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[PMID]:26968334
[Au] Autor:Zhou D; Gochman P; Broadnax DD; Rapoport JL; Ahn K
[Ad] Endereço:Child Psychiatry Branch, National Institute of Mental Health, NIH, Maryland.
[Ti] Título:15q13.3 duplication in two patients with childhood-onset schizophrenia.
[So] Source:Am J Med Genet B Neuropsychiatr Genet;171(6):777-83, 2016 Sep.
[Is] ISSN:1552-485X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report two cases of paternally inherited 15q13.3 duplications in carriers diagnosed with childhood-onset schizophrenia (COS), a rare neurodevelopmental disorder of proposed polygenic origin with onset in children before age 13. This study documents that the 15q13.3 deletion and duplication exhibit pathogenicity for COS, with both copy number variants (CNVs) sharing a disrupted CHRNA7 gene. CHRNA7 encodes the neuronal alpha7 nicotinic acetylcholine receptor (α7nAChR) and is a candidate gene that has been suggested as a pathophysiological process mediating adult-onset schizophrenia (AOS) and other neurodevelopmental disorders. These results support the incomplete penetrance and variable expressivity of this CNV and represent the first report of 15q13.3 duplication carriers exhibiting COS. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Esquizofrenia Infantil/genética
Esquizofrenia Infantil/psicologia
[Mh] Termos MeSH secundário: Criança
Deleção Cromossômica
Cromossomos Humanos Par 15/genética
Variações do Número de Cópias de DNA
Feminino
Seres Humanos
Deficiência Intelectual/genética
Masculino
Linhagem
Esquizofrenia/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.b.32439


  2 / 1275 MEDLINE  
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[PMID]:26802780
[Au] Autor:Watsky RE; Pollard KL; Greenstein D; Shora L; Dillard-Broadnax D; Gochman P; Clasen LS; Berman RA; Rapoport JL; Gogtay N; Ordóñez AE
[Ad] Endereço:Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health.
[Ti] Título:Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms.
[So] Source:J Am Acad Child Adolesc Psychiatry;55(2):130-136, 2016 Feb.
[Is] ISSN:1527-5418
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study investigated the relationship between regional cortical gray matter thinning and symptoms of schizophrenia spectrum personality disorders (PDs) in siblings of patients with childhood-onset schizophrenia (COS). METHOD: A total of 66 siblings of patients with COS were assessed for symptoms of schizophrenia spectrum PDs (avoidant, paranoid, schizoid, schizotypal). Structural magnetic resonance images were obtained at approximately 2-year intervals from the siblings and from 62 healthy volunteers matched for age, sex, ethnicity, and handedness. Cortical thickness measures were extracted. Mixed effect regression models were used to test the relationship between symptoms and cortical gray matter thickness in siblings. Cortical thinning was also tested longitudinally in healthy volunteers and siblings. RESULTS: Cortical thinning was found to correlate with symptoms of schizotypal and, to a lesser extent, schizoid PDs. Thinning was most pronounced in the left temporal and parietal lobes and right frontal and parietal regions. Gray matter loss was found to be continuous with that measured in COS. Longitudinal thinning trajectories were found not to differ between siblings and healthy volunteers. CONCLUSION: The present investigation of cortical thinning in siblings of patients with COS indicates that symptoms of schizophrenia spectrum PDs correlate with regional gray matter loss. This finding supports the idea of cortical thinning as a schizophrenia endophenotype.
[Mh] Termos MeSH primário: Córtex Cerebral/patologia
Esquizofrenia Infantil/patologia
Esquizofrenia/patologia
Transtorno da Personalidade Esquizotípica/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Mapeamento Encefálico
Estudos de Casos e Controles
Córtex Cerebral/diagnóstico por imagem
Deficiências do Desenvolvimento/diagnóstico por imagem
Deficiências do Desenvolvimento/patologia
Endofenótipos
Feminino
Seres Humanos
Masculino
Lobo Parietal/diagnóstico por imagem
Lobo Parietal/patologia
Esquizofrenia/diagnóstico por imagem
Esquizofrenia Infantil/diagnóstico por imagem
Transtorno da Personalidade Esquizotípica/diagnóstico por imagem
Irmãos/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160124
[St] Status:MEDLINE
[do] DOI:10.1016/j.jaac.2015.11.008


  3 / 1275 MEDLINE  
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[PMID]:26747855
[Au] Autor:Lancaster TM; Hall J
[Ad] Endereço:Neuroscience and Mental Health Research Institute, Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK HallJ10@cardiff.ac.uk.
[Ti] Título:Altered intra- and inter-network dynamics reflect symptom dimensions in childhood-onset schizophrenia.
[So] Source:Brain;139(Pt 1):10-2, 2016 Jan.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Cognição
Esquizofrenia Infantil/fisiopatologia
Esquizofrenia Infantil/psicologia
Comportamento Social
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160110
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awv330


