Base de dados : MEDLINE
Pesquisa : F03.625.984 [Categoria DeCS]
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[PMID]:27847985
[Au] Autor:Moser I; Vibert D; Caversaccio MD; Mast FW
[Ad] Endereço:Department of Psychology, University of Bern, Fabrikstrasse 8, Bern, 3012, Switzerland. ivan.moser@psy.unibe.ch.
[Ti] Título:Acute peripheral vestibular deficit increases redundancy in random number generation.
[So] Source:Exp Brain Res;235(2):627-637, 2017 Feb.
[Is] ISSN:1432-1106
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Unilateral peripheral vestibular deficit leads to broad cognitive difficulties and biases in spatial orientation. More specifically, vestibular patients typically show a spatial bias toward their affected ear in the subjective visual vertical, head and trunk orientation, fall tendency, and walking trajectory. By means of a random number generation task, we set out to investigate how an acute peripheral vestibular deficit affects the mental representation of numbers in space. Furthermore, the random number generation task allowed us to test if patients with peripheral vestibular deficit show evidence of impaired executive functions while keeping the head straight and while performing active head turns. Previous research using galvanic vestibular stimulation in healthy people has shown no effects on number space, but revealed increased redundancy of the generated numbers. Other studies reported a spatial bias in number representation during active and passive head turns. In this experiment, we tested 43 patients with acute vestibular neuritis (18 patients with left-sided and 25 with right-sided vestibular deficit) and 28 age-matched healthy controls. We found no bias in number space in patients with peripheral vestibular deficit but showed increased redundancy in patients during active head turns. Patients showed worse performance in generating sequences of random numbers, which indicates a deficit in the updating component of executive functions. We argue that RNG is a promising candidate for a time- and cost-effective assessment of executive functions in patients suffering from a peripheral vestibular deficit.
[Mh] Termos MeSH primário: Transtornos Cognitivos/etiologia
Orientação/fisiologia
Transtornos da Percepção/etiologia
Percepção Espacial/fisiologia
Doenças Vestibulares/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Análise de Variância
Progressão da Doença
Eletroencefalografia
Feminino
Lateralidade Funcional
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Transtorno de Movimento Estereotipado/etiologia
Potenciais Evocados Miogênicos Vestibulares/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE
[do] DOI:10.1007/s00221-016-4829-8


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[PMID]:27292128
[Au] Autor:Hedderly T
[Ad] Endereço:Evelina London Children's Healthcare - Paediatric Neurosciences, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[Ti] Título:Childhood motor stereotypies: questions of definition and management.
[So] Source:Dev Med Child Neurol;59(2):117-118, 2017 02.
[Is] ISSN:1469-8749
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Comportamento Estereotipado
Transtorno de Movimento Estereotipado
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE
[do] DOI:10.1111/dmcn.13181


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[PMID]:27259464
[Au] Autor:Specht MW; Mahone EM; Kline T; Waranch R; Brabson L; Thompson CB; Singer HS
[Ad] Endereço:Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[Ti] Título:Efficacy of parent-delivered behavioral therapy for primary complex motor stereotypies.
[So] Source:Dev Med Child Neurol;59(2):168-173, 2017 Feb.
[Is] ISSN:1469-8749
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: Primary complex motor stereotypies (CMS) are persistent, patterned, repetitive, rhythmic movements in young people with typical development. This study evaluated the efficacy of an instructional DVD as a home-based, parent-administered, behavioral therapy for primary CMS. METHOD: Eighty-one children with primary CMS were enrolled. Primary outcome measures included the Stereotypy Severity Scale (SSS) - Motor and Impairment scores, and Stereotypy Linear Analog Scale (SLAS). Mean CMS onset was 13.4 months (SD 13.1). Eligibility required observed CMS. Psychiatric disorders were not exclusionary and a stable medication regimen was required. Intellectual disability, neurological disorder, autism spectrum disorder, and tics were exclusionary. Initial assessments were completed via REDCap before receipt of the DVD. Fifty-four of the 81 children (34 male, 20 female; mean age 8y 2mo, SD 1.42, range 7-14y) completed assessments at 1, 2, or 3 months after receiving the DVD. RESULTS: Reductions (baseline to last assessment) in SSS Motor, SSS Impairment, and SLAS scores (all p<0.001) represented change ratios of -15%, -24%, and a -20% respectively. Greatest relative treatment benefit was observed by younger children (ages 7-8y), and by 1 month after receipt of DVD, while a parent global assessment scale showed progressive improvement throughout the study. INTERPRETATION: An instructional DVD for parent-delivered behavioral therapy was a safe, effective intervention for primary CMS.
[Mh] Termos MeSH primário: Terapia Comportamental/métodos
Relações Pais-Filho
Pais/psicologia
Transtorno de Movimento Estereotipado/reabilitação
[Mh] Termos MeSH secundário: Adolescente
Criança
Avaliação da Deficiência
Feminino
Seguimentos
Seres Humanos
Masculino
Índice de Gravidade de Doença
Inquéritos e Questionários
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE
[do] DOI:10.1111/dmcn.13164


