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[PMID]:28987057
[Au] Autor:Karakula-Juchnowicz H; Stecka M
[Ad] Endereço:I Klinika Psychiatrii, Psychoterapii i Wczesnej Interwencji UM w Lublinie.
[Ti] Título:Polish Adult Reading Test (PART) - construction of Polish test for estimating the level of premorbid intelligence in schizophrenia.
[Ti] Título:Polski Test Czytania Slów dla Doroslych (PART) ­ konstrukcja polskiego testu do pomiaru poziomu inteligencji przedchorobowej w schizofrenii..
[So] Source:Psychiatr Pol;51(4):673-685, 2017 Aug 29.
[Is] ISSN:2391-5854
[Cp] País de publicação:Poland
[La] Idioma:eng; pol
[Ab] Resumo:OBJECTIVES: In view of unavailability in Poland of the standardized methods to measure PIQ, the aim of the work was to develop a Polish test to assess the premorbid level of intelligence - PART(Polish AdultReading Test) and to measureits psychometric properties, such as validity, reliability as well as standardization in the group of schizophrenia patients. METHODS: The principles of PART construction were based on the idea of popular worldwide National Adult Reading Test by Hazel Nelson. The research comprised a group of 122 subjects (65 schizophrenia patients and 57 healthy people), aged 18-60 years, matched for age and gender. RESULTS: PART appears to be a method with high internal consistency and reliability measured by test-retest, inter-rater reliability, and the method with acceptable diagnostic and prognostic validity. The standardized procedures of PART have been investigated and described. CONCLUSIONS: Considering the psychometric values of PART and a short time of its performance, the test may be a useful diagnostic instrument in the assessment of premorbid level of intelligence in a group of schizophrenic patients.
[Mh] Termos MeSH primário: Testes de Inteligência/normas
Inteligência
Leitura
[Mh] Termos MeSH secundário: Adulto
Transtornos Cognitivos/diagnóstico
Feminino
Seres Humanos
Masculino
Psicometria
Transtornos Psicóticos/diagnóstico
Reprodutibilidade dos Testes
Psicologia do Esquizofrênico
Transtorno da Personalidade Esquizotípica/diagnóstico
Transtorno da Personalidade Esquizotípica/psicologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


  2 / 2406 MEDLINE  
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[PMID]:28832672
[Au] Autor:Pries LK; Guloksuz S; Menne-Lothmann C; Decoster J; van Winkel R; Collip D; Delespaul P; De Hert M; Derom C; Thiery E; Jacobs N; Wichers M; Simons CJP; Rutten BPF; van Os J
[Ad] Endereço:Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands.
[Ti] Título:White noise speech illusion and psychosis expression: An experimental investigation of psychosis liability.
[So] Source:PLoS One;12(8):e0183695, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An association between white noise speech illusion and psychotic symptoms has been reported in patients and their relatives. This supports the theory that bottom-up and top-down perceptual processes are involved in the mechanisms underlying perceptual abnormalities. However, findings in nonclinical populations have been conflicting. OBJECTIVES: The aim of this study was to examine the association between white noise speech illusion and subclinical expression of psychotic symptoms in a nonclinical sample. Findings were compared to previous results to investigate potential methodology dependent differences. METHODS: In a general population adolescent and young adult twin sample (n = 704), the association between white noise speech illusion and subclinical psychotic experiences, using the Structured Interview for Schizotypy-Revised (SIS-R) and the Community Assessment of Psychic Experiences (CAPE), was analyzed using multilevel logistic regression analyses. RESULTS: Perception of any white noise speech illusion was not associated with either positive or negative schizotypy in the general population twin sample, using the method by Galdos et al. (2011) (positive: ORadjusted: 0.82, 95% CI: 0.6-1.12, p = 0.217; negative: ORadjusted: 0.75, 95% CI: 0.56-1.02, p = 0.065) and the method by Catalan et al. (2014) (positive: ORadjusted: 1.11, 95% CI: 0.79-1.57, p = 0.557). No association was found between CAPE scores and speech illusion (ORadjusted: 1.25, 95% CI: 0.88-1.79, p = 0.220). For the Catalan et al. (2014) but not the Galdos et al. (2011) method, a negative association was apparent between positive schizotypy and speech illusion with positive or negative affective valence (ORadjusted: 0.44, 95% CI: 0.24-0.81, p = 0.008). CONCLUSION: Contrary to findings in clinical populations, white noise speech illusion may not be associated with psychosis proneness in nonclinical populations.
[Mh] Termos MeSH primário: Ruído
Transtorno da Personalidade Esquizotípica/fisiopatologia
Fala
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; TWIN STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183695


