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  1 / 2183 MEDLINE  
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[PMID]:28463241
[Au] Autor:Wurfel BE; Drevets WC; Bliss SA; McMillin JR; Suzuki H; Ford BN; Morris HM; Teague TK; Dantzer R; Savitz JB
[Ad] Endereço:Laureate Institute for Brain Research, Laureate Institute for Brain Research, Tulsa, OK, USA.
[Ti] Título:Serum kynurenic acid is reduced in affective psychosis.
[So] Source:Transl Psychiatry;7(5):e1115, 2017 May 02.
[Is] ISSN:2158-3188
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites. Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist. In contrast, schizophrenia and psychosis are hypothesized to arise from increased metabolism of the NMDA receptor antagonist, kynurenic acid (KynA), leading to hypofunction of GABAergic interneurons, the disinhibition of pyramidal neurons and striatal hyperdopaminergia. Here we present results that challenge the model of excess KynA production in affective psychosis. After rigorous control of potential confounders and multiple testing we find significant reductions in serum KynA and/or KynA/QA in acutely ill inpatients with major depressive disorder (N=35), bipolar disorder (N=53) and schizoaffective disorder (N=40) versus healthy controls (N=92). No significant difference was found between acutely ill inpatients with schizophrenia (n=21) and healthy controls. Further, a post hoc comparison of patients divided into the categories of non-psychotic affective disorder, affective psychosis and psychotic disorder (non-affective) showed that the greatest decrease in KynA was in the affective psychosis group relative to the other diagnostic groups. Our results are consistent with reports of elevations in proinflammatory cytokines in psychosis, and preclinical work showing that inflammation upregulates the enzyme, kynurenine mono-oxygenase (KMO), which converts kynurenine into 3-hydroxykynurenine and quinolinic acid.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/metabolismo
Ácido Cinurênico/sangue
Quinurenina 3-Mono-Oxigenase/metabolismo
[Mh] Termos MeSH secundário: Adulto
Transtornos Psicóticos Afetivos/sangue
Transtornos Psicóticos Afetivos/fisiopatologia
Transtorno Bipolar/metabolismo
Corpo Estriado/metabolismo
Citocinas/metabolismo
Depressão/metabolismo
Transtorno Depressivo Maior/metabolismo
Feminino
Neurônios GABAérgicos/metabolismo
Seres Humanos
Inflamação/enzimologia
Ácido Cinurênico/metabolismo
Cinurenina/análogos & derivados
Cinurenina/metabolismo
Masculino
Meia-Idade
Transtornos Psicóticos/metabolismo
Ácido Quinolínico/metabolismo
Receptores de N-Metil-D-Aspartato/metabolismo
Esquizofrenia/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Receptors, N-Methyl-D-Aspartate); 27723548JL (3-hydroxykynurenine); 343-65-7 (Kynurenine); EC 1.14.13.9 (Kynurenine 3-Monooxygenase); F6F0HK1URN (Quinolinic Acid); H030S2S85J (Kynurenic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1038/tp.2017.88


  2 / 2183 MEDLINE  
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[PMID]:28636572
[Au] Autor:Fountoulakis KN; Popovic D; Mosheva M; Siamouli M; Moutou K; Gonda X
[Ad] Endereço:3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece.
[Ti] Título:Mood Symptoms in Stabilized Patients with Schizophrenia: A Bipolar Type with Predominant Psychotic Features?
[So] Source:Psychiatr Danub;29(2):148-154, 2017 Jun.
