VR) to design a proof-of-concept application that exposes participants to social tasks of varying challenges. Results of a preliminary usability study indicate the potential of our VR-based Anxiety-Sensitive system to foster improved task performance, thereby serving as a potent complementary tool in the hands of therapist.
[Mh] Termos MeSH primário: Ansiedade/prevenção & controle
Transtorno Autístico/reabilitação
Biorretroalimentação Psicológica/instrumentação
Transtorno de Comunicação Social/reabilitação
Terapia Assistida por Computador/métodos
Interface Usuário-Computador
[Mh] Termos MeSH secundário: Adolescente
Ansiedade/fisiopatologia
Ansiedade/psicologia
Transtorno Autístico/fisiopatologia
Transtorno Autístico/psicologia
Biorretroalimentação Psicológica/métodos
Criança
Diagnóstico por Computador/instrumentação
Diagnóstico por Computador/métodos
Desenho de Equipamento
Análise de Falha de Equipamento
Feminino
Seres Humanos
Relações Interpessoais
Masculino
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Transtorno de Comunicação Social/fisiopatologia
Transtorno de Comunicação Social/psicologia
Terapia Assistida por Computador/instrumentação
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1109/TNSRE.2016.2613879


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[PMID]:27885547
[Au] Autor:Foley-Nicpon M; L Fosenburg S; G Wurster K; Assouline SG
[Ad] Endereço:The University of Iowa, N361 Lindquist Center, Iowa City, IA, 52242, USA. Megan-foley-nicpon@uiowa.edu.
[Ti] Título:Identifying High Ability Children with DSM-5 Autism Spectrum or Social Communication Disorder: Performance on Autism Diagnostic Instruments.
[So] Source:J Autism Dev Disord;47(2):460-471, 2017 Feb.
[Is] ISSN:1573-3432
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was a replication of Mazefsky et al.'s (Journal of Autism and Developmental Disabilities 43:1236-1242, 2013) investigation among a sample of 45 high ability children and adolescents diagnosed with ASD under DSM-IV-TR. Items from the ADOS and ADI-R were mapped onto DSM-5 diagnostic criteria for ASD and SCD to determine whether participants would meet either diagnosis under DSM-5. If the ADOS were administered alone, 62% of individuals diagnosed with ASD would no longer meet criteria under DSM-5; however, when the ADI-R and ADOS scores were combined, 100% of individuals would continue to meet ASD diagnosis. The ADOS was determined to be an insufficient measure for SCD due to the small number of algorithm items measuring SCD diagnostic criteria, suggesting the development of SCD measures is required.
[Mh] Termos MeSH primário: Transtorno Autístico/diagnóstico
Transtorno Autístico/psicologia
Manual Diagnóstico e Estatístico de Transtornos Mentais
Transtorno de Comunicação Social/diagnóstico
Transtorno de Comunicação Social/psicologia
[Mh] Termos MeSH secundário: Adolescente
Algoritmos
Criança
Pré-Escolar
Deficiências do Desenvolvimento/diagnóstico
Deficiências do Desenvolvimento/psicologia
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.1007/s10803-016-2973-4