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[PMID]:27498241
[Au] Autor:Maltête D
[Ad] Endereço:Department of Neurology, Rouen University Hospital, University of Rouen, 1, rue de Germont, 76031 cedex Rouen, France; Inserm U 1073, 22, boulevard Gambetta, 76183 Rouen cedex, France. Electronic address: david.maltete@chu-rouen.fr.
[Ti] Título:Adult-onset stereotypical motor behaviors.
[So] Source:Rev Neurol (Paris);172(8-9):477-482, 2016 Aug - Sep.
[Is] ISSN:0035-3787
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Stereotypies have been defined as non-goal-directed movement patterns repeated continuously for a period of time in the same form and on multiple occasions, and which are typically distractible. Stereotypical motor behaviors are a common clinical feature of a variety of neurological conditions that affect cortical and subcortical functions, including autism, tardive dyskinesia, excessive dopaminergic treatment of Parkinson's disease and frontotemporal dementia. The main differential diagnosis of stereotypies includes tic disorders, motor mannerisms, compulsion and habit. The pathophysiology of stereotypies may involve the corticostriatal pathways, especially the orbitofrontal and anterior cingulated cortices. Because antipsychotics have long been used to manage stereotypical behaviours in mental retardation, stereotypies that present in isolation tend not to warrant pharmacological intervention, as the benefit-to-risk ratio is not great enough.
[Mh] Termos MeSH primário: Transtorno de Movimento Estereotipado
[Mh] Termos MeSH secundário: Adulto
Idade de Início
Comportamento Compulsivo/diagnóstico
Comportamento Compulsivo/etiologia
Comportamento Compulsivo/terapia
Diagnóstico Diferencial
Demência Frontotemporal/diagnóstico
Demência Frontotemporal/etiologia
Demência Frontotemporal/terapia
Seres Humanos
Comportamento Estereotipado/fisiologia
Transtorno de Movimento Estereotipado/diagnóstico
Transtorno de Movimento Estereotipado/epidemiologia
Transtorno de Movimento Estereotipado/etiologia
Transtorno de Movimento Estereotipado/terapia
Discinesia Tardia/diagnóstico
Discinesia Tardia/etiologia
Discinesia Tardia/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160808
[St] Status:MEDLINE