  3 / 2406 MEDLINE  
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[PMID]:28759626
[Au] Autor:Ford TC; Nibbs R; Crewther DP
[Ad] Endereço:Centre for Human Psychopharmacology, Faculty of Heath, Arts and Design, Swinburne University of Technology, Melbourne, Victoria, Australia.
[Ti] Título:Glutamate/GABA+ ratio is associated with the psychosocial domain of autistic and schizotypal traits.
[So] Source:PLoS One;12(7):e0181961, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The autism and schizophrenia spectra overlap to a large degree in the social and interpersonal domains. Similarly, abnormal excitatory glutamate and inhibitory γ-aminobutyric acid (GABA) neurotransmitter concentrations have been reported for both spectra, with the interplay of these neurotransmitters important for cortical excitation to inhibition regulation. This study investigates whether these neurotransmitter abnormalities are specific to the shared symptomatology, and whether the degree of abnormality increases with increasing symptom severity. Hence, the relationship between the glutamate/GABA ratio and autism and schizophrenia spectrum traits in an unmedicated, subclinical population was investigated. METHODS: A total of 37 adults (19 female, 18 male) aged 18-38 years completed the Autism Spectrum Quotient (AQ) and Schizotypal Personality Questionnaire (SPQ), and participated in the resting state proton magnetic resonance spectroscopy study in which sequences specific for quantification of glutamate and GABA+ concentration were applied to a right and left superior temporal voxel. RESULTS: There were significant, moderate, positive relationships between right superior temporal glutamate/GABA+ ratio and AQ, SPQ and AQ+SPQ total scores (p<0.05), SPQ subscales Social Anxiety, No Close Friend, Constricted Affect, Odd Behaviour, Odd Speech, Ideas of Reference and Suspiciousness, and AQ subscales Social Skills, Communication and Attention Switching (p<0.05); increased glutamate/GABA+ coinciding with higher scores on these subscales. Only the relationships between glutamate/GABA+ ratio and Social Anxiety, Constricted Affect, Social Skills and Communication survived multiple comparison correction (p< 0.004). Left superior temporal glutamate/GABA+ ratio reduced with increasing restricted imagination (p<0.05). CONCLUSION: These findings demonstrate evidence for an association between excitatory/inhibitory neurotransmitter concentrations and symptoms that are shared between the autism and schizophrenia spectra.
[Mh] Termos MeSH primário: Transtorno Autístico/patologia
Transtorno Autístico/psicologia
Ácido Glutâmico/análise
Neurotransmissores/análise
Transtorno da Personalidade Esquizotípica/patologia
Transtorno da Personalidade Esquizotípica/psicologia
Ácido gama-Aminobutírico/análise
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ansiedade
Atenção
Comportamento
Comunicação
Feminino
Seres Humanos
Masculino
Testes de Personalidade
Fenótipo
Espectroscopia de Prótons por Ressonância Magnética
Escalas de Graduação Psiquiátrica
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotransmitter Agents); 3KX376GY7L (Glutamic Acid); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181961