[Is] ISSN:0353-5053
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) are traditionally distinguished on the basis of progressive deterioration and long-term outcome, but a more dimensional approach is warranted. There are limited data on the occurrence of manic symptoms in patients with schizophrenia. The aim of the current study was to search for patterns in the clinical symptomatology, which may suggest the presence of one or several mood disorders under the label of schizophrenia. SUBJECTS AND METHODS: Hundred-seventy-five patients diagnosed with schizophrenia according to DSM-5 were included in the study. The psychometric assessment included the Positive and Negative Syndrome Scale, Young Mania Rating Scale, The Montgomery-Åsberg Depression Rating Scale and the Calgary Depression Scale. The statistical analysis included MANOVA, Pearson Correlation coefficient and principal components analysis. RESULTS: Significant subthreshold manic symptoms were present in 25.14% of patients. Mood symptoms correlated with positive symptoms. The PCA revealed a complex structure with 15 factors (one positive, negative, somatic, anxiety, neurocognitive, disorganization and manic, five depressive and three psychomotor/excitement/hostility/violence). CONCLUSION: Psychotic mood disorders are often phenotypically indistinguishable from schizophrenia, so it is likely that psychotic affective patients have been misdiagnosed with schizophrenia. The current study suggests that there seem to be patients with mania misdiagnosed as 'schizophrenics' because of the presence of psychotic features, a condition better described as 'schizophreniform bipolar disorder'.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/diagnóstico
Transtornos Psicóticos Afetivos/psicologia
Transtorno Bipolar/diagnóstico
Transtorno Bipolar/psicologia
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Adulto
Transtornos Psicóticos Afetivos/classificação
Transtorno Bipolar/classificação
Diagnóstico Diferencial
Manual Diagnóstico e Estatístico de Transtornos Mentais
Feminino
Seres Humanos
Masculino
Meia-Idade
Escalas de Graduação Psiquiátrica/estatística & dados numéricos
Psicometria
Esquizofrenia/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE


  3 / 2183 MEDLINE  
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[PMID]:28441173
[Au] Autor:AbdelGawad N; Chotalia J; Parsaik A; Pigott T; Allen M
[Ad] Endereço:Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston; and Harris County Psychiatric Center, Houston, Texas.
[Ti] Título:Religiosity in Acute Psychiatric Inpatients: Relationship With Demographics, Clinical Features, and Length of Stay.
[So] Source:J Nerv Ment Dis;205(6):448-452, 2017 Jun.
[Is] ISSN:1539-736X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study examined the relationship between religiosity in 175 psychiatric inpatients as measured by the subscales of the Duke University Religion Index (DUREL) and sociodemographic (age, sex, and race), clinical (primary diagnosis, suicidality, and psychotic symptoms), and outcome (length of stay [LOS] and readmission rates) measures. Psychosis was assessed by Clinician-Rated Dimensions of Psychosis Symptom Severity (CRDPSS) scale. Bivariate and multivariate analyses were used to examine the association between the DUREL subscales and the outcome measures. High scorers on the nonorganized religiosity subscale were less likely to have psychosis (47% vs. 52%; p < 0.05) but had greater psychosis severity (mean ± SD, 14.5 ± 5 vs.12.4 ± 6; p < 0.05), as measured by the CRDPSS scale, and significantly longer LOS (mean ± SD, 8.3 ± 3.8 vs. 6.9 ± 3.4; p < 0.05). Conversely, they were less likely to report previous suicide attempts than low scorers (p < 0.05). These results suggest that a brief measure of religious activities may identify psychiatric inpatients at greater risk for psychosis, suicidality, and longer hospitalizations.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos
Pacientes Internados/estatística & dados numéricos
Tempo de Internação/estatística & dados numéricos
Readmissão do Paciente/estatística & dados numéricos
Transtornos Psicóticos
Religião e Psicologia
Esquizofrenia
Suicídio/estatística & dados numéricos
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Transtornos Psicóticos Afetivos/epidemiologia
Transtornos Psicóticos Afetivos/fisiopatologia
Transtornos Psicóticos Afetivos/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos Psicóticos/epidemiologia
Transtornos Psicóticos/fisiopatologia
Transtornos Psicóticos/psicologia
Esquizofrenia/epidemiologia
Esquizofrenia/fisiopatologia
Suicídio/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1097/NMD.0000000000000688


  4 / 2183 MEDLINE  
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[PMID]:28409714
[Au] Autor:Fredriksen KJ; Schoeyen HK; Johannessen JO; Walby FA; Davidson L; Schaufel MA
[Ti] Título:Psychotic Depression and Suicidal Behavior.