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[PMID]:27460002
[Au] Autor:Schertz HH; Odom SL; Baggett KM; Sideris JH
[Ad] Endereço:Department of Curriculum and Instruction, Indiana University School of Education, 201 N Rose Ave., Bloomington, IN, 47405, USA. hschertz@indiana.edu.
[Ti] Título:Parent-Reported Repetitive Behavior in Toddlers on the Autism Spectrum.
[So] Source:J Autism Dev Disord;46(10):3308-16, 2016 Oct.
[Is] ISSN:1573-3432
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Toddlers with autism spectrum disorder (ASD) were assessed on the Repetitive Behavior Scale-Revised (RBS-R), which we found to have acceptable internal consistency. Stereotypical subscale scores showed a negligible association with cognitive level, but correlated more strongly with adaptive and social indicators. Relative to earlier reported RBS-R scores for older age groups, toddlers' scores trended toward higher stereotyped behavior and lower ritualistic/sameness behavior. Our findings on associations with developmental indicators align with those of researchers who used more resource-intensive repetitive behavior measures. The convergence of these findings with those derived from other measurement methods suggests that the RBS-R, a cost effective parent-report measure, is a viable means of assessing repetitive behavior in toddlers with autism.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/diagnóstico
Transtorno do Espectro Autista/psicologia
Pais/psicologia
Transtorno de Movimento Estereotipado/diagnóstico
Transtorno de Movimento Estereotipado/psicologia
[Mh] Termos MeSH secundário: Transtorno do Espectro Autista/epidemiologia
Pré-Escolar
Feminino
Seres Humanos
Lactente
Intenção
Masculino
Comportamento Estereotipado
Transtorno de Movimento Estereotipado/epidemiologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE
[do] DOI:10.1007/s10803-016-2870-x


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[PMID]:26830142
[Au] Autor:Belinson H; Nakatani J; Babineau BA; Birnbaum RY; Ellegood J; Bershteyn M; McEvilly RJ; Long JM; Willert K; Klein OD; Ahituv N; Lerch JP; Rosenfeld MG; Wynshaw-Boris A
[Ad] Endereço:Department of Pediatrics, Institute for Human Genetics, Edyth and Eli Broad Institute of Regenerative Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
[Ti] Título:Prenatal ß-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.
[So] Source:Mol Psychiatry;21(10):1417-33, 2016 Oct.
[Is] ISSN:1476-5578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Social interaction is a fundamental behavior in all animal species, but the developmental timing of the social neural circuit formation and the cellular and molecular mechanisms governing its formation are poorly understood. We generated a mouse model with mutations in two Disheveled genes, Dvl1 and Dvl3, that displays adult social and repetitive behavioral abnormalities associated with transient embryonic brain enlargement during deep layer cortical neuron formation. These phenotypes were mediated by the embryonic expansion of basal neural progenitor cells (NPCs) via deregulation of a ß-catenin/Brn2/Tbr2 transcriptional cascade. Transient pharmacological activation of the canonical Wnt pathway during this period of early corticogenesis rescued the ß-catenin/Brn2/Tbr2 transcriptional cascade and the embryonic brain phenotypes. Remarkably, this embryonic treatment prevented adult behavioral deficits and partially rescued abnormal brain structure in Dvl mutant mice. Our findings define a mechanism that links fetal brain development and adult behavior, demonstrating a fetal origin for social and repetitive behavior deficits seen in disorders such as autism.
[Mh] Termos MeSH primário: Transtorno de Movimento Estereotipado/genética
Transtorno de Movimento Estereotipado/fisiopatologia
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/genética
Animais
Comportamento Animal
Encéfalo/embriologia
Encéfalo/metabolismo
Encéfalo/fisiologia
Proteínas Desgrenhadas/genética
Proteínas Desgrenhadas/metabolismo
Seres Humanos
Camundongos
Proteínas do Tecido Nervoso/metabolismo
Proteínas do Tecido Nervoso/fisiologia
Células-Tronco Neurais/metabolismo
Neurônios/metabolismo
Fatores do Domínio POU/metabolismo
Fatores do Domínio POU/fisiologia
Fosfoproteínas/genética
Transdução de Sinais/fisiologia
Comportamento Estereotipado/fisiologia
Proteínas com Domínio T-Box/metabolismo
Proteínas com Domínio T-Box/fisiologia
Proteínas Wnt/metabolismo
Via de Sinalização Wnt/genética
Via de Sinalização Wnt/fisiologia
beta Catenina/metabolismo
beta Catenina/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Dishevelled Proteins); 0 (Dvl1 protein, mouse); 0 (Dvl3 protein, mouse); 0 (Eomes protein, mouse); 0 (Nerve Tissue Proteins); 0 (POU Domain Factors); 0 (Phosphoproteins); 0 (T-Box Domain Proteins); 0 (Wnt Proteins); 0 (beta Catenin); 147258-11-5 (Pou3f2 protein, mouse)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160203
[St] Status:MEDLINE
[do] DOI:10.1038/mp.2015.207