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[PMID]:27758752
[Au] Autor:Kissine M; Clin E; de Villiers J
[Ad] Endereço:ACTE/LaDisco, Université libre de Bruxelles, Bruxelles, Belgique.
[Ti] Título:[Pragmatics in autism spectrum disorder: recent developments].
[Ti] Título:La pragmatique dans les troubles du spectre autistique - Développements récents..
[So] Source:Med Sci (Paris);32(10):874-878, 2016 Oct.
[Is] ISSN:1958-5381
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Autism spectrum disorder (ASD) is characterized by primary pragmatic difficulties, out of step with verbal and non-verbal developmental level. This selective survey paper addresses three recent domains of research on pragmatic functions in autism. First, we provide an up-to-date discussion of how lack of sensitivity to social cues impacts early acquisition of words. Second, we review recent findings on the comprehension of non-literal language, pointing to a more refined clinical reality. Third, we describe recent developments in the study of conversation skills in autism.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista
Transtorno de Comunicação Social
[Mh] Termos MeSH secundário: Transtorno do Espectro Autista/epidemiologia
Transtorno do Espectro Autista/fisiopatologia
Cognição
Comunicação
Compreensão
Seres Humanos
Relações Interpessoais
Linguagem
Desenvolvimento da Linguagem
Comportamento Estereotipado
Vocabulário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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[PMID]:27696182
[Au] Autor:Ibrahim GM; Morgan BR; Vogan VM; Leung RC; Anagnostou E; Taylor MJ
[Ad] Endereço:Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto, Suite 1403, 555 University Ave, Toronto, ON, M5G 1X8, Canada. george.m.ibrahim@gmail.com.
[Ti] Título:Mapping the Network of Neuropsychological Impairment in Children with Autism Spectrum Disorder: A Graph Theoretical Analysis.
[So] Source:J Autism Dev Disord;46(12):3770-3777, 2016 Dec.
[Is] ISSN:1573-3432
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Children with autism spectrum disorder (ASD) exhibit social-communicative impairments. Less is known about the neuropsychological profile of ASD, although cognitive and neuropsychological deficits are evident. We modelled neuropsychological function in 20 children with ASD and 20 sex, age and IQ matched typically-developing controls (ages 7-14) as a network of interacting parameters. Graph theoretical analysis was applied to identify critical topographic regions within this network. Two areas were significantly stronger hubs in typically-developing children, the ability to shift attention (p < 0.001) and overall executive function (p < 0.001). Planning/organization was a stronger hub in the cognitive networks of children with ASD (p = 0.001). We show that ASD is not only characterized by impairments in various neurocognitive domains, but also alterations in their interaction.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/fisiopatologia
Mapeamento Encefálico/métodos
Modelos Psicológicos
Transtorno de Comunicação Social/fisiopatologia
[Mh] Termos MeSH secundário: Atenção/fisiologia
Transtorno do Espectro Autista/psicologia
Estudos de Casos e Controles
Criança
Função Executiva/fisiologia
Feminino
Seres Humanos
Masculino
Pontuação de Propensão
Transtorno de Comunicação Social/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:27440144
[Au] Autor:Jeste SS; Varcin KJ; Hellemann GS; Gulsrud AC; Bhatt R; Kasari C; Wu JY; Sahin M; Nelson CA
[Ad] Endereço:From the UCLA Semel Institute of Neuroscience and Human Behavior (S.S.J., G.S.H., A.C.G., R.B., C.K.) and Division of Pediatric Neurology, Mattel Children's Hospital UCLA (R.B., J.Y.W.), David Geffen School of Medicine, Los Angeles, CA; Laboratories of Cognitive Neuroscience, Division of Development
[Ti] Título:Symptom profiles of autism spectrum disorder in tuberous sclerosis complex.
[So] Source:Neurology;87(8):766-72, 2016 Aug 23.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the extent to which deficits associated with autism spectrum disorder (ASD) in toddlers with tuberous sclerosis complex (TSC) overlap with those in toddlers with nonsyndromic ASD (nsASD) and to examine cognitive function and epilepsy severity in toddlers with TSC and comorbid ASD. This is the endpoint analysis from a longitudinal investigation of ASD risk factors in children with TSC. METHODS: Measures included the Autism Diagnostic Observation Schedule (ADOS), the Mullen Scales of Early Learning, and clinical epilepsy variables. A repeated-measures analysis of variance was performed with between-subjects factor of group (typically developing, TSC/no ASD, TSC/ASD, nsASD) and within-subjects factors of individual ADOS item scores in the social communication and repetitive behavior/restricted interest domains. Within the TSC group, comparisons of epilepsy characteristics and cognitive domains were performed using independent-samples t tests. RESULTS: Children with TSC/ASD demonstrated a profile of social communication impairment that had complete convergence with nsASD. Measured social communication impairments included gestures, pointing, eye contact, responsive social smile, and shared enjoyment. This convergence was observed despite the high comorbidity between ASD and cognitive impairment in TSC. CONCLUSIONS: This study supports the clinical diagnosis of ASD in young children with TSC and demonstrates remarkable convergence of autism symptoms between TSC/ASD and nsASD. Our results strongly suggest the need for early intervention in toddlers with TSC, with treatment strategies targeting social communication function as well as broader developmental domains, before the onset of autism symptoms.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/fisiopatologia
Disfunção Cognitiva/fisiopatologia
Epilepsia/fisiopatologia
Transtorno de Comunicação Social/fisiopatologia
Esclerose Tuberosa/fisiopatologia
[Mh] Termos MeSH secundário: Transtorno do Espectro Autista/etiologia
Pré-Escolar
Disfunção Cognitiva/etiologia
Epilepsia/etiologia
Feminino
Seres Humanos
Lactente
Masculino
Transtorno de Comunicação Social/etiologia
Esclerose Tuberosa/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000003002