[So] Source:Psychiatry;80(1):17-29, 2017.
[Is] ISSN:1943-281X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study investigated how severely depressed individuals experienced the relationship between psychotic symptoms and suicidal ideation and behavior. METHOD: Semi-structured qualitative interviews were conducted with a purposive sample of nine inpatients from a psychiatric university hospital between September 2012 and May 2013 fulfilling diagnostic criteria for a psychotic depressive episode as part of a unipolar or bipolar disorder. Analysis was conducted using systematic text condensation. RESULTS: Participants experienced (1) being directed to perform impulsive potentially fatal actions, (2) feeling hounded to death, (3) becoming trapped in an inescapable darkness, and (4) being left bereft of mental control. They described how impulsivity directed by delusions and hallucinations resulted in unpredictable actions with only moments from decision to conduct. Suicide was seen as an escape not only from life problems but also from psychotic experiences and intense anxiety. Participants reported being in a chaotic state, unable to think rationally or anticipate the consequences of their actions. Their ability to identify and communicate psychotic symptoms and suicidal ideation and behavior was compromised, leaving them to struggle alone with these terrifying experiences. CONCLUSIONS: Suicide risk assessments based on verbal reports from individuals with psychotic depression may not always be valid due to potential impulsivity and underreporting of suicidal ideation. It may be important for clinicians to explore the delusional content of such patients' experiences to assess the possibility of suicide as a result of shame, guilt, remorse, or altruistic intentions to save others from harm.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/psicologia
Transtorno Bipolar/psicologia
Transtorno Depressivo/psicologia
Suicídio/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Pesquisa Qualitativa
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1080/00332747.2016.1208002


  5 / 2183 MEDLINE  
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[PMID]:28399309
[Au] Autor:Bebbington P; Freeman D
[Ad] Endereço:UCL Division of Psychiatry, Faculty of Brain Sciences, Tottenham Court Road, London, UK.
[Ti] Título:Transdiagnostic Extension of Delusions: Schizophrenia and Beyond.
[So] Source:Schizophr Bull;43(2):273-282, 2017 03 01.
[Is] ISSN:1745-1701
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Delusion is central to the conceptualization, definition, and identification of schizophrenia. However, in current classifications, the presence of delusions is neither necessary nor sufficient for the diagnosis of schizophrenia, nor is it sufficient to exclude the diagnosis of some other psychiatric conditions. Partly as a consequence of these classification rules, it is possible for delusions to exist transdiagnostically. In this article, we evaluate the extent to which this happens, and in what ways the characteristics of delusions vary according to diagnostic context. We were able to examine their presence and form in delusional disorder, affective disorder, obsessive-compulsive disorder, borderline personality disorder, and dementia, in all of which they have an appreciable presence. There is some evidence that the mechanisms of delusion formation are, at least to an extent, shared across these disorders. This transdiagnostic extension of delusions is an argument for targeting them therapeutically in their own right. However there is a dearth of research to enable the rational transdiagnostic deployment of either pharmacological or psychological treatments.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/classificação
Transtorno da Personalidade Borderline/classificação
Comorbidade
Delusões/classificação
Demência/classificação
Transtorno Obsessivo-Compulsivo/classificação
Esquizofrenia Paranoide/classificação
Esquizofrenia/classificação
[Mh] Termos MeSH secundário: Transtornos Psicóticos Afetivos/epidemiologia
Transtorno da Personalidade Borderline/epidemiologia
Delusões/epidemiologia
Demência/epidemiologia
Seres Humanos
Transtorno Obsessivo-Compulsivo/epidemiologia
Esquizofrenia/epidemiologia
Esquizofrenia Paranoide/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1093/schbul/sbw191


  6 / 2183 MEDLINE  
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[PMID]:28338967
[Au] Autor:Morgan CJ; Coleman MJ; Ulgen A; Boling L; Cole JO; Johnson FV; Lerbinger J; Bodkin JA; Holzman PS; Levy DL
[Ad] Endereço:Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
[Ti] Título:Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls.