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[PMID]:26542237
[Au] Autor:Harris AD; Singer HS; Horska A; Kline T; Ryan M; Edden RA; Mahone EM
[Ad] Endereço:From the Russell H. Morgan Department of Radiology and Radiological Science (A.D.H., A.H., R.A.E.E.) F.M. Kirby Center for Functional Brain Imaging (A.D.H., A.H., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland. ashley.harris2@ucalgary.ca.
[Ti] Título:GABA and Glutamate in Children with Primary Complex Motor Stereotypies: An 1H-MRS Study at 7T.
[So] Source:AJNR Am J Neuroradiol;37(3):552-7, 2016 Mar.
[Is] ISSN:1936-959X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Complex motor stereotypies are rhythmic, repetitive, fixed, purposeful but purposeless movements that stop with distraction. They can occur in otherwise normal healthy children (primary stereotypies) as well in those with autism spectrum disorders (secondary stereotypies). The underlying neurobiologic basis for these movements is unknown but is thought to involve cortical-striatal-thalamo-cortical pathways. To further clarify potential neurochemical alterations, gamma-aminobutyric acid (GABA), glutamate, glutamine, N-acetylaspartate, and choline levels were measured in 4 frontostriatal regions by using (1)H MRS at 7T. MATERIALS AND METHODS: A total of 18 children with primary complex motor stereotypies and 24 typically developing controls, ages 5-10 years, completed MR spectroscopy at 7T. Single voxel STEAM acquisitions from the anterior cingulate cortex, premotor cortex, dorsolateral prefrontal cortex, and striatum were obtained, and metabolites were quantified with respect to Cr by using LCModel. RESULTS: The 7T scan was well tolerated by all the participants. Compared with the controls, children with complex motor stereotypies had lower levels of GABA in the anterior cingulate cortex (GABA/Cr, P = .049; GABA/Glu, P = .051) and striatum (GABA/Cr, P = .028; GABA/Glu, P = .0037) but not the dorsolateral prefrontal cortex or the premotor cortex. Glutamate, glutamine, NAA, and Cho levels did not differ between groups in any of the aforementioned regions. Within the complex motor stereotypies group, reduced GABA to Cr in the anterior cingulate cortex was significantly associated with greater severity of motor stereotypies (r = -0.59, P = .021). CONCLUSIONS: These results indicate possible GABAergic dysfunction within corticostriatal pathways in children with primary complex motor stereotypies.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Ácido Glutâmico/metabolismo
Transtorno de Movimento Estereotipado/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Mh] Termos MeSH secundário: Criança
Feminino
Ácido Glutâmico/análise
Seres Humanos
Espectroscopia de Ressonância Magnética/métodos
Masculino
Espectroscopia de Prótons por Ressonância Magnética
Ácido gama-Aminobutírico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3KX376GY7L (Glutamic Acid); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151107
[St] Status:MEDLINE
[do] DOI:10.3174/ajnr.A4547