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[PMID]:27230759
[Au] Autor:Brukner-Wertman Y; Laor N; Golan O
[Ad] Endereço:Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel. yaelbrukner@gmail.com.
[Ti] Título:Social (Pragmatic) Communication Disorder and Its Relation to the Autism Spectrum: Dilemmas Arising From the DSM-5 Classification.
[So] Source:J Autism Dev Disord;46(8):2821-9, 2016 Aug.
[Is] ISSN:1573-3432
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:DSM-5 introduced two diagnoses describing neurodevelopmental deficits in social communication (SC); Autism Spectrum Disorder (ASD) and Social (Pragmatic) Communication Disorder (SPCD). These diagnoses are differentiated by Repetitive and Restricted Behaviors (RRB), required for an ASD diagnosis and absent in SPCD. We highlight the gaps between the research into SPCD and DSM-5's diagnostic criteria, and discuss the clinical implications of this diagnostic decision. We argue that DSM-5's demand for full manifestation of both SC and RRB axes when diagnosing ASD, prematurely forced a categorical view on the continual nature of the potentially dependent SC and RRB phenotypes. We conclude by highlighting the implications of this differential diagnostic decision on public health policies, designated therapy, and the need for further research regarding SPCD.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/classificação
Transtorno do Espectro Autista/diagnóstico
Manual Diagnóstico e Estatístico de Transtornos Mentais
Transtorno de Comunicação Social/classificação
Transtorno de Comunicação Social/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE
[do] DOI:10.1007/s10803-016-2814-5


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[PMID]:27209514
[Au] Autor:Terzi A; Marinis T; Francis K
[Ad] Endereço:Department of Speech and Language Therapy, Technological Educational Institute of W. Greece, Meg. Alexandrou 1, Koukouli, 26334, Patras, Greece. aterzi@teipat.gr.
[Ti] Título:The Interface of Syntax with Pragmatics and Prosody in Children with Autism Spectrum Disorders.
[So] Source:J Autism Dev Disord;46(8):2692-706, 2016 Aug.
[Is] ISSN:1573-3432
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to study problems of individuals with Autism Spectrum Disorders (ASD) with morphosyntax, we investigated twenty high-functioning Greek-speaking children (mean age: 6;11) and twenty age- and language-matched typically developing children on environments that allow or forbid object clitics or their corresponding noun phrase. Children with ASD fell behind typically developing children in comprehending and producing simple clitics and producing noun phrases in focus structures. The two groups performed similarly in comprehending and producing clitics in clitic left dislocation and in producing noun phrases in non-focus structures. We argue that children with ASD have difficulties at the interface of (morpho)syntax with pragmatics and prosody, namely, distinguishing a discourse prominent element, and considering intonation relevant for a particular interpretation that excludes clitics.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Linguagem Infantil
Transtornos do Desenvolvimento da Linguagem/psicologia
Transtorno de Comunicação Social/psicologia
Distúrbios da Fala/psicologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Criança
Pré-Escolar
Comunicação
Compreensão
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160523
[St] Status:MEDLINE
[do] DOI:10.1007/s10803-016-2811-8



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