[So] Source:Schizophr Bull;43(3):523-535, 2017 05 01.
[Is] ISSN:1745-1701
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thought disorder (TD) has long been associated with schizophrenia (SZ) and is now widely recognized as a symptom of mania and other psychotic disorders as well. Previous studies have suggested that the TD found in the clinically unaffected relatives of SZ, schizoaffective and bipolar probands is qualitatively similar to that found in the probands themselves. Here, we examine which quantitative measures of TD optimize the distinction between patients with diagnoses of SZ and bipolar disorder with psychotic features (BP) from nonpsychiatric controls (NC) and from each other. In addition, we investigate whether these same TD measures also distinguish their respective clinically unaffected relatives (RelSZ, RelBP) from controls as well as from each other. We find that deviant verbalizations are significantly associated with SZ and are co-familial in clinically unaffected RelSZ, but are dissociated from, and are not co-familial for, BP disorder. In contrast, combinatory thinking was nonspecifically associated with psychosis, but did not aggregate in either group of relatives. These results provide further support for the usefulness of TD for identifying potential non-penetrant carriers of SZ-risk genes, in turn enhancing the power of genetic analyses. These findings also suggest that further refinement of the TD phenotype may be needed in order to be suitable for use in genetic studies of bipolar disorder.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/fisiopatologia
Transtorno Bipolar/fisiopatologia
Endofenótipos
Transtornos Psicóticos/fisiopatologia
Esquizofrenia/fisiopatologia
Pensamento/fisiologia
[Mh] Termos MeSH secundário: Adulto
Transtornos Psicóticos Afetivos/genética
Transtorno Bipolar/genética
Família
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos Psicóticos/genética
Esquizofrenia/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170723
[Lr] Data última revisão:
170723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1093/schbul/sbx016


  7 / 2183 MEDLINE  
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[PMID]:28029428
[Au] Autor:Golimbet V; Korovaitseva G; Lezheiko T; Abramova LI; Kaleda VG
[Ad] Endereço:Mental Health Research Center, Moscow, Russia.
[Ti] Título:The serotonin transporter gene 5-HTTLPR polymorphism is associated with affective psychoses but not with schizophrenia: A large-scale study in the Russian population.
[So] Source:J Affect Disord;208:604-609, 2017 Jan 15.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Affective syndrome is thought to be a key feature that differentiates schizophrenia from schizoaffective disorder (SA) and bipolar disorder with psychotic features (BDP). However genetic underpinnings of these differences remain unresolved. OBJECTIVES: We compared clinical variables of affective psychoses (SA, BDP and schizophrenia with affective symptoms (AFF SCZ)) and schizophrenia without affective symptoms (non-AFF SCZ) and searched for a genetic variant that may differentiate affective psychosis from non-AFF SCZ. METHODS: A total of 2677 subjects, including 831 patients with affective psychosis, 785 patients with non-AFF SCZ and 1061 healthy controls, were used. Clinical symptoms were assessed with the PANSS. The sample was genotyped for 5-HTTLPR polymorphism of the serotonin transporter gene. RESULTS: The diagnostic groups differed significantly on demographic and clinical variables. The percentage of men was higher, the current age and age at illness onset were lower in non-AFF SCZ and SA compared to AFF SCZ and BDP. The severity of positive and negative symptoms decreased significantly from group to group in the following manner: non-AFF SCZ>AFF SCZ>SA>BDP. There was the association between 5-HTTLPR polymorphism and affective psychosis (p=0.01). The frequency of the SS genotype was higher in the affective psychosis group compared to non-AFF SCZ and controls. No differences in the genotype distribution were identified between the non-AFF SCZ group and controls. LIMITATIONS: Difficulties in the differentiation between non-AFF SCZ and AFF SCZ or SA and between AFF SCZ and SA due to uncertain diagnostic boundaries between these conditions. CONCLUSIONS: SA is intermediate between non-AFF SCZ and BDP in the severity of positive and negative symptoms. The first episode patients, carriers of the SS genotype have a higher risk of developing affective psychosis than non-AFF SCZ. This finding carries implications for the prognosis of psychosis outcomes in the first-episode patients.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/genética