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[PMID]:26514642
[Au] Autor:Hoch J; Spofford L; Dimian A; Tervo R; MacLean WE; Symons FJ
[Ad] Endereço:University of Minnesota hoch0048@umn.edu.
[Ti] Título:A Direct Comparison of Self-Injurious and Stereotyped Motor Behavior Between Preschool-Aged Children With and Without Developmental Delays.
[So] Source:J Pediatr Psychol;41(5):566-72, 2016 Jun.
[Is] ISSN:1465-735X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare the prevalence of self-injurious behavior (SIB) and stereotyped motor behavior (STY) of preschool-aged children with developmental delays (DD group) and their peers without developmental delays (TD group) using a standardized caregiver report scale. METHODS: The Repetitive Behavior Scale-Revised was completed by caregivers of children with developmental delays and their peers without developmental delays. Frequency of occurrence and severity ratings for SIB and STY were compared between groups. RESULTS: SIB and STY were reported more often and at a greater level of severity in the DD group. Older chronological age was associated with more severe STY in the DD group but not the TD group. Gender was not related to STY or SIB for either group. CONCLUSIONS: Differences in STY and SIB were evident between preschoolers with and without DD. Findings are discussed from developmental and behavioral psychology perspectives regarding the expression of repetitive behavior in developmentally at-risk pediatric populations.
[Mh] Termos MeSH primário: Deficiências do Desenvolvimento/psicologia
Comportamento Autodestrutivo/etiologia
Transtorno de Movimento Estereotipado/etiologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Prevalência
Fatores de Risco
Comportamento Autodestrutivo/diagnóstico
Comportamento Autodestrutivo/epidemiologia
Transtorno de Movimento Estereotipado/diagnóstico
Transtorno de Movimento Estereotipado/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151031
[St] Status:MEDLINE
[do] DOI:10.1093/jpepsy/jsv102


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[PMID]:26209715
[Au] Autor:Jankovic J
[Ti] Título:Leg stereotypy disorder.
[So] Source:J Neurol Neurosurg Psychiatry;87(2):220-1, 2016 Feb.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Perna (Membro)
Transtorno de Movimento Estereotipado/diagnóstico
Transtorno de Movimento Estereotipado/fisiopatologia
[Mh] Termos MeSH secundário: Seres Humanos
Comportamento Estereotipado
Inquéritos e Questionários
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1605
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150726
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2015-310816


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[PMID]:26111945
[Au] Autor:Eussen ML; Van Gool AR; Louwerse A; Verhulst FC; Greaves-Lord K
[Ad] Endereço:Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical University Center/Sophia Children's Hospital, Rotterdam, The Netherlands.
[Ti] Título:Superior Disembedding Performance in Childhood Predicts Adolescent Severity of Repetitive Behaviors: A Seven Years Follow-Up of Individuals With Autism Spectrum Disorder.
[So] Source:Autism Res;9(2):282-91, 2016 Feb.
[Is] ISSN:1939-3806
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous research suggests that individuals with autism spectrum disorder (ASD) show a detail-focused cognitive style. The aim of the current longitudinal study was to investigate whether this detail-focused cognitive style in childhood predicted a higher symptom severity of repetitive and restrictive behaviors and interests (RRBI) in adolescence. The Childhood Embedded Figures Test (CEFT) and the Autism Diagnostic Observation Schedule (ADOS) were administered in 87 children with ASD at the age of 6-12 years old (T1), and the ADOS was readministered 7 years later when the participants were 12-19 years old (T2). Linear regression analyses were performed to investigate whether accuracy and reaction time in the complex versus simple CEFT condition and performance in the complex condition predicted T2 ADOS RRBI calibrated severity scores (CSS), while taking into consideration relevant covariates and ADOS RRBI CSS at T1. The CEFT performance (accuracy in the complex condition divided by the time needed) significantly predicted higher ADOS RRBI CSS at T2 (ΔR(2) = 15%). This finding further supports the detail-focused cognitive style in individuals with ASD, and shows that it is also predictive of future RRBI symptoms over time.
[Mh] Termos MeSH primário: Comportamento do Adolescente/fisiologia
Transtorno do Espectro Autista/fisiopatologia
Processamento Espacial/fisiologia
Transtorno de Movimento Estereotipado/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/complicações
Criança
Feminino
Seguimentos
Seres Humanos
Estudos Longitudinais
Masculino
Valor Preditivo dos Testes
Tempo de Reação/fisiologia
Índice de Gravidade de Doença
Transtorno de Movimento Estereotipado/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170112
[Lr] Data última revisão:
170112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150627
[St] Status:MEDLINE
[do] DOI:10.1002/aur.1510



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