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[PMID]:28291035
[Au] Autor:VAN Riel L; Ingenhoven TJ; VAN Dam QD; Polak MG; Vollema MG; Willems AE; Berghuis H; VAN Megen H
[Ad] Endereço:VAN RIEL: Novarum Centre for Eating Disorders and Obesity, Arkin Institute of Mental Health, Amsterdam, The Netherlands INGENHOVEN: Centre for Psychotherapy, Pro Persona, Lunteren, The Netherlands VAN DAM: Centre for Psychology and Psychotherapy Q.D. van Dam, Leiden, The Netherlands POLAK: Institute of Psychology, Erasmus University Rotterdam, The Netherlands VOLLEMA: Centre for Psychology, De Binnenkijk, Centre for psychotherapy, diagnostics and supervision, Ermelo, The Netherlands WILLEMS: Research Centre GZZ Centraal, Amersfoort, The Netherlands BERGHUIS: Institute of Mental Health, Pro Persona, Tiel, The Netherlands VAN MEGEN: Institute of Mental Health GGZ Centraal, Ermelo, The Netherlands.
[Ti] Título:Borderline or Schizotypal? Differential Psychodynamic Assessment in Severe Personality Disorders.
[So] Source:J Psychiatr Pract;23(2):101-113, 2017 Mar.
[Is] ISSN:1538-1145
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Considerable overlap in symptoms between patients with borderline personality disorder (BPD) and schizotypal personality disorder (STPD) complicates personality diagnostics. Yet very little is known about the level of psychodynamic functioning of both personality disorders. Psychodynamic assessment procedures may specify personality characteristics relevant for differential diagnosis and treatment planning. In this cross-sectional study we explored the differences and similarities in level of personality functioning and psychodynamic features of patients with severe BPD or STPD. In total, 25 patients with BPD and 13 patients with STPD were compared regarding their level of personality functioning (General Assessment of Personality Disorder), current quasipsychotic features (Schizotypal Personality Questionnaire), and psychodynamic functioning [Developmental Profile (DP) interview and Developmental Profile Inventory (DPI) questionnaire]. Both groups of patients showed equally severe impairments in the level of personality functioning and the presence of current quasipsychotic features. As assessed by the DP interview, significant differential psychodynamic patterns were found on the primitive levels of functioning. Moreover, subjects with BPD had significantly higher scores on the adaptive developmental levels. However, the self-questionnaire DPI was not able to elucidate all of these differences. In conclusion, our study found significant differences in psychodynamic functioning between patients with BPD and STPD as assessed with the DP interview. In complicated diagnostic cases, personality assessment by psychodynamic interviewing can enhance subtle but essential differentiation between BPD and STPD.
[Mh] Termos MeSH primário: Transtorno da Personalidade Borderline/diagnóstico
Transtorno da Personalidade Esquizotípica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Transtorno da Personalidade Borderline/fisiopatologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Determinação da Personalidade
Transtorno da Personalidade Esquizotípica/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1097/PRA.0000000000000225


  5 / 2406 MEDLINE  
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[PMID]:28288547
[Au] Autor:Siddi S; Petretto DR; Preti A
[Ad] Endereço:a Department of Education, Psychology, Philosophy , University of Cagliari , Cagliari , Italy.
[Ti] Título:Neuropsychological correlates of schizotypy: a systematic review and meta-analysis of cross-sectional studies.
[So] Source:Cogn Neuropsychiatry;22(3):186-212, 2017 May.
[Is] ISSN:1464-0619
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Cognitive deficits can precede the onset of psychotic episodes and predict the onset of the illness in individuals with schizotypy traits. In some studies, high levels of schizotypy were associated with impairments in memory, attention, executive functions, and verbal fluency. This review provides a more comprehensive understanding of cognitive impairments related to schizoytpy. METHODS:  A systematic review of "schizotypy and neuropsychological measures" was conducted, and it retrieved 67 studies. All papers with case-control design showing means and standard deviations from neuropsychological measures were included in a meta-analysis (n = 40). A comparison between our finding and another metaanalysis with patients with schizophrenia-spectrum disorders [Fatouros-Bergman, H., Cervenka, S., Flyckt, L., Edman, G., & Farde, L. (2014). Meta-analysis of cognitive performance in drugnaive patients with schizophrenia. Schizophrenia Research. doi: 10.1016/j.schres.2014.06.034 ] was performed to study the similarities on the MATRICS domains between the two disorders. RESULTS: We found evidence of worse functioning of verbal and visual-spatial working memory, and of language in people with schizotypy or with schizotypal traits. Working memory deficit is present in both schizotypy and schizophrenia with larger effect sizes compared to other domains. CONCLUSIONS: Working memory deficit might be a cognitive marker of the risk of psychosis. Interventions targeting cognitive deficits early may be crucial to the prevention of psychosis.
[Mh] Termos MeSH primário: Transtornos Cognitivos/psicologia
Transtorno da Personalidade Esquizotípica/psicologia
[Mh] Termos MeSH secundário: Estudos Transversais
Seres Humanos
Testes Neuropsicológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1080/13546805.2017.1299702


  6 / 2406 MEDLINE  
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[PMID]:28152990
[Au] Autor:Zhu Y; Tang Y; Zhang T; Li H; Tang Y; Li C; Luo X; He Y; Lu Z; Wang J
[Ad] Endereço:Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, South Wan Ping Road 600, Shanghai, 200030, People's Republic of China.
[Ti] Título:Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder.
[So] Source:BMC Psychiatry;17(1):48, 2017 Feb 02.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD. METHODS: Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method. RESULTS: Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left parahippocampus (r = -0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right parahippocampus (r = -0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left parahippocampus (r = -0.535, p = 0.018) in SPD group. CONCLUSIONS: Our findings suggest that the decreased functional connectivity between precuneus and contralateral parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder.
[Mh] Termos MeSH primário: Giro Para-Hipocampal/fisiopatologia
Lobo Parietal/fisiopatologia
Transtorno da Personalidade Esquizotípica/fisiopatologia
Lobo Temporal/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Neuroimagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-016-1146-5