  4 / 1275 MEDLINE  
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[PMID]:26508570
[Au] Autor:Ambalavanan A; Girard SL; Ahn K; Zhou S; Dionne-Laporte A; Spiegelman D; Bourassa CV; Gauthier J; Hamdan FF; Xiong L; Dion PA; Joober R; Rapoport J; Rouleau GA
[Ad] Endereço:Department of Human Genetics, McGill University, Montreal, QC, Canada.
[Ti] Título:De novo variants in sporadic cases of childhood onset schizophrenia.
[So] Source:Eur J Hum Genet;24(6):944-8, 2016 Jun.
[Is] ISSN:1476-5438
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Childhood-onset schizophrenia (COS), defined by the onset of illness before age 13 years, is a rare severe neurodevelopmental disorder of unknown etiology. Recently, sequencing studies have identified rare, potentially causative de novo variants in sporadic cases of adult-onset schizophrenia and autism. In this study, we performed exome sequencing of 17 COS trios in order to test whether de novo variants could contribute to this disease. We identified 20 de novo variants in 17 COS probands, which is consistent with the de novo mutation rate reported in the adult form of the disease. Interestingly, the missense de novo variants in COS have a high likelihood for pathogenicity and were enriched for genes that are less tolerant to variants. Among the genes found disrupted in our study, SEZ6, RYR2, GPR153, GTF2IRD1, TTBK1 and ITGA6 have been previously linked to neuronal function or to psychiatric disorders, and thus may be considered as COS candidate genes.
[Mh] Termos MeSH primário: Mutação de Sentido Incorreto
Esquizofrenia Infantil/genética
[Mh] Termos MeSH secundário: Criança
Exoma
Feminino
Estudo de Associação Genômica Ampla
Seres Humanos
Integrina alfa6/genética
Masculino
Proteínas Musculares/genética
Proteínas Nucleares/genética
Proteínas Serina-Treonina Quinases/genética
Receptores Acoplados a Proteínas-G/genética
Canal de Liberação de Cálcio do Receptor de Rianodina/genética
Transativadores/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GTF2IRD1 protein, human); 0 (Gpr153 protein, human); 0 (ITGA6 protein, human); 0 (Integrin alpha6); 0 (Muscle Proteins); 0 (Nuclear Proteins); 0 (Receptors, G-Protein-Coupled); 0 (RyR2 protein, human); 0 (Ryanodine Receptor Calcium Release Channel); 0 (Trans-Activators); EC 2.7.1.11 (tau-tubulin kinase); EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE
[do] DOI:10.1038/ejhg.2015.218


  5 / 1275 MEDLINE  
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Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
Texto completo
[PMID]:26493637
[Au] Autor:Berman RA; Gotts SJ; McAdams HM; Greenstein D; Lalonde F; Clasen L; Watsky RE; Shora L; Ordonez AE; Raznahan A; Martin A; Gogtay N; Rapoport J
[Ad] Endereço:1 Child Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda MD 20892, USA bermanr@mail.nih.gov.
[Ti] Título:Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia.
[So] Source:Brain;139(Pt 1):276-91, 2016 Jan.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Schizophrenia is increasingly recognized as a neurodevelopmental disorder with altered connectivity among brain networks. In the current study we examined large-scale network interactions in childhood-onset schizophrenia, a severe form of the disease with salient genetic and neurobiological abnormalities. Using a data-driven analysis of resting-state functional magnetic resonance imaging fluctuations, we characterized data from 19 patients with schizophrenia and 26 typically developing controls, group matched for age, sex, handedness, and magnitude of head motion during scanning. This approach identified 26 regions with decreased functional correlations in schizophrenia compared to controls. These regions were found to organize into two function-related networks, the first with regions associated with social and higher-level cognitive processing, and the second with regions involved in somatosensory and motor processing. Analyses of across- and within-network regional interactions revealed pronounced across-network decreases in functional connectivity in the schizophrenia group, as well as a set of across-network relationships with overall negative coupling indicating competitive or opponent network dynamics. Critically, across-network decreases in functional connectivity in schizophrenia predicted the severity of positive symptoms in the disorder, such as hallucinations and delusions. By contrast, decreases in functional connectivity within the social-cognitive network of regions predicted the severity of negative symptoms, such as impoverished speech and flattened affect. These results point toward the role that abnormal integration of sensorimotor and social-cognitive processing may play in the pathophysiology and symptomatology of schizophrenia.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Cognição
Esquizofrenia Infantil/fisiopatologia
Esquizofrenia Infantil/psicologia
Comportamento Social
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Imagem Ecoplanar
Feminino
Neuroimagem Funcional
Seres Humanos
Masculino
Vias Neurais/fisiopatologia
Esquizofrenia Infantil/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170511
[Lr] Data última revisão:
170511
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151024
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awv306