Polimorfismo Genético
Esquizofrenia/genética
Proteínas da Membrana Plasmática de Transporte de Serotonina/genética
[Mh] Termos MeSH secundário: Adulto
Feminino
Genótipo
Seres Humanos
Masculino
Transtornos Psicóticos/genética
Federação Russa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (SLC6A4 protein, human); 0 (Serotonin Plasma Membrane Transport Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE


  8 / 2183 MEDLINE  
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[PMID]:27306316
[Au] Autor:Reilly JL; Hill SK; Gold JM; Keefe RS; Clementz BA; Gershon E; Keshavan MS; Pearlson G; Tamminga CA; Sweeney JA
[Ad] Endereço:Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[Ti] Título:Impaired Context Processing is Attributable to Global Neuropsychological Impairment in Schizophrenia and Psychotic Bipolar Disorder.
[So] Source:Schizophr Bull;43(2):397-406, 2017 03 01.
[Is] ISSN:1745-1701
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Context processing may reflect a specific cognitive impairment in schizophrenia. Whether impaired context processing is observed across psychotic disorders or among relatives of affected individuals, and whether it is a deficit that is independent from the generalized neuropsychological deficits seen in psychotic disorders, are less established. Methods: Schizophrenia, schizoaffective, and psychotic bipolar probands (n = 660), their first-degree relatives (n = 741), and healthy individuals (n = 308) studied by the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium performed an expectancy task requiring use of contextual information to overcome a pre-potent response. Sensitivity for target detection and false alarm rates on trials requiring inhibition or goal maintenance were measured. Results: Proband groups and relatives with psychosis spectrum personality traits demonstrated reduced target sensitivity and elevated false alarm rates. False alarm rate was higher under inhibition vs goal maintenance conditions although this difference was attenuated in schizophrenia and schizoaffective proband groups. After accounting for global neuropsychological impairment, as reflected by the composite score from the Brief Assessment of Cognition in Schizophrenia neuropsychological battery, deficits in schizophrenia and bipolar proband groups were no longer significant. Performance measures were moderately familial. Conclusion: Reduced target detection, but not a specific deficit in context processing, is observed across psychotic disorders. Impairments in both goal maintenance and response inhibition appear to contribute comparably to deficits in schizophrenia and schizoaffective disorder, whereas greater difficulty with response inhibition underlies deficits in bipolar disorder. Yet, these deficits are not independent from the generalized neurocognitive impairment observed in schizophrenia and psychotic bipolar disorder.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/fisiopatologia
Transtorno Bipolar/fisiopatologia
Disfunção Cognitiva/fisiopatologia
Função Executiva/fisiologia
Inibição (Psicologia)
Transtornos Psicóticos/fisiopatologia
Esquizofrenia/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Transtornos Psicóticos Afetivos/complicações
Transtorno Bipolar/complicações
Disfunção Cognitiva/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos Psicóticos/complicações
Esquizofrenia/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1093/schbul/sbw081


  9 / 2183 MEDLINE  
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[PMID]:27260655
[Au] Autor:Bouwkamp CG; Kievit AJ; Olgiati S; Breedveld GJ; Coesmans M; Bonifati V; Kushner SA
[Ad] Endereço:Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.