  7 / 2406 MEDLINE  
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[PMID]:28081654
[Au] Autor:Rominger C; Fink A; Weiss EM; Bosch J; Papousek I
[Ad] Endereço:a Department of Psychology, Biological Psychology Unit , University of Graz , Graz , Austria.
[Ti] Título:Allusive thinking (remote associations) and auditory top-down inhibition skills differentially predict creativity and positive schizotypy.
[So] Source:Cogn Neuropsychiatry;22(2):108-121, 2017 Mar.
[Is] ISSN:1464-0619
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Positive schizotypy and creativity seem to be linked. However, the question still remains why they are related, and what may make the difference? As creative ideation is hypothesised as a dual process (association and inhibition), the propensity for remote associations might be a shared mechanism. However, positive schizotypy and creative thinking might be differentially linked to inhibition. Therefore, this study investigated a potentially overlapping feature of positive schizotypy and creativity (remote associations) as well as a potential dissociative factor (auditory inhibition). METHODS: From a large screening sample, 46 participants covering a broad range of positive schizotypy were selected. Association proneness was assessed via two association tasks, auditory inhibition skill with the forced-left condition of the Dichotic Listening Test, and creative thinking by means of two creative ideation tests. RESULTS: Positive schizotypy and creative thinking were positively associated. Both traits were linked to lower rates of common associations. However, creative thinking was associated with higher and positive schizotypy with lower inhibitory control in the auditory domain. CONCLUSIONS: While creativity and positive schizotypy shared some variance (related to remote associations), profound inhibition skills may be vital for creative performance and may coincide with lower levels of positive schizotypy.
[Mh] Termos MeSH primário: Criatividade
Psicometria
Transtorno da Personalidade Esquizotípica/psicologia
Pensamento/fisiologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Inibição (Psicologia)
Masculino
Testes Neuropsicológicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1080/13546805.2016.1278361


  8 / 2406 MEDLINE  
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[PMID]:28053132
[Au] Autor:Powers AR; Kelley MS; Corlett PR
[Ad] Endereço:Department of Psychiatry, Yale University, New Haven, CT.
[Ti] Título:Varieties of Voice-Hearing: Psychics and the Psychosis Continuum.
[So] Source:Schizophr Bull;43(1):84-98, 2017 Jan.
[Is] ISSN:1745-1701
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hearing voices that are not present is a prominent symptom of serious mental illness. However, these experiences may be common in the non-help-seeking population, leading some to propose the existence of a continuum of psychosis from health to disease. Thus far, research on this continuum has focused on what is impaired in help-seeking groups. Here we focus on protective factors in non-help-seeking voice-hearers. We introduce a new study population: clairaudient psychics who receive daily auditory messages. We conducted phenomenological interviews with these subjects, as well as with patients diagnosed with a psychotic disorder who hear voices, people with a diagnosis of a psychotic disorder who do not hear voices, and matched control subjects (without voices or a diagnosis). We found the hallucinatory experiences of psychic voice-hearers to be very similar to those of patients who were diagnosed. We employed techniques from forensic psychiatry to conclude that the psychics were not malingering. Critically, we found that this sample of non-help-seeking voice hearers were able to control the onset and offset of their voices, that they were less distressed by their voice-hearing experiences and that, the first time they admitted to voice-hearing, the reception by others was much more likely to be positive. Patients had much more negative voice-hearing experiences, were more likely to receive a negative reaction when sharing their voices with others for the first time, and this was subsequently more disruptive to their social relationships. We predict that this sub-population of healthy voice-hearers may have much to teach us about the neurobiology, cognitive psychology and ultimately the treatment of voices that are distressing.
[Mh] Termos MeSH primário: Percepção Auditiva/fisiologia
Alucinações/fisiopatologia
Transtornos Psicóticos/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Transtorno da Personalidade Borderline/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtorno da Personalidade Esquizotípica/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1093/schbul/sbw133