  6 / 1275 MEDLINE  
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[PMID]:25510512
[Au] Autor:Ahn K; An SS; Shugart YY; Rapoport JL
[Ad] Endereço:Childhood Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
[Ti] Título:Common polygenic variation and risk for childhood-onset schizophrenia.
[So] Source:Mol Psychiatry;21(1):94-6, 2016 Jan.
[Is] ISSN:1476-5578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Childhood-onset schizophrenia (COS) is a rare and severe form of the disorder, with more striking abnormalities with respect to prepsychotic developmental disorders and abnormities in the brain development compared with later-onset schizophrenia. We previously documented that COS patients, compared with their healthy siblings and with adult-onset patients (AOS), carry significantly more rare chromosomal copy number variations, spanning large genomic regions (>100 kb) (Ahn et al. 2014). Here, we interrogated the contribution of common polygenic variation to the genetic susceptibility for schizophrenia. We examined the association between a direct measure of genetic risk of schizophrenia in 130 COS probands and 103 healthy siblings. Using data from the schizophrenia and autism GWAS of the Psychiatric Genomic Consortia, we selected three risk-related sets of single nucleotide polymorphisms from which we conducted polygenic risk score comparisons for COS probands and their healthy siblings. COS probands had higher genetic risk scores of both schizophrenia and autism than their siblings (P<0.05). Given the small sample size, these findings suggest that COS patients have more salient genetic risk than do AOS.
[Mh] Termos MeSH primário: Predisposição Genética para Doença
Herança Multifatorial
Polimorfismo de Nucleotídeo Único
Esquizofrenia Infantil/genética
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Estudo de Associação Genômica Ampla
Seres Humanos
Masculino
Irmãos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141217
[St] Status:MEDLINE
[do] DOI:10.1038/mp.2014.158


  7 / 1275 MEDLINE  
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[PMID]:26101010
[Au] Autor:Aslam N
[Ad] Endereço:Department of Psychology, Quaid-i-Azam University, Islamabad.
[Ti] Título:Assessing and Treating Early Onset Schizophrenia at Schools.
[So] Source:J Coll Physicians Surg Pak;25(6):472-3, 2015 Jun.
[Is] ISSN:1681-7168
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Mh] Termos MeSH primário: Intervenção Médica Precoce
Esquizofrenia Infantil/diagnóstico
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Idade de Início
Seres Humanos
Esquizofrenia Infantil/terapia
Instituições Acadêmicas
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:150623
[Lr] Data última revisão:
150623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150624
[St] Status:MEDLINE
[do] DOI:06.2015/JCPSP.472473


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[PMID]:26038817
[Au] Autor:Cancel A; Comte M; Truillet R; Boukezzi S; Rousseau PF; Zendjidjian XY; Sage T; Lazerges PE; Guedj E; Khalfa S; Azorin JM; Blin O; Fakra E
[Ad] Endereço:Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France.
[Ti] Título:Childhood neglect predicts disorganization in schizophrenia through grey matter decrease in dorsolateral prefrontal cortex.
[So] Source:Acta Psychiatr Scand;132(4):244-56, 2015 Oct.
[Is] ISSN:1600-0447
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Psychosocial trauma during childhood is associated with schizophrenia vulnerability. The pattern of grey matter decrease is similar to brain alterations seen in schizophrenia. Our objective was to explore the links between childhood trauma, brain morphology and schizophrenia symptoms. METHOD: Twenty-one patients with schizophrenia stabilized with atypical antipsychotic monotherapy and 30 healthy control subjects completed the study. Anatomical MRI images were analysed using optimized voxel-based morphometry (VBM). Childhood trauma was assessed with the Childhood Trauma Questionnaire, and symptoms were rated on the Scale for the Assessment of Negative Symptoms (SANS) and Scale for the Assessment of Positive Symptoms (SAPS) (disorganization, positive and negative symptoms). In the schizophrenia group, we used structural equation modelling in a path analysis. RESULTS: Total grey matter volume was negatively associated with emotional neglect (EN) in patients with schizophrenia. Whole-brain VBM analyses of grey matter in the schizophrenia group revealed a specific inversed association between EN and the right dorsolateral prefrontal cortex (DLPFC). Path analyses identified a well-fitted model in which EN predicted grey matter density in DLPFC, which in turn predicted the disorganization score. CONCLUSION: Our findings suggest that EN during childhood could have an impact on psychopathology in schizophrenia, which would be mediated by developmental effects on brain regions such as the DLPFC.
[Mh] Termos MeSH primário: Maus-Tratos Infantis/psicologia
Substância Cinzenta/patologia
Córtex Pré-Frontal/patologia
Esquizofrenia Infantil/patologia
Esquizofrenia Hebefrênica/patologia
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico
Estudos de Casos e Controles
Criança
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Imagem por Ressonância Magnética/métodos
Masculino
Valor Preditivo dos Testes
Psicologia
Psicologia do Esquizofrênico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150916
[Lr] Data última revisão:
150916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150604
[St] Status:MEDLINE
[do] DOI:10.1111/acps.12455