[Ti] Título:A balanced translocation disrupting BCL2L10 and PNLDC1 segregates with affective psychosis.
[So] Source:Am J Med Genet B Neuropsychiatr Genet;174(3):214-219, 2017 Apr.
[Is] ISSN:1552-485X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Affective psychoses are a group of severe psychiatric disorders, including schizoaffective disorder and bipolar I disorder, together affecting ∼1% of the population. Despite their high heritability, the molecular genetics and neurobiology of affective psychosis remain largely elusive. Here, we describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder or schizoaffective disorder, bipolar type. A balanced translocation involving chromosomes 6 and 15 was detected by karyotyping and fluorescence in-situ hybridization (FISH). Using whole-genome sequencing, we rapidly delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/genética
Proteínas Proto-Oncogênicas c-bcl-2/genética
[Mh] Termos MeSH secundário: Adulto
Transtorno Bipolar/genética
Cromossomos Humanos Par 15/genética
Cromossomos Humanos Par 6/genética
Citogenética/métodos
Exorribonucleases
Feminino
Seres Humanos
Hibridização in Situ Fluorescente
Cariotipagem
Masculino
Linhagem
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Transtornos Psicóticos/genética
Esquizofrenia/genética
Análise de Sequência de DNA
Translocação Genética/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BCL2-like 10 protein); 0 (Proto-Oncogene Proteins c-bcl-2); EC 3.1.- (Exoribonucleases); EC 3.1.13.4 (poly(A)-specific ribonuclease)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.b.32465


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[PMID]:27998263
[Au] Autor:Okewole AO; Ogunwale A; Mosanya TJ; Ojo BM
[Ad] Endereço:a Neuropsychiatric Hospital , Aro Abeokuta, Nigeria.
[Ti] Título:A 12 year chart review of childhood and adolescent onset psychosis at a Nigerian tertiary mental health facility.
[So] Source:J Child Adolesc Ment Health;28(3):189-197, 2016 Oct.
[Is] ISSN:1728-0591
[Cp] País de publicação:South Africa
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To review the profile of children and adolescents presenting with psychosis at a specialist mental health facility, and to compare childhood with adolescent onset psychosis. METHOD: Hospital records of all children and adolescents over a 12-year period (1999-2010) were perused to identify those falling under the categories of psychotic disorders. Clinical, socio-demographic, obstetric, and developmental information was extracted. RESULTS: Mean age of the children ((n = 409)) was 15.9 years, with 8.1% aged 12 years or less. The most frequent diagnoses were schizophrenia (40.8%), brief psychotic disorder (25.9%), mood disorder with psychosis (15.2%), and organic psychosis (7.8%). Family history of mental illness was reported among 22.5%. Subjects with childhood onset were significantly less likely than those with adolescent onset to have a family history of mental illness (p = 0.016), more likely to report maternal illness during pregnancy (p = 0.005) and illness during infancy (p = 0.010), and more likely to have a diagnosis of psychotic disorder due to another general medical condition (p < 0.001). CONCLUSION: The study suggests that antenatal/obstetric factors and illness during infancy may be particularly relevant in psychosis of childhood onset. Family history of mental illness may however be of greater relevance in adolescent onset psychosis.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/epidemiologia
Transtornos Neurocognitivos/epidemiologia
Transtornos Psicóticos/epidemiologia
Esquizofrenia/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Idade de Início
Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia
Transtorno do Espectro Autista/epidemiologia
Criança
Pré-Escolar
Comorbidade
Enurese/epidemiologia
Epilepsia/epidemiologia
Feminino
Hospitais Psiquiátricos
Seres Humanos
Masculino
Nigéria/epidemiologia
Gravidez
Complicações na Gravidez/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Centros de Atenção Terciária
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.2989/17280583.2016.1245194



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