  9 / 2406 MEDLINE  
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[PMID]:27922907
[Au] Autor:Strandholm T; Kiviruusu O; Karlsson L; Pankakoski M; Pelkonen M; Marttunen M
[Ad] Endereço:*Mental Health Unit, Department of Health, National Institute for Health and Welfare; †Institute of Behavioural Sciences, University of Helsinki, Helsinki; ‡Department of Child Psychiatry, Turku University Central Hospital, Turku; and §Adolescent Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
[Ti] Título:Stability and Change in Personality Disorder Symptoms in 1-Year Follow-up of Depressed Adolescent Outpatients.
[So] Source:J Nerv Ment Dis;205(1):15-22, 2017 Jan.
[Is] ISSN:1539-736X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated stability and change in personality disorder (PD) symptoms and whether depression severity, comorbid clinical psychiatric disorders, and social support predict changes in personality pathology among adolescent outpatients. The 1-year outcome of PD symptoms among consecutive adolescent psychiatric outpatients with depressive disorders (N = 189) was investigated with symptom count of depression, comorbid psychiatric disorders, and perceived social support as predictors. An overall decrease in PD symptoms in most PD categories was observed. Decreases in depression severity and in number of comorbid diagnoses correlated positively with decreases in PD symptoms of most PD categories. Social support from close friends predicted a decrease in schizotypal and narcissistic, whereas support from family predicted a decrease in paranoid symptoms. Our results suggest that among depressed adolescent outpatients, PD symptoms are relatively unstable, changes co-occuring with changes/improvement in overall psychopathology. Social support seems a possibly effective point for intervention efforts regarding positive outcome of PD symptoms.
[Mh] Termos MeSH primário: Transtorno Depressivo/fisiopatologia
Progressão da Doença
Transtornos da Personalidade/fisiopatologia
Apoio Social
[Mh] Termos MeSH secundário: Adolescente
Adulto
Comorbidade
Transtorno Depressivo/epidemiologia
Transtorno Depressivo/terapia
Feminino
Finlândia/epidemiologia
Seguimentos
Seres Humanos
Masculino
Pacientes Ambulatoriais
Transtorno da Personalidade Paranoide/epidemiologia
Transtorno da Personalidade Paranoide/fisiopatologia
Transtorno da Personalidade Paranoide/terapia
Transtornos da Personalidade/epidemiologia
Transtornos da Personalidade/terapia
Transtorno da Personalidade Esquizotípica/epidemiologia
Transtorno da Personalidade Esquizotípica/fisiopatologia
Transtorno da Personalidade Esquizotípica/terapia
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.1097/NMD.0000000000000623


  10 / 2406 MEDLINE  
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[PMID]:27916709
[Au] Autor:Myles JB; Rossell SL; Phillipou A; Thomas E; Gurvich C
[Ad] Endereço:Monash Alfred Psychiatry research centre, The Alfred Hospital and Monash University Central Clinical School, Melbourne, Australia.
[Ti] Título:Insights to the schizophrenia continuum: A systematic review of saccadic eye movements in schizotypy and biological relatives of schizophrenia patients.
[So] Source:Neurosci Biobehav Rev;72:278-300, 2017 Jan.
[Is] ISSN:1873-7528
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myles, J.B., S. Rossell, A. Phillipou, Thomas, E and C. Gurvich. A systematic review of saccadic eye movements across the schizophrenia continuum: Characterisation, pathophysiology and genetic associations. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2015. One of the cognitive hallmarks of schizophrenia is impaired eye movements, particularly for the antisaccade task. Less saccade research has been conducted in relation to the broader schizophrenia continuum, that is, people with high schizotypy or first-degree relatives of people with schizophrenia. This systematic review sought to identify, collate and appraise prosaccade, antisaccade and memory-guided saccade studies involving behavioural, neuroimaging and genetic data published between 1980 and September 2016 in individuals with high schizotypy and first-degree relatives. A systematic literature search was conducted, using Ovid MEDLINE, PsycINFO, PubMed and SCOPUS databases. Of 913 references screened, 18 schizotypy, 29 family studies and two schizotypy and relatives articles studies were eligible for inclusion. Antisaccade error rate was the most consistent deficit found for high schizotypy. Relatives had intermediate antisaccade error rates between patients and healthy controls. Results from the limited genetic and neuroimaging studies echoed schizophrenia findings. Confounds were also identified. It was concluded that future research is required to refine the saccade endophenotype and to expand genetic and neuroimaging research.
[Mh] Termos MeSH primário: Movimentos Sacádicos
Esquizofrenia
Transtorno da Personalidade Esquizotípica
[Mh] Termos MeSH secundário: Família
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE



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