  9 / 1275 MEDLINE  
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[PMID]:25966588
[Au] Autor:Stepanov VA; Bocharova AV; Saduakassova KZ; Marusin AV; Koneva LA; Vagaitseva KV; Svyatova GS
[Ti] Título:[Replicative study of susceptibility to childhood-onset schizophrenia in Kazakhs].
[So] Source:Genetika;51(2):227-35, 2015 Feb.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This paper reports the results of replicative analysis of associations of 15 SNPs in a region of 14 genes previously identified in genome-wide association studies (GWAS) with early-onset schizophrenia in Kazakhs. An association of early-onset schizophrenia with genetic markers in three genes (VRK2, KCNB2, and CPVL) was found. An association of rs2312147 in the VRK2 gene with schizophrenia was also previously reported in the Chinese population, so this marker may be considered as possibly race-specific. Two groups consisting of four and six genes demonstrating intergenic epistatic interactions were revealed by multifactor dimensionality reduction methods. The gene ontologies of 14 studied genes were reduced to variants of one molecular function (peptidase activity) and one biological process (positive regulation of biosynthesis processes). Bioinformatic analysis of the protein-protein interactions of products of the genes under study demonstrates that the products of six out of 14 genes may be involved in a single interrelated network, the major connecting link of which is represented by their ubiquitination by the UBC protein.
[Mh] Termos MeSH primário: Idade de Início
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Esquizofrenia Infantil/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Grupo com Ancestrais do Continente Asiático/genética
Carboxipeptidases/genética
Criança
Pré-Escolar
Feminino
Seres Humanos
Cazaquistão
Masculino
Polimorfismo de Nucleotídeo Único/genética
Proteínas Serina-Treonina Quinases/genética
Esquizofrenia Infantil/patologia
Canais de Potássio Shab/genética
Adulto Jovem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (KCNB2 protein, human); 0 (Shab Potassium Channels); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.1 (VRK2 protein, human); EC 3.4.- (Carboxypeptidases); EC 3.4.16.- (CPVL protein, human)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:150513
[Lr] Data última revisão:
150513
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150514
[St] Status:MEDLINE


  10 / 1275 MEDLINE  
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[PMID]:25936396
[Au] Autor:Anvari AA; Friedman LA; Greenstein D; Gochman P; Gogtay N; Rapoport JL
[Ad] Endereço:Child Psychiatry Branch,National Institute of Mental Health, National Institutes of Health,Bethesda,MD,USA.
[Ti] Título:Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia.
[So] Source:Psychol Med;45(12):2667-74, 2015.
[Is] ISSN:1469-8978
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fixed hippocampal volume reductions and shape abnormalities are established findings in schizophrenia, but the relationship between hippocampal volume change and clinical outcome has been relatively unexplored in schizophrenia and other psychotic disorders. In light of recent findings correlating hippocampal volume change and clinical outcome in first-episode psychotic adults, we hypothesized that fewer decreases in hippocampal volume would be associated with better functional outcome and fewer psychotic symptoms in our rare and chronically ill population of childhood-onset schizophrenia (COS) patients. METHOD: We prospectively obtained 114 structural brain magnetic resonance images (MRIs) from 27 COS subjects, each with three or more scans between the ages of 10 and 30 years. Change in hippocampal volume, measured by fit slope and percentage change, was regressed against clinical ratings (Children's Global Assessment Scale, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms) at last scan (controlling for sex, time between scans and total intracranial volume). RESULTS: Fewer negative symptoms were associated with less hippocampal volume decrease (fit slope: p = 0.0003, and percentage change: p = 0.005) while positive symptoms were not related to hippocampal change. There was also a relationship between improved clinical global functioning and maintained hippocampal volumes (fit slope: p = 0.025, and percentage change: p = 0.043). CONCLUSIONS: These results suggest that abnormal hippocampal development in schizophrenia can be linked to global functioning and negative symptoms. The hippocampus can be considered a potential treatment target for future therapies.
[Mh] Termos MeSH primário: Hipocampo/fisiopatologia
Esquizofrenia Infantil/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antipsicóticos/uso terapêutico
Criança
Feminino
Seres Humanos
Modelos Lineares
Imagem por Ressonância Magnética
Masculino
National Institute of Mental Health (U.S.)
Estudos Prospectivos
Esquizofrenia Infantil/tratamento farmacológico
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Nm] Nome de substância:
0 (Antipsychotic Agents)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150803
[Lr] Data última revisão:
150803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150505
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1017/S0033291715000677



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